Abstract: Contact lens packages are provided and each includes a base member having a cavity and a sealing member coupled to the base member. An unworn contact lens is provided in a packaging solution within the sealed cavity. The base member is a thermoplastic or other recyclable material. The base member includes at least one latch and at least one slot. The latch and slot are configured to connect to the slot and latch, respectively, of another base member, after the contact lenses are removed from the cavities. A recyclable thermoplastic contact lens assembly is also provided that includes empty contact lens package base members stacked and connected together. A method to recycle used contact lens package base members, such as by curbside recycling, is also provided.

Abstract: A method of pre-treating a contaminated medical instrument that is to undergo decontamination involves inserting a distal tip of the instrument into a distal tip protector. The distal tip of the instrument is inserted through a rupturable resilient seal into an internal cavity of the protector that contains a fluid. The distal tip protector thereby maintains a fluid around the distal tip of the instrument until the distal tip protector is removed to allow reprocessing of the instrument to take place, facilitating decontamination of the instrument.

Abstract: The invention is to provide an ophthalmic lens comprising a lens body and an antimicrobial hydrophilic layer thereon and a manufacturing method thereof, wherein the antimicrobial hydrophilic layer comprises a polydopamine layer and a zwitterionic polymer non-covalently bonded on the polydopamine layer, and the zwitterionic polymer can be selected from one of the group consisting of phosphorylcholine polymer, sulfobetaine polymer, carboxybetaine polymer, mixed-charge polymer and a combination thereof.

Abstract: The invention is to provide an ophthalmic lens comprising a lens body, a polydopamine layer formed on the surface of the lens body and an antimicrobial layer bonded to the polydopamine layer, and manufacturing method thereof, wherein the antimicrobial layer is formed from a copolymer of carboxyl-containing polymer and zwitterionic polymer and a crosslinking agent, and the zwitterionic polymer can be selected from one of the group consisting of phosphorylcholine polymer, sulfobetaine polymer, carboxybetaine polymer and mixed-charge polymer or a combination thereof.

Abstract: The invention provides a method of introducing a sterilized product into a controlled environment. The sterilized product is enclosed in a substantially hermetically sealed first layer, which is enclosed in a substantially hermetically sealed second layer, which is enclosed in a substantially hermetically sealed third layer, which is enclosed in a substantially hermetically sealed fourth layer. The method includes removing the fourth layer in a first environment (having a first sterility), removing the third layer in a controlled second environment (having a predetermined second sterility that is higher than the first sterility), removing the second layer in a controlled third environment (having a predetermined third sterility that is higher than the second sterility), and removing the first layer in a controlled fourth environment (with a predetermined fourth sterility that is higher than the third sterility) to expose the sterilized product.

Abstract: A preform is easily and speedily sterilized. A number of preforms (1), each having a bottomed tubular shape, are laid on a conveyer (4) in a scraggly overturned manner, these preforms passes inside a chamber (5) together with the conveyer, and hydrogen peroxide water mist is sprayed from both sides of the conveyer in a direction crossing the conveyer in the chamber, thereby adhering the sprayed hydrogen peroxide water to inner and outer surfaces of the preforms (1) on the conveyer (4).

Abstract: The present invention is a method and an apparatus for packaging lyophilized implants and other medical devices. In accordance with the invention, a lyophilized implant may be packaged for delivery to the surgical site in a sealed, flexible/expandable, sterile inner pouch. The inner pouch may be further packaged within an outer, sterile package. The inner pouch contains a resealable port through which rehydration liquid may be introduced into the inner pouch without opening the inner pouch. The inner pouch may be made of a flexible, substantially non-stretchable material so that the pouch can expand only to a predetermined maximum size to accept a predetermined volume of rehydration liquid. After rehydration, any excess rehydration liquid within the pouch may be removed via the same port. Next, the pouch is opened via a second opening to expose the implant for removal from the package.

Abstract: A bale unloading device is provided for unloading bales off from an inline bale wrapping machine. The bale unloading device comprises a telescopic bale unloading member that is found on the unwrapped bale loading end of the bale wrapping machine or on a bale storage trailer attached thereto. When in use, the bale unloading device goes from a retracted state to an extended state, pushing the last bale through a bale wrapping device and towards a wrapped bale support structure located on the wrapped bale unloading end of the bale wrapping machine. The bale unloading member is powered by hydraulic valves/actuators and therefore does not necessitate any manual intervention to unload the last bale from the bale wrapping machine.

Abstract: A packaging machine includes a pair of brushes that hold a tubular film (Fm) therebetween while rotating and impeding the advancement of packaged articles. Consequently, an elongated stream of packaged articles aggregate at the leading end of the pair of brushes. When the pair of brushes release the tubular film, the packaged articles are again conveyed in a more closely aggregated state than the aggregated state thereof when the advancement of the packaged articles was temporarily impeded. The rotational axis of each brush is also biased a predetermined distance from the central axis of a core thereof. Since the brushes swing in conjunction with the rotation thereof, small vibrations and large swings cause the gaps between packaged articles to be readily filled and reduce the space occupied by the packaged articles. As a result, the bag size can be reduced.

Abstract: A system for preparing food product minimizes bacterial contamination and outgrowth within the packaged food product, includes a powered slicer to sequentially separate slices of food product to create a stack of food product slices. The system also includes a first spray nozzle for depositing a first predetermined amount of the antimicrobial preparation onto the first face of the log or other food product piece each time a slice is removed as well as a a second spray nozzle for depositing a second predetermined amount of the antimicrobial preparation into a vacuum pouch prior to reception of a stack within the pouch. In an embodiment, the spray system is implemented with respect to a mixer/blender to pretreat a mix prior to further processing.

Abstract: An apparatus and method for multi-stage printing teaches a 3D printer in combination with one or more additional dispensing nozzles. One or more additional dispensing nozzles are combined with the 3D for filling cavities with other compounds such as foam, sterilizing parts by spraying printed mold with disinfectant or antibacterial treatments, and embedding parts or other materials such as paper, fiberglass, or carbon fiber within the printing layers for additional strength and changing mold properties of a final product. In other embodiments, the apparatus of the present invention can be used in combination with a robotic packaging mechanism for bagging sterilized parts for shipment.

Abstract: A method of making a liquid or semi-liquid emulsion cleaning, waxing, and restoring product with applicability to painted motor vehicles. The emulsion removes bugs, tar and paint from other vehicles, etc. and is safe for paint, plastic, chrome and wheels. The emulsion is prepared using a unique sequence of mixing steps that result in a complete emulsification of ingredients that heretofore have been difficult or impossible to effectively combine. The emulsion may be provided in liquid or paste form or in microfiber cloths, or disposable towelettes, and other such carriers infused with the emulsion. The carrier is moistened with the emulsion and packaged in sealed individual packages. In other embodiments, multiple emulsion-soaked towels or towelettes may be packaged in reclosable cylinders from which individual towels may be extracted and the cylinder reclosed. These pre-soaked towelettes may be used to easily clean and wax vehicles or other similar surfaces.

Abstract: A package having an additive that does not adhere to a medical device enclosed therein.

Abstract: The present invention relates to removing disease material from the blood of a patient. Specifically, the invention relates to using biological binders to trap disease material that is desired to be removed from the blood of a patient.

Abstract: A method and system for injecting fluid into a sealed container that contains a consumable product is provided. The container is filled with a consumable product and then sealed with a closure. A fluid is injected through the closure into the container cavity after filling and sealing. The fluid increases the internal pressure of the container and scavenges oxygen in the container.

Abstract: Contact lens blister packages and methods of manufacturing packaged contact lenses are described.

Abstract: Embodiments described herein relate to articles and methods for forming liquid surface films on the interior surfaces of containers for holding one or more products comprising one or more Bingham plastic materials. Bingham plastic materials behave as a solid under no or low shear stress, and behave as viscous liquids when an applied shear stress exceeds a yield stress. In some embodiments, a container for containing a product includes an interior surface and a liquid disposed on the interior surface. Before introduction of a product into a container, the liquid may be surrounded by air. The liquid-air interface in contact with the interior surface makes a contact angle, ?os(a), with respect to the interior surface of the container, of about 0°. After a product has been introduced to the container, the liquid is at least partially covered by the product. The liquid-product interface in contact with the interior surface, makes a contact angle, ?os(p), with respect to the interior surface, of less about 60®.

Abstract: A cartridge for a liquid reservoir of a plant-treatment product sprayer is disclosed. The cartridge includes a liquid permeable pouch defining a pre-sealed internal volume, and a plant-treatment formulation in the internal volume. A method of providing a plant-treatment formulation to a liquid reservoir of a plant-treatment product sprayer, and a cartridge for dispensing a plant-treatment formulation are also disclosed.

Abstract: The present invention is synergistic antibiotic compositions having pH adjusted profiles for manufacturing combination, and administration, particularly for patients at risk or suffering from ventilator-associated pneumonia (VAP) and ventilator associated tracheal (VAT) bronchitis. Antibiotic compositions containing fosfomycin and aminoglycosides having individually predetermined and selected pH ranges are manufactured and stored for in combination prior to aerosolization, preferably with a specially designed in-line nebulizer attached to a ventilator.

Abstract: A method for sterile packaging of a surface modified implantable device includes irradiating a surface of the device such that the hydrophobicity of the surface is decreased and, optionally, the device is simultaneously sterilized. The surface of the sterile, surface-modified implantable device is then covered in a polar solution to prevent hydrophobic recovery of the surface.

Abstract: Some embodiments of a system or method for applying a barrier composition to a targeted skin surface can be used to as a preventative measure to reduce the likelihood of transmission of microbial entities from an external source (e.g., a floor surface or another surface) to the targeted skin surface.

Abstract: A soft impact projectile launcher including a launching mechanism that creates a burst of air or air pressure in order to launch a projectile. The launching mechanism includes an outer cylinder and a spring-loaded piston configured to generate the burst of air. The projectile launcher may also include a projectile reservoir and a loading member that positions projectiles for launching. The projectile launcher can launch projectiles that are made from a superabsorbent polymer and consist of mostly water.

Abstract: Asparagus spears may be stored and displayed for sale, and sold, in individual containers having a reservoir containing a volume of water, with a group of asparagus spears arranged in the container such that their white tips are in contact with the volume of water. This allows the asparagus spears to be moved from a retail display, to a shopping cart, to a shopping bag, and eventually to a customer's home, without having to remove the white tips of the asparagus from contact with the water. One exemplary container has a waist between the first end and the second end of the container and tapers inwardly from the waist toward the first end and toward the second end. This tapering shape permits air to flow between adjacent containers when the containers are packed together for shipping.

Abstract: A composition for loading into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and a chelator, a precipitation agent, or a combination thereof. Medical devices, such as stents, with a structural element defined by a lumen and at least one opening to access the lumen, filled with the compositions are also described.

Abstract: A method of filling CARC (chemical agent resistant coating) applicators ensures integrity of the CARC paint.

Abstract: Rechargeable containers and dispensers, in particular spray bottle dispensers including structures such as strips, pouches, pills, capsules, discs and the like for providing concentrates of chemical agents for charging or recharging the spray bottle dispenser, preferably, individual chemical refill charges containing chemical concentrate are deployed within the spray bottle dispenser to fully contain any inadvertent spillage of chemicals, and to insure a high degree of safety against accidental spills or ingestion. The device is specifically designed for reuse, having a wider opening which is easier to fill, clean and refill without spills, readily accommodates concentrate inserts in any format, minimizes trigger failure, and has a wide base for stability.

Abstract: A drug suspension agent and method of making same is used for curing or preventing diseases, or adjusting the physiological function of a human or animal body by drug information without contacting the skin. The basic configuration of the drug suspension agent consists of a drug holder (1), a container (4) and a connector (5). The contents (2) are drugs having pharmacological activity.

Abstract: Disclosed is a method for processing cut edges of a blank member, so galled “package sleeve”, made from packaging material, in particular paper/plastics composite material, the cut edges of which are open from above and/or below, by applying a processing medium. In order to develop a simple and cost-effective method, in which the risk of contamination of the packagings and the aseptic region of a filling installation when the package sleeves are filled and closed is reduced, the processing medium contains at least one sterilising medium and the sterilising medium remains after being applied to the cut edges and is introduced into the packaging material.

Abstract: This invention relates to an method of manufacture of an implantable medical device comprising an oxygen-sensitive rapamycin derivative that is protected by addition of an antioxidant during the manufacturing process where the amount of antioxidant added at the outset of the processing is such that when the device is fully fabricated, sterilized and packaged the amount of antioxidant has reduced to a minimal, preferably non-detect, amount.

Abstract: The present disclosure refers to a material impermeable to water vapour and oxygen for packaging dietary products, cosmetics and medicinal specialities. In particular, the present disclosure refers to primary packaging in the form of blister packs or sachets, which comes into direct contact with the formulations of medicinal specialities and dietary products and cosmetics, such as, for example, tablets, pills, pessaries, powders, granules, suppositories, rigid capsules and soft capsules (also known as soft gel capsules).

Abstract: The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising sodium chloride, at least one dry acid and at least one calcium salt, and optionally potassium salt, magnesium salt, and glucose. According to the invention said at least one calcium salt and said optional glucose, are present as anhydrous components in said dialysis acid precursor composition.

Abstract: The invention provides a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column.

Abstract: An attractive and compact device and an effective method to store and disinfect a manual shaving razor are disclosed. The method reduces corrosion of the razor's metal blades. A compact container has separate but Suitably connected chambers allowing for economy of use of as disinfectant liquid combining alcohol, detergent or soap and skin conditioner. By protecting the razor in one enclosed chamber, oxidative damage and rusting of blades is avoided. A knife edge element is placed at the bottom of another chamber to pierce the foil seal of a suitably inserted bottle within the other chamber. An optional third, drainage chamber below the other two chambers allows for appropriate drainage and removal both of excess fluid used, as well as hair and debris from the blades. The design of the device is compact and attractive, as is the method an extremely effective way of protecting and disinfecting the razor.

Abstract: Bioactive hydroforming luminal liner compositions are formed of an absorbable crystalline amphiphilic polyether-ester-urethane dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.

Abstract: One or more techniques, systems, or both are disclosed for an automotive container comprising a water dispersible, pre-moistened wiping product for an associated rotor. The wiping product may comprise a flexible substrate carrying a cleaning composition wherein the cleaning composition may comprise 1) about 70% to about 90% water; 2) about 1% to about 10% corrosion inhibitor; and 3) about 10% to about 25% surfactant. A single wiping product may be in the automotive container for single use application and may then be discarded with the automotive container through ordinary disposal means. A single use lubricating product may be carried in a separate pocket or container for use after the wiping product.

Abstract: A method for introducing at least one substance into a sealed enclosure holding at least one product. At least one conduit may be provided through which one of gas or fluid may flow into or out of the sealed enclosure. Air may be evacuated from the sealed enclosure through the at least one conduit to create a predetermined pressure within the sealed enclosure and a predetermined quantity of the at least one substance may be injected into the sealed enclosure through the at least one conduit.

Abstract: The invention is directed to the use of a wetting agent having a boiling point higher than 100° C. and a viscosity lower than 500 mPa.s, wherein the wetting agent comprises water in an amount between 0 and 4.9 wt % based on the total weight of the wetting agent, for the lubrication of a hydrophilic polymer coating. The invention further relates to a medical device comprising a hydrophilic polymer coating that is wetted by a wetting agent, a method for the preparation of a medical device and a package comprising a medical device.

Abstract: Contact lenses comprising phosphorylcholine groups release beneficial polyionic or guanidinium-containing agents.

Abstract: Antimicrobial ophthalmic devices such as contact lenses, ocular inserts, ocular bandages, and intraocular lenses comprise a hydrogel and an antimicrobially-effective amount of epsilon polylysine non-covalently attached to the hydrogel.

Abstract: The present invention relates to a multiparticulate extended-release pharmaceutical composition of mesalamine comprising a) an inert core, b) an active ingredient layer and one or more pharmaceutically acceptable excipients, c) an inner coating layer comprising a water-insoluble cellulose derivative, and d) an outer coating layer comprising an enteric polymer.

Abstract: This invention relates to a convenient and safe product and method of applying glycopyrrolate topically in order to reduce excessive sweating in localized areas for those who suffer from this condition. This invention also relates to combining oral and topical delivery of glycopyrrolate to reduce excessive sweating and minimize side effects. This invention also relates to a convenient and safe product and method of applying glycopyrrolate topically to areas of compensatory sweating after endoscopic thoracic sympathectomy.

Abstract: Bioprosthetic tissues are treated by immersing or otherwise contacting fixed, unfixed or partially fixed tissue with a glutaraldehyde solution that has previously been heat-treated or pH adjusted prior to its contact with the tissue. The prior heat treating or pH adjustment of the glutaraldehyde solution causes its free aldehyde concentration to decrease by about 25% or more, preferably by as much as 50%, and allows a “stabilized” glutaraldehyde solution to be obtained at the desired concentration and pH for an optimal fixation of the tissue at high or low temperature. This treatment results in a decrease in the tissue's propensity to calcify after being implanted within the body of a human or animal patient.

Abstract: A method for introducing at least one substance into a sealed enclosure holding at least one product. The sealed enclosure having at least one conduit through which one of gas or fluid may flow into or out of the sealed enclosure. Air is evacuated from the sealed enclosure through the at least one conduit to create a predetermined pressure within the sealed enclosure and a predetermined quantity of the at least one substance is injected into the sealed enclosure through the at least one conduit.

Abstract: A transdermal drug delivery device is disclosed for administering an oxidizably and/or hydrolyzably degradable drug, e.g., cholinesterase inhibitors such as rivastigmine. The device comprises a) a substantially impermeable backing layer; b) an adhesive layer substantially free of antioxidant and containing a therapeutically effective amount of the degradable drug, which adhesive drug-containing layer is capable of adhering directly to a subject's skin or to another adhesive layer which is capable of adhering to a subject's skin; and c) a substantially impermeable protective release liner layer which releasably contacts the adhesive drug-containing layer or another adhesive layer. The delivery device is sealed in a degradation protective packaging system, such as a substantially oxygen impermeable heat sealable plastic pouch that contains a substantially inert gas and/or a degradation protectant material for the drug, such as an antioxidant, which can be inserted separately to the pouch.

Abstract: An arrangement having a plurality of moistened cosmetic pads based on nonwovens which are piled into a closable packaging container in order to distribute to the final consumer and to prevent evaporation. The pads have, on average, a moisture content of at least 200% of the dry weight thereof in the arrangement, the pads have a fiber structure made of staple fibers, are individually moistened and have a homogeneous moisture content such that the difference of the average moisture content of the pads which are arranged in the upper and in the lower quarter of the stack is, at a maximum, 30% of the average moisture content of all of the pads.

Abstract: A candle includes a vessel of some volume containing some smaller volume of at least one variety of wax beads, having a diameter of less than or equal to 2.35 millimeters and in most embodiments also including a particular fragrance and color pigment. The was beads topped with a solid wax topping. The solid wax topping may cover the entire exposed surface of the candle, holding the wax beads in place during shipping and use and holding the wick in a centralized location.

Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a brush copolymer comprising (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer.

Abstract: A wipes product includes a wipes container filled with at least one wipe substrate. The wipes container is formed at least partially from a first polymer and the first polymer is synthetic and at least partially derived from a renewable resource via a first intermediate monomeric compound. The wipes container includes a lid and a base such that at least one of the lid and the base comprises a bio-based content of about 10% to about 100% using ASTM D6866-10, method B. Methods of forming a wipes product are also provided.

Abstract: The invention provides a method of manufacturing and packaging a room temperature stable cannabinoid dosage in an oil-based carrier, wherein the method employs the use of blister packaging and an inert gas atmosphere during blister packaging. The invention also provides a room temperature stable cannabinoid dosage prepared by the methods of the invention.

Abstract: The present disclosure relates to a dynamic bioactive bone graft material and a method of handling the material to prepare an implant. In one embodiment, a method of preparing a dynamic bioactive bone graft implant is provided. The method includes the step of providing a porous, fibrous composition of bioactive glass fibers, wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and wherein the porosity of the matrix ranges from about 100 nanometers to about 1 millimeter. The porous, fibrous composition is introduced into a mold tray, and a shaped implant is created using the mold tray. The composition may be wetted with a fluid such as saline or a naturally occurring body fluid like blood prior to creating the shaped implant. In another embodiment, the porous, fibrous composition is provided with the mold tray as a kit.