Muscle Relaxant Patents (Class 514/906)
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Patent number: 5013726Abstract: An external analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol to relieve pain in muscles, joints, or viscera distal at the site of application by stimulating cutaneous sensory receptors and a method of making such lotion and being made from camphor and menthol crystals.Type: GrantFiled: September 12, 1989Date of Patent: May 7, 1991Inventors: Jeffery W. Ivy, Curtis E. Payne
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Patent number: 5010096Abstract: The use of a compound of formula (I) or a physiologically acceptable salt or hydrate thereof in the treatment, relief or prevention of the effects of cerebral ischaemia ##STR1## Compounds of formula (I) are described in UK Published Patent Application No. 2157691A.The compounds of formula (I) have been found to protect mammals, including man, against neuronal damage resulting from cerebral ischaemia.The preferred compound for use in this indication is (.+-.)-trans-5-fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]-benzodioxino[2,3-c]- pyrrole (formula (I), R=H, R.sup.1 =F, R.sup.2 =H), especially in the form of its hydrochloride salt.Type: GrantFiled: November 30, 1989Date of Patent: April 23, 1991Assignee: Glaxo Group LimitedInventors: Ann G. Hayes, Phillip J. Birch
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Patent number: 4988716Abstract: Novel compounds and compositions which inhibit SRS-A in mammals are disclosed. Methods for preparing said compounds and compositions and methods for their use for treating allergic reactions, inflammation and for reducing the severity of myocardial infarction resulting from heart attack are disclosed.Useful intermediates for preparing said compounds are also disclosed.Type: GrantFiled: July 28, 1987Date of Patent: January 29, 1991Assignee: Schering CorporationInventors: Anil K. Saksena, Jesse K. Wong, Pietro Mangiaracina
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Patent number: 4961933Abstract: The invention features a medicament for simple relief of aches and pains. An aqueous solution of cayenne, alcohol and copper oxide in solution is applied to affected, aching joints and muscles by topical application. After drying, the solution imparts a soothing warmth and heating to the pained areas.Type: GrantFiled: December 14, 1987Date of Patent: October 9, 1990Inventor: Longino S. Campos Pino
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Patent number: 4948800Abstract: Imidazoheterocyclic compounds having the formula: ##STR1## wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, diloweralkylamino or nitro; Ar is phenyl, pyrido, thienyl or furanyl; and W forms a wide combination of groups with B, including acids, esters, alcohols, amides and ketones. The compounds have CNS activity in a method for treating a living animal body as muscle relaxants, anticonvulsants and antianxiety agents.Type: GrantFiled: June 30, 1989Date of Patent: August 14, 1990Assignee: A. H. Robins Company, IncorporatedInventors: Bruce E. Tomczuk, Deborah S. Sutherland
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Patent number: 4912116Abstract: A method for the treatment of pollakiurea in a subject in need thereof, comprising the step of administering to said subject an effective antipollakiurea amount of a propiophenone of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each independently represents hydrogen, halogen, lower alkyl- or halogeno-lower-alkyl, lower-alkoxy, or cycloalkyl having 3-8 carbon atoms, two of which R.sub.1, R.sub.2, and R.sub.3 groups may combine to form methylenedioxy or ethyleneoxy, R.sub.4 represents hydrogen or a lower-alkyl, and A represents pyrrolidinyl-, piperidinyl-, morpholinyl-, or azepinyl or a pharmaceutically-acceptable acid addition salt thereof, is disclosed.Type: GrantFiled: December 22, 1987Date of Patent: March 27, 1990Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itoh, Hideo Kato, Eiichi Koshinaka, Kouji Morikawa, Toshie Yamauchi
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Patent number: 4873251Abstract: Imidazoheterocyclic compounds having the formula: ##STR1## wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, di-loweralkylamino or nitro; Ar is phenyl, pyrido, thienyl or furanyl; and W forms a wide combination of groups with B, including acids, esters, alcohols, amides and ketones. The compounds have CNS activity in a method for treating a living animal body as muscle relaxants, anticonvulsants and antianxiety agents.Type: GrantFiled: July 5, 1988Date of Patent: October 10, 1989Assignee: A. H. Robins Company, IncorporatedInventors: Bruce E. Tomczuk, Deborah S. Sutherland
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Patent number: 4820818Abstract: The muscle relaxant (E)-3-(9-chloro-5,6-dihydro-11H-pyrrolo[2,1-b][3]benzazepin-11-ylidene-N,N -dimethyl-1-propanamine is prepared by the geometric stereoselective dehydration of the intermediate carbinol with acidic agents and organic bases and low temperatures.Type: GrantFiled: May 2, 1988Date of Patent: April 11, 1989Assignee: Merck & Co., Inc.Inventors: Ruth V. Wattley, Gerard R. Kieczykowski
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Patent number: 4764617Abstract: A novel quinaldinamide derivative having the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents a lower alkyl group or R.sup.1 and R.sup.2 are combined together with the adjacent nitrogen atom to form a 5-7 membered ring; and X represents the hydrogen atom, a lower alkyl group or a lower alkoxy group, and its acid-addition salt, which show prominent central muscle relaxant effect, namely rigidity relieving effect on anemic decerebrated rigidity.Type: GrantFiled: August 13, 1986Date of Patent: August 16, 1988Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mitsuo Masaki, Haruhiko Shinozaki, Masaru Satoh, Naoya Moritoh, Koichi Hashimoto, Toshiro Kamishiro
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Patent number: 4758594Abstract: Novel compounds and compositions which inhibit SRS-A in mammals are disclosed. Methods for preparing said compounds and compositions and methods for their use for treating allergic reactions, inflammation and for reducing the severity of myocardial infarction resulting from heart attack are disclosed.Useful intermediates for preparing said compounds are also disclosed.Type: GrantFiled: May 19, 1986Date of Patent: July 19, 1988Assignee: Schering CorporationInventors: Anil K. Saksena, Jesse K. Wong, Pietro Mangiaracina
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Patent number: 4755384Abstract: The invention relates to a process for preparing antispasmatic products which are to be attached to the skin. One or more kinds of metal or metallic substances and/or deficiency and/or trace elements and in a given case the active ingredients of some known pharmaceutical agent is applied to a carrier. The deficiency and/or trace element and in a given case the active ingredient of the known pharmaceutical agent medicament, which are present, are applied in form of a powder, a liquid or in gaseous form. The powdered, liquid and gaseous substances are placed into a recipient, e.g. bag with a permeable wall onto the carrier. Preferably, adhesive strips are provided on the margins of the carrier, while the substances on the carrier are covered with a removable protective layer. If required, the carrier is pretreated with a weak base or acid prior to the application thereof.Type: GrantFiled: March 15, 1984Date of Patent: July 5, 1988Assignee: Kozponti Valto- es Hitelbank RT, Innovacious AlapInventor: Otto Mallasz
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Patent number: 4737519Abstract: The present invention provides certain novel substituted naphthalenes, indoles, benzofurans, and benzothiophenes of Formula I which are useful as inhibitors of leukotriene biosynthesis and as inhibitors of lipoxygenase. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.Type: GrantFiled: June 25, 1986Date of Patent: April 12, 1988Assignee: The Upjohn CompanyInventors: Ayako Yamashita, Herbert G. Johnson
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Patent number: 4725442Abstract: Microdroplets of water-insoluble drugs coated with a phospholipid are prepared by sonication. As an example, microdroplets of the general anesthetic methoxyfluorane coated by a unimolecular layer of dimysistoyl phosphatidylcholine are prepared by sonication. The microdroplets so prepared remain stable in physiologically-compatible solution, and are suitable for injection, typically intradermally or intraveneously, into a patient for inducing local anesthesia. These methoxyflurane-containing microdroplets have been demonstrated to cause long-term local anesthesia when injected intradermally, giving duration of anesthesia 28 times longer than with other anesthetics, such as lidocaine and 11 times longer than with bupivacaine. The latter is considered longest acting conventional local anesthetic.Type: GrantFiled: April 22, 1986Date of Patent: February 16, 1988Inventor: Duncan H. Haynes
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Patent number: 4707480Abstract: A method for inhibiting unplanned or premature detrusor muscle contractions while at the same time increasing the force of contraction of the detrusor muscle is provided. The method comprises administering to the patient a di-N-substituted aminoethyl ester of diphenylthioacetic acid having the formula: ##STR1## in which R represents a disubstituted amino radical of the group consisting of the diethylamino group, the morpholino group or the piperidino group.Type: GrantFiled: October 3, 1985Date of Patent: November 17, 1987Assignee: United Pharmaceuticals, Inc.Inventor: William M. Davis
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Patent number: 4702916Abstract: An analgesic stick composition comprising(i) a delivery system comprising about 10 to about 65% by weight alcohol; about 6 to about 10% by weight of an alkali metal salt of a saturated fatty acid gelling agent having from about C.sub.8 to about C.sub.22 ; about 10 to about 30% water; and(ii) an analgesic compound selected from the group consisting of oleoresin capsicum, capsicum, capsaicin, camphor, allyl isothiocyanate, methyl nicotinate, menthol and mixtures thereof.Type: GrantFiled: December 3, 1985Date of Patent: October 27, 1987Assignee: Warner-Lambert CompanyInventor: Navin Geria
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Patent number: 4628056Abstract: There are disclosed novel oxopyrimidine derivatives of the general formula ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and are each hydrogen or lower alkyl optionally substituted by lower alkoxy, and R.sub.3 and R.sub.4 may be the same or different and are each phenyl optionally substituted by lower alkyl or halogen, provided that when R.sub.1 and R.sub.2 are both hydrogen, R.sub.3 and R.sub.4 are each substituted phenyl. Pharmaceutical compositions containing these compounds and their use as anticonvulsant, antianxiety and muscle relaxant agents are described.Type: GrantFiled: September 5, 1984Date of Patent: December 9, 1986Assignee: Taro Pharmaceutical Industries Ltd.Inventors: Barrie Levitt, Morris Stolar
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Patent number: 4626538Abstract: Novel [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines useful as anxiolytic, antiepileptic and sedative-hypnotic agents as well as skeletal muscle relaxants, methods of using these compounds, compositions of matter containing them and processes for their production.Type: GrantFiled: May 13, 1985Date of Patent: December 2, 1986Assignee: American Cyanamid CompanyInventors: John P. Dusza, Andrew S. Tomcufcik, Jay D. Albright
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Patent number: 4549988Abstract: There is presented 3H-2-benzazepines and 4,5-dihydro-3H-2-benzazepines of the formula ##STR1## wherein X is hydrogen, chloro or bromo, Y is hydrogen, fluoro or chloro with the proviso that X and Y cannot both be hydrogen and R.sub.1 is selected from the group consisting of hydrogen, bromo, chloro, iodo, a radical of the formula ##STR2## and a radical of the formula ##STR3## wherein R.sub.2 is hydrogen, phthalimido, lower alkyl, hydroxy, amino, monoalkylamino and dialkylamino and R.sub.3 is hydroxy, phthalimido or amino with the proviso that where R.sub.1 is other than hydrogen then the bonding at the 4,5-position is unsaturated,and the pharmaceutically acceptable salts thereof.Type: GrantFiled: June 29, 1983Date of Patent: October 29, 1985Assignee: Hoffmann-La Roche Inc.Inventors: Rodney I. Fryer, Eugene J. Trybulski, Armin Walser
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Patent number: 4537772Abstract: Acylcarnitines used as drug absorption enhancing agents for orally and rectally administered drugs.Type: GrantFiled: May 2, 1984Date of Patent: August 27, 1985Assignee: Merck & Co., Inc.Inventors: Jose Alexander, Joseph A. Fix
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Patent number: 4534974Abstract: Compositions for the relief of pain, muscle spasm and limited mobility associated with acute painful muscoloskeletal conditions are disclosed. Such compositions comprise in combination, a N-monosubstituted-2, 2-dialkyl-1, 3-propanediol dicarbamate, aspirin and codeine.Type: GrantFiled: July 31, 1984Date of Patent: August 13, 1985Assignee: Carter-Wallace, Inc.Inventor: Miwon S. Kim
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Patent number: 4521422Abstract: Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones which are new compounds active as anxiolytic, anticonvulsant, sedative-hypnotic and skeletal muscle relaxant agents in mammals and the novel process of making these compounds.Type: GrantFiled: May 24, 1984Date of Patent: June 4, 1985Assignee: American Cyanamid CompanyInventors: John P. Dusza, Andrew S. Tomcufcik, Jay D. Albright