Abstract: A vaginal suppository comprising a pharmaceutically acceptable salt of dehydroepiandrosterone sulfate and a hard fat with a hydroxyl value not exceeding 50. This vaginal suppository is useful for improving the ante-partum condition of pregnant women and features an extended shelf life.

Abstract: A disposable feminine hygiene kit and system that includes a douche composition for internal cleansing of the vagina, and a wipe solution for external cleansing of the vulva. The douche formulation may be a ready-to-use liquid solution, or a concentrate. It comprises inorganic salts, as well as a buffering agent for pH adjustment. The concentrate does not require a preservative. The ready-to-use liquid solution incorporates the ingredients of the concentrate, and also includes a preservative. The compositions of both the liquid and the concentrate comprise a multiple electrolyte solution, pH-adjusted and isotonic (after dilution of the concentrate), resulting in optimal vaginal compatibility. The douche composition is used in combination with a preserved anti-bacterial wipe solution for use upon the external vulva. The wiping solution is preferably incorporated into a towelette application.

Abstract: An antifungal vaginal suppository is disclosed comprising cis-2-(1H-imidazolylmethyl)-3-(2',6'-difluorobenzyloxy)-2,3-dihydro-5-fluo robenzo[b]thiophene in a suppository base containing biocompatible polymers, a surfactant and an absorbent in a vegetable oil phase.

Abstract: Iodophor-containing suppositories are provided with improved rate of iodine release from the suppository. The suppository composition comprises an iodophor, a water soluble suppository base, at least one water soluble sugar having a molecular weight of between about 90 and 550, and water in an amount of at least about 30% by weight. The molecular weight of the sugar is preferably between about 150 and 370. The preferred iodophors are providone iodine and polydextrose iodine. The preferred suppository bases are gelling polysaccharides and the preferred sugars are monosaccharides, disaccharides and sugar alcohols. The rate of iodine release is improved because of the high concentration of water together with the presence of the low molecular weight sugar.

Abstract: Polypeptides containing a substantial proportion of L-histidine are effective fungicidal agents. They are particularly effective against C. albicans and have a high degree of safety and nontoxicity because of their structural similarity to naturally occuring histidine-rich polypeptides which are unique to the salivas of humans and old world monkeys.

Abstract: A method of prophylactics with respect to deodorization by ascorbic acid, salts and esters, topically applied by means of carriers which are otherwise regularly employed in the vaginal area, such as a pharmacological appliance including gauze pads, an absorbant mass or pad associated with menses, douches, and contraceptive compositions.

Abstract: A method of prophylactics with respect to detoxification of Staphylococcus aureus and other toxins by ascorbic acid, salts and esters, topically applied by means of carriers which are otherwise regularly employed in the area where Staphylococcus aureus or other bacteria colonize, such as a pharmacological appliance including gauze pads, an absorbant mass or pad associated with menses, douches, and contraceptive compositions.

Abstract: Methods and compositions are described for the preparation of lipid vesicles, the bilayers of which comprise a salt form of an organic acid derivative of a sterol such as the tris-salt form of a sterol hemisuccinate. The method is rapid, efficient, and does not require the use of organic solvents. The sterol hemisuccinate vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility thus enabling administration in vivo.

Abstract: The invention relates to liquid, transparent, multicomponent systems for use in pharmaceutical products for cutaneous, peroral, vaginal and parenteral administration of pharmaceutical active agents. The multicomponent systems according to the invention contain the active agents in a solution of an oily and optionally an aqueous component in the presence of certain physiologically acceptable surfactants and cosurfactants. Under certain conditions, the cosurfactants can serve as oil components or the latter can optionally take over the cosurfactant function. The biological availability of the active agents applied in the form of the multicomponent systems according to the invention is much better than that of active agents applied in the form of known multicomponent systems.

Abstract: A controlled-release pharmaceutical unit dosage form is provided comprising a gelatin capsule enclosing a solid matrix formed by the cation-assisted gellation of a liquid fill incorporating a vegetable gum and a pharmaceutically-active compound, as well as methods for the preparation thereof.

Abstract: A vehicle which provides rapid release of a drug and prolonged release of a drug is disclosed.

Abstract: A medicated suppository for use in the vaginal or rectal cavity comprising a medicament, a mixture of triglycerides of fatty acids, a gel forming agent and a gel dispersing agent is described.

Abstract: A solid sustained release dosage form is disclosed comprising a gel matrix containing HPMC and a major amount of a plasticizer therefor into which gel matrix is reversibly dispersed a pharmaceutically active agent.

Abstract: Conditioning of the vaginal tract for sexual activity, by a method including adjusting and controlling its surface pH, with soluble means for accomplishing such conditioning. The specified conditioning favors increased duration of sexual intercourse, as is often desired, and is compatible here with such diverse goals as favoring or discouraging conception. Normally the human vagina is strongly acidic, which may render intercourse with some males unduly brief. Through this invention the vaginal pH is increased about several pH units, by applying thereto a capsule, tablet, or suppository containing an alkalizer, to be released upon dissolution, so that the surface of the vaginal tract nears and preferably reaches or somewhat exceeds a neutral pH of 7 for a desired period of time. Thereafter, the vagina is enabled to return to its normally acidic condition, or is preferably actively returned thereto by subsequent release of an acidifier from such topically applied means.

Abstract: This invention relates to a method of prophylaxis with respect to Toxic Shock Syndrome in warm blooded animals, comprising the placing of a propylactically effective dosage of ascorbic acid in the vagina or in the area of the vagina.