Collagen Patents (Class 530/356)
  • Patent number: 10493134
    Abstract: A composition of matter is disclosed which comprises crosslinked collagen, platelet rich plasma (PRP) and an inorganic salt. Methods of generating same and uses thereof are also disclosed.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: December 3, 2019
    Assignee: CollPlant Ltd.
    Inventors: Racheli Gueta, Oded Shoseyov, Frida Grynspan Gotlieb, Ofer Levy
  • Patent number: 10487135
    Abstract: A method for preparing low endotoxin collagen is disclosed. The method includes the following steps: providing an animal skin, removing residual adipose tissues and muscle tissues, swelling the animal skin by alkaline solution, peeling the upper and lower surfaces of the animal skin, hydrolyzing the animal skin by a solution including hydrolase, salting out the low endotoxin collagen by salt solutions, and washing the low endotoxin collagen by alcohols.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: November 26, 2019
    Assignee: GUANGDONG VICTORY BIOTECH CO., INC.
    Inventors: Chen-Chih Tsai, Kuan-Yen Tung
  • Patent number: 10456500
    Abstract: A new preparation for regenerating tissues or healing wounds, which can be administered to a patient, which comprises serum and globin being insoluble at physiological pH, said preparation being obtained by adding said serum to said globin being insoluble at physiological pH.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: October 29, 2019
    Assignee: KHORIONYX
    Inventors: Jean-Louis Tayot, Jean Bernasconi
  • Patent number: 10413636
    Abstract: Tissue scaffolds are described herein. Also described are devices for treating wounds and methods of treating wounds using tissue scaffolds.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: September 17, 2019
    Assignee: KCI LICENSING, INC.
    Inventors: Hugo Pedrozo, Edward S. Griffey, Christopher R. Kaufmann
  • Patent number: 10086079
    Abstract: In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: October 2, 2018
    Assignee: Fibralign Corporation
    Inventors: Mikhail Vitoldovich Paukshto, David Harwood McMurtry, George R. Martin, Tatiana Zaitseva
  • Patent number: 9962254
    Abstract: Methods and devices for management of fluids during skin graft transplantation are disclosed. In one aspect of the invention, absorbent substrates for transplanting skin grafts are disclosed having a surface adapted to contact at least one excised skin graft and engage said graft for removal from a donor site; a sealing member at least partially surrounding an absorbent material disposed within the enclosure; wherein at least a portion of the skin-contacting surface is porous and in fluid communication with the absorbent layer to capture fluids.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 8, 2018
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Timothy Mark Robinson, John R. Harper
  • Patent number: 9855372
    Abstract: Implants for tissue repair/regeneration include a porous layer combined with dry materials that are activated to form a hydrogel upon contact with aqueous physiological fluids.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: January 2, 2018
    Assignee: SOFRADIM PRODUCTION
    Inventor: Sébastien Ladet
  • Patent number: 9827323
    Abstract: Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: November 28, 2017
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Anthony Harris, Johnathan Thompson, Rebecca Rone, Sheila Grant, David Grant
  • Patent number: 9701937
    Abstract: A carrier for cell cultivation having stress of 10-30 kPa at 10% load, preparing a material, which has physical property similar to cartilage tissue of vivo, by lyophilization using high concentrated collagen dispersion, solution or mixture thereof as a starting material, then performing insolubilizing treatment to regulate physical strength and absorption speed in a living body.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: July 11, 2017
    Assignees: KOKEN CO., LTD., OSAKA UNIVERSITY
    Inventors: Ken Nakata, Kanae Kasai
  • Patent number: 9694106
    Abstract: Cosmetic threads for reducing wrinkle size include at least one synthetic collagen fiber that wells after placement under the skin.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: July 4, 2017
    Assignee: MiMedx Group, Inc.
    Inventors: Rebeccah Brown, Thomas J. Koob
  • Patent number: 9682173
    Abstract: The present invention provides for solutions and methods of preparing a decellularized tissue for recellularization. The solutions provide collagen conditioning to restore collagen triple helix structure, strengthening of the collagen structure of the tissue, and biologically preparing the decellularized tissue by placing it in an environment that promotes recellularization. Methods and solutions for recellularization of a decellularized tissue, in accordance with the present invention, are also provided.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: June 20, 2017
    Assignee: The Children's Mercy Hospital
    Inventor: Richard Hopkins
  • Patent number: 9649341
    Abstract: The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: May 16, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Abdulhafez A. Selem, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • Patent number: 9637841
    Abstract: A fiber for artificial hair that has an improved appearance with a suppressed gloss is obtained by combining regenerated collagen fibers having different shapes in cross section. An artificial hair product using the same is provided. The fiber for artificial hair according to the present invention is obtained by combining fibers having different shapes in cross section. The fiber for artificial hair includes regenerated collagen fibers, and the regenerated collagens fibers include at least two types of regenerated collagen fibers whose cross-sectional shapes are selected from the group consisting of shapes including an elliptical shape, a circular shape, and a multifoil shape. The artificial hair product of the present invention includes the above-described fiber for artificial hair.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: May 2, 2017
    Assignee: KANEKA CORPORATION
    Inventors: Yoshitomo Matsumoto, Shin Sudo, Mitsuru Furukawa, Kazuaki Fujiwara, Masahiko Mihoichi
  • Patent number: 9518106
    Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: December 13, 2016
    Assignee: Northeastern University
    Inventors: Nima Saeidi, Jeffrey W. Ruberti
  • Patent number: 9415022
    Abstract: According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: August 16, 2016
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Jianmin Li, Michael Madden
  • Patent number: 9382310
    Abstract: Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translational modifications and which may incorporate one or more functional domains of biological or structural importance. The polymers are capable of high-yield production for a variety of applications.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: July 5, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Oleg Mirochnitchenko, Masayori Inouye, Barbara Brodsky, John Ramshaw
  • Patent number: 9315561
    Abstract: The present invention relates to the newly identified timerization initiating and stagger determining capacity of the NC2 domain of collagen IX. The invention further relates to a hexavalent molecular building block wherein the linkage of additional moieties to the amino and carboxyl terminals of monomers comprising the NC2 domain of collagen IX promotes the directed association of those moieties via the trimerization initiating and stagger determining capacity of the NC2 domain of collagen IX.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: April 19, 2016
    Assignee: SHRINERS HOSPITAL FOR CHILDREN
    Inventors: Hans Peter Bachinger, Sergey P. Budko
  • Patent number: 9192696
    Abstract: An artifact for osseous repair includes a bioresorbable porous cage defining an internal space, and a biocompatible composite which includes a plurality of mineralized collagen-mimic fibrils filled in the internal space of the bioresorbable porous cage.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: November 24, 2015
    Assignee: FAR EASTERN NEW CENTURY CORPORATION
    Inventors: Jo-Ling Wang, Hui-Wan Chen
  • Patent number: 9186377
    Abstract: Articles for increasing lubrication of a joint are described herein. The articles include resorbable, biocompatible particles having a glass transition temperature within a joint of less than about 37° C. and capable of increasing fluid movement within the joint compared to synovial fluid, viscosupplemental fluid, or combinations thereof. A composition for increasing lubrication of a joint is also disclosed. The composition includes the resorbable, biocompatible particles and a carrier fluid. Methods of lubricating a joint and treating disease affecting the joint such as osteoarthritis are also described herein. The methods include introducing the resorbable, biocompatible particles into a joint.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: November 17, 2015
    Assignee: Maguire Abbey, LLC
    Inventor: Joseph P. Laico
  • Patent number: 9181404
    Abstract: Polymer blends and/or adducts obtainable from protein hydrolysates and/or gelatins used as raw material for the manufacture of regenerated leather and fabrics. Polymer adducts and/or blends conveniently prepared, tanned and finished can replace natural leather or fabric in the manufacture of clothing and consumer articles with particular technological properties.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: November 10, 2015
    Assignee: SICIT CHEMITECH S.P.A.
    Inventors: Massimo Costantino Neresini, Luciana Sartore, Manuela Cinzia Candido, Marco Fogato
  • Patent number: 9162006
    Abstract: The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 20, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Joris Hoefinghoff, Hans Christian Hedrich
  • Patent number: 9157070
    Abstract: A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having cells applied thereto under conditions suitable for cell culture. The combination comprises eukaryotic cells and a cell scaffold material. The cell scaffold material comprises a polymer of a spider silk protein.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: October 13, 2015
    Assignee: SPIBER TECHNOLOGIES AB
    Inventors: Jan Johansson, Anna Rising, My Hedhammar, Ulrika Johansson, Mona Widhe
  • Patent number: 9155818
    Abstract: The present invention relates to a multilayer structure (1) including a first upper layer (2) consisting of an organic matrix including collagen and at least a lower layer (3, 4, . . . 10) consisting of a composite matrix including hydroxylapatite and collagen. Furthermore, the present invention relates to a cartilaginous substitute including said multilayer structure (1) as well as an osteochondral substitute including said multilayer structure (1). Finally, the present invention relates to the use of said multilayer structure (1) for the preparation of said cartilaginous substitute and said osteochondral substitute for the treatment of cartilaginous defects and osteochondral defects or for the neo-formation of a cartilaginous tissue and/or a subchondral bone tissue.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: October 13, 2015
    Assignee: FIN-CERAMICA FAENZA S.P.A.
    Inventors: Anna Tampieri, Daniele Pressato, Claudio De Luca, Sergio Di Fede, Elena Landi
  • Patent number: 9096743
    Abstract: Disclosed is a process for forming films, fibers, and beads comprising a chitinous mass, for example, chitin, chitosan obtained from one or more biomasses. The disclosed process can be used to prepare films, fibers, and beads comprising only polymers, i.e., chitin, obtained from a suitable biomass, or the films, fibers, and beads can comprise a mixture of polymers obtained from a suitable biomass and a naturally occurring and/or synthetic polymer. Disclosed herein are the films, fibers, and beads obtained from the disclosed process. This Abstract is presented solely to aid in searching the subject matter disclosed herein and is not intended to define, limit, or otherwise provide the full scope of the disclosed subject matter.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: August 4, 2015
    Assignee: The Board of Trustees of the University of Alabama
    Inventors: Ying Qin, Robin D. Rogers, Daniel T. Daly
  • Patent number: 9095569
    Abstract: A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: August 4, 2015
    Assignee: CollPlant Ltd.
    Inventors: Oded Shoseyov, Or Dgany, Daniel L. Siegel
  • Patent number: 9096826
    Abstract: A culture substrate made of ceramics of any one or more of titania, alumina, zirconia, yttria, and carbon is used where minute pores having a pore diameter of from 0.1 ?m to 10 ?m are provided at least for a place to which a cell is seeded, and an undifferentiated cell is seeded to at least one place of a surface of the culture substrate, whereby a culture substrate and a culture method for efficiently culturing the undifferentiated cell to be formed into a 3-dimensional cell block shape without causing immune rejection, and an undifferentiated cultured cell.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: August 4, 2015
    Assignee: COVALENT MATERIALS CORPORATION
    Inventors: Fumihiko Kitagawa, Takafumi Imaizumi, Katsunori Sasaki
  • Patent number: 9040665
    Abstract: A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20×) can be added to the solution until the volume ratio of PBS buffer (20×) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: May 26, 2015
    Assignee: Case Western Reserve University
    Inventors: Gary Wnek, Linghui Meng
  • Publication number: 20150141619
    Abstract: The disclosure describes collagen constructs comprising anticancer agents, preferably, platinum, and related methods.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 21, 2015
    Inventor: Thomas J. Koob
  • Publication number: 20150139991
    Abstract: The invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XVIII protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes.
    Type: Application
    Filed: October 17, 2011
    Publication date: May 21, 2015
    Applicant: LEADARTIS, S.L.
    Inventors: Luis Álvarez Vallina, Ángel Cuesta Martinez, Noelia Sainz Pastor, Laura Sanz Alcober
  • Patent number: 9018354
    Abstract: An objective of the present invention is to provide methods of producing human collagen molecules that are easy to isolate and purify and that have a structure substantially equivalent to that of a natural collagen molecule, wherein host cells that are transduced with a collagen gene synthesize large amounts of human collagen protein derived from a gene introduced into a high exogenous gene expression vector. Another objective of the present invention is to provide collagen molecules produced by the production methods. The present inventors discovered that a large amount of human collagen hardly contaminated with host cell-derived collagen could be produced, by selecting from various mammalian cells a host cell that has low collagen expression and introducing a collagen gene construct into a vector capable of high exogenous gene expression.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: April 28, 2015
    Assignees: Fuso Pharmaceutical Industries, Ltd., Osaka Prefectural Government
    Inventors: Tetsuo Kase, Akio Kimura, Hiroshi Ueyama, Mizuki Nishihara, Yoko Kisaki, Aya Keshi
  • Patent number: 9018355
    Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: April 28, 2015
    Assignee: Northeastern University
    Inventors: Nima Saeidi, Jeffrey W. Ruberti
  • Publication number: 20150105323
    Abstract: The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 16, 2015
    Inventors: Tyler NOVAK, Kevin BLUM, Corey NEU, Sherry VOYTIK-HARBIN
  • Patent number: 9006182
    Abstract: A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: April 14, 2015
    Assignee: Conversion Energy Enterprises, Inc.
    Inventors: Barbara A. Soltz, Robert Soltz
  • Publication number: 20150094452
    Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventors: Oded SHOSEYOV, Shaul Lapidot, Sigal Meirovitch, Daniel L Siegel
  • Patent number: 8986728
    Abstract: The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the same.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: March 24, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Mikael O. Trollsas, Lothar W. Kleiner
  • Patent number: 8981059
    Abstract: A platelet aggregation inducing substance containing as an active ingredient a polypeptide having a peptide fragment represented by formula (1) (component A): -(Pro-X-Gly)n-??(1) wherein X represents Pro or Hyp; and n represents an integer of from 20 to 5,000.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: March 17, 2015
    Assignee: JNC Corporation
    Inventors: Yasuto Umeda, Shinichi Takasaki, Takafumi Takebayashi, Takahiro Kawai
  • Publication number: 20150065429
    Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.
    Type: Application
    Filed: October 29, 2014
    Publication date: March 5, 2015
    Inventors: W. Jerry Mezger, Keith E. Myers
  • Patent number: 8969522
    Abstract: An object is to provide a method for producing an ever-larger molecular weight collagen-like polypeptide single strand. Another object is to provide a method for controlling a molecular weight of a product to be obtained in desired magnitude upon producing a collagen-like polypeptide single strand. A solution is a method for producing a polypeptide including a step for allowing a condensation reaction of peptide oligomers represented by any one of formulas (1) to (3) (SEQ ID No:1 to SEQ ID No:3), wherein the condensation reaction is carried out in an aqueous solvent containing a phosphate ion in the range of 0 M to less than 0.01 M in the presence of a condensing agent, or a condensing agent and a condensing auxiliary: H-(Pro-Y-Gly)n-OH??(1); H-(Y-Gly-Pro)n-OH??(2); and H-(Gly-Pro-Y)n-OH??(3); wherein, in formulas (1) to (3), Y is hydroxyproline or proline, and n is an integer from 1 to 10.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: March 3, 2015
    Assignee: JNC Corporation
    Inventors: Akihiro Uchida, Shuji Sasaki, Akiko Shimatani, You Umebayashi, Kazushi Ishida
  • Patent number: 8969523
    Abstract: An object is to provide a sebum secretion inhibiting composition and a food or drink product using the same. The present inventors have conducted extensive studies and consequently found that the sebum secretion is inhibited by orally ingesting a collagen peptide, which is hydrolyzed collagen, and provide an oral sebum secretion inhibiting composition comprising a collagen hydrolysate and a food or drink product containing the composition.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: March 3, 2015
    Assignee: Lotte Co., Ltd.
    Inventors: Masanori Ito, Masayuki Yugi, Katsumasa Shimizu, Chiharu Takamatsu, Eriko Otani, Takaya Hashizume
  • Publication number: 20150044443
    Abstract: A method for producing a collagen-containing sheet material, wherein a collagen-containing suspension is dried in such a manner that the collagen settles during drying and forms a transparent skin.
    Type: Application
    Filed: February 26, 2013
    Publication date: February 12, 2015
    Inventors: Marco Wolfstaedter, Birgit Schaefer, Ellen Schubert
  • Patent number: 8951598
    Abstract: Nano scale collagen particles can be obtained from an embrittling and attrition process that reduces the size of collagen particles to the nano scale. These nano scale collagen particles have many favorable properties such as providing beneficial and enhanced properties for cell seeding and wound healing. The nano scale collagen particles can be included in biocompatible (e.g., biostable or biodegradable) compositions and are useful for wound treatment and management, as well as in cell cultures and tissue engineering implants.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: February 10, 2015
    Assignee: Empire Technology Development LLC
    Inventors: Hengky Chang, Henry Leung
  • Publication number: 20150037432
    Abstract: The present invention is a composition of a self-assembly of collagen fibers made from a plurality of sized pieces of a source material. The source material made from animal or human tissue selected from one of dermis, tendon, fascia or dura mater. The self-assembly occurring by induction of a magnetic field in a liquid medium.
    Type: Application
    Filed: July 31, 2013
    Publication date: February 5, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventor: Theodore I. Malinin
  • Patent number: 8946163
    Abstract: The disclosure describes collagen constructs comprising anticancer agents, preferably, platinum, and related methods.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 3, 2015
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Publication number: 20150017190
    Abstract: The present invention relates to a composition for use in the prevention of the rejection of skin tissue, comprising an effective amount of a peptide comprising an epitope of an antigen selected from the group of the polypeptides type XVII collagen, VII collagen, integrin alpha 6, integrin beta 4, chains of laminin, chains of laminin 322, type IV collagen, plectin, plakoglobin, bullous pemphigoid antigen 1, periplakin, envoplakin, desmoglein 1, desmoglein 3, a desmocollin and human bullous pemphigoid antigen 2 (hBPAG2) wherein said epitope induces immunological tolerance against its underlying polypeptide, and/or a nucleic acid for expressing a peptide comprising an epitope of said antigen as well as a gene therapy based on the composition, in the context of autoimmune blistering diseases, such as bullous pemphigoid or genetic skin diseases such as epidermolysisbullosa.
    Type: Application
    Filed: July 26, 2012
    Publication date: January 15, 2015
    Inventors: Johann Bauer, Monika Ettinger, Iris Gratz, Doris Schmid
  • Patent number: 8932620
    Abstract: Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described. Fibers of desired porosity can be obtained from non-structural ECM by lyophilization and/or electrospinning which can be useful for numerous tissue engineering applications requiring complex scaffolds, such as wound healing, artificial skin (burns), soft tissue replacement/repair and spinal cord injury.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: January 13, 2015
    Assignee: Drexel University
    Inventors: Peter I. Lelkes, Mengyan Li, Anat Perets, Honesto Poblete, Philip Lazarovici
  • Publication number: 20150011476
    Abstract: The present invention relates to a modified collagen obtainable by providing isolated collagen; freezing the isolated collagen; dehydrating the frozen collagen; and maturing the dehydrated collagen. Also disclosed are methods of preparing the modified collagen and uses thereof.
    Type: Application
    Filed: January 9, 2013
    Publication date: January 8, 2015
    Inventors: Alexandra Dietrich, Michael Myers
  • Publication number: 20150011733
    Abstract: Disclosed are methods of making collagen 7, or functional fragments thereof, as well as collagen 7, and functional fragments thereof produced by such methods, nucleic acids encoding collagen 7, and functional fragments thereof, as well as vectors and host cells comprising such nucleic acids.
    Type: Application
    Filed: August 3, 2012
    Publication date: January 8, 2015
    Inventors: Malini Viswanathan, Mark DeSouza
  • Publication number: 20150005182
    Abstract: This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells that did not give rise to recurrent breast cancer disease after initial diagnosis and primary breast cancer cells that did give rise to recurrent breast cancer disease after initial diagnosis. These proteins can be used either individually or in specific combinations in diagnostic and prognostic protein assays on various biological samples from breast cancer patients to indicate the likelihood that a breast cancer patient's cancer will recur after initial diagnosis and treatment. Determination of differential expression of these proteins can also be useful for indicating additional therapies to combat the likelihood of recurrent breast cancer. The full length intact proteins can be assayed or peptides derived from these proteins can be assayed as reporters for these proteins.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 1, 2015
    Applicant: EXPRESSION PATHOLOGY, INC.
    Inventors: David Krizman, Marlene M. Darfler, Thomas P. Conrads, Brian L. Hood
  • Publication number: 20150005183
    Abstract: This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells histologicaly defined as early stage (stage 0) breast cancer and primary breast cancer cells histologicaly defined as late stage (stage 3) breast cancer. These proteins can be used either individually or in specific combinations in diagnostic and prognostic protein assays on various biological samples from breast cancer patients to indicate the that a breast cancer patient's cancer is in an early, non-aggressive stage or in a late, aggressive stage. Determination of differential expression of these proteins can also be useful for indicating additional therapies to combat the aggressiveness of late stage breast cancer. The full length intact proteins can be assayed or peptides derived from these proteins can be assayed as reporters for these proteins.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 1, 2015
    Applicant: EXPRESSION PATHOLOGY, INC.
    Inventors: David Krizman, Marlene M. Darfler, Thomas P. Conrads, Brian L. Hood
  • Patent number: 8921312
    Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: December 30, 2014
    Assignee: University of South Florida
    Inventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou