Sustained Or Differential Release Type Patents (Class 514/964)
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Patent number: 6165513Abstract: A novel oral dosage to be delivered to the stomach comprising a safe and effective amount of an active ingredient selected from the group consisting of emepronium bromidebromide, doxycycline, and other tetracyclines/antibiotics, iron preparations, quinidine, nonsteroidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine (AZT), bisphosphonates and mixtures thereof and pharmaceutically-acceptable excipients, wherein said oral dosage form is a generally oval form and film coated to facilitate rapid esophageal transit and avoid irritation in the mouth, buccal cavity, pharynx, and esophagus.Type: GrantFiled: June 10, 1998Date of Patent: December 26, 2000Assignee: The Procter & Gamble Co.Inventors: Richard John Dansereau, Petrus Jakobus Bekker
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Patent number: 6143288Abstract: Described is (i) a method of repelling Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae for a finite period of time from a three-dimensional space inhabitable by Musca domnestica L.(Diptera:Muscidae) or Aedes aegyptae consisting essentially of the step of exposing a three-dimensional space to an effective Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae-repelling concentration and quantity of a geraniol-containing composition consisting essentially of 50-100% of geraniol with the remainder of the composition being a compound selected from the group consisting of citronellol and nerol and (ii) a method of attracting Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae using lavender absolute, benzoin, dimethyl benzyl carbinyl acetate, jasmine absolute, racemic borneol, d-limonene and/or dihydrolinalool. The attractants taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.Type: GrantFiled: May 12, 1994Date of Patent: November 7, 2000Assignees: International Flavors & Fragrances Inc., The University of FloridaInventors: Craig B. Warren, Jerry F. Butler, Richard A. Wilson, Braja D. Mookherjee, Leslie C. Smith, Anna Belle Marin
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Patent number: 6136343Abstract: A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic cross-linking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.Type: GrantFiled: December 8, 1998Date of Patent: October 24, 2000Assignee: Edward Mendell Co., Inc.Inventor: Anand R. Baichwal
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Patent number: 6126967Abstract: An extended release acetaminophen composition comprises a plurality of discrete particles containing acetaminophen which, when contained within a gelatin capsule and assayed in a USP Apparatus I rotating basket at 50 rpm in 900 mL of phosphate buffer at pH 5.8 and 37.degree. C., exhibits about 40 percent to about 53 percent acetaminophen dissolution at one-half hour, about 50 percent to about 68 percent dissolution at 45 minutes, about 57 percent to about 77 percent acetaminophen dissolution at one hour, and about 82 percent to about 92 percent acetaminophen dissolution at two hours. After six hours, the contemplated extended release acetaminophen composition exhibits substantially complete dissolution. A process for treating a human patient with the extended release acetaminophen composition is also disclosed.Type: GrantFiled: September 3, 1998Date of Patent: October 3, 2000Assignee: Ascent PediatricsInventors: Emmett Clemente, Aloysius O. Anaebonam, Robert W. Mendes, Abdel A. Fawzy, Eric M. Morrel
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Patent number: 6123961Abstract: A method for treating or preventing urinary incontinence and other motility disorders involving the urethrogenital tract, by administering to a mammal an effective amount of the R-isomers of 4-diethylamino-2-butynyl cyclohexylphenylglycolate and 4-ethylamino-2-butynyl cyclohexylphenylglycolate and pharmaceutically acceptable salts thereof.Type: GrantFiled: September 23, 1997Date of Patent: September 26, 2000Assignee: Bridge Pharma, Inc.Inventor: A. K. Gunnar Aberg
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Patent number: 6106821Abstract: The invention relates to fly attractant compositions that comprise at least one volatile short chain carboxylic acid, at least one organic sulfide and at least one nitrogen heterocycle. In a preferred embodiment the composition additionally comprises at least one ammonia-releasing compound. In a particularly preferred example, the composition is preparable by combining, for example, the carboxylic acid, the organic sulfide and the nitrogen heterocycle. The invention also relates to an insect trap comprising a means for retaining flies and an insect attractant composition of this invention. The trap is useful in commercial, residential and livestock facilities.Type: GrantFiled: December 5, 1997Date of Patent: August 22, 2000Assignee: Iowa State University Research Foundation, Inc.Inventors: Thomas C. Baker, Allard A. Cosse
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Patent number: 6083532Abstract: Depot drug formulations include the pharmaceutical itself and a three component release rate controlling matrix composition. The three components of the matrix composition are (1) a pH dependent gelling polymer such as an alginate component, (2) an enteric polymer component, such as Eudragit.RTM. L or S, and (3) a pH independent gelling polymer, such as hydroxy propyl methyl cellulose or polyethylene oxide. The drug release rate can be adjusted by changing the amount of one or more of these components of the composition.Type: GrantFiled: December 5, 1997Date of Patent: July 4, 2000Assignee: Duramed Pharmaceuticals, Inc.Inventors: Guohua Zhang, Prasad Pinnamaraju, Muhammad Ali
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Patent number: 6074634Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.Type: GrantFiled: October 5, 1998Date of Patent: June 13, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
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Patent number: 6068981Abstract: A method of monitoring a therapeutic regimen in an animal, the method involving a) providing to the animal a therapeutic compound and a detectable compound that passes into the bloodstream, excretory system, or other tissue or body fluid in detectable form; b) after a period of time, following step (a), sufficient for passage of a detectable amount of the detectable compound into the body fluid or tissue, collecting a sample of the fluid or tissue from the animal; and c) measuring or detecting the detectable compound, or a detectable metabolite thereof, in the sample, wherein the detectable compound involves one member of a specific binding pair, and detection is carried out using the second member of the specific binding pair.Type: GrantFiled: October 3, 1997Date of Patent: May 30, 2000Assignee: Biocode, Inc.Inventors: James H. Rittenburg, Frank G. Angella, Michael G. Pappas
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Patent number: 6060060Abstract: This invention relates to analgesic compositions obtained from the fruit of the Capsicum genus, in particular Capsicum annuum and more particularly to purees or extracts of sweet peppers. This invention further relates to therapeutic uses of such analgesic compositions.Type: GrantFiled: January 31, 1997Date of Patent: May 9, 2000Assignee: BMB Patent Holding CorporationInventor: Barry Miles Belgorod
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Patent number: 6046177Abstract: Sulfoalkyl ether cyclodextrin (SAE-CD) based controlled release pharmaceutical formulations are provided by the present invention. The present solid pharmaceutical formulations consist of a core comprising a physical mixture of one or more SAE-CD derivatives, an optional release rate modifier, a therapeutic agent, a major portion of which is not complexed to the SAE-CD, and an optional release rate modifying coating surrounding the core. The present formulations are advantageously easier to prepare than other SAE-CD based formulations in the art yet provide similar or improved effectiveness. The SAE-CD derivative is used to modify the bioavailability and/or rate of bioabsorption of therapeutic agents. Multi-layered, osmotic pump, coated, and uncoated tablet, minitablet, pellet, micropellet, particle, powder, and granule dosage forms are disclosed herein.Type: GrantFiled: January 13, 1999Date of Patent: April 4, 2000Assignee: Cydex, Inc.Inventors: Valentino J. Stella, Roger A. Rajewski, Venkatramana M. Rao, James W. McGinity, Gerold L. Mosher
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Patent number: 6037374Abstract: Gel compositions of formic acid and a gelling agent such as fumed silica or polyacrylic acid have been prepared for controlling parasitic mites of honey bees. The gels provide slow-release capability and have been found effective against both Varroa jacobsoni and Acarapis woodi. They are advantageous in that they have improved handling characteristics and are safer than liquid formic acid, which is quite corrosive.Type: GrantFiled: November 19, 1997Date of Patent: March 14, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Jan P. Kochansky, Hachiro Shimanuki, Mark Francis Feldlaufer, Jeffery S. Pettis
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Patent number: 6034101Abstract: A dosage form and a method are disclosed and claimed for administering a drug in a sustained and constantly ascending rate per unit time to provide an intended therapeutic effect while concomitantly lessening the development of unwanted effects.Type: GrantFiled: July 31, 1997Date of Patent: March 7, 2000Assignee: ALZA CorporationInventors: Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks
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Patent number: 6028113Abstract: Solid sanitizing compositions have advantages over corresponding liquids and powders. A solid sanitizing product can be contained within a plastic bottle with a label indicating that the contents have antimicrobial or deodorizing properties containing a non-flowable solid composition having greater than about 0.02 percent by weight antimicrobial compounds. The preferred solid sanitizing compositions consist essentially of an antimicrobial compound selected from the group consisting of quaternary ammonium salts, fatty amines and diamines, chlorhexidine gluconate, phenol, derivatives of phenol, parachloro metaxylenol and mixtures thereof, and between 0 and 99.98 percent by weight of a cleaning composition. The solid sanitizing compositions can be effectively used with solid dispensers. The solid dispensers have a bowl with a drain at the bottom and an upward pointing spray nozzle.Type: GrantFiled: September 27, 1995Date of Patent: February 22, 2000Assignee: Sunburst Chemicals, Inc.Inventor: William H. Scepanski
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Patent number: 6004973Abstract: Disclosed are pharmaceutical compositions containing solid dispersions in the form of co-precipitates, which solid dispersions contain rapamycin and a carrier medium, and methods of treatment utilizing such pharmaceutical compositions.Type: GrantFiled: January 26, 1998Date of Patent: December 21, 1999Assignee: Novartis AGInventors: Patrice Guitard, Barbara Haeberlin, Rainer Link, Friedrich Richter
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Patent number: 6001346Abstract: A sprayable or solid biodegradable wax carrier for insect pheromones and a method for constant release rate of the pheromone from the biodegradable wax. A composition comprising a pheromone and paraffin wax formulated as an aqueous emulsion or a solid suitable for application to a surface of a tree or crop for mating disruption of insect pests. Pheromone is released by diffusion or by partitioning from the biodegradable wax carrier or by pheromone exposure due to the biodegradable wax carrier degradation.Type: GrantFiled: September 9, 1996Date of Patent: December 14, 1999Assignee: The Regents of the University of CaliforniaInventors: Michael Delwiche, John M. Krochta, Richard E. Rice, Cynthia Atterholt
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Patent number: 5998365Abstract: A pharmaceutical composition in the form of a microemulsion preconcentrate comprising a cyclosporin dissolved in a solvent system further comprising a hydrophobic component, a hydrophilic component, and a surfactant, wherein either the hydrophobic component is selected from tocol, tocopherols, tocotrienols, and derivatives thereof, or the hydrophilic component is selected from propylene carbonate or polyethylene glycol having an average molecular weight of less than 1000.Type: GrantFiled: June 15, 1998Date of Patent: December 7, 1999Assignee: Bernard C. ShermanInventor: Bernard Charles Sherman
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Patent number: 5976547Abstract: The present invention relates to topical over-the-counter and prescription strength analgesic and antiphlogistic blended compositions which are useful for reducing inflammation and providing relief from both peripheral and central pain as well as to a flexible therapeutic wrap for topical delivery of said blended compositions. More particularly, the invention is a blended composition comprising from about 3% to about 30% by weight of extract of arnica montana in combination with an effective amount of one or more therapeutic or pharmaceutical agents selected from the group consisting of menthol crystal, camphor, oil of mint, eucalyptus oil, guaifenesin, non-steroidal anti-inflammatory medications, topical analgesics, or transdermal opioid analgesics blended in either a pluronic lecithin organogel (PLO) or a petrolatum base. The particular agents selected and the percent composition of each selected ingredient in a given blend being determined by the needs and sensitivities of the given patient.Type: GrantFiled: April 22, 1997Date of Patent: November 2, 1999Assignee: Niblick Pharmaceuticals, Inc.Inventors: Heidi K. Archer, Mitchell S. Pettit
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Patent number: 5977183Abstract: Substantially solid (or nonflowable) antimicrobial compositions have advantages over corresponding liquids and powders. Such a composition may be contained within a plastic bottle with a label indicating that the contents have antimicrobial or deodorizing properties containing a substantially solid, non-flowable composition having greater than about 0.02 percent by weight antimicrobial compounds. The preferred compositions consist essentially of an antimicrobial compound selected from the group consisting of quaternary ammonium salts, fatty amines and diamines, chlorhexidine gluconate, phenol, derivatives of phenol, parachloro metaxylenol and mixtures thereof, and between 0 and 99.98 percent by weight of a cleaning composition. The compositions can be effectively used with solid dispensers. The solid dispensers have a bowl with a drain at the bottom and an upward pointing spray nozzle.Type: GrantFiled: January 10, 1997Date of Patent: November 2, 1999Assignee: Sunburst Chemicals, Inc.Inventor: William H. Scepanski
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Patent number: 5958463Abstract: The present invention relates generally to the method for the production of liposomal microencapsulated boron-containing products to be used for agricultural formulations. More specifically, a new method of production of liposomal microencapsulated is disclosed for active agents such as pesticides. A lecithin is mixed with an organic solvent in a certain proportion so as to provide solutions with varied levels of solubilized lecithin. The particular solvent being used will depend on the amount of active agent (AA) desired in the final solution. The formulation of the lecithin/organic solvent mixture is then allowed to settle. After settling, the top layer is separated and saved, while the bottom layer is discarded. An AA is then added to form a concentrate that is added to water for vesicle formation. Boron-containing materials formulated according to the invention may now be applied to agricultural field crops and fruits.Type: GrantFiled: November 22, 1996Date of Patent: September 28, 1999Assignee: Agri-Tek, Inc.Inventors: Christopher G. Milne, Paulus P. Shelby, Jr.
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Patent number: 5955103Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.Type: GrantFiled: June 9, 1997Date of Patent: September 21, 1999Assignee: ALZA CorporationInventors: Frank Jao, Patrick S. -L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
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Patent number: 5948440Abstract: A pharmaceutical composition in the form of a tablet for controlled release of an active ingredient comprises cefaclor, cephalexin, or their pharmaceutically acceptable hydrates, salts, or esters as active ingredient, and a mixture of hydrophilic polymers of different viscosity grades selected from the group consisting of at least one hydroxypropyl methylcellulose and at least one hydroxypropylcellulose. The composition optionally also contains one or more of a water soluble or water dispersible diluent. The quantities of the hydrophilic polymers and water soluble or water dispersible diluent are such that the therapeutically effective active ingredient is released at a rate suitable for twice daily administration of the pharmaceutical composition to human subjects. The tablets may also be coated with a rapidly dissolving water soluble polymeric film coat.Type: GrantFiled: December 17, 1997Date of Patent: September 7, 1999Assignee: Ranbaxy Laboratories LimitedInventors: Jagdish Arora, Girish Jain, Himadri Sen
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Patent number: 5939380Abstract: Implant preparations capable of sustained action when inserted are comprised of powder of a natural lipoidal substance in thorough admixture with bioactive macromolecule, followed by compression under pressure into a disc or rod that can be broken and used in small pieces as well.Type: GrantFiled: November 22, 1991Date of Patent: August 17, 1999Inventor: Paul Yao-Cheung Wang
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Patent number: 5928667Abstract: A drug delivery device comprising a single phase matrix of a rigid polymer and a flexible polymer, useful for sustained release of a pharmaceutically active ingredient, as well as a method for employing the same, are disclosed.Type: GrantFiled: November 25, 1996Date of Patent: July 27, 1999Assignee: University of MarylandInventors: Joel Rosenblatt, Vivek Shenoy
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Patent number: 5916552Abstract: A semi-solid deer attractant lure comprised of liquid deer urine plus a sufficient amount of flavorless gelatin to produce a semi-solid rubbery composition is disclosed. Also disclosed is a method of making and a method of using the deer attractant lure composition.Type: GrantFiled: February 23, 1998Date of Patent: June 29, 1999Inventor: Mark D. Perry
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Patent number: 5914334Abstract: The present invention provides a stable gel formulation for topical treatment of skin conditions in humans. The stable gel formulation includes an active agent, having activity for treatment of acne and psoriasis, which is insoluble in water and a plurality of nonaqueous vehicles for both solubilizing said active agent and forming a gel therewith enabling topical application of the gel to a skin condition. The plurality of vehicles are each present in amounts, and in combination, to control release of the active agent from the gel to the skin condition.Type: GrantFiled: March 28, 1996Date of Patent: June 22, 1999Assignee: Allergan, Inc.Inventor: Prakash M. Charu
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Patent number: 5910322Abstract: Pharmaceutical formulations for oral administration, comprising a matrix which comprises a .beta.-lactam antibiotic optionally in combination with a .beta.-lactamase inhibitor, granules in a delayed release form dispersed within the matrix, which comprise a .beta.-lactam antibiotic optionally in combination with a .beta.-lactamase inhibitor, the overall tablet formulation including a .beta.-lactam antibiotic and a .beta.-lactamase inhibitor.Type: GrantFiled: October 2, 1997Date of Patent: June 8, 1999Assignee: SmithKline Beecham p.l.c.Inventors: Ernest Lionel Gilbert Rivett, Francis Walter Grimmett, Michael William Hartnell
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Patent number: 5902797Abstract: A nutritional supplement comprising approximately from about 5 to about 25 grams carbohydrate; approximately from about 1 to about 25 grams protein; and approximately from about 1 to about 10 grams fat, for use in treating low appetite that may result in weight loss, is described.Type: GrantFiled: November 10, 1997Date of Patent: May 11, 1999Assignees: Beth Israel Deaconess Medical Center, Medical Foods, Inc.Inventors: Stacey J. Bell, R. Armour Forse, Bruce R. Bistrian, Robert C. Jones
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Patent number: 5888545Abstract: An oral administration carbamazepine medicament with a retarded active substance release is disclosed. An aqueous plasticised polymer dispersion is applied on carbamazepine crystals without causing formation of carbamazepine dihydrate. The carbamazepine crystals with their aqueous coating may be mixed with appropriate auxiliarly substances, shaped into divisible tablets or filled into capsules.Type: GrantFiled: April 24, 1997Date of Patent: March 30, 1999Assignee: Arzneimittelwerk Dresden GmbHInventors: Karl-Friedrich Landgraf, Sabine Reiss, Eberhard Schubert
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Patent number: 5889051Abstract: A stable solid dispersion of prostaglandin drug, particularly Misoprostol, (.+-.)methyl 7-?3(.alpha.)-hydroxy-2-.beta.-(4 (RS)-4-hydroxy-4-methyl-trans-1-octen-1-yl)-oxycyclopent-1.alpha.-yl!hepta noate, comprising ammonio methacrylate copolymers. The ammonio methacrylate copolymers comprise Eudragit RS series, Eudragit RL series, Eudragit S, Eudragit L, and the mixture thereof. The stable solid dispersion is a sustained release type.Type: GrantFiled: July 15, 1997Date of Patent: March 30, 1999Assignee: Development Center for BiotechnologyInventors: David Chen, Rong-Jer Tsay, Hue-In Lin, Shu-Bin Lu
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Patent number: 5888930Abstract: A durable and sprayable controlled release bead of active ingredient in the pores of a polymeric micro-porous bead having an anisotropic pore structure of large pores in the interior and small pores at the surface, the gradation of pore sizes between the interior and the surface being continuous.Type: GrantFiled: March 13, 1997Date of Patent: March 30, 1999Assignee: Bend Research, Inc.Inventors: Kelly L. Smith, Matthew F. Holmes, James W. Brooke
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Patent number: 5879713Abstract: Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriate sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.Type: GrantFiled: January 23, 1997Date of Patent: March 9, 1999Assignee: Focal, Inc.Inventors: Laurence A. Roth, Stephen Jack Herman
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Patent number: 5880150Abstract: An antimicrobial agent comprising allyl isothiocyanate (AIT) packaged in a packaging material having a structure wherein part of the pores of a porous packaging substrate is filled with, or said pores are partially or entirely narrowed by a resin impervious to AIT vapor, and a method for controlling the AIT vapor release speed comprising enclosing AIT in the above-mentioned packaging material. According to the present invention, the AIT vapor release speed can be controlled, whereby enabling sustained release of AIT vapor and persistent effect of antimicrobial action. In addition, the antimicrobial agent of the present invention can be widely applied to food industries and various other fields where breeding and reproduction of deleterious microorganisms pose problems, since it is economical, compact and easy to use.Type: GrantFiled: July 10, 1995Date of Patent: March 9, 1999Assignees: The Green Cross Corporation, Rengo Co., Ltd.Inventors: Masao Fujita, Kiyoshi Kamei, Kiyoko Kawazu, Yuichi Mizukami, Yasushi Sekiyama
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Patent number: 5876750Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.Type: GrantFiled: June 9, 1997Date of Patent: March 2, 1999Assignee: ALZA CorporationInventors: Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
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Patent number: 5876756Abstract: A microcapsule contains a pharmaceutically effective amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof and a polymer binder and a method of preparing said microcapsule. The microcapsule is produced by dispersing in an aqueous phase a dispersion of the amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof in a solution of a polymer in an organic solvent to give an s/o/w type emulsion and subjecting the emulsion to in-water drying. The sustained-release microcapsule entraps 2-piperazinone-1-acetic acid compound or the salt thereof, as a drug, in high concentration, and in reducing the initial release of the drug, thereby reducing undesirable side effects of the drug.Type: GrantFiled: September 30, 1996Date of Patent: March 2, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Shigeyuki Takada, Tomofumi Kurokawa, Susumu Iwasa
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Patent number: 5874418Abstract: Sulfoalkyl ether-cyclodextrin (SAE-CD) based pharmaceutical formulations are provided by the present invention. These formulations comprise SAE-CD derivatives and a therapeutic agent, a major portion of which is not complexed to the SAE-CD. The present formulations are advantageously easier to prepare than other SAE-CD based formulations in the art yet provide similar or improved effectiveness. The SAE-CD derivative can be used to modify the bioavailability and/or rate of bioabsorption of therapeutic agents.Type: GrantFiled: May 5, 1997Date of Patent: February 23, 1999Assignee: Cydex, Inc.Inventors: Valentino Stella, Roger A. Rajewski, James W. McGinity
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Patent number: 5874417Abstract: A composition of matter comprising a hyaluronate functionalized with a hydrazide at glucuronic acid sites of said hyaluronate, wherein the hydrazide is chosen from a group consisting of: monohydrazide and hydrazides comprising three or more amine groups.Type: GrantFiled: May 10, 1996Date of Patent: February 23, 1999Assignee: The Research Foundation of State University of New YorkInventors: Glenn D. Prestwich, Dale M. Marecak
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Patent number: 5871776Abstract: A nifedipine formulation for oral administration is described that provides controlled, constant release of the pharmaceutical for about twenty four hours after a short delay following oral administration. There is also provided a method for preparing a controlled release formulation of nifedipine, which method includes coating pellets with multiple nifedipine-containing layers, along with an outer controlled release coating comprised of a water permeable polymer and lubricant/glidant. The pellets are then cured at an elevated temperature over several days. A method of using the formulations of the present invention for the treatment of patients is also described.Type: GrantFiled: October 28, 1996Date of Patent: February 16, 1999Inventor: Atul M. Mehta
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Patent number: 5869081Abstract: The present invention relates to a method of administering progesterone to a normogonadal or a functionally agonadal human female undergoing an assisted reproduction technique. The invention further provides a method of hormone replacement for a human female. In a preferred embodiment of the present invention, progesterone is provided by intravaginal administration of a progesterone-containing polysiloxane ring.Type: GrantFiled: June 28, 1996Date of Patent: February 9, 1999Assignee: The Population CouncilInventors: Theodore Jackanicz, Horacio B. Croxatto Avoni, Leopoldo Glasser Drexler, Fernando Zegers-Hochschild
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Patent number: 5869094Abstract: A solid form of oral administration of isosorbide 5-mononitrate with a controlled, pH-independent release of the active substance in the gastro-intestinal tract is constituted by a pellet coated with a depot layer and a release prolonging lacquer layer. The lacquer layer contains ethyl cellulose and polymethacrylate in a weight ratio from 3:1 to 3:2. The new form of administration is characterized in that it is less costly to produce.Type: GrantFiled: January 24, 1997Date of Patent: February 9, 1999Assignee: BYK Gulden Lomberg Chemische Fabrik GmbHInventors: Cornelia Alida Maria Van Egmond, Andre Pullen, Sibo Wytse De Jong, Adrianus Petrus De Jong, Jan Bron
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Patent number: 5861387Abstract: Methods of treatment and prevention of estrogen-related diseases, and of fertility control, include low dose (e.g. less than 50 nanomolar serum concentration) administration of certain anabolic steroids, progestins and other substantially non-masculinizing androgenic compounds. Sustained release formulations substantially free of organic solvent, and sustained release formulations for maintaining low serum levels of androgen are disclosed.Type: GrantFiled: June 7, 1995Date of Patent: January 19, 1999Assignee: Endorecherche Inc.Inventors: Fernand Labrie, Martin Lepage
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Patent number: 5856271Abstract: The invention is a method of making a controlled release device that is free of defects. According to one aspect of the present invention, a method has the steps of first combining an active chemical with a dried carrier into a bound friable mixture followed by combining the bound friable mixture with a polymer preform prior to forming a device. According to another aspect of the present invention, a method has the steps of heating and mixing a casting urethane with an active chemical into a first solution, heating and mixing a trialkanolamine with a soft segment cross-linker into a second solution, and mixing the two solutions. A further aspect of the present invention is a composition of a casting urethane.Type: GrantFiled: August 19, 1996Date of Patent: January 5, 1999Assignee: Battelle Memorial InstituteInventors: Dominic C. Cataldo, Peter Van Voris
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Patent number: 5853760Abstract: A device for the controlled release of active substances in liquid media from an active substance-containing matrix exhibiting active substance releasing-surfaces has, the active substance releasing surfaces of the matrix covered, at least partially, by an erodible mass of solids; the thickness of the erodible mass across its extent on the active substance releasing-areas is determined by gradients.Type: GrantFiled: December 2, 1994Date of Patent: December 29, 1998Assignee: LTS Lohmann Therapie-Systeme GmbH & Co. KGInventor: Karsten Cremer
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Patent number: 5851579Abstract: The present invention sets forth an enteric coating composition comprising a blend ofa) an alkali-soluble acrylic latex polymer andb) an aqueous solution of ammonium or alkaline salts of cellulose polymers.The invention also sets forth a method for preparing an enterically-coated dosage form and a method for preparing the present compositions.Type: GrantFiled: October 8, 1997Date of Patent: December 22, 1998Assignee: Eastman Chemical CompanyInventors: Stephen Hong-Wei Wu, Warren Kent Hopkins
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Patent number: 5847010Abstract: The present invention is a method of preventing or ameliorating the episodic recurrence of MS, comprising administering an effective amount of selective phosphodiesterase inhibitors of Type IV, e.g., Rolipram, e.g., wherein the severity of the episodic recurrences is ameliorated or the time period between episodes is lengthened.Type: GrantFiled: September 22, 1997Date of Patent: December 8, 1998Assignee: Berlex Laboratories, Inc.Inventors: Joel Hedgpeth, Helmut Wachtel
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Patent number: 5846563Abstract: A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic cross-linking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.Type: GrantFiled: April 18, 1997Date of Patent: December 8, 1998Assignee: Edward Mendell Co., Inc.Inventor: Anand R. Baichwal
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Patent number: 5820880Abstract: Depending on the antigen encapsulated, liposomal formulations are subject to instability in the presence of alum. Formulations containing a nonionic detergent as a stabilizing agent avoid this instability.Type: GrantFiled: June 7, 1995Date of Patent: October 13, 1998Assignees: The United States of America as represented by the Secretary of the Army, Jenner TechnologiesInventors: Carl R. Alving, Jean M. Muderhwa
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Patent number: 5814340Abstract: Methods of treatment and prevention of estrogen-related diseases, and of fertility control, include low dose (e.g. less than 50 nanomolar serum concentration) administration of certain anabolic steroids, progestins and other substantially non-masculinizing androgenic compounds. Sustained release formulations substantially free of organic solvent, and sustained release formulations for maintaining low serum levels of androgen are disclosed.Type: GrantFiled: June 7, 1995Date of Patent: September 29, 1998Assignee: Endorecherche Inc.Inventors: Fernand Labrie, Martin Lepage
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Patent number: 5770231Abstract: The instant invention is related to a sustained-release microparticle produced by dissolving in a solvent an active agent and a biodegradable and biocompatible polymer to form an organic phase.Type: GrantFiled: February 28, 1997Date of Patent: June 23, 1998Assignees: Alkermes Controlled Therapeutics, Inc. II, Janssen PharmaceuticaInventors: Jean Mesens, Michael E. Rickey, Thomas J. Atkins
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Patent number: 5753639Abstract: A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose of a progestin or other steroid derivative having androgenic activity and low masculinizing activity. Pharmaceutical compositions useful for such treatment and pharmaceutical kits containing such compositions are disclosed. An in vitro assay permitting specific measurements of androgenic activity of potentially useful compounds is also disclosed.Type: GrantFiled: January 4, 1996Date of Patent: May 19, 1998Assignee: Endorecherche Inc.Inventor: Fernand Labrie