Antigen-antibody Patents (Class 524/900)
  • Patent number: 7550419
    Abstract: This invention relates to a composition useful as an oral care composition comprising an organophosphate material, additional oral care composition ingredients, for example, a surfactant agent, and optionally an abrasive agent.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: June 23, 2009
    Assignee: Rhodia Inc.
    Inventors: Tobias Johannes F├╝tterer, Lawrence Alan Hough, Robert Lee Reierson
  • Patent number: 6197599
    Abstract: A device comprises a solid support and multiple immobilized agents for protein detection is described. The immobilized agents are mainly proteins, such as antibodies and recombinant proteins. The immobilized agents can be synthesized peptides or other small chemicals. Agents are individually deposited in a predetermined order, so that each of the agents can be identified by the specific position it occupies on the support. The immobilized agents on the solid support retain their protein binding capability and specificity. Methods employing the device are extremely powerful in screening protein expression patterns, protein posttranslational modifications and protein—protein interactions.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: March 6, 2001
    Inventors: Guorong Chin, Yingyi Wang
  • Patent number: 6143537
    Abstract: A method for stabilizing analyses with antibodies and antibody fragments comprises dissolving the analyte in a liquid to form a solution, adding analyte-specific antibodies, fragments of such antibodies, or both to the solution, heating the solution, and then cooling and filtering the solution. The filtered solution may be diluted in a suitable matrix.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: November 7, 2000
    Assignee: Medical Analysis Systems, Inc.
    Inventors: Shing F. Kwan, Ivan E. Modrovich, Rebecca J. Hunt
  • Patent number: 5922618
    Abstract: The invention relates to a dye-labeled antibody conjugate comprising an antibody conjugate and a cyanine dye. The dye-labeled antibody conjugate is prepared by polymerizing an antibody such as mouse IgG in phosphate buffer using a polyfunctional reagent such as dithiobis(sulfosuccinimidylpropionate), and stirring the antibody and a cyanine dye represented by Formula I . The dye-labeled antibody conjugate is more sensitive to antigens than conventional dye-labeled antibodies because it has many reactive sites to antigens.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: July 13, 1999
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Nobuyuki Shigetou, Jinsei Miyazaki, Mahito Hirai
  • Patent number: 5308749
    Abstract: Biologically active reagents are prepared from particles of copolymers having highly active succinimid groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through amide groups by displacement of highly active succinimid groups on the particle surface. These reagents are used to advantage in analytical elements, methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods such as affinity chromatography.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: May 3, 1994
    Assignee: Eastman Kodak Company
    Inventors: Richard C. Sutton, Ignazio S. Ponticello, Susan J. Danielson, Marsha D. B. Oenick
  • Patent number: 5166077
    Abstract: A latex for immobilization of a physiologically active substance is prepared by copolymerizing a monomer mixture comprising:(a) 100 parts by weight of an aromatic vinyl monome4r;(b) 0.01 to 5 parts by weight of a vinyl monomer having a sulfonic acid group;(c) 1 to 20 parts by weight of an .alpha.,.beta.-unsaturated carboxylic acid monomer; and(d) 0.05 to 5 parts by weight of a polyfunctional monomer for internal cross-linking; in water using a water-soluble radical polymerization initiator in the absence of an emulsifying agent. An antigen or antibody or a hapten can be covalently bound to particles of the latex to form a reagent for use in immuno nephelometry.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: November 24, 1992
    Assignee: Nitto Denko Corporation
    Inventors: Yasuo Kihara, Kenjiro Mori, Tetsuo Watanabe, Takashi Tsuji