Nitrogen-containing Reactant Patents (Class 528/208)
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Patent number: 9822070Abstract: A method for the manufacture of a 2-hydrocarbyl-3,3-bis(hydroxyaryl)phthalimidine composition comprises: reacting a phthalimide with a phenol in the presence of a catalyst and optionally a solvent at an elevated temperature to form the 2-hydrocarbyl-3,3-bis(hydroxyaryl)phthalimidine composition.Type: GrantFiled: January 14, 2015Date of Patent: November 21, 2017Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Venkata Ramanarayanan Ganapathy Bhotla, Bhaskar Reddy Aluri, S Shubashree
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Publication number: 20150133625Abstract: This disclosure relates to polyetherimide compositions whose residual phenolic monomers exhibit little or no estradiol binding activity. Also disclosed are methods for making the disclosed polyetherimides and articles of manufacture comprising the disclosed polyetherimides.Type: ApplicationFiled: January 20, 2015Publication date: May 14, 2015Inventors: Robert R. Gallucci, James A. Mahood, Roy R. Odle, Steve Dimond
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Publication number: 20150030560Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.Type: ApplicationFiled: February 24, 2014Publication date: January 29, 2015Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, YEDA RESEARCH AND DEVELOPMENT CO., LTD.Inventors: Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger
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Publication number: 20140364579Abstract: The present invention provides a method for conveniently and inexpensively producing an amino-hydroxybenzoic acid-type compound such as 3-amino-4-hydroxybenzoic acid by utilizing Escherichia coli that is a bacterium commonly used for a production process by biosynthesis. Specifically, the present invention provides an Escherichia coli having an ability to produce 3-amino-4-hydroxybenzoic acid, which is modified to reduce an activity of N-hydroxyarylamine O-acetyltransferase (NhoA); a method for producing a 3-amino-4-hydroxybenzoic acid-type compound using such Escherichia coli; and the like.Type: ApplicationFiled: August 25, 2014Publication date: December 11, 2014Applicant: AJINOMOTO CO., INC.Inventors: Fumi Shozui, Yoshinori Tajima
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Publication number: 20140363760Abstract: Provided are a polycarbonate copolymer, comprising: a repeating unit A represented by the following general formula (1); a repeating unit B represented by the following general formula (2); and a repeating unit C represented by the following general formula (3), in which: the polycarbonate copolymer has a presence ratio represented by Ar1/(Ar1+Ar2+Ar3) of from 50 to 65 mol %, a presence ratio represented by Ar2/(Ar1+Ar2+Ar3) of from 25 to 45 mol %, and a presence ratio represented by Ar3/(Ar1+Ar2+Ar3) of from 3 to 25 mol %; and the repeating units B are not directly bonded to each other, and a coating liquid and an electrophotographic photosensitive body each obtained by using the copolymer, and as a result, provided are a polycarbonate copolymer remarkably improved in abrasion resistance while maintaining its stable solubility in an organic solvent, and a coating liquid and an electrophotographic photosensitive body each obtained by using the copolymer: in the formulae, Ar1, Ar2, and Ar3 each independentType: ApplicationFiled: December 26, 2012Publication date: December 11, 2014Inventor: Kengo Hirata
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Publication number: 20140357830Abstract: Disclosed herein is a method for producing a purified 2-aryl-3,3-bis(4-hydroxyaryl) phthalimidine of formula (I) wherein R1 is hydrogen or a C1-25 hydrocarbyl group and R2 is a hydrogen, a C1-25 hydrocarbyl group, or a halogen, and wherein the method comprises dissolving a crude phthalimidine compound in an aqueous base solution; precipitating the dissolved, crude phthalimidine compound from the aqueous base solution by adding an acid in an amount effective to lower the pH of the solution to 9.0 to 12.0, to provide a semicrude phthalimidine compound; and isolating the semicrude phthalimidine compound from the aqueous base solution, to provide the purified 2-aryl-3,3-bis(4-hydroxyaryl) phthalimidine of formula (I), and having a phenolphthalein compound content of less than 2,500 ppm, based on the weight of the purified 2-aryl-3,3-bis(4-hydroxyaryl)phthalimidine.Type: ApplicationFiled: August 18, 2014Publication date: December 4, 2014Inventors: Venkata Rama Narayanan Ganapathy BHOTLA, Balakrishnan GANESAN, Kishan GURRAM, Salkod Parameshwar MALLIKA, Kumar Arun SATYANARAYANA, Swaminathan SHUBASHREE
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Publication number: 20140349222Abstract: Provided is a photosensitive resin composition which comprises: (A-1) a resin containing a structure represented by general formula (1); and (B) a photo-acid generating agent. In general formula (1), X, R1 to R7, m1 to m4, n1, n2, Y and W are each as defined in the description.Type: ApplicationFiled: December 6, 2012Publication date: November 27, 2014Applicant: ASAHI KASEI E-MATERIALS CORPORATIONInventors: Satoshi Shibui, Tatsuya Hirata, Takahiro Sasaki, Taisuke Yamada
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Publication number: 20140171590Abstract: A facile synthesis of amphiphilic hyperbranched polymers consisting of poly(amic acid) and polyimide was developed via “A2+B3” approach from difunctional anhydride and trifunctional hydrophilic poly(oxyalkylene)triamine. Various amphiphilic hyperbranched poly(amic acid)s (HBPAAs) with terminal amine functionalities and amic acid structures were prepared through ring-opening polyaddition at room temperature, followed by thermal imidization process for the formation of hyperbranched polyimides (HBPIs), accordingly. The resulting HBPIs were analyzed by GPC, indicating the molecule weights of 5000˜7000 g/mol with a distribution of polydispersity between 2.0 and 3.8. The amine titration for HBPIs indicated the peripheral total-amine contents to be 8.32˜18.32 mequiv/g dependent on compositions.Type: ApplicationFiled: December 13, 2012Publication date: June 19, 2014Inventors: Wen-Chiung Su, Ru-Jong Jeng, Tzong-Yuan Juang, Shi-Min Shau, Guan-Liang Chen, Han-Sheng Lin
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Patent number: 8697831Abstract: The invention is directed to a process for preparing polyamide polymers, particularly nylon 6, 6 and nylon 6, comprising fluoroether functionalized aromatic repeat units. In one embodiment, 1,6 diaminohexane, adipic acid, and fluoroether functionalized terephthallic or isophthallic acid or diester are reacted to form a polymer. The polymers so formed are useful for imparting soil resistance to polyamides, particularly in the form of films, molded parts, fibers, fabrics, and carpets.Type: GrantFiled: June 22, 2011Date of Patent: April 15, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Neville Everton Drysdale, David Neil Marks, Fredrik Nederberg
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Publication number: 20140058057Abstract: Polyimide oligomers of the general formula: M-(Z-Y-X-Y-Z)n-M wherein n is an integer of 1 to 20; X comprises an aromatic diamine containing 2-4 aryl moieties, each of which contains 0-4 substituents; Z is independently the same as X or is a different aromatic diamine containing 1-4 aryl moieties, each of which contains 0-4 substituents; Y comprises an aromatic dianhydride containing 1-4 aryl moieties, each of which contains 0-4 substituents; and M is independently the same as Y or is a substituted or unsubstituted anhydride, a substituted or unsubstituted dianhydride, a substituted or unsubstituted bisimide, or a substituted or unsubstituted monomeric or oligomeric phthalonitrile.Type: ApplicationFiled: August 24, 2012Publication date: February 27, 2014Inventors: Sajal Das, Vilas M. Chopdekar, Megan B. Casey
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Publication number: 20140016450Abstract: Compositions and methods for producing compositions comprising a monoamine-endcapped polyimide component. Based on a gas chromatography mass spectroscopy analysis of a surface rinse of the composition performed at room temperature, the composition can have at least one surface with less than or equal to 5 ppb releasable phosphorous residuals, and less than or equal to 5 ppb releasable volatile organic compound residuals. The composition can also comprise less than or equal to 10 ppb combined releasable residuals. Because of the very low levels of residual contamination, the compositions can be used to produce a variety of articles including a disk drive.Type: ApplicationFiled: September 16, 2013Publication date: January 16, 2014Applicant: SABIC INNOVATIVE PLASTICS IP B.V.Inventors: Daniel Francis Lowery, Jamuna Chakravarti, Aaron Royer
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Publication number: 20140001950Abstract: The purpose of the invention is to provide a resin, which has a high refractive index, excellent heat resistance and moldability, and high transparency, and is useful as a material for configuring optical devices, etc. The invention provides a resin comprising acyl hydrazone bonds and having a number average molecular weight of 500-500,000, wherein the acyl hydrazone bond equivalent is 100-4000.Type: ApplicationFiled: March 9, 2012Publication date: January 2, 2014Applicant: MITSUI CHEMICALS, INC.Inventors: Shunsuke Fujii, Shintaro Maekawa, Hitoshi Onishi, Akifumi Kagayama
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Publication number: 20140004060Abstract: The present invention includes an ultraviolet radiation absorbing polymer composition that includes polymers containing a UV-chromophore, as described in the specification and as claimed the reaction product of a monoglyceride and a poly-acid monomer containing a UV-chromophore.Type: ApplicationFiled: March 13, 2013Publication date: January 2, 2014Applicant: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.Inventor: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.
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Publication number: 20130317118Abstract: The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.Type: ApplicationFiled: July 25, 2013Publication date: November 28, 2013Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S Bezwada
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Patent number: 8535792Abstract: Compositions and methods for producing compositions comprising a monoamine-endcapped polyimide component. Based on a gas chromatography mass spectroscopy analysis of a surface rinse of the composition performed at room temperature, the composition can have at least one surface with less than or equal to 5 ppb releasable phosphorous residuals, and less than or equal to 5 ppb releasable volatile organic compound residuals. The composition can also comprise less than or equal to 10 ppb combined releasable residuals. Because of the very low levels of residual contamination, the compositions can be used to produce a variety of articles, including a disk drive.Type: GrantFiled: June 30, 2011Date of Patent: September 17, 2013Assignee: Sabic Innovative Plastics IP B.V.Inventors: Daniel Francis Lowery, Jamuna Chakravarti, Aaron Royer
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Patent number: 8497025Abstract: A novel polyimide as a high molecular weight material having a low dielectric constant, a low dielectric loss tangent and low water absorptivity, a polyamic acid capable of generating the above polyimide, the above polyimide and the polyamic acid being obtained by reacting an aromatic diamine, obtained by introducing aromatic amino groups into both terminals of a specific bifunctional phenylene ether oligomer, with an acid anhydride, a process for the production of the polyimide, a process for the production of the polyimide, a film of the polyimide, and a laminate comprising the above film.Type: GrantFiled: May 13, 2009Date of Patent: July 30, 2013Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Kazuyoshi Uera, Daisuke Ohno, Kenji Ishii
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Publication number: 20130157930Abstract: The present invention is directed to linear, biodegradable polyesteramide (PEA) polymers synthesized with repeating units derived from aminophenol esters and diacids. These PEAs have a monomer repeat represented by as well as a variety of uses to coat, form or comprise medical devices, combination medical devices and pharmaceutical compositions, including sustained release formulations.Type: ApplicationFiled: February 13, 2013Publication date: June 20, 2013Applicant: TYRX, INC.Inventor: TYRX, INC.
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Publication number: 20130150545Abstract: Novel benzoxazine-thiol adducts are described, which may be may be cured to produce compositions useful in coating, sealants, adhesive and many other applications.Type: ApplicationFiled: February 11, 2013Publication date: June 13, 2013Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventor: 3M INNOVATIVE PROPERTIES COMPANY
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Patent number: 8461289Abstract: New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles.Type: GrantFiled: May 29, 2012Date of Patent: June 11, 2013Assignee: Rutgers, The State University of New JerseyInventors: Joachim B. Kohn, Durgadas Bolikal
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Publication number: 20130041045Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.Type: ApplicationFiled: September 5, 2012Publication date: February 14, 2013Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S. Bezwada
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Publication number: 20130003227Abstract: Compositions and methods for producing compositions comprising a monoamine-endcapped polyimide component. Based on a gas chromatography mass spectroscopy analysis of a surface rinse of the composition performed at room temperature, the composition can have at least one surface with less than or equal to 5 ppb releasable phosphorous residuals, and less than or equal to 5 ppb releasable volatile organic compound residuals. The composition can also comprise less than or equal to 10 ppb combined releasable residuals. Because of the very low levels of residual contamination, the compositions can be used to produce a variety of articles, including a disk drive.Type: ApplicationFiled: June 30, 2011Publication date: January 3, 2013Inventors: Daniel Francis Lowery, Jamuna Chakravarti, Aaron Royer
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Publication number: 20120329976Abstract: The invention is directed to a process for preparing polyamide polymers, particularly nylon 6, 6 and nylon 6, comprising fluoroether functionalized aromatic repeat units. In one embodiment, 1,6 diaminohexane, adipic acid, and fluoroether functionalized terephthallic or isophthallic acid or diester are reacted to form a polymer. The polymers so formed are useful for imparting soil resistance to polyamides, particularly in the form of films, molded parts, fibers, fabrics, and carpets.Type: ApplicationFiled: June 22, 2011Publication date: December 27, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Neville Everton Drysdale, David Neil Marks, Fredrik Nederberg
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Publication number: 20120316313Abstract: The invention provides halogen-free, bisphenol triazole resins and polymers having exceptional flame retarding properties, related compositions and methods of making and use thereof.Type: ApplicationFiled: June 6, 2012Publication date: December 13, 2012Inventors: Todd Emrick, Beom-Young Ryu
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Publication number: 20120302719Abstract: New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profilesType: ApplicationFiled: May 29, 2012Publication date: November 29, 2012Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Joachim B. Kohn, Durgadas Bolikal
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Patent number: 8288590Abstract: Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.Type: GrantFiled: July 14, 2011Date of Patent: October 16, 2012Assignee: Rutgers, The State University of New JerseyInventors: Joachim B. Kohn, Durgadas Bolikal, Jaap Schut, Ernest G. Baluca
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Patent number: 8247521Abstract: New multifunctional aromatic copolymers bearing pyridine or pyrimidine units either in the main chain or side chain and single wall carbon nanotubes or multi wall carbon nanotubes as side chain pendants have been prepared. These multifunctional materials will combine both high proton and electrical conductivity due to the existence of polar pyridine or pyrimidine groups and carbon nanotubes within the same chemical structure. The prepared multifunctional materials can be used in the catalyst ink of the electrodes in high temperature PEM fuel cells.Type: GrantFiled: June 25, 2008Date of Patent: August 21, 2012Assignee: Advent TechnologiesInventors: Christos Chochos, Nora Gourdoupi, Nikolas Triantafyllopoulos, Joannis Kallitsis
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Publication number: 20120189713Abstract: The invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorbable and/or biodegradable and have desirable mechanical properties, such as fracture and/or fatigue toughness, which have not been a primary design criteria for such polymers previously. The polymers or polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices. Therefore, methods for preparing these polymers or polymer compositions and medical devices are also encompassed by this disclosure.Type: ApplicationFiled: July 31, 2010Publication date: July 26, 2012Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Joachim B. Kohn, Durgadas Bolikal, Ramiro Rojas
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Publication number: 20120190813Abstract: To provide an easily-manufactured liquid-crystalline polymer having high thermal conductivity, as well as a molded article that is formed of the liquid crystalline polymer and has a property of being highly mechanical. A liquid-crystalline polymer is used that is formed by polymerizing monomers having an asymmetrical molecular structure, in which the enthalpy of fusion ?H measured by way of DSC (Differential Scanning calorimetry) is greater than or equal to 2.5 J/g (joules per gram) and less than or equal to 10 J/g, and the inherent viscosity (I.V.) is greater than or equal to 5 dl/g and less than or equal to 7 dl/g. It is preferable for the monomer having asymmetrical molecular structure to be at least one selected from a group consisting of 4-hydroxybenzoic acid (HBA), 6-hydroxy-2-naphthoic acid (HNA), N-acetyl-p-aminophenol (APAP), and 4-hydroxy-4?-biphenylcarboxylic acid (HBCA).Type: ApplicationFiled: September 3, 2010Publication date: July 26, 2012Applicant: POLYPLASTICS CO., LTD.Inventor: Yoshiaki Taguchi
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Publication number: 20120158127Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the corresponding diamines or diisocyanates thereof, wherein each X independently represents —CH2COO—, —CH(CH3)COO—, —CH2CH2OCH2COO—, —CH2CH2CH2CH2CH2COO—, —(CH2)yCOO— where y is 2 to 4 or 6 to 24, or —(CH2CH2O)z?CH2COO— where z? is 2 to 24; each Y represents —COCH2O—, —COCH(CH3)O—, —COCH2OCH2CH2O—, —COCH2CH2CH2CH2CH2O—, —CO(CH2)mO— where m is 2 to 4 or 6 to 24, or —COCH2O(CH2CH2O)n— where n is 2 to 24; R? is hydrogen, benzyl or straight-chained or branched alkyl; p is 1 to 4; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO2, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.Type: ApplicationFiled: February 22, 2012Publication date: June 21, 2012Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S. Bezwada
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Publication number: 20120116045Abstract: Disclosed is a liquid crystal alignment agent including a polymer including polyamic acid including a repeating unit represented by Chemical Formula 1, polyimide including a repeating unit represented by Chemical Formula 2, or a combination thereof.Type: ApplicationFiled: June 17, 2011Publication date: May 10, 2012Applicant: Cheil Industries Inc.Inventors: Tae-Hyoung KWAK, Bum-Jin LEE, Won-Seok DONG, Yo-Choul PARK, Hyo-Ju SEO, Hwan-Sung CHEON, Won-Ho CHOI
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Publication number: 20120116046Abstract: A process for the preparation of diaminodinitropyridine or diaminodinitrobenzene by contacting an aminopyridine or aminobenzene with oleum and nitric acid, wherein the improvement comprises adding at least about 1% molar excess of nitric acid, based upon the aminopyridine or aminobenzene, with stirring for at least two hours to form first the intermediate sulfonic acid, and then diaminodinitropyridine or diaminodinitrobenzene, and use of such products in the preparation of rigid rod polymers is disclosed.Type: ApplicationFiled: January 9, 2012Publication date: May 10, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: HASAN DINDI, James Arnold Schultz
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Publication number: 20120101213Abstract: Provided are a polyimide which is inexpensive, has various excellent material properties including strength, heat resistance, low moisture absorption, mold releasability (detachability), dielectric properties, electrical properties, and optical properties, and can exhibit a high level of water repellency, and a polyamic acid composition useful as a raw material therefor. Also provided are the polyimide which can give a polyimide composition that, besides having such excellent material properties, is capable of having a controlled surface resistivity, and a polyamic acid composition useful as a raw material therefor.Type: ApplicationFiled: June 28, 2010Publication date: April 26, 2012Applicant: NIPPON SHOKUBAI CO, LTDInventors: Kozo Tajiri, Go Masuda, Tomomi Makino, Atsushi Okada
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Patent number: 8143366Abstract: The present invention provides a compound having a formula: where R1 is selected from the group consisting of alkyl, CH2(OC2H4)OCH3, and —(OC2H4)OCH3; n is 0-4; Olig is an oligomer having a formula: -L-O-PAGR.R2]q where L is a optional linker moiety selected from the group consisting of —CH2O—, —CH2OX—, —OX—, —C(O)—, —C(O)X, —NH—, —NHC(O)—, —XNHC(O)—, —NHC(O)X—, —C(O)NH—, —C(O)NHX—, and where X is alkyl1-6 or is not present, Y is N or O or is not present, and R3 is alkyl1-6; PAG is a linear or branched polyalkylene glycol moiety; R2 is an alkyl1-22 capping moiety if X is present or alkyl2-22 if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.Type: GrantFiled: November 20, 2009Date of Patent: March 27, 2012Assignee: Biocon LimitedInventors: Nnochiri N. Ekwuribe, Amy L. Odenbaugh
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Patent number: 8106147Abstract: The present invention discloses a polyimide membrane synthesized by one or more emeraldine amine-capped aniline trimer oligomers, one or more dianhydrides, and an optional diamine, whereby the weight-average molecular weight of the polyimide membrane ranges from 50,000 to 200,000, and the Young's Modulus of the polyimide membrane is equal to or more than 3 GPa.Type: GrantFiled: July 15, 2010Date of Patent: January 31, 2012Assignee: Chung Yuan Christian UniversityInventors: Jui-Ming Yeh, Kuan-Yeh Huang, Yu-Sian Jhuo, Chang-Jian Weng
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Patent number: 8093346Abstract: Provided is a method for efficiently producing a 3-amino-4-hydroxybenzoic acid-type compound by culturing a coryneform bacterium that has a gene encoding a mutated aspartokinase not subject to feedback inhibition, and that is transformed with a recombinant vector containing a DNA encoding a protein having an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde.Type: GrantFiled: January 3, 2011Date of Patent: January 10, 2012Assignee: Ajinomoto Co., Inc.Inventors: Mototaka Suzuki, Keiichi Yokoyama, Yoshimi Kikuchi
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Patent number: 8084569Abstract: A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.Type: GrantFiled: December 18, 2007Date of Patent: December 27, 2011Assignee: E.I. DuPont de Nemours and CompanyInventors: Aaron Minter, Berlin Stokes
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Publication number: 20110286959Abstract: Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymers efficiently suppressed the mouse disease EAE, which was induced in a susceptible SJL/J (H-2s) strain of mice with either whole spinal cord homogenate (WSCH) or with the encephalitogenic epitope PLP 139-151 (SEQ ID NO:4). YFAK 50-mer having a molar ratio of about Y 0.8:F 0.2 inhibited binding of biotinylated MBP 85-99 epitope to HLA-DR-2 molecules more efficiently than either unlabeled MBP 85-99 or Copaxone®. YFAK and FAK copolymers efficiently suppressed EAE induced in SJL/J (H-2S) mice with the encephalitogenic epitope PLP 139-151.Type: ApplicationFiled: July 12, 2011Publication date: November 24, 2011Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Jack L. Strominger, Masha Fridkis-Hareli
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Publication number: 20110275782Abstract: New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profilesType: ApplicationFiled: September 16, 2009Publication date: November 10, 2011Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Joachim B. Kohn, Durgadas Bolikal
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Publication number: 20110269848Abstract: Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.Type: ApplicationFiled: July 14, 2011Publication date: November 3, 2011Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Joachim B. Kohn, Durgadas Bolikal, Jaap Schut, Ernest G. Baluca
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Patent number: 8022167Abstract: A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.Type: GrantFiled: December 18, 2007Date of Patent: September 20, 2011Inventors: Aaron Minter, Berlin Stokes
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Publication number: 20110223254Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.Type: ApplicationFiled: March 25, 2011Publication date: September 15, 2011Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S. Bezwada
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Publication number: 20110212050Abstract: Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.Type: ApplicationFiled: May 5, 2011Publication date: September 1, 2011Applicant: REVA Medical, Inc.Inventors: Donald K. Brandom, Joan Zeltinger, Eric V. Schmid, Joseph J. Mallon
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Publication number: 20110213090Abstract: Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.Type: ApplicationFiled: May 5, 2011Publication date: September 1, 2011Applicant: REVA Medical, Inc.Inventors: Donald K. Brandom, Joan Zeltinger, Eric V. Schmid, Joseph J. Mallon
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Patent number: 7999057Abstract: A gas-phase, continuous process is provided for the manufacture of 2,6-diaminopyridine and related compounds from glutaronitriles, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.Type: GrantFiled: July 8, 2008Date of Patent: August 16, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Keith W. Hutchenson, Aaron Minter, Gregg Sunshine
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Publication number: 20110151262Abstract: The present invention relates to thermoplastic high-Tg polycarbonates and moulding materials which are distinguished by improved thermal properties and improved mechanical properties, in particular by reduced thermal expansion. The present invention furthermore relates to a process for the preparation of these polycarbonates. In particular, this invention relates to polycarbonates which the structural unit which derives from phthalimide of the formula (I) and polycarbonate compositions and moulding materials therefrom as well as a process for the preparation of these polycarbonates, and the use thereof, in particular as reflectors and display substrates.Type: ApplicationFiled: December 20, 2010Publication date: June 23, 2011Applicant: Bayer MaterialScience AGInventors: Helmut-Werner Heuer, Rolf Wehrmann
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Publication number: 20110137007Abstract: Provided is a method for efficiently producing a 3-amino-4-hydroxybenzoic acid-type compound by culturing a coryneform bacterium that has a gene encoding a mutated aspartokinase not subject to feedback inhibition, and that is transformed with a recombinant vector containing a DNA encoding a protein having an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde.Type: ApplicationFiled: January 3, 2011Publication date: June 9, 2011Inventors: Mototaka Suzuki, Keiichi Yokoyama, Yoshimi Kikuchi
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Publication number: 20110123476Abstract: The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a multifunctional amine or multifunctional polyol core, with isocyanate and/or polyalkylene oxide arms, which may optionally be capped with electrophilic or nucleophilic groups. These biocompatible components may, in embodiments, be combined with optional cross linkers to form adhesive and/or sealant compositions.Type: ApplicationFiled: January 25, 2011Publication date: May 26, 2011Inventors: Mbiya Kapiamba, Ahmad Robert Hadba
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Publication number: 20100317821Abstract: Disclosed is a polyimide resin, which is colorless and transparent and has superior properties, including mechanical properties and heat stability, and thus is usable in various fields, including semiconductor insulating films, TFT-LCD insulating films, transparent electrode films, passivation films, liquid crystal alignment layers, optical communication materials, protective films for solar cells, and flexible display substrates. Also, a liquid crystal alignment layer and a polyimide film using the polyimide resin are provided.Type: ApplicationFiled: December 13, 2007Publication date: December 16, 2010Applicant: KOLON INDUSTRIES, INC.Inventors: Hak Gee Jung, Sang Wook Park, Hyo Jun Park
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Patent number: 7838122Abstract: Compounds exhibiting angiogenic properties incorporating the structure of Formula I: R3—NH—NH—C(?O)—R2—P—R1??(I) wherein P is a water-soluble, biodegradable polymer, R1 is hydrogen, lower alkyl, lower alkoxy or —R2—C(?O)—NH—NH—R3; each R2 is independently —CH2—, —NH— or O; and each R3 is independently hydrogen or a residue of a naturally occurring alpha-L-amino acid or dipeptide thereof. Polymer networks crosslinked with hydrazide compounds are also disclosed, together with implantable medical devices incorporating the compounds and crosslinked polymers, and angiogenesis-promoting treatment methods, including wound-treatment methods.Type: GrantFiled: May 6, 2008Date of Patent: November 23, 2010Assignee: Rutgers, the State University of New JerseyInventors: Joachim B. Kohn, Kristen S. Labazzo, Durgadas Bolikal
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Patent number: 7838614Abstract: The invention relates to novel polyester-polysiloxane block copolymers, to a process for their preparation and to the use of these polymers as a base oil or as an additive in lubricants, especially silicone oils.Type: GrantFiled: September 15, 2008Date of Patent: November 23, 2010Assignee: Evonik Goldschmidt GmbHInventors: Oliver Thum, Peter Schwab