Abstract: Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein.

Abstract: The present invention relates inter alia to novel organic metal complexes comprising, e.g., platinum and specific side groups, their preparation und their use in electronic devices.

Abstract: A composition for fixing wound items is provided. In one example, the composition comprises 5 to 97 wt % of at least one ?,?-unsaturated polyester resin and/or ?,?-unsaturated polyester imide resin comprising components of at least one ?,?-ethylenically unsaturated mono-, di- and/or tricarboxylic acid, and/or its anhydride and/or ester, at least one polyol, at least one (meth)acrylic group containing component, possibly at least one mono-, di-, tri- and/or tetracarboxylic acid, which is not ?,?-ethylenically unsaturated, and/or its anhydride and/or ester.

Abstract: A comb copolymer with a polymer backbone having grafted lateral macromonomer segments, the method of preparing, and the use thereof as a thickener in cosmetics. The polymer backbone is more than 55% and up to 90% molar ATBS, between 1% and 20% molar cationic monomer or monomer of formula (I): CH2?C(R1)—C(?O)—Y—(CH2)m-N(R2) (R3), where m is between 1 and 4, Y is O or NH, R1 is H or CH2, and R2 and R3 are each a methyl or ethyl radical, and optionally 0.005% to 1% molar of at least one cross-linking monomer with at least two C?C bonds. The lateral macromonomer segments are polymerized from 9% to 30% molar of N-alkyl acrylamide or N,N-dialkyl acrylamide of formula (II): CH2?C(R4)—C(?O)—N(R5) (R6), where R4 is H or CH2 and R5 and R6 are H or a C1 to C3 alkyl radical, with at least one of R5 or R6 not being H.

Abstract: The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing useful properties. For example, use of one or more wedge group-containing blocks in some block copolymers of the invention significantly inhibits chain entanglement and, thus, the present block copolymers materials provide a class of polymer materials capable of efficient molecular self-assembly to generate a range of structures, such as periodic nanostructures and microstructures. Materials of the present invention include copolymers having one or more wedge group-containing blocks, and optionally for some applications copolymers also incorporating one or more polymer side group-containing blocks. The present invention also provides useful methods of making and using wedge-type block copolymers.

Abstract: There are provided a novel cyclic olefin compound having a photoreactive group and a photoreactive polymer. The cyclic olefin compound is applicable to various photoreactions, such as of liquid crystal alignment layers and can be preferably used as a precursor of various organic compounds or polymers.

Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer. Some of the microcarriers support attachment of human embryonic stem cells.

Abstract: The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing useful properties. For example, use of one or more wedge group-containing blocks in some block copolymers of the invention significantly inhibits chain entanglement and, thus, the present block copolymers materials provide a class of polymer materials capable of efficient molecular self-assembly to generate a range of structures, such as periodic nanostructures and microstructures. Materials of the present invention include copolymers having one or more wedge group-containing blocks, and optionally for some applications copolymers also incorporating one or more polymer side group-containing blocks. The present invention also provides useful methods of making and using wedge-type block copolymers.

Abstract: The present invention is directed to polymeric materials comprising biodegradable, dioxanone-based copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The polymeric materials can also contain at least one additional biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.

Abstract: An ink composition includes a graft copolymer including a repeating unit having a partial structure represented by Formula (1) described below and a repeating unit having a hydrophilic group in which a graft chain includes the repeating unit and water.

Abstract: Compositions are described that are blends of a grafted copolymer and a polyamide. Methods of making the blended compositions are also described. The grafted copolymers are the reaction product of (1) a first compound having both an aziridinyl group and a polymeric group with (2) a second polymeric material having an acidic group. Blending the grafted copolymer with the polyamide can be used, for example, to increase the cohesive strength of the grafted copolymer.

Abstract: Provided are multifunctional polymers comprising at least one anhydride repeating unit with at least one pseudo-cationic moiety graft and at least one hydrophobic graft. The grafting functionalizations can occur before, during, or after polymerizing the monomer(s). The anhydride employed may be partially or fully opened to provide amic acids, carboxylic acids, carboxylic acidic salts, imides, esters, and mixtures thereof. The polymers also may comprise other repeating units, including, but not limited to, alpha-olefins. In one embodiment the polymers exhibit antimicrobial activity, and can be employed in a wide variety of compositions, including those where antimicrobial activity is useful. A method of providing microbial activity also is provided.

Abstract: Disclosed herein are a cyclic olefin compound, a photoreactive polymer, and an alignment layer comprising the photoreactive polymer, where the cyclic olefin compound can be used to provide the photoreactive polymer having not only excellences in liquid crystal alignment and alignment rate but also readiness for change in the alignment direction depending on the polarization direction.

Abstract: A method for producing a modified conjugated diene polymer comprising a polymerization step of obtaining a conjugated diene polymer containing a nitrogen atom in a polymer chain and an active end by copolymerizing a conjugated diene compound and a nitrogen atom-containing vinyl compound, or a conjugated diene compound, an aromatic vinyl compound and a nitrogen atom-containing vinyl compound by use of an alkali metal compound and/or an alkaline earth metal compound as a polymerization initiator, and a modification step of reacting a modifier.

Abstract: In one aspect, catalytic membranes are described herein. In some embodiments, a catalytic membrane comprises a surface functionalized with a polymer, the polymer comprising cellulose solubilization functionalities and acid functionalities for the catalytic hydrolysis of cellulose and/or hemicellulose.

Abstract: Substituted phenacyl molecules are provided and employed to create molecules and polymers/copolymers that exhibit photoresponsiveness. In some instances, the substituted phenacyl molecule is incorporated into the polymer/copolymer backbone, and photoirradiation of the polymer/copolymer causes the substituted phenacyl group to break down and the polymer/copolymer to undergo degradation. In other instances, the substituted phenacyl molecules extend as a side chain from the polymer/copolymer backbone. In yet other instances the substituted phenacyl molecules extend as a side chain from the polymer/copolymer backbone, and a drug or polymer additive is linked to the photoresponsive substituted phenacyl group such that photoirradiation releases the drug or additive. In yet other embodiments the substituted phenacyl molecules extend as a side chain from the polymer/copolymer backbone, and serve to link the polymer/copolymer to another polymer/copolymer backbone, and photoirradiation breaks the links.

Abstract: The present invention relates to modular sterically enhanced emission dye (SEED) clusters, wherein multiple SEED molecules are appended to a single polymeric chain.

Abstract: We disclose methods and compositions for preparation of stimuli-responsive plastics that are capable of responding to chemical and/or physical signals in their environment. In one embodiment the plastics consist of patterned mixtures of poly(phthalaldehyde) polymers in which each polymer contains a different end-capping group (also called a “trigger”), responsive to a different signal. Other embodiments use different polymers and different triggers. The plastics may be homogeneous in composition, but each polymer within the plastic is capable of responding to a different signal and depolymerizing once this signal reacts with the trigger. This process of depolymerization enables the plastic to alter its physical features non-linearly to external signals: i.e., the degree of change in physical form is much larger than the intensity of the initial signal.

Abstract: Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand.

Abstract: Grafted compounds are formed by reacting (1) a first compound having both an aziridinyl group and a polymeric group with (2) a second compound having at least one acidic group. This reaction results in the opening of the aziridinyl ring on the first compound by the acidic group on the second compound and the formation of an attachment group that connects polymeric group of the first compound to the second compound. In some embodiments, the second compound is a polymeric material having multiple acidic groups and the product of the reaction of the first compound with the second compound results in the formation of a grafted copolymer.

Abstract: The present invention relates to compositions for household care which include a cationic nanogel, particularly for treating and/or modifying hard or textile surfaces. The composition particularly enables a hydrophilization of hard surfaces, particularly useful in cleaning or rinsing operations.

Abstract: A resin composition which has low stress, and good adhesive property in high temperature and high moisture environments and which is useful in adhesive applications in low stress, high moisture sensitivity level electronic packages. Preferably, a flexible epoxy anhydride adduct modified solid bismaleimide and solid benzoxazine resin composition that can survive high temperature and high moisture conditions and maintain good adhesion strength and minimize the stress resulting from a coefficient of thermal expansion mismatch between a silicon die and a substrate which is Ball Grid Array solder mask or a smart card polyethylene terephthalate or silver or copper metal lead frame.

Abstract: Compounds are described that have both an aziridinyl group as well as a polymeric group. Methods of making these compounds are also described. The aziridinyl group of the compound can be reacted with an acidic group on a second compound resulting in the opening of the aziridinyl ring and the attachment of the polymeric group to the second compound.

Abstract: Stabilizers that include hydrophobically modified amine-containing polymers may be utilized as compositions or in methods for controlling particulate migration in a subterranean formation. For example, a method may include providing a treatment fluid that comprises a base fluid and a hydrophobically modified amine-containing polymer (HMAP), the HMAP comprising a plurality of hydrophobic modifications on an amine-containing polymer; introducing the treatment fluid into a wellbore penetrating a subterranean formation, the subterranean formation comprising a plurality of particulates; and allowing the HMAP to coat at least some of the particulates.

Abstract: A meta-stable state nitrogen-containing polymer formed by reacting Compound (A) and Compound (B) is described. Compound (A) is a monomer having a reactive terminal functional group. Compound (B) is a heterocyclic amino aromatic derivative as an initiator. The molar ratio of Compound (A) to Compound (B) is from 10:1 to 1:10. The meta-stable state nitrogen-containing polymer has a variance less than 2% in its narrow molecular weight distribution after being retained at 55° C. for one month.

Abstract: Disclosed herein are high structured carbon blacks, methods of synthesis and treatment, and dispersions and inkjet ink formulations prepared therefrom. The carbon black can have the following properties: OAN?170 mL/100 g; and STSA ranging from 160 to 220 m2/g. The carbon black can also have the following properties: OAN?170 mL/100 g; and a ratio of STSA/BET surface area ranging from 0.7 to 1.

Abstract: Conventional cross-linked cyclic olefin polymers do not have a sufficiently low linear expansion coefficient. A compound having a structure represented by the following formula (a).

Abstract: Provided herein are copolymers of a polyaminopolymer and polyanhydride, wherein the polyaminopolymer comprises a polyaminopolyolefin; and methods of their preparation.

Abstract: The present disclosure provides polymer compounds binding with lipoamide produced by the reaction of the primary amine group of lipoamide with the carboxy group of polysaccharide compounds such as chondroitin sulfates, carboxymethyl celluloses, or hyaluronic acids; functional compounds such as peptides, proteins, growth factors; or drugs; or biocompatible polymers such as poly(ethylene oxide), poly(vinyl alcohol), or poly(vinyl pyrrolidone). The present disclosure also provides their synthesis methods, products of hydrogels and films using the same as and methods for manufacturing the products.

Abstract: An organic crystalline composition is provided. The organic crystalline composition includes a main material having ?-conjugated back bone and a functional group containing an atom having an unshared electron pair, and a linking material combining with the adjacent main material at the functional group by quaternization, organic material-metal interaction, ionic bonding, or hydrogen bonding.

Abstract: Composition and method for surface-functionalized SPION-based agents. Such agents can provide highly pH-sensitive MRI contrast in tissue.

Abstract: The present invention discloses a non-aqueous solution process for making cross-linked polymers. The cross-linked polymers are characterized by a repeat unit that includes at least one amino group. Amino groups can be part of the polymer backbone (e.g., polyethyleneimine), pendant from the polymer backbone (e.g., polyallylamine), or both types of amino groups can exist within the same repeat unit and/or polymer. The present invention discloses more specifically non-aqueous solution cross-linking to prepare Sevelamer and its salts, Colesevelam and its salts.

Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol(meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.

Abstract: The present invention relates inter alia to the use of moisture-conditioned disintegrants or expanding agents in tablet manufacture for the selective adjustment of the mechanical properties, the dissolution kinetics (dissolution) and/or the water loading of tablets.

Abstract: An antibiofilm complex formed of a polyvinylpyrrolidone (PVP) backbone, iodine anchored to the PVP backbone, Rifampin anchored to the PVP backbone, and a second antibiotic selected from the group consisting of Tobramycin and Gentamicin anchored to the PVP backbone.

Abstract: Shape memory polymer compositions and methods of using those compositions to make products are provided. The compositions include a thermoplastic polymer and a high thermal stability free radical source, and they are extruded together to form the final shape memory product.

Abstract: In one aspect, the invention relates to silicone prepolymer compositions comprising a silicone prepolymer and a solvent. A soluble silicone prepolymer can be provided having increased average silicon content, thereby attaining a desired oxygen permeability. A solvent can be provided with a desired balance between hydrophilicity and hydrophobicity by selection and modification of the solvent molecular structure, resulting in molded polymer films and articles that exhibit minimal or nonexistent eye irritation and exhibit highly transparent products. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A retardation film, formed by stretching a film having a norbornene-based ring-opening copolymer containing a structural unit (A) represented by the general formula (1) and a structural unit (B) represented by the general formula (2), wherein the content of structural unity (A) is not less than 5 mol % but not more than 95 mol % relative to the total amount of structural units (A) and (B).

Abstract: A room temperature crosslinkable polymer system comprising an anhydride containing polymer and an oxyalkylene amine and a polymer electrolyte derived therefrom are prepared and employed as ion conducting materials for batteries such as lithium ion battery, solar cells and electrochromic devices is disclosed.

Abstract: The invention relates to nitric oxide-releasing compositions comprising polyacrylonitrile polymers that are diazeniumdiolated, and to medical devices comprising such compositions, as well as to methods of making and using the compositions and medical devices.

Abstract: A polymer comprising a conducting or semiconducting segment coupled to a polymer segment having an insulating polymer backbone, the polymer further comprising a RAFT functional group coupled to the polymer segment, wherein there is no RAFT functional group in between the conducting or semiconducting segment and the polymer segment.

Abstract: A pressure-sensitive adhesive of the invention includes a (meth)acryl-based polymer obtained by polymerization of a monomer component including: an alkyl(meth)acrylate (a1) having a branched alkyl group of 8 to 24 carbon atoms at an ester end; and an alkyl(meth)acrylate (a2) having a linear alkyl group of 8 to 24 carbon atoms at an ester end. The pressure-sensitive adhesive can has a satisfactory level of adhesive performance and can form a pressure-sensitive adhesive layer with a lower dielectric constant.

Abstract: Novel acrylamide and methacrylamide hydantoin monomers which can be reacted with other acrylamide, methacrylamide, acrylate, and methacrylate monomers to form copolymers, which upon halogenation, provide oxidative coatings which are biocidal for use with various materials including, but not limited to, textiles, filters, and latex paints.

Abstract: The present invention relates to modular sterically enhanced emission dye (SEED) clusters, wherein multiple SEED molecules are appended to a single polymeric chain.

Abstract: A pharmaceutical aerosol composition comprising at least one hydrofluoroalkane propellant; at least one active agent complexed with an adjuvant; and, optionally, at least one pharmaceutically acceptable excipient.

Abstract: The present disclosure is directed to a continuous process for preparing cellulose reactive adducts of polyvinylamide.

Abstract: The present invention relates to the reaction product of (A) a polymeric backbone with (B) A chromophore; and with (C) at least one sulfide containing compound. Very good dyeing results are obtained with this new technology.

Abstract: Low amidine content poly(N-vinylformamide-co-vinylamine) (PVAm), is described, as well as processes of making and providing same in fresh or aged formats, and the usage of such polymer to increase papermaking retention and drainage rate and enhance paper dry strength, and other applications.

Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.

Abstract: A proton exchange membrane comprising modified hyper-branched polymer is disclosed. The proton exchange membrane includes 85-90 wt % of sulfonated tetrafluorethylene copolymer and 15-10 wt % of modified hyper-branched polymer. The modified hyper-branched polymer comprises the bismaleimide (BMI)-based hyper-branched polymer, and parts of the chain ends of the hyper-branched polymer are sulfonated by the sulfonic compound. Also, the modified hyper-branched polymer and sulfonated tetrafluorethylene copolymer are interpenetrated to form an interpenetrating polymer. Furthermore, the modification step could be performed before or after forming the interpenetrating polymer. For example, the sulfonation is proceeded after forming the interpenetrating polymer. Alternatively, the sulfonation of the hyper-branched polymer could be proceeded before the formation of the interpenetrating polymer.