Containing Chemically Combined Protein Or Biologically Active Polypeptide Patents (Class 525/54.1)
  • Patent number: 10563094
    Abstract: Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: February 18, 2020
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation, Regents of the University of Minnesota
    Inventors: Hongfei Jia, Ping Wang, Liting Zhang, Andreas Buthe, Xueyan Zhao, Songtao Wu, Masahiko Ishii, Minjuan Zhang
  • Patent number: 10494453
    Abstract: Conjugate compounds of hyaluronic acid bonded to pentosan polysulfate, or salts or derivatives thereof, are shown to induce chondrogenic differentiation of a population of mesenchymal stem cells as observed by, amongst other indications, increased glycosaminogSycan (GAG) production.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: December 3, 2019
    Assignee: THE UNIVERSITY OF QUEENSLAND
    Inventors: Justin Cooper-White, Peter Ghosh
  • Patent number: 10413529
    Abstract: Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a ?-crystallin charge masking agent. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: September 17, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Murugappan Muthukumar, Benjamin Mohr
  • Patent number: 10413769
    Abstract: Disclosed herein are novel coatings and paints comprising a biomolecule composition, wherein the biomolecule composition comprises a phosphoric triester hydrolase. Also disclosed herein are methods of detoxification of a surface contaminated with an organophosphorus compound by contacting the surface with such a coating or paint. Also disclosed herein are novel coating and paint components derived from microorganisms.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: September 17, 2019
    Assignee: Reactive Surfaces, Ltd., LLP
    Inventor: C. Steven McDaniel
  • Patent number: 10301590
    Abstract: The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, T cell or stem cell expansion. In another aspect, the disclosure provides for an electrospun mesh substrate and methods of using thereof comprising a silicone rubber composition, for example, polydimethylsiloxane, PLC, or combinations thereof.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: May 28, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Lance C. Kam, Helen H. Lu, Sarah E. De Leo, Keenan T. Bashour, Danielle Bogdanowicz, Philip Chuang
  • Patent number: 10251958
    Abstract: The invention provides a dispersion of assemblies. The assemblies comprise an albumin derivative comprising albumin having a polymer chain coupled thereto, wherein the assemblies comprise a core comprising the polymer chains and a shell comprising the albumin. A process for making the dispersion and methods of using the dispersion are also described.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: April 9, 2019
    Assignee: NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Martina Heide Stenzel, Wei Scarano, Domenic Svejkar, Mingtao Liang
  • Patent number: 10227289
    Abstract: Provided herein are methods of treating diseases of the lung in a mammal, including cancer of the lung, mesothelioma, emphysema, and bronchopleural fistula. The methods comprise delivering a biocompatible hydrogel polymer optionally comprising a therapeutic agent directly to a target site using a minimally invasive delivery device, wherein the biocompatible hydrogel polymer gels at the target site.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: March 12, 2019
    Assignee: MEDICUS BIOSCIENCES, LLC
    Inventors: Syed H. Askari, George Horng
  • Patent number: 10189773
    Abstract: Provided herein are in vivo gelling pharmaceutical pre-formulations forming biocompatible hydrogel polymers that are polymerized in vivo and kits comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally at least one therapeutic agent. The biocompatible hydrogel polymer is bioabsorbable and releases the therapeutic agent at a target site, avoiding systemic exposure.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: January 29, 2019
    Assignee: MEDICUS BIOSCIENCES, LLC
    Inventors: Syed H. Askari, George Horng
  • Patent number: 10172962
    Abstract: This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 8, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Dong Wang, Jindrich Kopecek, Scott C. Miller, Pavla Kopeckova
  • Patent number: 10156670
    Abstract: A polarizing film includes a high-temperature elongation film of a polyolefin and a dichroic dye, and the polyolefin has zero shear viscosity (?0) ranging from about 2600 Pa·s to about 17400 Pa·s at a temperature of about 210° C. (±3° C.).
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: December 18, 2018
    Assignees: SAMSUNG ELECTRONICS CO., LTD., SAMSUNG SDI CO., LTD.
    Inventors: Feifei Fang, Beom Seok Kim, Seong-Jun Yoon, Dong Yun Lee, Boreum Jeong, Myung Sup Jung, Won Suk Chang
  • Patent number: 10138273
    Abstract: Methods and compositions for identifying and using polypeptides that target hepatic stellate cells are described. Embodiments include a targeting composition that may include one or more polypeptides including an amino acid sequence that binds to an insulin-like growth factor 2 receptor. Other embodiments relate to targeting systems that may include a one or more polypeptides including an amino acid sequence that binds to an insulin-like growth factor 2 receptor of hepatic stellate cells. Further embodiments relate to methods for treating health disorders in which the methods include the targeting composition or targeting systems as well as an agent capable of treating the disorder.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: November 27, 2018
    Assignee: The Curators of the University of Missouri
    Inventors: Kun Cheng, Zhijin Chen
  • Patent number: 10092662
    Abstract: This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: October 9, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Dong Wang, Jindrich Kopecek, Scott C. Miller, Pavla Kopeckova
  • Patent number: 9981205
    Abstract: Provided is a purification device for purifying a useful substance (i.e., target substance) without using an acidic eluent. The purification device purifying the target substance comprises a column and a filler packed in the column. The filler contains a carrier, a temperature responsive polyamino acid bonded to the carrier, and a binding substance bonded to the temperature responsive polyamino acid and specifically bonding to the target substance.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: May 29, 2018
    Assignee: HITACHI, LTD.
    Inventors: Keisuke Shibuya, Yui Sugita, Ryouichi Haga, Masaru Nanba
  • Patent number: 9925140
    Abstract: Described herein is a cell tissue gel containing collagen and hyaluronan at a weight ratio of 0.01-100:1.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: March 27, 2018
    Assignee: National Cheng Kung University
    Inventor: Lynn L. H. Huang
  • Patent number: 9896484
    Abstract: The present invention includes influenza Hemagglutinin protein fragments that fold properly when expressed in bacteria.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: February 20, 2018
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Surender Khurana, Hana Golding
  • Patent number: 9884074
    Abstract: The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: February 6, 2018
    Assignee: Eyeon Particle Sciences LLC
    Inventors: Eugene Rex Cooper, David Maxwell Kleinman, Andrew Loxley, Mark A. Mitchnick
  • Patent number: 9833767
    Abstract: This invention relates to novel non-composite and composite superabsorbents, wherein the dry superabsorbents are xerogels, more particularly the bio-xerogels or the composites, particularly the biocomposites, more particularly the bionanocomposites and the method(s) of obtaining the same characterized by simultaneous in situ grafting and cross linking of ethylinically unsaturated monomers on to a single biopolymer of plant or animal origin, or on combination of different biopolymers or biopolymer(s) or/and clay(s), in a homogeneous polar phase, in the presence of initiator and crosslinker of chemical or non-chemical origin, at a temperature of 40 to 90° C., achieved by conventional or microwave heating, reaction time varying from instantaneous to 48 hours, involving use of alkali, either in situ or post reaction at room or elevated temperatures for achieving superior absorbency, in an inert or ambient reaction environment, to yield a neutral or near neutral product.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 5, 2017
    Assignee: Indian Council of Agricultural Research
    Inventors: Anupama Singh, Druba Jyoti Sarkar, Balraj Singh Parmar
  • Patent number: 9814778
    Abstract: Underwater adhesive materials, methods of making the same, and methods of using the same are described.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: November 14, 2017
    Assignee: The University of Toledo
    Inventors: Yakov Lapitsky, Yan Huang
  • Patent number: 9801980
    Abstract: Methods of forming and/or manufacturing polymeric stents are disclosed. Polymeric stents are also disclosed.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: October 31, 2017
    Assignee: MicroVention, Inc.
    Inventors: Wataru Karino, Steve Plotkin, Gregory M. Cruise
  • Patent number: 9796769
    Abstract: A method of preparing a crosslinked, collagen-based medical scaffold is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for wound care dressings, hernia repair prosthetics, and surgical incision closure members, prepared using the method above.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: October 24, 2017
    Assignee: ENSION INC.
    Inventors: Ali Hussain, Patrick Cahalan, Linda Cahalan
  • Patent number: 9770527
    Abstract: One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m?3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer.
    Type: Grant
    Filed: January 2, 2012
    Date of Patent: September 26, 2017
    Assignee: Bender Analytical Holding B.V.
    Inventors: Richard Hoogenboom, Johannes Caspar Mathias Elizabeth Bender, Jan Cornelis Maria van Hest
  • Patent number: 9700650
    Abstract: Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: July 11, 2017
    Assignee: SpotLight Technology Partners LLC
    Inventors: Glen Gong, Suresh Subraya Pai, Scott Robert Sershen
  • Patent number: 9522382
    Abstract: Methods for making designed carbohydrate affinity columns and lectin columns are provided. Reducing sugar of choice is dissolved in pH 6.0 acetate buffer and injected onto a primary amino group functionality column. The column is washed with pH 6.0 acetate buffer and the column effluent monitored with a variable wavelength UV detector. Lectin columns are made by injecting appropriate lectin to the designed carbohydrate and the lectin binds to this scaffold. The lectin column is formed.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: December 20, 2016
    Assignee: BioLogistics LLC
    Inventor: Michael Madson
  • Patent number: 9522192
    Abstract: The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: December 20, 2016
    Assignee: EPITECH GROUP S.r.l.
    Inventors: Antonio Calignano, Giuseppe D'Agostino, Sonia Laneri, Rosaria Meli, Carmine Ostacolo, Roberto Russo, Antonia Sacchi, Diana Tronino, Francesco Della Valle, Maria Federica Della Valle, Gabriele Marcolongo
  • Patent number: 9505867
    Abstract: The invention features a triblock copolymer including a hydrophilic block; a hydrophobic block; and a positively charged block capable of reversibly complexing a negatively charged molecule, e.g., a nucleic acid, wherein the hydrophobic block is disposed between the hydrophilic block and the positively charged block. Desirably, the triblock copolymer is capable of self-assembling into a supramolecular structure, such as a micelle or vesicle. The invention further features methods of delivering negatively charged molecules and methods of treating a disease or condition using the polymers of the invention.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: November 29, 2016
    Assignee: Ecole Polytechmique Fédérale De Lausanne
    Inventors: Tatiana Segura, Jeffrey A. Hubbell
  • Patent number: 9480775
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: November 1, 2016
    Assignee: Allergan, Inc.
    Inventors: Karina Heredia Guillen, Ahmet Tezel
  • Patent number: 9433700
    Abstract: The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: September 6, 2016
    Assignee: MediBeacon Inc.
    Inventors: Bob O. Basore, William L. Neumann, Richard B. Dorshow, Raghavan Rajagopalan
  • Patent number: 9416228
    Abstract: One aspect of the invention relates to a biocompatible medical product comprising at least 1% by weight of dry matter of a covalently cross-linked polymer that is obtained by reacting a nucleophilically activated polyoxazoline (NU-POX) with an electrophilic cross-linking agent other than an electrophilically activated polyoxazoline, said NU-POX comprising m nucleophilic groups; and said electrophilic cross-linking agent comprising n electrophilic groups, wherein the m nucleophilic groups are capable of reaction with the n electrophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; and wherein the NU-POX comprises at least 30 oxazoline units in case the electrophilic cross-linking agent is an isocyanate. Also provided is a kit for producing the aforementioned biocompatible cross-linked polymer. The biocompatible cross-linked polymers according to the invention have excellent implant and/or sealing characteristics.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 16, 2016
    Assignee: Bender Analytical Holding B.V.
    Inventors: Johannes Caspar Mathias Elizabeth Bender, Richard Hoogenboom, Jan Cornelis Maria Van Hest, Harry Van Goor
  • Patent number: 9365650
    Abstract: The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of the agent to a subject the second element directs the first element to the activated platelet. Also provided is a probe for detecting a blood vessel abnormality including (a) a binding element capable of targeting an activated platelet and (b) a label. Applicant has shown that agents and probes directed to activated platelets are useful in the diagnosis and therapy of coagulation disorders.
    Type: Grant
    Filed: January 2, 2008
    Date of Patent: June 14, 2016
    Assignee: Baker IDI Heart and Diabetes Institute Holdings Limited
    Inventor: Karlheinz Peter
  • Patent number: 9346917
    Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: May 24, 2016
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Patent number: 9242010
    Abstract: Water soluble polymers having formula I: Y-(L1)n1-(C(O))n2—(R1)n3—R2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: January 26, 2016
    Assignee: Research Foundation of The City University of New York
    Inventors: Krishnaswami Raja, Wei Shi, Sukanta Dolai, Saadyah Averick, William L'Amoreaux, Probal Banerjee
  • Patent number: 9243274
    Abstract: This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2?-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a Methanococcus jannaschii (Mj) tyrosyl-tRNA synthetase/tRNACUA pair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1).
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: January 26, 2016
    Assignee: Franklin and Marshall College
    Inventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
  • Patent number: 9221886
    Abstract: Compositions, preparations, systems, and related methods for delivering a supercharged protein, or a complex of a supercharged protein and an agent (e.g., nucleic acids, peptides, proteins, small molecules) to cells are provided. Such systems and methods include the use of supercharged proteins. For example, superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. In some embodiments, such systems and methods involve altering the primary sequence of a protein in order to “supercharge” the protein (e.g., to generate a superpositively-charged protein). In some embodiments, complexes comprising supercharged proteins and one or more agents to be delivered are useful as therapeutic agents. In some embodiments, complexes and/or pharmaceutical compositions thereof are administered to a subject in need thereof.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: December 29, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Brian R. McNaughton, James Joseph Cronican, David B. Thompson
  • Patent number: 9220812
    Abstract: A method for improving the retention between the surfaces of medical devices. The method includes coating a surface of one medical device such as a stent with a coating that includes a functional group and coating a surface of another medical device such as a balloon with a coating that includes an identical or different functional group. The method further includes interacting the coated surfaces to produce a plurality of bonds between the surfaces, thereby improving retention.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: December 29, 2015
    Assignee: ABBOTT LABORATORIES
    Inventors: Randolf Von Oepen, John Toner
  • Patent number: 9175053
    Abstract: The present invention discloses latent thioester functionalities attached to the C-terminus of a first polypeptide, or a first fragment thereof having a Cys residue at its N-terminus, and a process using this functionality for the preparation of polypeptide thioesters, in particular of ubiquitin thioesters, this process comprising preparing a polypeptide or a fragment thereof, being attached to a latent thioester functionality, which can then be ligated with a second polypeptide fragment, followed by selective activation of the latent thioester functionality group, to provide the requested polypeptide thioester. There are also provided the polypeptides obtained by this method, specific unnatural amino acids useful to be incorporated within the polypeptide thioesters, and kits for preparing them.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: November 3, 2015
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Ashraf Brik, Mahmood Haj-Yahya, Ajish Kumar, Leslie Erlich, Liat Spasser
  • Patent number: 9173949
    Abstract: The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: November 3, 2015
    Assignees: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., MIKROBIOLOGICKY USTAV AV CR, V.V.I.
    Inventors: Tomas Etrych, Petr Chytil, Jiri Strohalm, Karel Ulbrich, Blanka Rihova
  • Patent number: 9134308
    Abstract: Provided is a method for immobilizing a macromolecule to a solid support material using poly(ethylene glycol), and a device obtained from the method. The macromolecule can be a polypeptide, such as an antibody.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: September 15, 2015
    Assignee: Drexel University
    Inventors: David R. Hansberry, Peter M. Clark, Elisabeth Papazoglou, Sundar Babu Nadarajan, Constantinos Papathomas
  • Patent number: 9125814
    Abstract: Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: September 8, 2015
    Assignee: Angiotech Pharmaceuticals, Inc.
    Inventors: Yuehua He, Aniko Takacs-Cox, Anthony Boey, Brent Zaluski, Roger A. Smith, Audrey A. Deschamps, Rui Avelar
  • Patent number: 9115240
    Abstract: A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: August 25, 2015
    Assignees: University of Maryland, College Park, The United States of America as Represented by the Secretary of the Army
    Inventors: Peter Kofinas, Omar B. Ayyub, Jennifer W. Sekowski, Ta-I Yang
  • Patent number: 9090665
    Abstract: Provided is a filler for affinity chromatography which is useful for protein purification and contains porous particles that have a high dynamic binding capacity for proteins and excellent pressure characteristics. The filler for affinity chromatography of the present invention is characterized in that it includes a porous particle consisting of a polymer of vinyl monomer including a cross-linkable vinyl monomer that contains hydroxyl group but does not contain epoxy group and an epoxy group-containing non-cross-linkable vinyl monomer, or a cross-linkable vinyl monomer that contains hydroxyl group and epoxy group, ligands bound to the porous particle, and ring-opened epoxy groups.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: July 28, 2015
    Assignee: JSR CORPORATION
    Inventors: Kouji Tamori, Takayoshi Abe, Yusuke Okano, Masaki Momiyama, Hiroshi Kawai, Satoshi Hyugaji, Yong Wang
  • Patent number: 9072814
    Abstract: Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: July 7, 2015
    Assignee: Pathak Holdings LLC
    Inventors: Chandrashekhar P. Pathak, Sanjay M. Thigle
  • Publication number: 20150148486
    Abstract: An object of the present invention is to provide a method of immobilizing the biologically active substance which has an excellent capability of immobilizing a target biologically active substance, and exhibits low nonspecific adsorption of the biologically active substance to provide a high S/N ratio, without using a functional group for fixing the biologically active substance and without having a process of inactivating the functional group for fixing the biologically active substance after immobilizing the biologically active substance. The above object is achieved by a method of immobilizing a biologically active substance comprising the step of: bringing a solution into contact with a compound-side surface of an immobilizing substrate to immobilize the biologically active substance on a surface of the immobilizing substrate, the solution being prepared by dissolving the biologically active substance in a phosphate buffer having a phosphate concentration of 0.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 28, 2015
    Applicant: SUMITOMO BAKELITE COMPANY, LTD.
    Inventors: Sohei FUNAOKA, Midori ABE
  • Publication number: 20150141574
    Abstract: The present invention is generally directed to a new class of TPEs made from peptide terminated low Tg polymers and methods for making them. The middle block of these TPE is a telechelic polymer with a Tg that is below the intended service temperature of the TPE. The terminal peptide segments of these TPEs are short (from about 1 to about 10 amino acids long) and tend to from sheet type secondary structures through intermolecular hydrogen bonds, creating physical crosslinks between polymer chains. The dissimilarity of the peptide hard component and the elastomeric soft component results in very strong segregation between the microphase domains and a low plastic deformation for the resulting TPE. And since the Tm of the crystalline peptide phase can be adjusted, these new TPEs may be tailored to fit the intended service temperature and are melt-processable.
    Type: Application
    Filed: April 24, 2013
    Publication date: May 21, 2015
    Applicant: THE UNIVERSITY OF AKRON
    Inventors: Li JIA, Joseph SCAVUZZO, Joseph KENNEDY
  • Patent number: 9029473
    Abstract: Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: May 12, 2015
    Assignee: University of Strathclyde
    Inventors: Peter Cormack, Duncan Graham, Aaron Hernandez-Santana, Arun Prasath Ramaswamy, William Ewen Smith
  • Publication number: 20150118178
    Abstract: Conjugates comprising a N-oxime bond are disclosed. In one embodiment, a suitable conjugate is represented by the following Formula (I): wherein R? is derived from a compound comprising at least one reactive amide group, R? is derived from a compound comprising at least one reactive aminooxy group, and X is H, CnH(n+2) or other atoms. Additional methods are also provided.
    Type: Application
    Filed: December 31, 2014
    Publication date: April 30, 2015
    Inventors: Cory Berkland, Joshua Sestak
  • Publication number: 20150118692
    Abstract: Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast acoustic particles, wherein the particles can contain a functional group available for covalent modification.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 30, 2015
    Inventors: Leah M. Johnson, Gabriel P. Lopez, Lu Gao, Charles Wyatt Shields, IV
  • Patent number: 9018305
    Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: April 28, 2015
    Assignee: EMD Millipore Corporation
    Inventors: Shari Spector, Robert Smith, Joe Orlando, Nanying Bian
  • Publication number: 20150110732
    Abstract: The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 23, 2015
    Inventors: Darren H. Wakefield, Nicholas A. Rossi, Dan Sheik
  • Publication number: 20150112022
    Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 23, 2015
    Inventors: Ashutosh Chilkoti, Felipe Garcia Quiroz, Miriam Amiram
  • Patent number: 9012596
    Abstract: Copolymers, such as block copolymers, having at least one block that is a random copolymer of ?-caprolactone and ?-carboxy-?-caprolactone are described. Also described are methods of using such copolymers, such as, for example, in medical devices.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: April 21, 2015
    Assignee: Vanderbilt University
    Inventors: Hak-Joon Sung, Lucas L. Hofmeister, Mukesh Kumer Gupta, Spencer W. Crowder, Shann S. Yu, Angela L. Zachman, Dae Kwang Jung