Abstract: A compound of the formula ##STR1## wherein X.sup.1 is a free or an esterified carboxyl group, or a group of the formula: ##STR2## (R.sup.a and R.sup.b are each independently a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group, a benzyl group, a phenyl group, a phenyl group substituted with a halogen atom or a C.sub.1 -C.sub.4 alkyl group, or, when taken together with the adjacent nitrogen atom to which they are attached, they represent a 5 to 7 membered saturated heterocyclic group), Y is a group of the formula: ##STR3## (R.sup.6 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group) or ##STR4## (R.sup.6 is as defined above), R.sup.1 is a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R.sup.2 is a hydrogen atom or R.sup.1 and R.sup.2, when taken together, mean a single linkage to form a double bond between the carbon atoms which they are linked, R.sup.3 is a hydroxyl group or a protected hydroxyl group, R.sup.4 is a hydrogen atom or a C.sub.1 -C.sub.
Abstract: There are described a new pharmaceutically active derivative of ursolic acid, 3.beta.-(3-carboxypropionyloxy)ursa-9(11),12-dien-28-oic acid, which possesses activity as an anti-ulcer and anti-viral agent, pharmaceutically acceptable, non-toxic salts thereof, a method of preparing the same and compositions containing the same.
Type:
Grant
Filed:
July 25, 1983
Date of Patent:
July 23, 1985
Assignee:
I.S.F. Spa
Inventors:
Gaetano Clavenna, Carlo Farina, Mario Pinza, Giorgio Pifferi
Abstract: Biologically active 8-aza-13-thiaprostanoids having the formula: ##STR1## wherein A is CH.dbd.CH (cis or trans), C.tbd.C, CH.sub.2 CH.sub.2, ##STR2## or CHOHCH.sub.2 ; R is H, C.sub.1 to C.sub.12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation;R.sup.1 is H, CH.sub.3 or C.sub.2 H.sub.5 ;R.sup.2 is CH.sub.3 or CF.sub.3 ; andn is an integer from 4 to 9.
Abstract: New furan derivatives and the addition salts thereof having the formula: ##STR1## where R is a straight or branched alkylene chain having 1 to 6 carbon atoms, the processes for the preparation of said derivatives and the salts thereof and the pharmaceutical compositions containing them. These furan derivatives and the addition salts thereof are applicable for the treatment of gastroduodenal ulcer and all syndromes sustained or accompanied by acid secretion.