Dispersion Or Emulsion Patents (Class 514/937)
  • Patent number: 9017650
    Abstract: Aminofunctional silicone emulsions are prepared by forming a mixture of A) 100 parts of a polydialkylsiloxane Having a viscosity of at least 50,000 mm/s at 23° C., and B) 0.1 to 100 parts of an aminofunctional organopolysiloxane, admixing C) 0.1 to 50 parts of a halide free quaternary ammonium surfactant containing at least 10 carbon atoms, and a sufficient amount of water to form an emulsion.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: April 28, 2015
    Assignee: Dow Corning Corporation
    Inventors: Thomas Daniel Bekemeier, Anne-Lise Girboux, Marie-Agnes Leboucher, Scott B. Poplawski
  • Patent number: 9017704
    Abstract: The present invention provides a cosmetic composition comprising, in a cosmetically acceptable organic liquid medium, at least one film-forming ethylenic linear block polymer, and another film former. The film former may be soluble or dispersible in the said organic liquid medium. The composition may include an aqueous phase, in which case the film former may be soluble or dispersible in the aqueous phase. The invention further provides for the use of the combination of such a block polymer and a film former for enhancing the staying power of the said composition on the keratin materials.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: April 28, 2015
    Assignee: L'Oreal
    Inventors: Xavier Blin, Valerie De La Poterie, Veronique Ferrari
  • Patent number: 8992961
    Abstract: This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10?7 reciprocal second.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: March 31, 2015
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: Stephen A. Berry, Pamela J. Fereira, Houdin Dehnad, Anna Muchnik
  • Patent number: 8974804
    Abstract: Composition for topical application in the form of an oil-in-water emulsion containing an oily phase dispersed in an aqueous phase, and a hydrophilic polymer, the composition further containing (1) at least one elastomeric organopolysiloxane and (2) at least one lipophilic compound chosen from lipophilic amino acid compounds and lipophilic salicylic acid compounds. Uses thereof, including topical application to the skin, lips, hair, etc. Stabilization of certain emulsions using a lipophilic compound.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 10, 2015
    Assignee: L'Oreal
    Inventors: Christine Noel, Anne-France Livernette
  • Patent number: 8962000
    Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: February 24, 2015
    Assignee: Stiefel West Coast LLC
    Inventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Viyayakumar, Phoebe Sun
  • Patent number: 8889189
    Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: November 18, 2014
    Assignee: Phares Pharmaceutical Research, N.V.
    Inventors: Steve Leigh, Mathew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
  • Patent number: 8865021
    Abstract: The present invention relates to compositions containing at least one cationic peptide active agent, at least one neutral structure forming amphiphile, at least one anionic structure forming amphiphile and optionally at least one solvent wherein the composition is in the form of a non-lamellar phase structure and/or forms a nonlamellar phase structure on exposure to body fluids. The invention also relates to methods for protecting peptides from enzymic degredation in vivo and to compositions in which the peptide active agent is so protected.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: October 21, 2014
    Assignee: Camurus AB
    Inventors: Fredrik Joabsson, Fredrik Tiberg
  • Patent number: 8852629
    Abstract: Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: October 7, 2014
    Assignee: Valeant Pharmaceuticals International, Inc.
    Inventors: Ronald Erwin Boch, Dev Mitra Ranji Singh, Iman Karmadi
  • Patent number: 8834919
    Abstract: The present invention provides lipid emulsions and methods of intravenously administering lipid emulsions to treat systemic toxicity caused by foreign lipophilic and amphiphilic substances. In particular, methods are provided to treat cardiovascular impairment, such as cardiotoxicity, asystole and ischemia of the brain and heart, and neurological impairments, such as seizures and comas, caused by foreign lipophilic and amphiphilic substances, including cardiovascular impairment caused by local anesthetics, tricyclic antidepressants, sodium channel blockers, and calcium channel blockers.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: September 16, 2014
    Inventors: Guy Weinberg, Paul Hertz
  • Patent number: 8791145
    Abstract: The present invention provides a formulation comprising a pesticide and/or a plant growth regulator; an acyl morpholine of the formula (I) where R is H, CH3 or C2H5; and a polar aprotic co-solvent different from an acyl morpholine of formula (I). The formulation can be used in treatment of plants, and is especially well suited for use as a soluble liquid formulation.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: July 29, 2014
    Assignee: Akzo Nobel Chemicals International B.V.
    Inventor: Peter Westbye
  • Patent number: 8765181
    Abstract: The present invention provides a nano-micellar preparation containing vinca alkaloids antitumor agent for intravenous injection, which cincludes a therapeutically effective amount of vinca alkaloids antitumor agent (vinblastine, vincristine, vindesine and vinorelbine), a phosphatide derivatized with polyethylene glycol, together with pharmaceutically acceptable adjuvants. The preparation is prepared by encapsulating the medicament with a nano-micelle to obtain the nano-micellar preparation containing vinca alkaloids antitumor agent for injection. The vinca alkaloids antitumor agent and the phosphatide derivatized with polyethylene glycol form a nano-micelle with a highly uniform particle size.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: July 1, 2014
    Assignee: Beijing Diacrid Medical Technology Co., Ltd
    Inventors: Wei Liang, Min'an Lou, Wei Si
  • Patent number: 8734762
    Abstract: The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: May 27, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bong Hyun Chung, Yong Taik Lim, Bang Sil Choi, Jung Hyun Han
  • Patent number: 8728518
    Abstract: The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 20, 2014
    Assignee: CSPC ZhongQi Pharmaceutical Technology (Shijiazhuang) Co., Ltd
    Inventors: Zhentao Liu, Liying Yang, Hanyu Yang, Yuqing Gao, Dongmin Shen, Wenmin Guo, Xiaolong Feng, Jia Zheng
  • Patent number: 8709454
    Abstract: At least one phytosphingosine salicylate derivative and at least one lysate of at least one microorganism of the genus Bifidobacterium. Composition, combination. Use, including cosmetic use for reinforcing the repair and regeneration capacity of an epithelium, especially an epidermis, in particular an aged epidermis.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: April 29, 2014
    Assignee: L'Oreal
    Inventors: David Amar, Bruno Bernard, Dominique Bernard, Isabelle Castiel
  • Patent number: 8703164
    Abstract: Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: April 22, 2014
    Assignee: NanoBio Corporation
    Inventors: Ted C. Annis, James R. Baker, Tarek Hamouda
  • Patent number: 8691878
    Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: April 8, 2014
    Assignee: AbbVie Inc.
    Inventors: Jeorg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
  • Patent number: 8652493
    Abstract: The present invention pertains to oil-in-water emulsion compositions having hydrophobic materials stably dispersed therein and methods for making such. The preferred method of making the emulsion compositions the formation of two O/W emulsions. A first O/W emulsion is for wetting or otherwise pre-treating the hydrophobic components. Thereafter, the first emulsion is added to a second O/W emulsion after the second emulsion has been formed. Both emulsions use a ternary surfactant blend of cationic, anionic and bridging surfactants, making the finished product a double or “binary-CAN” emulsion system. Generally, the system has a bi-modal oil droplet distribution.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: February 18, 2014
    Assignee: ELC Management, LLC
    Inventors: Monica Apostol, Liliana George, Charles Craig Tadlock, Rachel Culhane
  • Patent number: 8652443
    Abstract: Described are ethanol-free foamable microemulsions for topical application, and method of making them. The propellants used in the compositions may be environmentally-friendly hydrofluoroalkanes. The foam compositions may also comprise one or more of a variety of active ingredients, including anti-inflammatory agents, anesthetics, and keratolytic agents.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: February 18, 2014
    Assignee: Precision Dermatology, Inc.
    Inventors: Ravi K. Varanasi, Roman V. Rariy
  • Patent number: 8628626
    Abstract: A heavy oil cleaning composition comprising: a) a blend of dibasic esters comprising dialkyl methylglutarate and at least one of a dialkyl adipate or dialkyl ethylsuccinate; b) at least one terpene; and c) at least one surfactant. Also described are methods for delivering a solvent at reduced concentration comprising the steps of: a) obtaining a terpene-based solvent; and b) mixing the terpene-based solvent with a carrier fluid (the carrier fluid comprising a microemulsion of i) a blend of dibasic esters selected from the group consisting of dialkyl methylglutarate, dialkyl adipate, dialkyl ethylsuccinate, dialkyl succinate, dialkyl glutarate and any combination thereof, ii) at least one surfactant selected from the group consisting of a terpene alkoxylate, an alcohol alkoxylate and any combination thereof; and iii) water) in order to obtain a mixture to clean heavy oils.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: January 14, 2014
    Assignee: Rhodia Operations
    Inventors: David Fluck, Amit Sehgal, Satyen Trivedi, Ruela Talingting Pabalan, Charles Aymes
  • Patent number: 8618081
    Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: December 31, 2013
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Irakliy Papiashvili
  • Patent number: 8617598
    Abstract: A pharmaceutical composition comprising a macrolide solid dispersion, a disintegrant and colloidal silicon dioxide, wherein the composition comprises 1 to 5% colloidal silicon dioxide by weight.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: December 31, 2013
    Assignee: Novartis AG
    Inventors: Barbara Haeberlin, Andrea Kramer, Silvia Heuerding
  • Patent number: 8613911
    Abstract: A cosmetic composition comprising a first emulsion and a second emulsion and optionally one or more additional emulsions, each of the two or more emulsions being discretely contained within the composition and comprising an inner phase and an outer phase, each of the two or more emulsions being independently a water-in-oil emulsion, an oil-in-water emulsion, an oil-in-oil emulsion, a polyol-in-oil emulsion, a water-in-silicone emulsion, a silicone-in-water emulsion, or a polyol-in-silicone emulsion in physical contact with at least one other emulsion, at least one of the two or more emulsions being visually distinct from the others, and each of the two or more emulsions as well as the composition being independently both physically and visually stable within the composition for at least six months at ambient temperature.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: December 24, 2013
    Assignee: Avon Products, Inc
    Inventors: Faith A. Corbo, Qi Hong, Anthony D. Gonzalez
  • Patent number: 8592490
    Abstract: Self-microemulsifying drug delivery systems and microemulsions used to enhance the solubility of pharmaceutical ingredients comprising a polyoxyethylene sorbitan fatty acid ester emulsifier; a fatty acid ester co-emulsifier and an oil.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: November 26, 2013
    Assignee: LEK Pharmaceuticals D.D.
    Inventors: Igor Legen, Janez Kerc, Polona Jurkovic
  • Patent number: 8569218
    Abstract: A gelled cleaning composition is provided that includes a standard temperature and pressure (STP) liquid oil or STP malleable wax present from 0.1 to 9.9 total weight percent. An emulsifier is present from 0.01 to 10 total weight percent, along with an alkylene glycol present from 0.002 to 11 total weight percent. A microemulsion is present in the composition from 0.2 to 15 total weight percent. Water forms a majority of the composition such that the composition is monophasic for at least 4 months storage at 20° Celsius. The composition is well suited for use in a process to remove a lipophilic substance from hands or an inanimate substrate by applying the composition and after allow sufficient time for the substance to be softened or solubilized, removing the composition and at least a portion of the substance. Silicone gaskets, as well as other cured resins and paints are readily removed.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: October 29, 2013
    Assignee: Illinois Tool Works, Inc.
    Inventor: Claudia E. Britton
  • Patent number: 8563016
    Abstract: The present invention is directed to a lamellar oil-in-glycol gel comprising (a) at least one glycol, (b) at least one fatty alcohol, (c) at least one cationic surfactant and optionally (d) at least one benefit agent, said lamellar gel capable of providing enhanced mass and promoting the permeation of the benefit agent through a keratinous substrate such as the skin, hair and fingernails, providing both deep and superficial treatment thereof.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: October 22, 2013
    Assignee: ISP Investments Inc.
    Inventors: Alexandra Bazito Agarelli, Yan Zhou, Nelson Luis Perassinoto, Maria Regina Bartuccio Raponi, Ligia Vairoletto, Liliana Calore Brenner
  • Patent number: 8541359
    Abstract: Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: September 24, 2013
    Assignee: CPEX Pharmaceuticals, Inc.
    Inventors: Robert J. Gyurik, Carl Reppucci
  • Patent number: 8529921
    Abstract: Polyamide-5 compounds show an increase of the care and/or efficacy properties of cosmetic or dermatological preparations, such as waterproofness, long-term stability, skin moisture and stickiness. The preparations preferably comprise one or more care agents or active ingredients selected from the group of UV filter substances, anti-wrinkle active ingredients, skin moisturizers and/or lipids.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: September 10, 2013
    Assignee: Beiersdorf AG
    Inventors: Alexander Filbry, Rainer Kroepke, Silke Heinecke, Alexandra Blohm, Jens Nielsen
  • Patent number: 8512754
    Abstract: A composition comprising a glassified, stabilized particle preparation having a low water activity (between about 0.1 and 0.9) is provided. The preparations provide improved products with enhanced storage stability, less expensive cost of processing, and extended shelf life. The glassified, stabilized particle preparations are particularly efficacious in the preparation of perishable products, especially pharmaceutical agents, such as human blood and blood products (e.g., red blood cells). A single emulsion process comprising a 2-phase system for preserving food and pharmaceutical products is also provided. Stabilized biological products as glassified beads are also provided, as well as a method for rehydrating and/or reconstituting the glassified beads to provide useful and fully active reconstituted and/or rehydrated materials is also presented.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: August 20, 2013
    Inventor: David Needham
  • Patent number: 8475779
    Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: July 2, 2013
    Assignee: Ares Trading SA
    Inventors: James Rasmussen, Jianxin Zhang, Sam Baldwin, Eric Zanelli, Bei Yu, Dustan Bonnin, Keith Johnson
  • Patent number: 8475774
    Abstract: Aqueous compositions including a discontinuous oil phase containing an ultraviolet radiation-absorbing polymer stabilized in a continuous aqueous phase, an oil-gelling polymer, and which are substantially free of non-polymeric ultraviolet radiation-absorbers.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: July 2, 2013
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Rudy Clemente, Curtis Cole, Susan Daly
  • Patent number: 8460644
    Abstract: Drugs which are difficult to solubilize in water, and especially those which otherwise cause pain on injection, can be readily formulated and typically administered with substantially less pain when solubilized in synergistic, aqueous micellar preparations of poloxamers. Such preparations may also be prepared with less, or without, co-solvents.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: June 11, 2013
    Assignee: IS Pharmaceuticals Limited
    Inventors: John Meadows, Colum Martin Dwyer
  • Patent number: 8460641
    Abstract: An oil-in-water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, comprising: a first part including at least one occlusive agent and one or more lipophilic surfactants dispersed throughout a second part including water and at least one hydrophilic surfactant, and a non-surfactant amphiphilic type compound, pharmaceutically active ingredient, and water. It has been found that if a non-surfactant amphiphilic type compound is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: June 11, 2013
    Assignee: Stiefel Research Australia Pty Ltd
    Inventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Vijayakumar, Phoebe Sun
  • Patent number: 8461214
    Abstract: A one-phase microemulsion composition, which can be easily prepared without the use of special equipment, has high safety, and stays stable for a long period in an ultrafine emulsion state when the composition is added to an aqueous formulation, is provided by appropriately adjusting the ratio of (A) a hydrophilic nonionic surfactant, (B) a lipophilic nonionic surfactant, (C) an oil component, (D) a water-miscible solvent that does not interdissolve with the oil component, and the critical micelle concentration (CMC) of the hydrophilic nonionic surfactant in the water-miscible solvent is higher than that of the hydrophilic nonionic surfactant in water, and (E) water.
    Type: Grant
    Filed: January 6, 2005
    Date of Patent: June 11, 2013
    Assignee: Shiseido Co., Ltd.
    Inventors: Reiji Miyahara, Hiroyuki Kakoki, Nozomi Oguchi, Takashi Ohmori, Toshihiko Nakane
  • Patent number: 8449866
    Abstract: This disclosure provides, in part, fluorocarbon imaging reagents and formulations for the ex vivo labeling of cells. Labeled cells may be detected in vivo or ex vivo by a nuclear magnetic resonance technique, such as magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS). The disclosure additionally provides methods for using the imaging reagents in a variety of clinical procedures.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: May 28, 2013
    Assignee: Carnegie Mellon University
    Inventor: Eric T. Ahrens
  • Patent number: 8449867
    Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: May 28, 2013
    Assignee: Stiefel Research Australia Pty Ltd
    Inventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Vijayakumar, Phoebe Sun
  • Patent number: 8444993
    Abstract: A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that comprises (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion. The adjuvant composition comprises: (i) a continuous aqueous phase comprising H2O; (ii) an oil phase comprising oil dispersed in the continuous aqueous phase, comprising an internal aqueous phase comprising H2O, being dispersed in the oil phase; and a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil phase to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-?-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: May 21, 2013
    Assignee: National Health Research Institutes
    Inventors: Ming-Hsi Huang, Pele Choi-Sing Chong, Chih-Hsiang Leng, Shih-Jen Liu, Hsin-Wei Chen
  • Patent number: 8440726
    Abstract: A solubilizing composition containing (A) at least one oily component selected from esters of oleic acid with alcohols having 1 to 3 carbon atoms and triglycerides of fatty acids having 6 to 12 carbon atoms, (B) a polyoxyethylenesorbitan fatty acid ester, (C) a polyhydric alcohol which is liquid between 15° C. and 25° C., and (D) one or more acidic phospholipids where the fatty acid constituting an acyl group thereof is selected from saturated fatty acids having 6 to 14 carbon atoms and unsaturated fatty acids having 16 to 18 carbon atoms, which contains 20 to 40% by weight of the component (A), 30 to 45% by weight of the component (B), 15 to 40% by weight of the component (C), and 0.5 to 4% by weight of the component (D), based on 100% by weight of a total amount of the components (A) to (D).
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: May 14, 2013
    Assignee: NOF Corporation
    Inventor: Yusuke Ohkawa
  • Patent number: 8420066
    Abstract: Provided is an O/W emulsion cosmetic composition, which contains the following components (A), (B) and (C): (A) a polymer which is either a nonionic or cationic polymer composed of a hydrophobic monomer unit and a hydrophilic monomer unit and contains from 40 to 80 wt. % of a hydrophilic group; (B) a dispersion containing the following components (a), (b), (c) and (d): (a) powders having ultraviolet screening ability and having a surface subjected to hydrophobic treatment, (b) a polymer composed of a hydrophobic monomer unit and a hydrophilic monomer unit, (c) a silicone oil, and (d) an alcohol having from 1 to 3 carbon atoms, at an (a):(b):(c):(d) weight ratio of (from 25 to 65):(from 0.1 to 5):(from 10 to 50):(from 10 to 50); and (C) water.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: April 16, 2013
    Assignee: Kao Corporation
    Inventors: Yukio Inomata, Toshio Uesaka, Satoshi Sugawara, Yasumitsu Sakuma, Masahiro Umehara
  • Patent number: 8414904
    Abstract: The present invention refers to an oil-in-water emulsion for ophthalmic application comprising at least one prostaglandin as active agent and a surfactant component comprising a combination of at least two non-ionic surfactants. The emulsion is suitable for medical applications, particularly for the treatment of glaucoma, and has an increased chemical stability of the prostaglandin active agent so to allow long-term storage also at room temperature.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: April 9, 2013
    Assignee: AZAD Pharma AG
    Inventors: Fabio Carli, Mihran Baronian, Rene Schmid, Elisabetta Chiellini
  • Patent number: 8399015
    Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: March 19, 2013
    Assignee: AbbVie Inc.
    Inventors: Joerg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
  • Patent number: 8354466
    Abstract: The invention pertains to a new method for formulating any agrochemical active ingredient so as to protect the user, protect this active ingredient from outside stresses, and control its release kinetics. It relies on the use of acrylic and thickening emulsions with a pH greater than five and containing hydrophobic groups in order to trap said active ingredient. The invention also pertains to the various embodiments of the active ingredient thereby formulated: a mixture in water of that active ingredient with these thickening emotions, a dispersion of solid particles of these polymers and this active ingredient after a certification, and the solid particles obtained in a dried state after the water has been removed. Finally, the invention pertains to the use of these various formulations in order to protect and active ingredient, protect its user, and slow its release kinetics.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: January 15, 2013
    Assignee: Coatex S.A.S.
    Inventors: Olivier Guerret, Jean-Marc Suau, Yves Kensicher
  • Patent number: 8334321
    Abstract: A fat emulsion comprises a prostaglandin as an active ingredient, the fat emulsion comprising a phospholipid that comprises phosphatidylcholine (PC) and phosphatidylglycerol (PG) and has a ratio of PC to PG (PC:PG) of 85:15 to 99.7:0.3.
    Type: Grant
    Filed: September 3, 2007
    Date of Patent: December 18, 2012
    Assignee: Q.P. Corporation
    Inventors: Satomi Kamiya, Tomonori Uchida, Hideto Yoshida, Yasutaka Inoue, Noboru Yamada, Kenichi Kajihara
  • Patent number: 8333990
    Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: December 18, 2012
    Assignee: Abbott Laboratories
    Inventors: Joerg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
  • Patent number: 8329760
    Abstract: A pharmaceutical compositions in the form of an emulsion and containing a continuous liquid phase, for example, an aqueous phase, liquid droplets dispersed in the continuous phase, a pharmaceutically active compound, a Hseih enhancer, and a hydrocolloid emulsifying agent and in which, for example, the active compound is dissolved in the aqueous phase or in the liquid droplets, and the use of such composition to treat a condition in a patient, for example, diabetes.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: December 11, 2012
    Assignee: CPEX Pharmaceuticals, Inc.
    Inventor: Robert J. Gyurik
  • Patent number: 8329761
    Abstract: An stable oil-in-oil emulsion is disclosed containing a first oil phase dispersed as droplets in a continuous second oil phase, which droplets have a number median diameter of 10 nm to 1000 nm, wherein the first oil phase is substantially immiscible in the second oil phase and wherein the first oil phase comprises a liquid organic phosphate compound. In one preferred embodiment, the first oil phase comprises colorants, polymers, and/or other additives, depending on the particular use of the emulsion.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: December 11, 2012
    Assignee: Eastman Kodak Company
    Inventors: Mridula Nair, Tamara K. Jones, Mary C. Brick
  • Patent number: 8309613
    Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: November 13, 2012
    Assignee: AbbVie Inc.
    Inventors: Joerg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
  • Patent number: 8287846
    Abstract: The present invention relates to odour improved dermatological or cosmetic preparations comprising N-acetylcysteine and a polyol system containing one or more polyols as masking odour agents. The emulsions of the present invention are useful in the treatment of dermatological disorders or cosmetic skin conditions.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: October 16, 2012
    Assignee: ZAMBON S.p.A.
    Inventors: Luca Rampoldi, Alberto Moretto, Alessandro Grassano
  • Patent number: 8287907
    Abstract: There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: October 16, 2012
    Assignee: Phares Pharmaceutical Research, N.V.
    Inventors: Steve Leigh, Matthew Louis Steven Leigh, Peter Van Hoogevest, Daniel Streich, Jacques Quinton
  • Patent number: 8268349
    Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: September 18, 2012
    Assignee: Abbott Laboratories
    Inventors: Joerg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
  • Patent number: 8263666
    Abstract: Composition for topical application in the form of an oil-in-water emulsion containing an oily phase dispersed in an aqueous phase, and a hydrophilic polymer, the composition further containing (1) at least one elastomeric organopolysiloxane and (2) at least one lipophilic compound chosen from lipophilic amino acid compounds and lipophilic salicylic acid compounds. Uses thereof, including topical application to the skin, lips, hair, etc. Stabilization of certain emulsions using a lipophilic compound.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: September 11, 2012
    Assignee: L'Oreal
    Inventors: Christine Noel, Anne-France Livernette