Gingival Patents (Class 514/902)
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Patent number: 5939047Abstract: Compositions and methods for treating periodontal disease and other related disorders utilizing a therapeutic treatment composition, including at lease one chemotherapeutic agent in combination with at least one carrier agent, are disclosed. Oral care products and a method preventing periodontal disease and related disorders are also provided.Type: GrantFiled: April 16, 1996Date of Patent: August 17, 1999Inventor: Gary R. Jernberg
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Patent number: 5939050Abstract: Antimicrobial compositions comprising at least two antimicrobial agents exhibit reduced MIC values relative to the MIC for the agents making up the combination when measured alone. The compositions are useful as therapeutic agents such as in oral hygiene products.Type: GrantFiled: April 4, 1997Date of Patent: August 17, 1999Assignee: Optiva Corp.Inventors: Lokanathan M. Iyer, James R. Scott, Douglas F. Whitfield
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Patent number: 5914099Abstract: Alendronate, a bisphosphonate can prevent tooth loss not necessarily associated with periodontal disease. Preferably, alendronate (or a pharmaceutically acceptable salt thereof) is given daily for an extended period of time.Type: GrantFiled: November 4, 1997Date of Patent: June 22, 1999Assignee: Merck & Co., Inc.Inventors: Ashley John Yates, David B. Karpf
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Patent number: 5904928Abstract: The invention relates to an anti-tartar composition comprising:(a) 0.5 to 5% by weight of at least one compound selected from among zirconium silicate and hydrated silica;(b) 0.5 to 5% by weight of at least one compound selected from among chlorhexidine digluconate and zinc digluconate;(c) 0.5 to 5% by weight of at least one compound selected from among potassium thiocyanate, glucose oxidase, lysozyme, and lactoperoxidase; and(d) 1 to 5% by weight of at least one acid compound selected from among vitamin C and citric acid.It also concerns the use thereof in combination with food supplements or chewable supports for animals as well as the food supplements and chewable articles thus obtained.The invention applies, in particular, to the control of the formation of tartar in domestic animals such as dogs.Type: GrantFiled: April 18, 1997Date of Patent: May 18, 1999Assignee: Societe a Responsabilite LimiteeInventors: Jean-Paul Cyr, Jean-Marc Denoun
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Patent number: 5849266Abstract: The invention relates to an oral composition for the treatment and prevention of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.Type: GrantFiled: April 4, 1995Date of Patent: December 15, 1998Assignee: Perio Products Ltd.Inventor: Michael Friedman
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Patent number: 5834427Abstract: The present invention relates to a purified casein phosphopeptide(CPP) having a novel amino acid sequence and a purified casein including same wherein the 25th Arg from N-terminal in a conventional CPP is replaced by Cys, rendering the CPPs to forming a dimer by disulfide bond. In the corresponding DNA sequence, cytosine is replaced by thymine to cause the amino acid replacement from Arginine(Arg) to Cysteine(Cys). The CPP or the casein containing same has an improved ability of solubilizing minerals and absorbing thereof in animals. The CPP or the beta-casein H containing same can be added to foodstuffs, beverages, medication, cosmetics, feed in an effective amount of enhancing a mineral absorption in animals. An oral composition comprising the beta-casein H or the inventive CPP and a pharmaceutically acceptable carrier can reduce or relieve a dentinal hypersensitivity.Type: GrantFiled: March 25, 1996Date of Patent: November 10, 1998Assignee: Sang Kee HanInventors: Sang Kee Han, Yoo Cheol Shin
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Patent number: 5830915Abstract: The invention provides compounds which are useful as inhibitors of matrix metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are described in the claims, a stereoisomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester acyloxyamide, imide or derivative thereof.Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by matrix metalloprotease activity using these compounds or the pharmaceutical compositions containing them.Type: GrantFiled: August 26, 1997Date of Patent: November 3, 1998Assignee: The Procter & Gamble CompanyInventors: Stanislaw Pikul, Kelly Lynn McDow-Dunham, Biswanath De, Yetunde Olabisi Taiwo
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Patent number: 5783201Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.Type: GrantFiled: April 3, 1997Date of Patent: July 21, 1998Assignee: Hemogen, Inc.Inventors: Richard D. Levere, Nadar G. Abraham, Michal L. Schwartzman, Michael W. Dunn
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Patent number: 5759544Abstract: An oral composition comprises an effective amount of an antibody obtained by immunizing an animal with an antigen comprised of at least one polysaccharide derived from the surface layer of periodontal disease associated bacteria. The at least one polysaccharide may be conjugated with polypeptides to further enhance the efficacy.Type: GrantFiled: July 5, 1995Date of Patent: June 2, 1998Assignee: Lion CorporationInventor: Yoshihiro Harada
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Patent number: 5709873Abstract: The use of a sulphated saccharide or a salt or a complex thereof as an ingredient in a topical preparation for the prophylaxis or treatment of diseases or conditions of the tooth or tooth-supporting tissue, in particular for the prophylaxis or treatment of inflammatory and plaque-related conditions, a method of preventing or treating such diseases or conditions by topically applying the sulphated saccharide or salt or complex thereof, and a topical preparation containing the sulphated saccharide or salt or complex thereof for the prophylaxis or treatment of such diseases or conditions. The sulphated saccharide is especially a polysulphated or persulphated saccharide, e.g. sucralfate (sucrose octakis(hydrogen sulphate) aluminum complex) or a sodium and/or potassium salt of sucrose octakis(hydrogen sulphate). The preparation may be in the form of a solution, suspension, salve, paste, powder, gel, cream, dental fixative, periodontal implant, chewing gum, chewable tablet, effervescent tablet or lozenge.Type: GrantFiled: June 5, 1995Date of Patent: January 20, 1998Assignee: Niels Bukh A/SInventors: Daniel Bar-Shalom, Niels Bukh, Jesper Hamburger
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Patent number: 5665374Abstract: The present invention relates to unique interdental delivery devices, other than dental floss, which are suitable for cleaning, massaging, and/or treating surfaces of teeth and gums including interproximal and subgingival areas; wherein these devices contain ULTRAMULSION.TM. dispersions of high viscosity silicones dispersed in surfactants, these dispersions are released into the oral cavity from these devices during use wherein the dispersed silicone:a. is insoluble in the surfactant and oriented so as to form coatings in the oral cavity with enhanced substantivity,b. functions as a reservoir for various lipid soluble and/or liquid dispersible ingredients to be released onto oral cavity surfaces, andc. has a particle size from between about 0.1 and about 10 microns with from between about 80% and about 95% of the particles within this range.Type: GrantFiled: June 5, 1995Date of Patent: September 9, 1997Assignee: WhiteHill Oral Technologies, Inc.Inventors: Ira D. Hill, Peter P. Walters, Dale G. Brown
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Patent number: 5656593Abstract: Disclosed are methods and compositions for inducing periodontal tissue morphogenesis in a mammal which include a therapeutically effective concentration of a morphogen. The methods and compositions are useful for integrating an implanted tooth in a tooth socket and for inhibiting tissue loss associated with periodontal disease or injury.Type: GrantFiled: November 15, 1993Date of Patent: August 12, 1997Assignee: Creative BioMolecules, Inc.Inventors: Thangavel Kuberasampath, David C. Rueger, Hermann Oppermann, Charles M. Cohen, Roy H. L. Pang
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Patent number: 5648399Abstract: The invention relates to methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.Type: GrantFiled: April 25, 1995Date of Patent: July 15, 1997Assignees: Perio Products, Ltd., Yissum Research Development Company of the Hebrew University of JerusalemInventors: Michael Friedman, Amnon Sintov
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Patent number: 5646174Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.Type: GrantFiled: July 18, 1995Date of Patent: July 8, 1997Inventors: Gary Robert Kelm, Harvey Marvin Pickrum, Matthew Joseph Doyle, William Buchanan
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Patent number: 5626838Abstract: The present invention provides novel methods for prevention or treatment of primary and recurring squamous cell carcinoma of the oral cavity or oropharynx comprising topical administration, to the oral cavity or oropharynx, of an effective amount of an NSAID, especially a composition administering from about 0.001% to about 0.2% ketorolac to the oral cavity, alone or as an adjunct to surgery and/or radiation therapy.Type: GrantFiled: March 13, 1995Date of Patent: May 6, 1997Assignee: The Procter & Gamble CompanyInventor: Paul F. Cavanaugh, Jr.
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Patent number: 5622940Abstract: Methods of treating or preventing infection-induced oral tissue destruction or gingivitis in a mammal, comprising administering a therapeutically effective amount of a .beta.(1,3)-glucan, such as poly-.beta.(1-6)-glucotriosyl-.beta.(1-3)-glucopyranose glucan (PGG-glucan), are disclosed.Type: GrantFiled: July 14, 1994Date of Patent: April 22, 1997Assignee: Alpha-Beta TechnologyInventor: Gary R. Ostroff
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Patent number: 5540913Abstract: The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. Additionally, a method for prophylaxis and treatment of oral lesions incident the use of chemotherapeutic agents is included in the present invention.Type: GrantFiled: April 26, 1994Date of Patent: July 30, 1996Inventor: Robert E. Turner
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Patent number: 5512278Abstract: An ointment base useful for preparing topically applied medicament formulations. The base can be provided in the form of a stable emulsion including paraffin(s), polyol, beeswax, cetostearyl alcohol, a 4-hydroxy benzoic acid lower alkyl ester, a surface active agent and a dispersing agent. The base can be combined with large volumes containing a variety of medicaments to form stable, useful formulations.Type: GrantFiled: January 11, 1994Date of Patent: April 30, 1996Assignee: PhyloMed CorporationInventor: David D. Mundschenk
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Patent number: 5510122Abstract: The preparation of a saliva composition substantially viable for therapeutic use in saliva-deficient individuals involves exogenously treating saliva to inactivate microorganisms by contacting with chlorhexidine or ionizing radiation. Pharmaceutically active agents may be added to the saliva composition.Type: GrantFiled: September 28, 1994Date of Patent: April 23, 1996Assignee: The Research Foundation of State University of New YorkInventors: Leo M. Sreebny, Steven S. Schwartz, Allen G. Meek
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Patent number: 5500228Abstract: Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer of preferably, the dry microparticles and dispersed into the periodontal pocket whereby upon contact with the moist environment of the pocket, they hydrate, become tacky and adhere to one another and to the tissues surrounding the pocket so as to maintain intimate contact with the involved tissue so as to induce long term therapeutic benefits.Type: GrantFiled: November 26, 1990Date of Patent: March 19, 1996Assignee: American Cyanamid CompanyInventors: James R. Lawter, Michael G. Lanzilotti
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Patent number: 5500448Abstract: The present invention relates to the use of Triclosan in the manufacture of a composition for the prevention, inhibition and/or reduction of aphthous ulcers. Preferably, the compositions are oral compostions such as toothpastes and mouthwashes. The oral composition is especially preferably in a gel form. Preferably the Triclosan is used together with a zinc salt such as zinc citrate, and or a polymer that enhances the delivery of the Triclosan.Type: GrantFiled: May 12, 1994Date of Patent: March 19, 1996Assignee: Chesebrough-Pond's USA Co., Division of Conopoco, Inc.Inventors: Diane Cummins, Franciscus J. Van Der Ouderaa, Michael D. Traudt
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Patent number: 5464609Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.Type: GrantFiled: July 25, 1994Date of Patent: November 7, 1995Assignee: The Procter & Gamble CompanyInventors: Gary R. Kelm, Harvey M. Pickrum, Matthew J. Doyle, William Buchanan
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Patent number: 5462728Abstract: Composition for the treatment of gingivitis and other afflictions of the oral cavity, as well as for the reduction of dental plaque. These are in the form of gels, solutions or similar forms which comprise a therapeutically active agent in a polymeric carrier which contains a solvent. The nature of the preparation is such that when these are applied to an aqueous environment of the oral cavity, the polymer and the active agent precipitate and form a coating.Type: GrantFiled: April 5, 1994Date of Patent: October 31, 1995Inventors: Izhak Blank, Alon Blank
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Patent number: 5460802Abstract: The present invention is generally related to an oral disinfectant for companion animals. A preferred disinfectant is a concentrated composition containing a fatty acid monoester, one or more fatty acids, an acid or chelating agent, a polyalcohol, a surfactant and water. When used the concentrate is diluted with water and then applied to the teeth and oral cavity tissues of the animal.Type: GrantFiled: July 18, 1994Date of Patent: October 24, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Takao Asami, Manabu Takhashi, Jeffrey F. Andrews, Thomas E. Boettcher
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Patent number: 5447725Abstract: Methods for aiding periodontal tissue regeneration with compositions containing bioresorbable polymers, leachable solvents, and bioavailable drug actives. The compositions useful for these methods are characterized by becoming harder upon contact with the periodontal tissue such that the composition is effective for aiding tissue regeneration and by releasing a therapeutically-effective amount of drug active agent.Type: GrantFiled: June 11, 1993Date of Patent: September 5, 1995Assignee: The Procter & Gamble CompanyInventors: Nalinkant C. Damani, Douglas C. Mohl, Robert E. Singer, Jr.
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Patent number: 5438076Abstract: The invention relates methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.Type: GrantFiled: January 4, 1993Date of Patent: August 1, 1995Assignee: Perio Products, Ltd.Inventors: Michael Friedman, Amnon Sintov
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Patent number: 5403577Abstract: The invention relates to an oral composition for the treatment and prevenn of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.Type: GrantFiled: June 12, 1992Date of Patent: April 4, 1995Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Michael Friedman
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Patent number: 5397694Abstract: This invention relates to a novel protease-inhibitor,--which we called GELIN--and to pharmaceutical and cosmetic preparations thereof, containing this compound. GELIN is an inhibitor of human and porcine leucocyte elastase and chymotrypsin. GELIN has specific antibiotic properties. It also relates to the novel use of EGLIN, another chymotrypsin-inhibitor in cosmetic preparations.Type: GrantFiled: October 24, 1991Date of Patent: March 14, 1995Assignee: Merck Patent GmbHInventors: Anthony Atkinson, Asgar Electricwala, Roy T. Sawyer, Nils von Sicard, Gerard Voerman
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Patent number: 5395615Abstract: A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.Type: GrantFiled: September 30, 1992Date of Patent: March 7, 1995Assignee: Vipont Pharmaceutical, Inc.Inventors: Kenneth C. Godowski, Ronald J. Harkrader, Richard L. Dunn, Arthur J. Tipton
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Patent number: 5393745Abstract: The invention disclosed relates to treating aphthae by applying dimeticone to the afflicted oral mucosa.Type: GrantFiled: March 8, 1994Date of Patent: February 28, 1995Inventors: Alfred Schmidt, Hans-Jurgen Upmeyer
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Patent number: 5380530Abstract: Disclosed are several oral hygiene preparations including plaque disrupting and gingivitis control preparations in the form of chewing gums, wherein a chewing gum is coated with a plaque disrupting emulsion containing an ingestible surfactant and a polydimethyl siloxane emulsified therein, and wherein the emulsion coating can further contain a therapeutic substance such as the gingivitis control substance stannous fluoride.Type: GrantFiled: December 29, 1992Date of Patent: January 10, 1995Assignee: WhiteHill Oral TechnologiesInventor: Ira D. Hill
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Patent number: 5378465Abstract: Described herein is an aqueous solution for application to an oral cavity generally as a mouthwash comprising an effective amount of echinacea, hydrastis canadensis, sanguinaria canadensis, quercus alba, grapefruit seed extract, aloe vera juice, water, vegetable glycerin, and peppermint oil.Type: GrantFiled: May 24, 1993Date of Patent: January 3, 1995Inventor: Victor Zeines
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Patent number: 5376374Abstract: There is disclosed a pleasant tasting oral rinse composition and a method of using the same. The composition consists essentially of cayenne pepper, calendula, echinacea, goldenseal, propolis, vinegar, and water in certain proportions.Type: GrantFiled: May 24, 1993Date of Patent: December 27, 1994Inventor: Luz M. Zelaya
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Patent number: 5364616Abstract: The subject invention relates to methods for prevention or treatment of gingivitis or periodontitis comprising topical administration, to gingival tissues of the oral cavity, of a composition comprising a safe and effective amount of a selective histamine-2 receptor antagonist compound, and oral care compositions used therefore.Type: GrantFiled: December 22, 1993Date of Patent: November 15, 1994Assignee: The Procter & Gamble CompanyInventors: Robert E. Singer, James P. Ebel
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Patent number: 5362737Abstract: A method of treating aphthous ulcers and other mucocutaneous disorders is disclosed. The method comprises contacting the mucocutaneous disorder with a composition in the form of a paste, solution, gel, quick-disintegrating tablet, mouthwash, ointment, cream, powder, adhesive patch, aerosolized spray, lozenge, troche, dentifrice, or dental floss that contains an effective amount of an active compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy, carboxyalkyl (i.e. esters), cyano, acylamino, or amino group which may be unsubstituted or substituted by up to two alkyl groups; m is 0, 1 or 2 and R.sub.2 is alkyl, alkenyl, alkoxy, halgoen, nitro, hydroxy, carboxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms, cyano, carboxyalkyl, trifluoromethyl, or amino group which may be unsubstituted or substituted by at least one alkyl; and R.sub.Type: GrantFiled: January 19, 1993Date of Patent: November 8, 1994Assignee: Chemex Pharmaceuticals, Inc.Inventors: Kakubhai R. Vora, Atul Khandwala, Charles G. Smith
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Patent number: 5330746Abstract: The invention relates to an oral composition for plaque prevention or tooth hypersensitivity comprising either an antibacterial agent or a hypersensitivity agent embedded in a sustained release carrier such as an acrylic polymer, and a method for the use of said compositions in preventing dental caries, periodontal disease, and tooth hypersensitivity.Type: GrantFiled: June 21, 1989Date of Patent: July 19, 1994Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Petro Products Ltd.Inventors: Michael M. Friedman, Amnon Sintov
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Patent number: 5314915Abstract: Bioadhesive pharmaceutical carrier consisting essentially of a polymer blend of sodium carboxymethyl cellulose and xanthan gum or sodium alginate. The invention also provides for a method of control releasing a pharmaceutical active comprising incorporating an active into the bioadhesive pharmaceutical carrier. The invention is particularly adaptable for oral use and teething gels.Type: GrantFiled: December 16, 1992Date of Patent: May 24, 1994Assignee: McNeil-PPC, Inc.Inventor: William F. Rencher
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Patent number: 5298237Abstract: The present invention provides a gel composition useful for the prevention or treatment of gingivitis, periodontal disease, and dental plaque which comprises ascorbic acid, copper sulfate, and essentially no added oxidizing agent, in concentrations sufficient for the prevention or treatment of gingivitis, periodontal disease, and dental plaque; and a gel carrier. The invention also provides a method for the prevention or treatment of gingivitis, periodontal disease, and dental plaque in the oral cavity of a subject which comprises applying for an effective period of time within the oral cavity of a subject an amount of the gel composition effective to prevent or treat gingivitis, periodontal disease, and dental plaque.Type: GrantFiled: January 24, 1992Date of Patent: March 29, 1994Assignee: The Trustees of Columbia University in the City of New YorkInventor: Daniel H. Fine
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Patent number: 5283057Abstract: The present invention relates to compositions and methods which are effective against alveolar bone resorption and enhance the ability of a tooth moved in orthodontic therapy to remain in its new position or to stay in its original position when adjacent teeth are moved.Type: GrantFiled: April 24, 1992Date of Patent: February 1, 1994Assignee: The Procter & Gamble CompanyInventor: Hisashi Shinoda
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Patent number: 5279813Abstract: An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula.Type: GrantFiled: August 18, 1992Date of Patent: January 18, 1994Assignee: Colgate-Palmolive CompanyInventors: Abdul Gaffar, Richard S. Robinson, Jeffrey Miller, Chimpiramma Potini, Michael A. Collins, Theresa G. Shackil
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Patent number: 5275804Abstract: A process for enhancing oral hygiene by reducing oral microflora and for inhibiting the formation of dental plaque by applying, to the oral cavity a composition containing (a)0.1 to 40 parts, by weight, of a higher acyl-N-betaine having the structure ##STR1## where R is a higher alkyl group of from 10 to 18 carbon atoms, or mixtures thereof, and (b) 0.Type: GrantFiled: September 25, 1992Date of Patent: January 4, 1994Assignee: E. B. Michaels Research Associates, Inc.Inventor: Edwin B. Michaels
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Patent number: 5273741Abstract: An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.Type: GrantFiled: July 30, 1992Date of Patent: December 28, 1993Assignee: Colgate-Palmolive CompanyInventors: Abdul Gaftar, Richard S. Robinson, Jeffrey Miller, Chimpiramma Potini, Michael A. Collins, Theresa G. Shackil
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Patent number: 5270032Abstract: A method for treating Candida infections of surfaces and cavities of dentures, the oral and vaginal cavities is disclosed. The method includes contacting an antifungal formulation onto the surface or cavity which is infected with the Candida fungus. The antifungal formulation includes a humectant in a concentration from about 20% to about 80%, lytic activating agents including inorganic monovalent anions and detergents. The antifungal formulation is contacted to the infected surface or cavity by suitable carrier or dispenser. The method is preferably directed towards the treatment of denture stomatitis in the oral cavity. The method preferably includes forming a replica of the denture surface using a suitable fungal growth medium to determine the location and, then, contacting the infected denture surface and surface of the oral cavity with the antifungal formulation.Type: GrantFiled: August 6, 1992Date of Patent: December 14, 1993Assignee: The Research Foundation of State University of New YorkInventors: Jerry P. Pollock, Robert Renner, Ralph P. Santarpia, III
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Patent number: 5270365Abstract: This invention claims a method for treating periodontal disease in mammals, including humans, by administering an effective amount of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or a pharmaceutically acceptable salt including the monosodium salt tridydrate (alendronate) of the formula: ##STR1## The compounds are useful in the treatment of alveolar bone loss associated with peridontitis and periodontal disease.Type: GrantFiled: December 17, 1991Date of Patent: December 14, 1993Assignee: Merck & Co., Inc.Inventors: Barry J. Gertz, Gideon A. Rodan
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Patent number: 5242910Abstract: This invention relates to compositions/devices and methods for treating diseases of the oral cavity in humans and lower animals using polylactide/glycolide compositions/devices also containing triacetin for releasing drugs in the oral cavity.Type: GrantFiled: October 13, 1992Date of Patent: September 7, 1993Assignee: The Procter & Gamble CompanyInventor: Nalinkant C. Damanj
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Patent number: 5225441Abstract: Omega-3, 20-22 carbon atom, hexa- or penta-unsaturated fatty acids are used in the treatment of periodontal disease.Type: GrantFiled: June 18, 1987Date of Patent: July 6, 1993Assignee: Block Drug Company, Inc.Inventors: Richard I. Vogel, Kuo-Chen Yeh, Frank J. Sena
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Patent number: 5202113Abstract: A purified, characterized surface protein from Bacteroides loeschei is an adhesin which is useful in inhibiting plaque formation. The adhesin is also useful in a diagnostic assay for gingivitis, a diagnostic indicator for changes in the surface components of certain human tissues, and as a binding agent to purify polysaccharides.Type: GrantFiled: April 30, 1990Date of Patent: April 13, 1993Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Jack London
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Patent number: 5192802Abstract: Bioadhesive pharmaceutical carrier consisting essentially of a polymer blend of sodium carboxymethyl cellulose and xanthan gum or sodium alginate. The invention also provides for a method of control releasing a pharmaceutical active comprising incorporating an active into the bioadhesive pharmaceutical carrier. The invention is particularly adaptable for oral use and teething gels.Type: GrantFiled: September 25, 1991Date of Patent: March 9, 1993Assignee: McNeil-PPC, Inc.Inventor: William F. Rencher
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Patent number: 5190981Abstract: A method of reducing bone loss and promoting bone regrowth, once loss has occurred, particularly alveolar bone loss associated wtih periodontal disease, and a composition useful in the method. The method comprises applying to buccal membranes a therapeutically effective quantity of at least one S enantiomer, generally an S(+) enantiomer, of a nonsteroidal anti-inflammatory drug, such as S(+) flurbiprofen or S(+) ketoprofen. The composition is a formulation which is a toothpaste or which is a mouthwash.Type: GrantFiled: May 28, 1991Date of Patent: March 2, 1993Assignee: Sepracor Inc.Inventor: William J. Wechter
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Patent number: 5188817Abstract: A method of treatment for periodontitis comprises the topical or systemic administration of a pharmaceutical composition containing at least one retinoid compound other than Vitamin A. Preferred retinoids include Vitamin A aldehyde, Vitamin A acid, Vitamin A esters, isotretinoin, etretinate and acitretin.Type: GrantFiled: August 31, 1990Date of Patent: February 23, 1993Inventor: Julius Ozick