Publication number: 20030220249
Abstract: The application is related to the field of nucleic acids with identified utility, and more particularly, to genes, related nucleic acids, their complements, polypeptides, and methods of using the same for blood vessel, cartilage, and bone formation, as well as inhibition thereof. The application describes discoveries made using the zebrafish embryo technique, as well as other techniques that are described herein. The discoveries include genes, related nucleic acids, and their complements, as well as sequences, polypeptides, other molecules, and methods for using them, e.g., TDE1, PTV, MOESIN, and HKE4. Also described are polypeptide products, inhibition of expression, administration of materials and products, screening procedures, and techniques for making drugs. Moreover, uses of these discoveries in appropriate contexts are set forth.
Type:
Application
Filed:
February 7, 2003
Publication date:
November 27, 2003
Inventors:
Perry B. Hackett, Aidas Nasevicius, Shannon Wadman, Jeffrey Essner, Jon Larson, Karl J. Clark, Sharon Roberg-Perez, Stephen C. Ekker
Publication number: 20030130186
Abstract: This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HSA) derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.
Type:
Application
Filed:
July 22, 2002
Publication date:
July 10, 2003
Inventors:
Chandra Vargeese, Jasenka Matulic-Adamic, Alexander Karpeisky, Leonid Beigelman, Lawrence Blatt, Shawn Zinnen