15 To 23 Amino Acid Residues In Defined Sequence Patents (Class 530/326)
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Publication number: 20140322790Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the ?1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: December 13, 2013Publication date: October 30, 2014Applicant: WOUNDCHEK LABORATORIESInventors: Shite Sebastian, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Harvard, Mitchell C. Sanders
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Publication number: 20140323410Abstract: Molecules and compositions are described for use in the treatment and prevention of pro-inflammatory conditions. HDL-related molecules, including ApoA-I, bovine HDL and HDL mimetics, in particular, are demonstrated to prevent UV-induced cell death and oxidative stress in skin cells and to inhibit tumor growth and development in a variety of cancers. HDL-related molecules can be used as an oral supplement and in other compositions to prevent or treat pro-inflammatory skin conditions and systemic proinflammatory conditions, including Alzheimer's disease and various cancers.Type: ApplicationFiled: August 29, 2012Publication date: October 30, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Robin Farias-Eisner, Srinivasa T. Reddy
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Publication number: 20140323397Abstract: The present invention provides new uroguanylin derivatives that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.Type: ApplicationFiled: May 11, 2012Publication date: October 30, 2014Applicant: Ironwood Pharmaceuticals, incInventors: Mark G. Currie, Daniel P. Zimmer, Marco Kessler
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Publication number: 20140323392Abstract: Disclosed herein are compositions and methods for inhibiting viral entry.Type: ApplicationFiled: March 28, 2012Publication date: October 30, 2014Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: J. Nicholas Francis, Joseph S. Redman, Michael S. Kay
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Publication number: 20140322302Abstract: Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising the therapeutic peptides are also disclosed.Type: ApplicationFiled: May 11, 2014Publication date: October 30, 2014Applicant: COMBIMAB, INCInventors: Henry Wolfe, Reinhard Ebner
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Publication number: 20140322253Abstract: Compositions and methods are provided for eliciting antigen-specific T-cell responses against human cyclin A1 (CCNA1), which is herein identified as a leukemia-associated antigen based on its overexpression in acute myeloid leukemia (AML) including leukemia stem cells (LSC) and in immunologically privileged testis cells, but not in other normal cell types. CCNA1-derived peptide epitopes that are immunogenic for T-cells including CTL are disclosed, as are immunotherapeutic approaches using such peptides for vaccines and generation of adoptive transfer therapeutic cells.Type: ApplicationFiled: November 9, 2012Publication date: October 30, 2014Inventors: Philip Greenberg, Sebastian Ochsenreither
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Publication number: 20140322132Abstract: Provided are fragments of human p97 (melanotransferrin) polypeptides having blood-brain barrier (BBB) transport activity, including variants and combinations thereof, conjugates comprising said p97 fragments, and related methods of use thereof, for instance, to facilitate delivery of therapeutic or diagnostic agents across the BBB.Type: ApplicationFiled: March 13, 2014Publication date: October 30, 2014Inventors: Timothy Z. Vitalis, Reinhard Gabathuler
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Publication number: 20140322161Abstract: The present invention relates to a pharmaceutical composition comprising, by way of active ingredient, at least one polypeptide comprising, or constituted by a sequence constituted by at least 8 contiguous amino acids and from at the most 30 contiguous amino acids chosen from within the interleukin-6 sequence and from at the most 30 contiguous amino acids chosen from within the complete IL-6 sequence.Type: ApplicationFiled: August 9, 2012Publication date: October 30, 2014Applicant: PEPTINOV SASInventors: Lucille Desallais, Mattieu Montes, Jean-Francois Zagury
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Patent number: 8871899Abstract: The present invention relates to a peptide having one or more stable, internally-constrained HBS ?-helices, where the peptide mimics at least a portion of a class I C-peptide helix or at least a portion of a class I N-peptide helix of a viral (e.g., HIV-I) coiled-coil assembly. Methods of inhibiting viral infectivity of a subject by administering these peptides are also disclosed.Type: GrantFiled: December 31, 2008Date of Patent: October 28, 2014Assignee: New York UniversityInventors: Deyun Wang, Paramjit Arora
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Patent number: 8871900Abstract: The invention relates to novel peptide comprising FGF-P and methods of use thereof.Type: GrantFiled: June 16, 2009Date of Patent: October 28, 2014Assignee: University of RochesterInventors: Paul Okunieff, Lurong Zhang
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Patent number: 8871719Abstract: Isolated peptides composed of the amino acid sequence of the modified MELK epitope peptide or immunologically active fragments thereof that bind to HLA antigens and have higher cytotoxic T lymphocyte (CTL) inducibility than that of the wild type MELK epitope peptide and thus are suitable for use in the context of cancer immunotherapy or endometriosis immunotherapy, more particularly cancer or endometriosis vaccines are described herein. The present invention further provides peptides that include one, two, or several amino acid insertions, substitutions or additions to the aforementioned peptides or fragments, but yet retain the requisite cytotoxic T cell inducibility. Further provided are nucleic acids encoding any of these aforementioned peptides as well as pharmaceutical substances and compositions including any of the aforementioned peptides or nucleic acids.Type: GrantFiled: January 24, 2011Date of Patent: October 28, 2014Assignee: OncoTherapy Science, Inc.Inventors: Yusuke Nakamura, Takuya Tsunoda, Ryuji Ohsawa, Sachiko Yoshimura, Tomohisa Watanabe
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Patent number: 8871901Abstract: Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals, which include landscape bacteriophage. The disclosed compositions may include immunogenic compositions or vaccines.Type: GrantFiled: March 22, 2011Date of Patent: October 28, 2014Assignee: Auburn UniversityInventors: Tatiana I. Samoylova, Nancy R. Cox, Alexandre M. Samoylov, Anna M. Cochran, Valery A. Petrenko
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Publication number: 20140315784Abstract: The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (PTrCP), and modulate the activity of 13TrCP. In particular, the invention relates to compounds which demonstrate optimised binding to PTrCP. The invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds as medicaments, specifically for the treatment of disorders associated with aberrant protein degradation, such as cancer. The preferred binding inhibitors are peptides derived from the motive DSGXXS, e.g. DEGFWE, DDGFWD and Succinyl-EGFWE.Type: ApplicationFiled: June 27, 2012Publication date: October 23, 2014Inventors: Mark Bradley, Jeffrey George Andrew Walton, Sunay Vijaykumar Chankeshwara, Mazen Sleiman, George S. Baillie, Lucien Gibson
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Publication number: 20140314800Abstract: The present invention relates to a nutritional, preferably enteral, composition for use in the treatment of cow's milk allergy in infants allergic to cow's milk containing specific beta-lactoglobulin peptides, which are able to reduce, in particular abolish the acute symptoms of cow's milk protein allergy.Type: ApplicationFiled: December 6, 2012Publication date: October 23, 2014Inventors: Léon Mathieu Johannes Knippels, Johann Garssen, Laura Antoinette Petronella Maria Muelenbroek
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Publication number: 20140314831Abstract: Disclosed is a recombinant polypeptide for facilitating membrane fusion. The recombinant polypeptide having a sequence with at least 80% sequence identity with the ectodomain of p14 fusion-associated small transmembrane (FAST) protein and having a functional myristoylation motif, a transmembrane domain from a FAST protein and a sequence with at least 80% sequence identity with the endodomain of p15 FAST protein. A targeting ligand can be added to the recombinant polypeptide for selective fusion. The recombinant polypeptide can be included in the membrane of a liposome, or the like, to facilitate the delivery of bioactive compounds, such as siRNA, or the recombinant polypeptide can be mixed with a lipid carrier and added to cultured cells to induce cell-cell fusion and heterokaryon formation.Type: ApplicationFiled: September 29, 2011Publication date: October 23, 2014Applicant: Innovascreen Inc.Inventors: Roy Duncan, John Lewis, Roberto Justo De Antueno, Rae-Lynn Nesbitt, Eileen Kathryn Clancy
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Publication number: 20140314734Abstract: A peptide composition is provi'deo!which specifically inhibits the ability of ? protein kinase C (?PKC) to phosphor/late pyruvate dehydrogenase kinase (PDK) under ischemic conditions. The peptide composition is useful for treating or reducing tissue damage resulting from ischemia and/or reperfusion.Type: ApplicationFiled: August 10, 2012Publication date: October 23, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Daria Mochly-Rosen, Nir Qvit, Marie-Helene Disatnik Dziesietnik
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Publication number: 20140314823Abstract: The present invention provides novel therapeutic antimicrobial peptides that are bactericides and have an inhibitory effect on biofilms produced by biofilm-forming bacteria and especially biofilm-forming staphyloccocal bacteria. The invention includes the nucleic acids encoding the polypeptides, methods of treating bacterial infections, medical devices or implants or prosthetics impregnated with, covered or coated in the polypeptides, and means of delivery of the peptide to the oral cavity.Type: ApplicationFiled: May 15, 2014Publication date: October 23, 2014Applicant: The University of ManchesterInventors: Mathew Upton, Stephanie Sandiford
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Publication number: 20140317786Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 16, 2012Publication date: October 23, 2014Inventor: Marc Morant
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Publication number: 20140315824Abstract: The subject of the present invention are peptide preparations obtained via the enzymatic digestion of hair, wool, bristles, animal fur and individual peptides with sequences corresponding to individual components of a peptide preparation with antitumour activity, for use in the treatment of tumours or oncological prophylaxis as basal components or components of compositions of substances for treating tumours or components of substances used in oncological prophylaxis.Type: ApplicationFiled: December 6, 2011Publication date: October 23, 2014Applicant: Instytut Medycyny Doswiadczalnej i Klinicznej PanInventors: Andrzej Lipkowski, Sergiusz Markowicz
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Publication number: 20140315231Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.Type: ApplicationFiled: November 16, 2012Publication date: October 23, 2014Inventors: James Butler, Renta Hutabarat, Rene Alvarez, Bob Xiong, Lily Y.T. Li
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Publication number: 20140308306Abstract: The invention provides compositions comprising immunogenic fragments of ApoB-100 for eliciting an immune response in a subject or vaccinating a subject, so as to treat, prevent, 5 inhibit and/or reduce symptoms of kidney diseases in the subject. The compositions include immunogenic fragments of ApoB-100, CD8+ T cells activated with immunogenic fragments of ApoB-100 or a combination thereof.Type: ApplicationFiled: November 6, 2012Publication date: October 16, 2014Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Kuang-Yuh Chyu, Prediman K. Shah, Paul Dimayuga
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Publication number: 20140309161Abstract: The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.Type: ApplicationFiled: June 20, 2012Publication date: October 16, 2014Applicant: Universitat LeipzigInventors: Ralf Hoffmann, Nicole Berthold, Friederike Nollmann
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Publication number: 20140308261Abstract: This invention concerns HY epitopic polypeptides specifically presented by the HLA-DR7 molecule, a method for preparing these epitopic polypeptides, isolated T-lymphocytes capable of specifically recognizing an epitope from these polypeptides or from a polypeptide comprising the complete sequence of the protein encoded by the RPS4Y gene and presented by the HLA-DR7 molecule expressed on the surface of antigen-presenting cells, a method for preparing these T-lymphocytes, as well as the use of these epitopic polypeptides and these T-lymphocytes as medicaments, in particular for the treatment of cancers of immune cells.Type: ApplicationFiled: November 21, 2012Publication date: October 16, 2014Inventors: Assia El Jaafari, Dominique Rigal, Diane Scott
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Publication number: 20140309170Abstract: Provided are peptide sequences derived from prostate serum antigen (PSA). The peptides are provided in cyclic and linear form. Methods for using the peptides for inhibition of angiogenesis, such as angiogenesis in a tumor, are provided.Type: ApplicationFiled: July 23, 2012Publication date: October 16, 2014Applicant: HEALTH RESEARCH, INC.Inventors: Kailash C. Chadha, Gary J. Smith
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Patent number: 8859727Abstract: A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.Type: GrantFiled: December 19, 2012Date of Patent: October 14, 2014Assignee: The Board of Regents of the University of Texas SystemInventors: Jacki Lin, Ralph Arlinghaus, Tong Sun, Lin Ji, Bulent Ozpolat, Gabriel Lopez-Berestein, Jack A. Roth
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Patent number: 8859492Abstract: It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.Type: GrantFiled: May 12, 2012Date of Patent: October 14, 2014Assignee: MetalloPharm, LLCInventors: James A. Cowan, Ada S. Cowan, Donna T. Palmer
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Patent number: 8859725Abstract: The invention provides novel healthy kidney biomarkers useful in the monitoring of renal function and in the prognosis and diagnosis of renal dysfunctions, especially those related to graft rejection. The invention further relates to methods for aiding in the evaluation, and design of personalized therapies in transplantation nephrology.Type: GrantFiled: July 31, 2008Date of Patent: October 14, 2014Assignees: Queen Mary and Westfield College, University of London, Hospital Clinic I Provincial de Barcelona, Institut de Investigacions Biomediques August PI I SunyerInventors: Luis F. Quintana Porras, Amanda Sole Gonzalez, Elisenda Bañón-Maneus, Josep M. Campistol, Pedro Rodriguez Cutillas
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Publication number: 20140302074Abstract: The present disclosure relates generally to epitopes of an antibody known as PAT-LM1, and methods for using said epitopes.Type: ApplicationFiled: October 29, 2012Publication date: October 9, 2014Inventors: Arndt-Rene Kelter, Frank Hensel, Vic Ilag, Barbara Power, Christopher Garth Hosking
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Publication number: 20140303073Abstract: The present invention relates to antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal.Type: ApplicationFiled: April 11, 2014Publication date: October 9, 2014Applicant: Sarepta Therapeutics, Inc.Inventor: Patrick L. Iversen
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Publication number: 20140303069Abstract: Anti-microbial peptides and methods of use are provided.Type: ApplicationFiled: November 20, 2012Publication date: October 9, 2014Inventors: Guangshun Wang, Biswajit Mishra
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Publication number: 20140302124Abstract: Influenza virus infection and the resulting complications are a significant global public health problem and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Improving humoral immunity to influenza is the target of current conventional influenza vaccines, however, these are generally not cross-protective. On the contrary, cell-mediated immunity generated by primary influenza infection provides substantial protection against serologically distinct viruses due to recognition of cross-reactive T cell epitopes, often from internal viral proteins conserved between viral subtypes. Efforts are underway to develop a universal flu vaccine that would stimulate both the humoral and cellular immune responses leading to long-lived memory. Such a universal vaccine should target conserved influenza virus antibody and T cell epitopes that do not vary from strain to strain.Type: ApplicationFiled: October 18, 2012Publication date: October 9, 2014Applicant: Immunotape, Inc.Inventor: Ramila Philip
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Publication number: 20140303084Abstract: Provided are pro-coagulant compounds (e.g., pro-coagulant peptides or peptide derivatives) and methods of using and making those compounds. Further provided are conjugates between a pro-coagulant compound of the present disclosure (e.g., pro-coagulant peptide or peptide derivative) and a polypeptide selected from FIX, FVIIa, FVIII, and platelet targeting moieties (e.g., PDG-13), wherein the compound is linked to the polypeptide optionally via a linker. The compounds and conjugates are useful for the treatment of coagulation disorders, such as hemophilia A and hemophilia B. Further provided are methods of using and making the conjugates.Type: ApplicationFiled: June 9, 2012Publication date: October 9, 2014Applicant: Biogen IDEC MA Inc.Inventors: Karina Thorn, Garabet G. Toby, Adam R. Mezo
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Patent number: 8852608Abstract: The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection.Type: GrantFiled: December 23, 2009Date of Patent: October 7, 2014Assignee: MedImmune, LLCInventors: Josephine McAuliffe, Frances Palmer-Hill, Qing Zhu, Joann Suzich
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Patent number: 8853164Abstract: The present disclosure relates to oligopeptides applicable to a dental implant, which are selected from the group consisting of PEP7 (SEQ ID NO:1), PEP71 (SEQ ID NO:2), EP72 (SEQ ID NO:3), PEP73 (SEQ ID NO:4), PEP74 (SEQ ID NO:5), PEP75 (SEQ ID NO:6) and PEP76 (SEQ ID NO:7). The oligopeptides have very high reactivity for a BMP-specific receptor to increase osteoblastic differentiation and calcification, thereby showing improved osteointegration and osteogenesis.Type: GrantFiled: February 26, 2010Date of Patent: October 7, 2014Assignee: Osstemimplant Co., Ltd.Inventors: Eun Jung Kang, Tae Gwan Eom, Gyu Ok Choi
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Patent number: 8853165Abstract: The present invention relates to a peptide having bone tissue regeneration capacity and binding to a surface of apatite. More particularly, a peptide is provided having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral. A composition for bone tissue regeneration containing the peptide is further provided.Type: GrantFiled: March 9, 2011Date of Patent: October 7, 2014Assignee: Nano Intelligent Biomedical Engineering Corporation Co., Ltd.Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Sang Hoon Rhee, Jue-Yeon Lee
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Publication number: 20140296132Abstract: The present invention provides polypeptides, compositions thereof, and methods for use of the polypeptides in treating bacterial infection and for use as disinfectants.Type: ApplicationFiled: November 1, 2012Publication date: October 2, 2014Applicant: Arizona Board of Regents of behalf of Arizona State UniversityInventors: Stephen Johnston, Valeriy Domenyuk, Chris Diehnelt
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Publication number: 20140296481Abstract: Methods for the determination of renal failure, especially chronic renal failure and acute kidney injury, by measurement of peptide or protein biomarkers are described. The methods are useful to determine stages of renal failure, especially the early stages such as stage 1, 2, and 3 of chronic renal failure and stages R and I of acute kidney injury. Furthermore there are described peptides and test kits used in the invention. The described methods are intended to replace or complement the measurement of creatinine and/or cystatin C and/or NGAL for diagnosis of renal failure.Type: ApplicationFiled: February 18, 2014Publication date: October 2, 2014Applicant: PXBiosciences LLCInventors: Harald TAMMEN, Leif HONDA, Michael JURGENS, Andrew PECK
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Publication number: 20140295544Abstract: The present invention relates to fluorescent proteins, in particular green fluorescent proteins (GFPs), with increased activity in cells, and thus increased signal strength. A further aspect of the present invention relates to the use of peptides for increasing the expression and/or stability of a protein in a cell.Type: ApplicationFiled: June 13, 2014Publication date: October 2, 2014Inventor: Khalid S. Abu KHABAR
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Publication number: 20140294871Abstract: The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia (Oreochromis niloticus) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions to for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.Type: ApplicationFiled: October 1, 2012Publication date: October 2, 2014Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Jannel Acosta Alba, Mario Pablo Estrada Garcia
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Publication number: 20140296131Abstract: The invention relates to truncated GLP-1 analogues, in particular a GLP-1 analogue which is a modified GLP-1(7-35) (SEQ ID No 1) having: i) a total of 2, 3, 4, 5 6, 7, 8, or 9 amino acid substitutions as compared to GLP-1(7-35), including a) a Glu residue at a position equivalent to position 22 of GLP-1(7-35), and b) an Arg residue at a position equivalent to position 26 of GLP-1(7-35); as well as derivatives thereof, and therapeutic uses and compositions. These analogues and derivatives are highly potent, have a good binding affinity to the GLP-1 receptor, also to the extracellular domain of the GLP-1 receptor, which is of potential relevance achieving long-acting, stable GLP-1 compounds with a potential for once weekly administration.Type: ApplicationFiled: June 9, 2014Publication date: October 2, 2014Applicant: NOVO NORDISK A/SInventors: Jane Spetzler, Lauge Schaeffer, Jesper Lau, Janos T. Kodra, Kjeld Madsen, Patrick W. Garibay, Jacob Kofoed, Steffen Reedtz-Runge, Henning Thoegersen, Ingrid Pettersson
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Publication number: 20140296139Abstract: MOTS3 is a novel polypeptide. Methods of treating diseases such as diabetes, obesity, fatty liver, and cancer using MOTS3 and pharmaceutical compositions thereof are disclosed herein.Type: ApplicationFiled: March 14, 2014Publication date: October 2, 2014Inventors: Pinchas COHEN, Changhan LEE, Laura J. COBB
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Publication number: 20140294898Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.Type: ApplicationFiled: March 10, 2014Publication date: October 2, 2014Inventors: Michael Matthew Miller, Claudio Mapelli, Martin Patrick Allen, Michael S. Bowsher, Kenneth M. Boy, Eric P. Gillis, David R. Langley, Eric Mull, Maude A. Poirier, Nishith Sanghvi, Li-Qiang Sun, Daniel J. Tenney, Kap-Sun Yeung, Juliang Zhu, Patrick C. Reid, Paul Michael Scola
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Publication number: 20140296482Abstract: The invention relates to the biotechnology sector involving the area of human health. More specifically, the invention is based on the surprising usefulness of peptides LxVPc1, c3 and c4 as efficient selective inhibitors of the calcineurin signalling pathway (CN)-NFAT and the phosphate activity of CN. Said compounds are useful immunosuppressors and serve as a base for the preparation of therapeutic compositions for the prophylactics and treatment of human diseases associated with T-lymphocyte activation, including, but not limited to, autoimmune diseases, inflammation and allergy or transplant rejections. In addition, said peptides and the associated biological and genetic material can form useful tools for the development of tests that can be used to find compounds that have a selective antagonist activity in relation to CN.Type: ApplicationFiled: June 17, 2014Publication date: October 2, 2014Inventors: Juan Miguel Redondo Moya, Antonio Rodriguez Marquez, Sara Martinez Martinez
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Publication number: 20140294942Abstract: In certain embodiments this invention provides novel antiviral peptide(s) that are effective against positive sense RNA viruses that have an internal ribosome entry site (IRES). The peptide(s) can be used to inhibit propagation of such viruses and thereby provide a effective modality for the treatment of infections such as hepatitis C, and the like.Type: ApplicationFiled: September 6, 2012Publication date: October 2, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Samuel Wheeler French, Ronik Khachatoorian, Piotr Pawel Ruchala
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Publication number: 20140296091Abstract: There is provided a diagnostic reagent for use in the detection of M. bovis or M. tuberculosis infection in an animal, comprising a peptide which has an epitope from Mycobacterium bovis hypothetic protein Mb3645c (SEQ ID NO: 1) or an epitope from a polypeptide having at least 76% identity with SEQ ID NO: 1.Type: ApplicationFiled: February 21, 2014Publication date: October 2, 2014Inventors: Hans Martin Vordermeier, Benjamin Sidders, Neil Graham Stoker, Katie Ewer
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Patent number: 8846860Abstract: A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.Type: GrantFiled: February 19, 2013Date of Patent: September 30, 2014Assignee: Wisconsin Alumni Research FoundationInventors: William L. Murphy, Jae Sung Lee, Mark D. Markel, Ben K. Graf
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Patent number: 8846623Abstract: Cancer-targeting peptides having a PX1LX2 motif, in which X1 is His or an amino acid residue with a hydrophobic side chain and X2 is Pro, Phe, or Trp. Also disclosed herein are conjugates containing the cancer-targeting peptides and uses thereof in cancer treatment and diagnosis.Type: GrantFiled: October 25, 2011Date of Patent: September 30, 2014Assignee: Academia SinicaInventors: John Yu, Alice L. Yu, H. C. Wu, Sheng-Hung Wang, I-Ju Chen
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Patent number: 8846608Abstract: The present invention relates to new peptides and to use thereof, in particular for treatment and/or prevention of infections, inflammations, pain, wounds, scar and/or tumors.Type: GrantFiled: January 25, 2012Date of Patent: September 30, 2014Assignee: Pergamum ABInventors: Margit Mahlapuu, Camilla Björn, Veronika Sjöstrand, Björn Walse, Bo Svenson
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Publication number: 20140286904Abstract: An antimicrobial peptide having potent antibacterial activity against Listeria monocytogenes and Staphylococcus aureus is described. Also described is an isolated Lactobacillus salivarius DPC6502 strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 41840, and variants thereof, wherein the isolated bacteria and variants thereof express an antimicrobial peptide of the invention.Type: ApplicationFiled: July 27, 2012Publication date: September 25, 2014Applicants: AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC), UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORKInventors: Paul Ross, Eileen O'Shea, Colin Hill
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Publication number: 20140286952Abstract: The chain of events that explains calcitonin receptor (CTR)-stimulated invasion and metastasis of prostate cancer cells was identified. The CTR-stimulated events depend on the interaction of CTR with the PDZ3 domain of ZO-1. Small peptides and small molecules were identified that inhibit this interaction. The small inhibitory peptides were synthesized and can be used to attenuate or inhibit metastasis in solid cancer tumors.Type: ApplicationFiled: March 30, 2012Publication date: September 25, 2014Applicant: Board of Supervisors for the University of Louisia System, acting on behalf of the University of LouInventor: Girish V. Shah