Significant, Tablet Formulation (e.g., Designated Excipient, Disintegrant, Glydent Or Lubricant, Etc.) Patents (Class 514/960)

Cross-Reference Art Collections

Binder therefor (Class 514/961)
  • Patent number: 9624163
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: April 18, 2017
    Assignees: NOVARTIS AG, ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD.
    Inventors: Guoliang Zhu, Wenfa Ye, Hui Zheng, Lingfeng Qian, Junhui Wei, Lijun Yang, Yunguang Li, Lijun Luo
  • Patent number: 9018250
    Abstract: The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention; and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: April 28, 2015
    Assignee: Sanofi
    Inventors: Bernard Abramovici, Stephane Beilles, Sandra Chambonnet, Jean-Claude Gautier
  • Patent number: 8993599
    Abstract: In one general aspect of the present invention, pharmaceutical formulations comprising both a proton pump inhibitor microencapsulated or dry coated with a material that enhances the shelf-life of the pharmaceutical composition and one or more antacid are described. In another general aspect of the present invention, pharmaceutical formulations comprising both a proton pump inhibitor microencapsulated or dry coated with a taste-masking material and one or more antacid are described.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: March 31, 2015
    Assignee: Santarus, Inc.
    Inventors: Warren Hall, Kay Olmstead, Laura Weston
  • Patent number: 8975296
    Abstract: The instant invention relates to pharmaceutical compositions containing cathespin K inhibitors. Also disclosed are processes for making said pharmaceutical compositions.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: March 10, 2015
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Haihong Fan, Majid Mahjour, Justin Moser, Bhagwant Rege
  • Patent number: 8974821
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 10, 2015
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton, Roger Fu, Michael S. Zamloot
  • Patent number: 8968795
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: March 3, 2015
    Assignee: Delavau LLC
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8951556
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: February 10, 2015
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton, Roger Fu, Michael S. Zamloot
  • Patent number: 8945614
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: February 3, 2015
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton, Roger Fu, Michael S. Zamloot
  • Patent number: 8906940
    Abstract: The present invention relates to pharmaceutical formulations comprising at least one acid-labile proton pump inhibiting agent and at least one antacid, which have improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, safety, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties. The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to, a gastrointestinal disorder or disease in a subject in need thereof.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: December 9, 2014
    Assignee: Santarus, Inc.
    Inventors: Kay Olmstead, Warren Hall, Gerald T. Proehl
  • Patent number: 8900642
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: December 2, 2014
    Assignee: Delavau LLC
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8877239
    Abstract: Nutritional supplement formulations suitable for specific enhancement of cell and mitochondrial function comprise enriched formulations of phospholipids and chemical precursors containing specifically identified concentrations of phosphatidylglycerol, phosphatidic acid and phosphatidylcholine, and mitochondrial and cell membrane phospholipid molecules as well as other desirable constituents. Methods of enriching extracted sources of cell and mitochondrial membrane molecules and precursors from microbes, plants and other sources are also set forth. The formulae can be combined with nutritional, prebiotic, and probiotic (microbial) factors that increase bioavailability through the digestive tract and increase absorption at the cellular and subcellular levels. These lipid combinations can be used to treat mitochondrial disorders associated with medical pathologies, chronic illnesses and syndromes, or to maintain lipid balance for normal mitochondrial function, and can be administered in many different forms.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: November 4, 2014
    Assignee: Nutritional Therapeutics, Inc.
    Inventors: Robert Settineri, James F. Palmer
  • Patent number: 8859011
    Abstract: Compositions comprising calcium carbonate and processes for making such compositions are provided. The invention provides a granulation comprising about 95% to about 99% by weight calcium carbonate, about 0.5% to about 5% by weight of a binder and about 0.03% to about 3% by weight of a porosity increasing agent. A pharmaceutical or nutritional composition prepared from such a granulation comprises about 90% to about 99% by weight calcium carbonate, about 0.03% to about 3% by weight of a porosity increasing agent, and about 1% to about 10% by weight of other excipients. The composition provides a smaller tablet than conventional calcium carbonate compositions, for improved ease of swallowing.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: October 14, 2014
    Assignee: Particle Dynamics International, LLC
    Inventors: Denis Stotler, Steven R. Freebersyser, R. Saul Levinson
  • Patent number: 8858997
    Abstract: The present invention provides compositions, methods for lyophilizing compounds and making pharmaceutical compositions, and kits providing solutions and lyophilized formulations of compounds. The compositions, methods, and kits are particularly useful in pharmaceutical applications involving therapeutic agents that have low solubility at low pH and medium pH values. Certain embodiments provide methods for lyophilizing compounds in liquid solutions, which include the steps of: a) preparing aqueous solutions of a compound of interest in the absence of buffer; b) adjusting the pH to high values of pH in order to increase the solubility of the compound of interest; and c) freeze-drying the solution to provide a lyophilized solid composition. Aqueous solutions including buffer are also disclosed. Lyophilized formulations, including micronized and non-micronized powders, are provided.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: October 14, 2014
    Assignee: Remedy Pharmaceuticals, Inc.
    Inventor: Sven Jacobson
  • Patent number: 8821946
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: September 2, 2014
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8815302
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: August 26, 2014
    Assignee: Delavau LLC
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8790713
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: July 29, 2014
    Assignee: Delavau, L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8784902
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: July 22, 2014
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8770201
    Abstract: Condoms having an elastomeric layer and coating containing an anhydrous warming lubricant and at least one or more ingredients dispersed therein, the coating being disposed on one or both surfaces are provided. The ingredients disposed on the elastomeric layer can be solid particles or encapsulated ingredients that are insoluble in the anhydrous warming lubricant and soluble in water. Methods of producing and using these condoms are also provided.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: July 8, 2014
    Assignee: GlycoBioSciences Inc.
    Inventors: Michael S. Zedalis, Beng Sim Chuah, David M. Lucas, Angela M. Shiokawa, Jose R. Siqueira, Dave Narasimhan
  • Patent number: 8741355
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: June 3, 2014
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8728538
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: May 20, 2014
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8716244
    Abstract: The present invention relates to pharmaceutical compositions, food supplement compositions and cosmetic compositions comprising diaminooxidase, and to the use thereof.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: May 6, 2014
    Assignee: Sciotec Diagnostic Technologies GmbH
    Inventors: Albert Missbichler, Franz Gabor, Herwig Reichl
  • Patent number: 8709499
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: April 29, 2014
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8697142
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: April 15, 2014
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8668936
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: March 11, 2014
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8663706
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: March 4, 2014
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8617598
    Abstract: A pharmaceutical composition comprising a macrolide solid dispersion, a disintegrant and colloidal silicon dioxide, wherein the composition comprises 1 to 5% colloidal silicon dioxide by weight.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: December 31, 2013
    Assignee: Novartis AG
    Inventors: Barbara Haeberlin, Andrea Kramer, Silvia Heuerding
  • Patent number: 8617619
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: December 31, 2013
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8603544
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: December 10, 2013
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8440236
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: May 14, 2013
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 8420120
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: April 16, 2013
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
  • Patent number: 8354124
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: January 15, 2013
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
  • Patent number: 8337892
    Abstract: The invention concerns a microgranule tablet comprising a low dose of active principle containing a directly compressible diluent. The invention is characterized in that the directly compressible diluent consists exclusively of neutral microgranules, and the active principle is set on the neutral microgranules and is not coated with an agent designed to modify its release or mask its taste.
    Type: Grant
    Filed: July 25, 2000
    Date of Patent: December 25, 2012
    Assignee: ETHYPHARM
    Inventors: Guy Couaraze, Bernard Leclerc, Pierre Tchoreloff, Patrick Sanial
  • Patent number: 8323680
    Abstract: A nutritional or therapeutic composition for oral administration which comprises a naturally occurring precursor that is metabolised to a compound having anandamide activity for use as a medicament or nutritive product. In addition the invention includes a method of production of the composition, use of the composition in the manufacture of a nutritional composition for the treatment or prevention of a behavioral disorder; and a method of treatment or prevention of a behavioral disorder which comprises administering an effective amount of the composition. In a preferred embodiment the composition comprises a triacylglycerol having palmitate and arachidonate attached to its backbone wherein arachidonate is at the sn-1 and sn-2 positions.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: December 4, 2012
    Assignee: Nestec S.A.
    Inventors: Alvin Berger, Gayle Crozier
  • Patent number: 8318800
    Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: November 27, 2012
    Assignee: Sanofi
    Inventors: Bernard Abramovici, Jean-Claude Gautier, Jean-Claude Gromenil, Jean-Marie Marrier
  • Patent number: 8277845
    Abstract: The present invention provides compositions, methods for lyophilizing compounds and making pharmaceutical compositions, and kits providing solutions and lyophilized formulations of compounds. The compositions, methods, and kits are particularly useful in pharmaceutical applications involving therapeutic agents that have low solubility at low pH and medium pH values. Certain embodiments provide methods for lyophilizing compounds in liquid solutions, which include the steps of: a) preparing aqueous solutions of a compound of interest in the absence of buffer; b) adjusting the pH to high values of pH in order to increase the solubility of the compound of interest; and c) freeze-drying the solution to provide a lyophilized solid composition. Aqueous solutions including buffer are also disclosed. Lyophilized formulations, including micronized and non-micronized powders, are provided.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: October 2, 2012
    Assignee: Remedy Pharmaceuticals, Inc.
    Inventor: Sven Jacobson
  • Patent number: 8236345
    Abstract: A pharmaceutical composition, comprising a thiazolidinedione, such as Compound (I), metformin hydrochloride and a pharmaceutically acceptable carrier, wherein the thiazolidinedione and metformin hydrochloride are each dispersed within its own pharmaceutically acceptable carrier in the pharmaceutical composition and the use of such a composition in medicine.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: August 7, 2012
    Assignee: SmithKline Beecham Limited
    Inventors: Karen Lewis, Nicola Jayne Lilliott, Donald Colin MacKenzie
  • Patent number: 8168217
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: May 1, 2012
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
  • Patent number: 8153152
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: April 10, 2012
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
  • Patent number: 8147870
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: April 3, 2012
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
  • Patent number: 8133507
    Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: March 13, 2012
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
  • Patent number: 8084059
    Abstract: The invention pertains to a dosage form 10 and to administering an antidepressant medicament 16 for an extended period of time in a rate-known dose.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: December 27, 2011
    Assignee: ALZA Corporation
    Inventors: David Emil Edgren, Gurdish Kaur Bhatti, Zahedeh Hatamkhani, Patrick S. L. Wong
  • Patent number: 8030355
    Abstract: A tamsulosin controlled release tablet is formed using a water-swellable matrix-forming composition as a release controlling mechanism. The matrix forming composition comprises (i) a pH-sensitive swellable hydrophilic polymer, which is a cross-linked polyacrylic acid polymer, and (ii) a pH-insensitive swellable hydrophilic polymer. The tablet optionally contains a water insoluble binder as well.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: October 4, 2011
    Assignee: Synthon BV
    Inventors: Korinde Annemarie Jansen, Farid Abedin Dorkoosh
  • Patent number: 8007825
    Abstract: Oral dosage forms, and particles used therein, containing salivation inducing agents are disclosed. The salivation agents may be in the core of the dosage form and/or in coatings applied thereto, or alternatively may be within particles and/or the matrix of such dosage forms, in coatings applied to such particles, or on the surface of such coated particles. The particles may be produced into a tablet form, such as a chewable tablet form, that provides for the immediate release of the active ingredient. Other oral dosage forms include thin film strips, gummi, foam tabs, and lozenges.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: August 30, 2011
    Assignee: McNeil-PPC, Inc.
    Inventors: David W. Wynn, Ronni Robinson
  • Patent number: 7902208
    Abstract: A method of treating and/or preventing allergic and inflammatory conditions of the skin or upper and lower airway passages, e.g. seasonal allergic rhinitis, perennial allergic rhinitis, or chronic idopathic urticaria, in a human more 12 years old, by administering an amount of desloratadine, e.g. 2×2.5 mg or 5 mg/day for a time sufficient to produce a geometric mean steady state maximum plasma concentration of desloratadine in the range of about 2.90 ng/mL to about 4.54 ng/mL, or a arithmetic mean steady state maximum plasma concentration of desloratadine in the range of about 3.2 ng/mL to about 5.0 ng/mL is disclosed.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: March 8, 2011
    Assignee: Schering Corporation
    Inventors: Melton B. Affrime, Christopher R. Banfield, Samir K. Gupta, Desmond Padhi
  • Patent number: 7879901
    Abstract: The present invention refers to pharmaceutical compositions based on ketorolac or one of its salts pharmaceutically acceptable, as well as the use of ketorolac or one of its salts acceptable from pharmaceutical viewpoint, for preparation of a pharmaceutical composition (tablets) for sublingual administration, with the purpose of accelerating the pharmacological response to ketorolac, without making use of the injectable via. On the other hand, a pharmaceutical composition is described encompassing, as one of its active principles, ketorolac or one of its salts acceptable from pharmaceutical viewpoint, representing from 10 to 15% by weight, in relation to the total weight of the compound and as the essential excipient, a ternary mixture of lactose/sorbitol/cellulose, eventually in a mixture with other excipients acceptable from pharmaceutical viewpoint.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: February 1, 2011
    Assignee: Nature's Plus Farmaceutica Ltda.
    Inventors: Guido Vandoni, Carlo Oliani, Adriano Coelho, Heny Zaniboni
  • Patent number: 7858656
    Abstract: A controlled release melatonin tablet having a slow release nucleus of melatonin, hydroxypropyl methylcellulose, a lubricant, a volume excipient and a glidant, wherein 95% of the melatonin is released within 5 hours in an oscillating tray containing gastric/intestinal juice at 37° C. and a fast release cortex coating on said nucleus of melatonin, hydroxypropyl methylcellulose and a volume excipient, wherein at least 95% of the melatonin is released within 10 minutes in an oscillating tray containing gastric/intestinal juice at 37° C.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: December 28, 2010
    Assignee: Ambros Pharma S.R.L.
    Inventor: Bojidar M. Stankov
  • Patent number: 7780986
    Abstract: The present invention relates to an orally administrable preparation comprising a quinolone antibiotic which releases the active compound with a delay.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: August 24, 2010
    Assignee: Bayer Schering Pharma AG
    Inventors: Venkata-Rangarao Kanikanti, Roland Rupp, Wolfgang Weber, Peter Deuringer, Jan-Olav Henck, Heino Stab, Takaaki Nishioka, Yoshifumi Katakawa, Chika Taniguchi, Hitoshi Ichihashi
  • Patent number: 7619001
    Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: November 17, 2009
    Assignee: Biogen IDEC International GmbH
    Inventors: Rajendra Kumar Joshi, Hans-Peter Strebel
  • Patent number: 7612110
    Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: November 3, 2009
    Assignee: Biogen Idec International AG
    Inventors: Rajendra Kumar Joshi, Hans-Peter Strebel
  • Patent number: 7572641
    Abstract: The present invention encompasses a method of evaluating pharmaceutical compositions of meloxicam whereby one can correlate in vitro properties to in vivo properties, and pharmaceutical compositions developed using the method.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: August 11, 2009
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Michal Agami, Julia Hrakovsky, Ruth Tenengauzer