Nitrogen-containing Reactant Patents (Class 528/208)
  • Patent number: 9822070
    Abstract: A method for the manufacture of a 2-hydrocarbyl-3,3-bis(hydroxyaryl)phthalimidine composition comprises: reacting a phthalimide with a phenol in the presence of a catalyst and optionally a solvent at an elevated temperature to form the 2-hydrocarbyl-3,3-bis(hydroxyaryl)phthalimidine composition.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: November 21, 2017
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Venkata Ramanarayanan Ganapathy Bhotla, Bhaskar Reddy Aluri, S Shubashree
  • Publication number: 20150133625
    Abstract: This disclosure relates to polyetherimide compositions whose residual phenolic monomers exhibit little or no estradiol binding activity. Also disclosed are methods for making the disclosed polyetherimides and articles of manufacture comprising the disclosed polyetherimides.
    Type: Application
    Filed: January 20, 2015
    Publication date: May 14, 2015
    Inventors: Robert R. Gallucci, James A. Mahood, Roy R. Odle, Steve Dimond
  • Publication number: 20150030560
    Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
    Type: Application
    Filed: February 24, 2014
    Publication date: January 29, 2015
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger
  • Publication number: 20140363760
    Abstract: Provided are a polycarbonate copolymer, comprising: a repeating unit A represented by the following general formula (1); a repeating unit B represented by the following general formula (2); and a repeating unit C represented by the following general formula (3), in which: the polycarbonate copolymer has a presence ratio represented by Ar1/(Ar1+Ar2+Ar3) of from 50 to 65 mol %, a presence ratio represented by Ar2/(Ar1+Ar2+Ar3) of from 25 to 45 mol %, and a presence ratio represented by Ar3/(Ar1+Ar2+Ar3) of from 3 to 25 mol %; and the repeating units B are not directly bonded to each other, and a coating liquid and an electrophotographic photosensitive body each obtained by using the copolymer, and as a result, provided are a polycarbonate copolymer remarkably improved in abrasion resistance while maintaining its stable solubility in an organic solvent, and a coating liquid and an electrophotographic photosensitive body each obtained by using the copolymer: in the formulae, Ar1, Ar2, and Ar3 each independent
    Type: Application
    Filed: December 26, 2012
    Publication date: December 11, 2014
    Inventor: Kengo Hirata
  • Publication number: 20140364579
    Abstract: The present invention provides a method for conveniently and inexpensively producing an amino-hydroxybenzoic acid-type compound such as 3-amino-4-hydroxybenzoic acid by utilizing Escherichia coli that is a bacterium commonly used for a production process by biosynthesis. Specifically, the present invention provides an Escherichia coli having an ability to produce 3-amino-4-hydroxybenzoic acid, which is modified to reduce an activity of N-hydroxyarylamine O-acetyltransferase (NhoA); a method for producing a 3-amino-4-hydroxybenzoic acid-type compound using such Escherichia coli; and the like.
    Type: Application
    Filed: August 25, 2014
    Publication date: December 11, 2014
    Applicant: AJINOMOTO CO., INC.
    Inventors: Fumi Shozui, Yoshinori Tajima
  • Publication number: 20140357830
    Abstract: Disclosed herein is a method for producing a purified 2-aryl-3,3-bis(4-hydroxyaryl) phthalimidine of formula (I) wherein R1 is hydrogen or a C1-25 hydrocarbyl group and R2 is a hydrogen, a C1-25 hydrocarbyl group, or a halogen, and wherein the method comprises dissolving a crude phthalimidine compound in an aqueous base solution; precipitating the dissolved, crude phthalimidine compound from the aqueous base solution by adding an acid in an amount effective to lower the pH of the solution to 9.0 to 12.0, to provide a semicrude phthalimidine compound; and isolating the semicrude phthalimidine compound from the aqueous base solution, to provide the purified 2-aryl-3,3-bis(4-hydroxyaryl) phthalimidine of formula (I), and having a phenolphthalein compound content of less than 2,500 ppm, based on the weight of the purified 2-aryl-3,3-bis(4-hydroxyaryl)phthalimidine.
    Type: Application
    Filed: August 18, 2014
    Publication date: December 4, 2014
    Inventors: Venkata Rama Narayanan Ganapathy BHOTLA, Balakrishnan GANESAN, Kishan GURRAM, Salkod Parameshwar MALLIKA, Kumar Arun SATYANARAYANA, Swaminathan SHUBASHREE
  • Publication number: 20140349222
    Abstract: Provided is a photosensitive resin composition which comprises: (A-1) a resin containing a structure represented by general formula (1); and (B) a photo-acid generating agent. In general formula (1), X, R1 to R7, m1 to m4, n1, n2, Y and W are each as defined in the description.
    Type: Application
    Filed: December 6, 2012
    Publication date: November 27, 2014
    Applicant: ASAHI KASEI E-MATERIALS CORPORATION
    Inventors: Satoshi Shibui, Tatsuya Hirata, Takahiro Sasaki, Taisuke Yamada
  • Publication number: 20140171590
    Abstract: A facile synthesis of amphiphilic hyperbranched polymers consisting of poly(amic acid) and polyimide was developed via “A2+B3” approach from difunctional anhydride and trifunctional hydrophilic poly(oxyalkylene)triamine. Various amphiphilic hyperbranched poly(amic acid)s (HBPAAs) with terminal amine functionalities and amic acid structures were prepared through ring-opening polyaddition at room temperature, followed by thermal imidization process for the formation of hyperbranched polyimides (HBPIs), accordingly. The resulting HBPIs were analyzed by GPC, indicating the molecule weights of 5000˜7000 g/mol with a distribution of polydispersity between 2.0 and 3.8. The amine titration for HBPIs indicated the peripheral total-amine contents to be 8.32˜18.32 mequiv/g dependent on compositions.
    Type: Application
    Filed: December 13, 2012
    Publication date: June 19, 2014
    Inventors: Wen-Chiung Su, Ru-Jong Jeng, Tzong-Yuan Juang, Shi-Min Shau, Guan-Liang Chen, Han-Sheng Lin
  • Patent number: 8697831
    Abstract: The invention is directed to a process for preparing polyamide polymers, particularly nylon 6, 6 and nylon 6, comprising fluoroether functionalized aromatic repeat units. In one embodiment, 1,6 diaminohexane, adipic acid, and fluoroether functionalized terephthallic or isophthallic acid or diester are reacted to form a polymer. The polymers so formed are useful for imparting soil resistance to polyamides, particularly in the form of films, molded parts, fibers, fabrics, and carpets.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: April 15, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Neville Everton Drysdale, David Neil Marks, Fredrik Nederberg
  • Publication number: 20140058057
    Abstract: Polyimide oligomers of the general formula: M-(Z-Y-X-Y-Z)n-M wherein n is an integer of 1 to 20; X comprises an aromatic diamine containing 2-4 aryl moieties, each of which contains 0-4 substituents; Z is independently the same as X or is a different aromatic diamine containing 1-4 aryl moieties, each of which contains 0-4 substituents; Y comprises an aromatic dianhydride containing 1-4 aryl moieties, each of which contains 0-4 substituents; and M is independently the same as Y or is a substituted or unsubstituted anhydride, a substituted or unsubstituted dianhydride, a substituted or unsubstituted bisimide, or a substituted or unsubstituted monomeric or oligomeric phthalonitrile.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 27, 2014
    Inventors: Sajal Das, Vilas M. Chopdekar, Megan B. Casey
  • Publication number: 20140016450
    Abstract: Compositions and methods for producing compositions comprising a monoamine-endcapped polyimide component. Based on a gas chromatography mass spectroscopy analysis of a surface rinse of the composition performed at room temperature, the composition can have at least one surface with less than or equal to 5 ppb releasable phosphorous residuals, and less than or equal to 5 ppb releasable volatile organic compound residuals. The composition can also comprise less than or equal to 10 ppb combined releasable residuals. Because of the very low levels of residual contamination, the compositions can be used to produce a variety of articles including a disk drive.
    Type: Application
    Filed: September 16, 2013
    Publication date: January 16, 2014
    Applicant: SABIC INNOVATIVE PLASTICS IP B.V.
    Inventors: Daniel Francis Lowery, Jamuna Chakravarti, Aaron Royer
  • Publication number: 20140004060
    Abstract: The present invention includes an ultraviolet radiation absorbing polymer composition that includes polymers containing a UV-chromophore, as described in the specification and as claimed the reaction product of a monoglyceride and a poly-acid monomer containing a UV-chromophore.
    Type: Application
    Filed: March 13, 2013
    Publication date: January 2, 2014
    Applicant: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.
    Inventor: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.
  • Publication number: 20140001950
    Abstract: The purpose of the invention is to provide a resin, which has a high refractive index, excellent heat resistance and moldability, and high transparency, and is useful as a material for configuring optical devices, etc. The invention provides a resin comprising acyl hydrazone bonds and having a number average molecular weight of 500-500,000, wherein the acyl hydrazone bond equivalent is 100-4000.
    Type: Application
    Filed: March 9, 2012
    Publication date: January 2, 2014
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Shunsuke Fujii, Shintaro Maekawa, Hitoshi Onishi, Akifumi Kagayama
  • Publication number: 20130317118
    Abstract: The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: July 25, 2013
    Publication date: November 28, 2013
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Rao S Bezwada
  • Patent number: 8535792
    Abstract: Compositions and methods for producing compositions comprising a monoamine-endcapped polyimide component. Based on a gas chromatography mass spectroscopy analysis of a surface rinse of the composition performed at room temperature, the composition can have at least one surface with less than or equal to 5 ppb releasable phosphorous residuals, and less than or equal to 5 ppb releasable volatile organic compound residuals. The composition can also comprise less than or equal to 10 ppb combined releasable residuals. Because of the very low levels of residual contamination, the compositions can be used to produce a variety of articles, including a disk drive.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: September 17, 2013
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Daniel Francis Lowery, Jamuna Chakravarti, Aaron Royer
  • Patent number: 8497025
    Abstract: A novel polyimide as a high molecular weight material having a low dielectric constant, a low dielectric loss tangent and low water absorptivity, a polyamic acid capable of generating the above polyimide, the above polyimide and the polyamic acid being obtained by reacting an aromatic diamine, obtained by introducing aromatic amino groups into both terminals of a specific bifunctional phenylene ether oligomer, with an acid anhydride, a process for the production of the polyimide, a process for the production of the polyimide, a film of the polyimide, and a laminate comprising the above film.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: July 30, 2013
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Kazuyoshi Uera, Daisuke Ohno, Kenji Ishii
  • Publication number: 20130157930
    Abstract: The present invention is directed to linear, biodegradable polyesteramide (PEA) polymers synthesized with repeating units derived from aminophenol esters and diacids. These PEAs have a monomer repeat represented by as well as a variety of uses to coat, form or comprise medical devices, combination medical devices and pharmaceutical compositions, including sustained release formulations.
    Type: Application
    Filed: February 13, 2013
    Publication date: June 20, 2013
    Applicant: TYRX, INC.
    Inventor: TYRX, INC.
  • Publication number: 20130150545
    Abstract: Novel benzoxazine-thiol adducts are described, which may be may be cured to produce compositions useful in coating, sealants, adhesive and many other applications.
    Type: Application
    Filed: February 11, 2013
    Publication date: June 13, 2013
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventor: 3M INNOVATIVE PROPERTIES COMPANY
  • Patent number: 8461289
    Abstract: New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: June 11, 2013
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Publication number: 20130041045
    Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: September 5, 2012
    Publication date: February 14, 2013
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Rao S. Bezwada
  • Publication number: 20130003227
    Abstract: Compositions and methods for producing compositions comprising a monoamine-endcapped polyimide component. Based on a gas chromatography mass spectroscopy analysis of a surface rinse of the composition performed at room temperature, the composition can have at least one surface with less than or equal to 5 ppb releasable phosphorous residuals, and less than or equal to 5 ppb releasable volatile organic compound residuals. The composition can also comprise less than or equal to 10 ppb combined releasable residuals. Because of the very low levels of residual contamination, the compositions can be used to produce a variety of articles, including a disk drive.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 3, 2013
    Inventors: Daniel Francis Lowery, Jamuna Chakravarti, Aaron Royer
  • Publication number: 20120329976
    Abstract: The invention is directed to a process for preparing polyamide polymers, particularly nylon 6, 6 and nylon 6, comprising fluoroether functionalized aromatic repeat units. In one embodiment, 1,6 diaminohexane, adipic acid, and fluoroether functionalized terephthallic or isophthallic acid or diester are reacted to form a polymer. The polymers so formed are useful for imparting soil resistance to polyamides, particularly in the form of films, molded parts, fibers, fabrics, and carpets.
    Type: Application
    Filed: June 22, 2011
    Publication date: December 27, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Neville Everton Drysdale, David Neil Marks, Fredrik Nederberg
  • Publication number: 20120316313
    Abstract: The invention provides halogen-free, bisphenol triazole resins and polymers having exceptional flame retarding properties, related compositions and methods of making and use thereof.
    Type: Application
    Filed: June 6, 2012
    Publication date: December 13, 2012
    Inventors: Todd Emrick, Beom-Young Ryu
  • Publication number: 20120302719
    Abstract: New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles
    Type: Application
    Filed: May 29, 2012
    Publication date: November 29, 2012
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Patent number: 8288590
    Abstract: Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: October 16, 2012
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Joachim B. Kohn, Durgadas Bolikal, Jaap Schut, Ernest G. Baluca
  • Patent number: 8247521
    Abstract: New multifunctional aromatic copolymers bearing pyridine or pyrimidine units either in the main chain or side chain and single wall carbon nanotubes or multi wall carbon nanotubes as side chain pendants have been prepared. These multifunctional materials will combine both high proton and electrical conductivity due to the existence of polar pyridine or pyrimidine groups and carbon nanotubes within the same chemical structure. The prepared multifunctional materials can be used in the catalyst ink of the electrodes in high temperature PEM fuel cells.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: August 21, 2012
    Assignee: Advent Technologies
    Inventors: Christos Chochos, Nora Gourdoupi, Nikolas Triantafyllopoulos, Joannis Kallitsis
  • Publication number: 20120190813
    Abstract: To provide an easily-manufactured liquid-crystalline polymer having high thermal conductivity, as well as a molded article that is formed of the liquid crystalline polymer and has a property of being highly mechanical. A liquid-crystalline polymer is used that is formed by polymerizing monomers having an asymmetrical molecular structure, in which the enthalpy of fusion ?H measured by way of DSC (Differential Scanning calorimetry) is greater than or equal to 2.5 J/g (joules per gram) and less than or equal to 10 J/g, and the inherent viscosity (I.V.) is greater than or equal to 5 dl/g and less than or equal to 7 dl/g. It is preferable for the monomer having asymmetrical molecular structure to be at least one selected from a group consisting of 4-hydroxybenzoic acid (HBA), 6-hydroxy-2-naphthoic acid (HNA), N-acetyl-p-aminophenol (APAP), and 4-hydroxy-4?-biphenylcarboxylic acid (HBCA).
    Type: Application
    Filed: September 3, 2010
    Publication date: July 26, 2012
    Applicant: POLYPLASTICS CO., LTD.
    Inventor: Yoshiaki Taguchi
  • Publication number: 20120189713
    Abstract: The invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorbable and/or biodegradable and have desirable mechanical properties, such as fracture and/or fatigue toughness, which have not been a primary design criteria for such polymers previously. The polymers or polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices. Therefore, methods for preparing these polymers or polymer compositions and medical devices are also encompassed by this disclosure.
    Type: Application
    Filed: July 31, 2010
    Publication date: July 26, 2012
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal, Ramiro Rojas
  • Publication number: 20120158127
    Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the corresponding diamines or diisocyanates thereof, wherein each X independently represents —CH2COO—, —CH(CH3)COO—, —CH2CH2OCH2COO—, —CH2CH2CH2CH2CH2COO—, —(CH2)yCOO— where y is 2 to 4 or 6 to 24, or —(CH2CH2O)z?CH2COO— where z? is 2 to 24; each Y represents —COCH2O—, —COCH(CH3)O—, —COCH2OCH2CH2O—, —COCH2CH2CH2CH2CH2O—, —CO(CH2)mO— where m is 2 to 4 or 6 to 24, or —COCH2O(CH2CH2O)n— where n is 2 to 24; R? is hydrogen, benzyl or straight-chained or branched alkyl; p is 1 to 4; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO2, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.
    Type: Application
    Filed: February 22, 2012
    Publication date: June 21, 2012
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Rao S. Bezwada
  • Publication number: 20120116045
    Abstract: Disclosed is a liquid crystal alignment agent including a polymer including polyamic acid including a repeating unit represented by Chemical Formula 1, polyimide including a repeating unit represented by Chemical Formula 2, or a combination thereof.
    Type: Application
    Filed: June 17, 2011
    Publication date: May 10, 2012
    Applicant: Cheil Industries Inc.
    Inventors: Tae-Hyoung KWAK, Bum-Jin LEE, Won-Seok DONG, Yo-Choul PARK, Hyo-Ju SEO, Hwan-Sung CHEON, Won-Ho CHOI
  • Publication number: 20120116046
    Abstract: A process for the preparation of diaminodinitropyridine or diaminodinitrobenzene by contacting an aminopyridine or aminobenzene with oleum and nitric acid, wherein the improvement comprises adding at least about 1% molar excess of nitric acid, based upon the aminopyridine or aminobenzene, with stirring for at least two hours to form first the intermediate sulfonic acid, and then diaminodinitropyridine or diaminodinitrobenzene, and use of such products in the preparation of rigid rod polymers is disclosed.
    Type: Application
    Filed: January 9, 2012
    Publication date: May 10, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: HASAN DINDI, James Arnold Schultz
  • Publication number: 20120101213
    Abstract: Provided are a polyimide which is inexpensive, has various excellent material properties including strength, heat resistance, low moisture absorption, mold releasability (detachability), dielectric properties, electrical properties, and optical properties, and can exhibit a high level of water repellency, and a polyamic acid composition useful as a raw material therefor. Also provided are the polyimide which can give a polyimide composition that, besides having such excellent material properties, is capable of having a controlled surface resistivity, and a polyamic acid composition useful as a raw material therefor.
    Type: Application
    Filed: June 28, 2010
    Publication date: April 26, 2012
    Applicant: NIPPON SHOKUBAI CO, LTD
    Inventors: Kozo Tajiri, Go Masuda, Tomomi Makino, Atsushi Okada
  • Patent number: 8143366
    Abstract: The present invention provides a compound having a formula: where R1 is selected from the group consisting of alkyl, CH2(OC2H4)OCH3, and —(OC2H4)OCH3; n is 0-4; Olig is an oligomer having a formula: -L-O-PAGR.R2]q where L is a optional linker moiety selected from the group consisting of —CH2O—, —CH2OX—, —OX—, —C(O)—, —C(O)X, —NH—, —NHC(O)—, —XNHC(O)—, —NHC(O)X—, —C(O)NH—, —C(O)NHX—, and where X is alkyl1-6 or is not present, Y is N or O or is not present, and R3 is alkyl1-6; PAG is a linear or branched polyalkylene glycol moiety; R2 is an alkyl1-22 capping moiety if X is present or alkyl2-22 if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: March 27, 2012
    Assignee: Biocon Limited
    Inventors: Nnochiri N. Ekwuribe, Amy L. Odenbaugh
  • Patent number: 8106147
    Abstract: The present invention discloses a polyimide membrane synthesized by one or more emeraldine amine-capped aniline trimer oligomers, one or more dianhydrides, and an optional diamine, whereby the weight-average molecular weight of the polyimide membrane ranges from 50,000 to 200,000, and the Young's Modulus of the polyimide membrane is equal to or more than 3 GPa.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: January 31, 2012
    Assignee: Chung Yuan Christian University
    Inventors: Jui-Ming Yeh, Kuan-Yeh Huang, Yu-Sian Jhuo, Chang-Jian Weng
  • Patent number: 8093346
    Abstract: Provided is a method for efficiently producing a 3-amino-4-hydroxybenzoic acid-type compound by culturing a coryneform bacterium that has a gene encoding a mutated aspartokinase not subject to feedback inhibition, and that is transformed with a recombinant vector containing a DNA encoding a protein having an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: January 10, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mototaka Suzuki, Keiichi Yokoyama, Yoshimi Kikuchi
  • Patent number: 8084569
    Abstract: A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: December 27, 2011
    Assignee: E.I. DuPont de Nemours and Company
    Inventors: Aaron Minter, Berlin Stokes
  • Publication number: 20110286959
    Abstract: Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymers efficiently suppressed the mouse disease EAE, which was induced in a susceptible SJL/J (H-2s) strain of mice with either whole spinal cord homogenate (WSCH) or with the encephalitogenic epitope PLP 139-151 (SEQ ID NO:4). YFAK 50-mer having a molar ratio of about Y 0.8:F 0.2 inhibited binding of biotinylated MBP 85-99 epitope to HLA-DR-2 molecules more efficiently than either unlabeled MBP 85-99 or Copaxone®. YFAK and FAK copolymers efficiently suppressed EAE induced in SJL/J (H-2S) mice with the encephalitogenic epitope PLP 139-151.
    Type: Application
    Filed: July 12, 2011
    Publication date: November 24, 2011
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Jack L. Strominger, Masha Fridkis-Hareli
  • Publication number: 20110275782
    Abstract: New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles
    Type: Application
    Filed: September 16, 2009
    Publication date: November 10, 2011
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Publication number: 20110269848
    Abstract: Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.
    Type: Application
    Filed: July 14, 2011
    Publication date: November 3, 2011
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal, Jaap Schut, Ernest G. Baluca
  • Patent number: 8022167
    Abstract: A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: September 20, 2011
    Inventors: Aaron Minter, Berlin Stokes
  • Publication number: 20110223254
    Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: March 25, 2011
    Publication date: September 15, 2011
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Rao S. Bezwada
  • Publication number: 20110213090
    Abstract: Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
    Type: Application
    Filed: May 5, 2011
    Publication date: September 1, 2011
    Applicant: REVA Medical, Inc.
    Inventors: Donald K. Brandom, Joan Zeltinger, Eric V. Schmid, Joseph J. Mallon
  • Publication number: 20110212050
    Abstract: Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
    Type: Application
    Filed: May 5, 2011
    Publication date: September 1, 2011
    Applicant: REVA Medical, Inc.
    Inventors: Donald K. Brandom, Joan Zeltinger, Eric V. Schmid, Joseph J. Mallon
  • Patent number: 7999057
    Abstract: A gas-phase, continuous process is provided for the manufacture of 2,6-diaminopyridine and related compounds from glutaronitriles, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: August 16, 2011
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Aaron Minter, Gregg Sunshine
  • Publication number: 20110151262
    Abstract: The present invention relates to thermoplastic high-Tg polycarbonates and moulding materials which are distinguished by improved thermal properties and improved mechanical properties, in particular by reduced thermal expansion. The present invention furthermore relates to a process for the preparation of these polycarbonates. In particular, this invention relates to polycarbonates which the structural unit which derives from phthalimide of the formula (I) and polycarbonate compositions and moulding materials therefrom as well as a process for the preparation of these polycarbonates, and the use thereof, in particular as reflectors and display substrates.
    Type: Application
    Filed: December 20, 2010
    Publication date: June 23, 2011
    Applicant: Bayer MaterialScience AG
    Inventors: Helmut-Werner Heuer, Rolf Wehrmann
  • Publication number: 20110137007
    Abstract: Provided is a method for efficiently producing a 3-amino-4-hydroxybenzoic acid-type compound by culturing a coryneform bacterium that has a gene encoding a mutated aspartokinase not subject to feedback inhibition, and that is transformed with a recombinant vector containing a DNA encoding a protein having an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde.
    Type: Application
    Filed: January 3, 2011
    Publication date: June 9, 2011
    Inventors: Mototaka Suzuki, Keiichi Yokoyama, Yoshimi Kikuchi
  • Publication number: 20110123476
    Abstract: The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a multifunctional amine or multifunctional polyol core, with isocyanate and/or polyalkylene oxide arms, which may optionally be capped with electrophilic or nucleophilic groups. These biocompatible components may, in embodiments, be combined with optional cross linkers to form adhesive and/or sealant compositions.
    Type: Application
    Filed: January 25, 2011
    Publication date: May 26, 2011
    Inventors: Mbiya Kapiamba, Ahmad Robert Hadba
  • Publication number: 20100317821
    Abstract: Disclosed is a polyimide resin, which is colorless and transparent and has superior properties, including mechanical properties and heat stability, and thus is usable in various fields, including semiconductor insulating films, TFT-LCD insulating films, transparent electrode films, passivation films, liquid crystal alignment layers, optical communication materials, protective films for solar cells, and flexible display substrates. Also, a liquid crystal alignment layer and a polyimide film using the polyimide resin are provided.
    Type: Application
    Filed: December 13, 2007
    Publication date: December 16, 2010
    Applicant: KOLON INDUSTRIES, INC.
    Inventors: Hak Gee Jung, Sang Wook Park, Hyo Jun Park
  • Patent number: 7838614
    Abstract: The invention relates to novel polyester-polysiloxane block copolymers, to a process for their preparation and to the use of these polymers as a base oil or as an additive in lubricants, especially silicone oils.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: November 23, 2010
    Assignee: Evonik Goldschmidt GmbH
    Inventors: Oliver Thum, Peter Schwab
  • Patent number: 7838122
    Abstract: Compounds exhibiting angiogenic properties incorporating the structure of Formula I: R3—NH—NH—C(?O)—R2—P—R1??(I) wherein P is a water-soluble, biodegradable polymer, R1 is hydrogen, lower alkyl, lower alkoxy or —R2—C(?O)—NH—NH—R3; each R2 is independently —CH2—, —NH— or O; and each R3 is independently hydrogen or a residue of a naturally occurring alpha-L-amino acid or dipeptide thereof. Polymer networks crosslinked with hydrazide compounds are also disclosed, together with implantable medical devices incorporating the compounds and crosslinked polymers, and angiogenesis-promoting treatment methods, including wound-treatment methods.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: November 23, 2010
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Joachim B. Kohn, Kristen S. Labazzo, Durgadas Bolikal