Non- >n-c(=x)-n< Nitrogen Reactant Is An Organic Compound Containing Two Or More Amino Groups Patents (Class 528/263)
  • Patent number: 9035014
    Abstract: The present invention relates to a new process for preparing condensation resins, constructed formally from urea, formaldehyde, and CH-acidic aldehydes.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: May 19, 2015
    Assignee: BASF SE
    Inventors: Stefan Meuer, Klaus Menzel, Kai Stehmeier, Guenter Scherr
  • Patent number: 8741430
    Abstract: Amino-formaldehyde resins may be prepared using formulations including formaldehyde, glycerin and at least one amino compound selected from the group consisting of urea, melamine, and mixtures thereof; under reaction conditions sufficient to prepare a resin, wherein; the amino-formaldehyde resin is prepared in a substantial absence of a sulfonating agent, ethylene glycol, and polyalkylene glycols. If the amino compound is urea, then the urea is present in a molar ratio of formaldehyde to urea ranging from 0.70 to 1.30; if the amino compound is melamine, then the melamine is present in a molar ratio of formaldehyde to melamine ranging from 1.3 to 2.2; and if the amino compound is a mixture of urea and melamine, then the mixture of urea and melamine is present in a molar ratio of formaldehyde to urea and melamine ranging from 0.35 to 1.3.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: June 3, 2014
    Assignee: Momentive Specialty Chemicals Inc.
    Inventors: Byung Young No, David M. Harmon, Todd R. Miller
  • Publication number: 20040152855
    Abstract: A composition, comprising, in an appropriate medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of make-up and are capable of being applied to keratinous fibres, in particular to the nails, eyelashes, eyebrows and hair. In particular, these compositions can make it possible to obtain a film which exhibits good resistance to chipping, to impacts, to rubbing movements, to scratches and/or to pressing actions.
    Type: Application
    Filed: January 17, 2003
    Publication date: August 5, 2004
    Applicant: L'Oreal
    Inventor: Nathalie Mougin
  • Patent number: 6720392
    Abstract: An aqueous amino resin blend comprises aliphatic linear, branched or cyclic amines A containing at least one primary, secondary or tertiary amino group, at least one hydroxyl group and 2 to 20 carbon atoms, and amino resins B, and is used as an impregnating resin in the production of finished foils and edgings.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: April 13, 2004
    Assignee: Solutia Germany GmbH & Co. KG
    Inventors: Frank Scholl, Johann Wonner, Wolfgang Scholz
  • Publication number: 20030135004
    Abstract: A composition, comprising, in an appropriate medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of make-up and are capable of being applied to keratinous fibres, in particular to the nails, eyelashes, eyebrows and hair. In particular, these compositions can make it possible to obtain a film which exhibits good resistance to chipping, to impacts, to rubbing movements, to scratches and/or to pressing actions.
    Type: Application
    Filed: January 17, 2003
    Publication date: July 17, 2003
    Applicant: L'Oreal
    Inventor: Nathalie Mougin
  • Patent number: 6552146
    Abstract: A composition, comprising, in an appropriate medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of make-up and are capable of being applied to keratinous fibers, in particular to the nails, eyelashes, eyebrows and hair. In particular, these compositions can make it possible to obtain a film which exhibits good resistance to chipping, to impacts, to rubbing movements, to scratches and/or to pressing actions.
    Type: Grant
    Filed: April 5, 2000
    Date of Patent: April 22, 2003
    Assignee: L'Oreal S.A.
    Inventor: Nathalie Mougin
  • Patent number: 6455631
    Abstract: The present invention relates to aqueous polyurethane dispersions wherein the polyurethanes contain terminal hydrazide groups and correspond to the formula wherein the terminal, modified hydrazide groups are present in an amount of 1 to 25% by weight [calculated as C(O)—NH—NH—C(O), MW 84], based on the weight of the polyurethanes, and wherein X represents OR′ or NHR′, R represents the residue obtained by removing the isocyanate groups from an NCO prepolymer, R′ represents a group which is inert to Isocyanate groups under the conditions used to form the polyurethane of in formula I, R″ represents a divalent, linear or branched aliphatic group containing 2 to 10 carbon atoms, provided that there are at least two carbons between the oxygen atoms, wherein the aliphatic group may optionally be substituted by heteroatoms to form ether or ester groups, m is 0 or 1 and n is 2 to 4.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: September 24, 2002
    Assignees: Bayer Corporation, Bayer Aktiengesellschaft
    Inventors: Harald Blum, Lyubov K. Gindin, Karen M. Henderson, Patricia B. Jacobs, Sze-Ming Lee, Brian Long, Robert A. Sylvester, Douglas A. Wicks
  • Patent number: 6362359
    Abstract: The present invention relates to compounds containing modified hydrazide groups and corresponding to formula I wherein R represents the residue obtained by removing the isocyanate groups from a monomeric polyisocyanate, a polyisocyanate adduct or an NCO prepolymer, X represents OR′ or NHR′ and R′ represents a group which is inert to isocyanate groups under the conditions used to form the compound of formula I, R″ represents a divalent, linear or branched aliphatic group containing 2 to 10 carbon atoms, provided that there are at least two carbons between the oxygen atoms wherein the aliphatic group may optionally be substituted by heteroatoms to form ether or ester groups, and n is 2 to 6.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: March 26, 2002
    Assignee: Bayer Corporation
    Inventors: Sze-Ming Lee, Karen M. Henderson, Patricia B. Jacobs, Robert A. Sylvester, Douglas A. Wicks
  • Patent number: 6200683
    Abstract: The invention pertains to compositions which can be coated onto substrates. These compositions include a combination of a resin blend comprising a first polyester resin and a second polyester resin, wherein the first polyester is different from the second polyester, an aminoplast crosslinking resin, an acid catalyst, and a urea-aldehyde resin. Films prepared from coating compositions made in accordance with the present invention having improved stain resistance. In many instances, films prepared from coating compositions made in accordance with the present invention not only have improved stain resistance, but also have low temperature flexibility.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: March 13, 2001
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Robert A. Montague, W. Scott Huffman, Jamel S. Richardson, Padmanabhan Sundararaman
  • Patent number: 6150457
    Abstract: The present invention relates to compounds containing modified hydrazide groups and corresponding to formula I ##STR1## wherein R represents the residue obtained by removing the isocyanate groups from a monomeric polyisocyanate, a polyisocyanate adduct or an NCO prepolymer,X represents OR' or NHR' andR' represents a group which is inert to isocyanate groups under the conditions used to form the compound of formula I andn has a value of 2 to 6.The present invention also relates to one-component, thermoset coating compositions containing the compounds of formula I and a cross-linking component that is reactive with these compounds. Finally, the present invention relates coatings, sealants and adhesives prepared from these thermoset compositions.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: November 21, 2000
    Assignees: Bayer Corporation, Bayer Aktiengesellscaft
    Inventors: Sze-Ming Lee, Douglas A. Wicks, Eberhard Koenig, Carol L. Kinney, Karen M. Henderson
  • Patent number: 5961965
    Abstract: A description is given of water-soluble or water-dispersible polyaspartic acid derivatives, their preparation and their use in cosmetology, especially in hair cosmetology.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: October 5, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Son Nguyen Kim, Axel Sanner, Peter Hossel, Matthias Kroner
  • Patent number: 5712363
    Abstract: The present invention relates to coating compositions including a particular class of oligomeric sterically hindered polyamines as replacements for traditional blocked and unblocked polyamine crosslinkers. The use of these oligomeric sterically hindered polyamine crosslinkers resultss in a desirable pot life/cure speed relationship not generally available with traditional unblocked polyamine crosslinkers, as well as a lower VOC and often better appearance characteristics than generally available with the traditional blocked varieties.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: January 27, 1998
    Assignee: Akzo Nobel NV
    Inventors: Arie Noomen, Thomas Mezger, Klaus Hobel, Keimpe Jan van den Berg
  • Patent number: 5182360
    Abstract: Tris(norbornenyl) isocyanurate compounds of the formula: ##STR1## wherein R.sup.1 is either H or methyl group, are prepared from the base-catalyzed trimerization of norbornenyl isocyanate. Tris(norbornenyl) isocyanurate is suitable for use as a crosslinker in thiol-ene formulations containing a difunctional thiol oligomer or in systems containing norbornene-difunctional oligomers and polyfunctional thiols, producing improved high temperature properties for the cured compositions.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: January 26, 1993
    Assignee: Loctite Corporation
    Inventors: Anthony F. Jacobine, Steven T. Nakos
  • Patent number: 5158611
    Abstract: A process for producing a resin is disclosed, comprising reacting (a) a polyalkylenepolyamine, (b) an alicyclic dibasic carboxylic acid and/or a reaction product having a free carboxyl group that is obtained by reacting an alicyclic dibasic carboxylic acid with a glycol, (c) a urea, and (d) an aldehyde and/or an alkylating agent. The resulting resin is useful as a wet strength agent to provide a paper coating composition having improved printability and printing effects.
    Type: Grant
    Filed: August 22, 1991
    Date of Patent: October 27, 1992
    Assignee: Sumitomo Chemical Co., Ltd.
    Inventors: Shigeru Ura, Haruo Tanaka, Hisao Takagishi, Yoshiya Fukuyama, deceased, Hiroko Fukuyama, heir, Takuya Fukuyama, heir, Yuko Fukuyama, heir
  • Patent number: 5039754
    Abstract: A polymeric peroxide comprising a dilvalent recurring unit having the formula: ##STR1## wherein the recurring unit of Formula I has a 10 hour half-life temperature of at least 80.degree. C. and optionally a divalent recurring unit having the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.5, X, X.sup.1, Y, Z, y and z are as defined in the Detailed Description of the Preferred Embodiments and the polymeric peroxide has a molecular weight of 1,000 to 200,000. The polymeric peroxides are derived from hydroxy-hydroperoxides of dihydroxy dialkyl peroxides. These polymeric peroxides can be used for preparing block copolymers and compatibilizing polymer blends and alloys.
    Type: Grant
    Filed: August 30, 1990
    Date of Patent: August 13, 1991
    Assignee: Atochem North America, Inc.
    Inventor: Jose Sanchez
  • Patent number: 5034501
    Abstract: A process for producing a resin is disclosed, comprising reacting (a) a polyalkylenepolyamine, (b) an alicyclic dibasic carboxylic acid and/or a reaction product having a free carboxyl group that is obtained by reacting an alicyclic dibasic carboxylic acid with a glycol, (c) a urea, and (d) an aldehyde and/or an alkylating agent. The resulting resin is useful as a wet strength agent to provide a paper coating composition having improved printability and printing effects.
    Type: Grant
    Filed: September 18, 1990
    Date of Patent: July 23, 1991
    Assignee: Sumitomo Chemical Co., Ltd.
    Inventors: Shigeru Ura, Haruo Tanaka, Hisao Takagishi, Yoshiya Fukuyama, deceased
  • Patent number: 4981944
    Abstract: A liquid coating composition is provided which comprises, as a binder, an addition polymer containing on average 2 or more pendant activated unsaturated groups and, as a crosslinking agent, a compound containing on average 2 or more primary amino groups. The pendant activated unsaturated groups of the addition polymer are based upon fumaric, maleic and/or itaconic acid and/or anhydrides thereof. The liquid coating compositions of the present invention provide the particular advantage of rapid cure at ambient temperatures.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: January 1, 1991
    Assignee: Akzo N. V.
    Inventors: Tamme Bartels, Gerardus J. W. M. Maters
  • Patent number: 4906726
    Abstract: A water-based coating composition comprising as the first component, a mixture of a polyaldehyde chosen from the group consisting of glyoxal, glutaraldehyde and derivatives of glyoxal and glutaraldehyde, and a water dispersible component chosen from the group consisting of epoxy resin emulsions which can be emulsified in water, synthetic latexes stable at about pH 7 or less, low molecular weight resin emulsions, epoxy ester emulsions, water emulsified alkyds, and cationic, anionic and non-ionic asphalt emulsions and, as the second component, the non-gel reaction product of (I) urea-formaldehyde ether monomer, urea-formaldehyde phenol monomer, urea-nonylphenol formaldehyde monomer, thiourea-formaldehyde ether monomer, melamine formaldehyde ether monomer hexamethoxymethyl melamine, with (II) a polyamine chosen from a group consisting of primary and secondary amines and/or a monoamine, combined with (III) a hydroxide or oxide of calcium, strontium or barium.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: March 6, 1990
    Assignee: Adhesive Coatings Co.
    Inventor: Lowell Cummings
  • Patent number: 4855394
    Abstract: Condensates based on substituted ureas, their reaction products with di- and/or polyisocyanates, derivatives of di- and/or polycarboxylic acids or p-substituted phenols and/or their methylol derivatives, their preparation and their use. These condensates each contain two or more cyclic urea units and can be prepared either by reacting primary di- or polyamines with ureas and reacting the product with predominantly CH-acidic aldehydes or by reacting primary amines with isocyanates and reacting the product with predominantly CH-acidic aldehydes in the presence of an acidic catalyst. The said condensates and their reaction products are useful for the preparation of heat-curable coating materials and of binders for cathodic electrocoating.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: August 8, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Goeckel, Harro Petersen, Rolf Osterloh, Eberhard Schupp, Werner Loch, Thomas Schwerzel
  • Patent number: 4847315
    Abstract: A water-soluble, thermosetting resin comprising units derived from tris(2-aminoethyl)amine, and preferably units derived from dicyandiamide and/or epichlorohydrin, is useful as an accelerator in paper sizing, e.g. using an alkyl ketene dimer.
    Type: Grant
    Filed: June 3, 1987
    Date of Patent: July 11, 1989
    Assignee: W. R. Grace AB
    Inventor: Thord G. G. Hassler
  • Patent number: 4814422
    Abstract: In the proposed pulverulent aminoplast adhesive resin for wood-base materials having a low formaldehyde emission, the resin is a mixture of(a) from 40 to 90 parts by weight of a urea/formaldehyde resin having a molar ratio of urea to formaldehyde of from 1:1.4 to 1:2,(b) from 2 to 20 parts by weight of melamine, some or all of which may have been reacted with the urea/formaldehyde resin component,(c) from 2 to 20 parts by weight of urea and(d) if required, from 0.1 to 10 parts by weight of an agent for increasing the shelf life,together with not more than 10 parts by weight of water and, if required, not more than 10 parts by weight of other additives, the numbers of parts by weight of the components summing to 100.In the process for the preparation of the pulverulent aminoplast adhesive resin, powdered melamine is stirred into a solution of the urea/formaldehyde resin, urea is added and the solution is spray dried.
    Type: Grant
    Filed: June 19, 1987
    Date of Patent: March 21, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans Diem, Friedrich Kraus, Guenther Matthias, Bruno Maurer, Otto Wittmann
  • Patent number: 4659787
    Abstract: A new class of epoxy curing agents has been discovered that utilizes the monomer of (a) urea-formaldehyde, (b) phenol modified urea-formaldehyde, or (c) thiourea-formaldehyde as the center of a polyamine molecule. The ether monomers are reacted with conventional aliphatic, cycloaliphatic, and aromatic polyamines to split off alcohol and water-yielding urea-formaldehyde etc., polyamine epoxy curing agents.
    Type: Grant
    Filed: November 14, 1985
    Date of Patent: April 21, 1987
    Assignee: Chemcrete International Partnership
    Inventor: Lowell O. Cummings
  • Patent number: 4574145
    Abstract: A new class of epoxy curing agents has been discovered that utilizes the monomer of (a) urea-formaldehyde, (b) phenol modified urea-formaldehyde, or (c) thiourea-formaldehyde as the center of a polyamine molecule. The ether monomers are reacted with conventional aliphatic, cycloaliphatic, and aromatic polyamines to split off alcohol and water-yielding urea-formaldehyde etc., polyamine epoxy curing agents.
    Type: Grant
    Filed: September 28, 1984
    Date of Patent: March 4, 1986
    Assignee: Chemcrete International
    Inventor: Lowell O. Cummings
  • Patent number: 4511707
    Abstract: The wet fastness properties of direct or reactive dyeings on cellulosic substrates are improved by aftertreatment with a precondensate of(A) the product of reacting a mono- or polyfunctional primary or secondary amine with cyanamide, dicyandiamide (DCDA), guanidine or biguanidine; or ammonia with cyanamide or DCDA; whereby up to 50 mole % of the cyanamide, DCDA, guanidine or biguanide may be replaced with a dicarboxylic acid or a mono- or di-ester thereof, said product (A) containing reactive hydrogen atoms bound to nitrogen, and either(B) an epihalohydrin or a precursor thereof, or(C) formaldehyde or a formaldehyde precursor, or(D) a dihydroxyalkyleneurea or a methyl ether thereof,followed by formaldehyde or a formaldehyde precursor optionally together with(E) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amideand, if (A) is used with (C) or (D), or if (E) is present, together with(F) a catalyst for the cross-linking of N-methylol compounds of the type (E) abov
    Type: Grant
    Filed: January 25, 1984
    Date of Patent: April 16, 1985
    Assignee: Sandoz Ltd.
    Inventors: James R. Runyon, Salvatore Valenti
  • Patent number: 4475918
    Abstract: Aftertreatment of dyeings on cotton or nylon with (A) a polybasic compound which is the product of reacting a primary or secondary amine with cyanamide, dicyandiamide, guanidine or biguanidine and, sequentially or simultaneously (B) a precondensate formed by reacting a compound of type (A) with an N-methylol derivative gives wet fastness properties superior to those given by either (A) or (B) used alone.
    Type: Grant
    Filed: August 24, 1983
    Date of Patent: October 9, 1984
    Assignee: Sandoz Ltd.
    Inventors: Bruno Kissling, Tibor Robinson
  • Patent number: 4452606
    Abstract: The wet fastness properties of direct or reactive dyeings on cellulosic substrates are improved by aftertreatment with a precondensate or mixture of(A) the product of reacting a polyalkylenepolyamine in free base or salt form with an epihalohydrin or a precursor thereofand (B) and N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amidein the presence of(C) a catalyst for the cross-linking of N-methylol compounds of the type (B) above,followed by a heat-curing step.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: June 5, 1984
    Assignee: Sandoz Ltd.
    Inventors: Joseph van Diest, Salvatore Valenti
  • Patent number: 4443223
    Abstract: The fastness of direct dyes on cellulose substrates is improved by after-treatment with the reaction product of a quaternary polyalkylene polyamine with an N-methylol resin precursor, and heat curing in the presence of a catalyst. The unfixed portion of reactive dyes substantive to cellulose may also be given improved wet and light fastness by this treatment.
    Type: Grant
    Filed: August 30, 1982
    Date of Patent: April 17, 1984
    Assignee: Sandoz Ltd.
    Inventors: Bruno Kissling, Walter Knobel, Tibor Robinson
  • Patent number: 4439208
    Abstract: The fastness properties of basic dyeings on cellulosic substrates are improved by treating the substrate with a fixing agent comprising a precondensate or mixture of(A) the reaction product of an amine with cyanamide, dicyandiamide, guanidine or biguanidine, or,(B) a quaternary polyalkylene polyamine with(C) formaldehyde and/or,(D) an N-methylol compound optionally together with(E) a catalyst, e.g. MgCl.sub.2.The fixing agents are normally applied as an aftertreatment, with a subsequent heat-curing step.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: March 27, 1984
    Assignee: Sandoz Ltd.
    Inventors: Helmut Moser, Tibor Robinson
  • Patent number: 4439203
    Abstract: The wet fastness properties of direct or reactive dyeings on cellulosic substrates are improved by aftertreatment with a precondensate of(A) the product of reacting a mono- or polyfunctional primary or secondary amine with cyanamide, dicyandiamide (DCDA), guanidine or biguanidine; or ammonia with cyanamide or DCDA; whereby up to 50 mole % of the cyanamide, DCDA, guanidine or biguanidine may be replaced with a dicarboxylic acid or a mono- or di-ester thereof, said product (A) containing reactive hydrogen atoms bound to nitrogen,and either (B) an epihalohydrin or a precursor thereofor (C) formaldehyde or a formaldehyde precursoror (D) a dihydroxyalkyleneurea or a methyl ether thereof, followed by formaldehyde or a formaldehyde precursoroptionally together with (E) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amideand, if (A) is used with (C) or (D), or if (E) is present, together with (F) a catalyst for the cross-linking of N-methylol compounds of the type (E) ab
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: March 27, 1984
    Assignee: Sandoz Ltd.
    Inventors: James R. Runyon, Salvatore Valenti
  • Patent number: 4390340
    Abstract: Mineral tanned leather is frequently retanned with synthetic tanning agents to improve the fullness and softness, but leather retanned by the prior art methods is difficult to dye in full shades with anionic dyes. According to the invention, condensation products of C.sub.1-4 aldehydes with certain aromatic sulfonic acids or carboxylic acids containing amino groups are employed for retanning, thereby improving the receptivity of the leather for anionic dyes. These acids have the general formula ##STR1## where X and X' are independently H, --CH.sub.2 --SO.sub.3 H or --CH.sub.2 --OH, A is a benzene radical, Y and Z are independently H, --SO.sub.3 H or --CO.sub.2 H, R is H or C.sub.1-4 -alkyl and n is from 0 to 10, with the proviso that at least one sulfonic acid or carboxyl group is present in the molecule.
    Type: Grant
    Filed: June 30, 1981
    Date of Patent: June 28, 1983
    Assignee: BASF Aktiengesellschaft
    Inventor: Dietrich Lach
  • Patent number: 4383077
    Abstract: Disclosed are novel water-soluble, thermosettable resinous compositions derived by reacting a precondensate of dicyandiamide, formaldehyde, a salt of a water-soluble polyaminopolyamide and an ammonium salt with urea and then condensing the reaction product with additional formaldehyde. The resinous compositions are cationic and have particular utility in the manufacture of paper sized with cellulose reactive sizing agents such as ketene dimer sizing agents.
    Type: Grant
    Filed: December 8, 1981
    Date of Patent: May 10, 1983
    Assignee: Hercules Incorporated
    Inventor: Ralph A. Bankert
  • Patent number: 4316005
    Abstract: A cationic adsorption agent which is obtained by reaction of(a) an amino compound which contains at least one amino group and at least one free or methylolated carboxamide group, with(b) an aminoplast precondensate which does not contain amino groups.The novel adsorption agent is suitable in particular for removing anionic substances, such as acid dyes or reactive dyes, from aqueous solutions, especially from wastewaters.
    Type: Grant
    Filed: June 23, 1980
    Date of Patent: February 16, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Rudolf F. Wurster, Jurg Merz
  • Patent number: 4297264
    Abstract: An improved process for the preparation of alkoxylated formaldehyde-amino compound resins. By using a sequential procedure, and an alkanol of up to 8 carbon atoms it is possible to remove both the water in the aqueous formaldehyde used and the water from the alkoxylation reaction azeotropically. The products of this invention afford resins of better quality, especially in terms of color and clarity, than the products derived from alcoholic formaldehyde solutions.
    Type: Grant
    Filed: June 6, 1980
    Date of Patent: October 27, 1981
    Assignee: Reichhold Limited
    Inventors: Robert S. De Ruiter, Stamatis M. Kambanis
  • Patent number: 4267235
    Abstract: Suspension polymerization of aqueous glutaraldehyde in basic conditions in presence of surfactants such as isobutoxy acrylamide copolymers and/or cross-linking agents yield cross-linked, water insoluble glutaraldehyde polymer microspheres ranging in size from 200 A to 10.mu.. Addition of fluorochromes, e.g., FITC, during polymerization yields microspheres of high fluorescent intensity and addition of a suspension of metal containing particles such as Fe.sub.3 O.sub.4 during polymerization yields magnetic microspheres. Immunopolyglutaraldehyde microspheres can be obtained by interacting the polyglutaraldehyde microspheres with antibodies. The immunomicrospheres were used to label and separate cell subpopulations. The labeling specificity is considerably improved by increasing the amount of isobutoxy polyacrylamide incorporated in the microspheres.
    Type: Grant
    Filed: March 19, 1979
    Date of Patent: May 12, 1981
    Assignee: California Institute of Technology
    Inventors: Alan Rembaum, Shlomo Margel
  • Patent number: 4267234
    Abstract: Polyglutaraldehyde (PGL) is polymerized in aqueous base or in aqueous highly polar solvent basic media to prepare powders, castable films or coatings for substrates such as amine substituted microbeads. PGL microspheres can be prepared by suspension polymerization in presence of a surfactant or by precipitating PGL from solution containing surfactant. Magnetic PGL microspheres are formed by suspension polymerization in the presence of magnetic particles such as iron oxide. Polyglutaraldehyde can be converted to a fluorescent polymer by reaction with m-aminophenol or other reagent. Proteins can be readily covalently bound to the polyglutaraldehyde.
    Type: Grant
    Filed: March 19, 1979
    Date of Patent: May 12, 1981
    Assignee: California Institute of Technology
    Inventor: Alan Rembaum