Collagen Patents (Class 530/356)
  • Patent number: 11814422
    Abstract: The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: November 14, 2023
    Assignee: COLZYX AB
    Inventors: Matthias Mörgelin, Suado Abdillahi
  • Patent number: 11717657
    Abstract: A dermal adhesive patch is provided. The dermal adhesive patch is adhered to skin through an ampoule containing a mixing ingredient, a drying ingredient, a viscosity control ingredient, and a moisturizing ingredient. The dermal adhesive patch includes: a support body; and a membrane layer formed as a nanofiber web having pores to block moisture and to allow air to pass through the membrane layer, and detachably laminated on one surface of the support body.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: August 8, 2023
    Inventors: In Yong Seo, Ji Hyun Lee
  • Patent number: 11702447
    Abstract: Disclosed herein are methods for efficiently isolating collagen form a collagen source. The methods are inexpensive and do not require the use of proteolytic enzymes, decolorizing agents, antibacterial and antifungal agents, and the like. Further, the collagen produced by the methods described herein is substantially free of odor and discoloration. Still further, the collagen produced by the methods described herein is suitable to be used in cosmetics, food products, and pharmaceuticals or nutritional supplements.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: July 18, 2023
    Inventors: Ali Elnajjar, Ali Mourad, Mark Ernst Brandt, Christopher Lippelt
  • Patent number: 11684675
    Abstract: Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine, wherein X and Y are any amino acid, and wherein n is any number between 3 and 12. Also disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising any one of the disclosed peptide conjugates to a sample, wherein the active agent comprises a therapeutic agent, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, the presence of binding indicating the presence of denatured collagen in the sample.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: June 27, 2023
    Inventors: Julian Kessler, Michael S. Yu, Yang Li
  • Patent number: 11559603
    Abstract: To provide a collagen sponge excellent in mechanical strength and a production method for the collagen sponge. A collagen sponge including a porous construct having a pore structure, the collagen sponge having a tensile strength of 1 N or more and 5 N or less in every direction including a length direction and a width direction. The collagen sponge may be produced by a production method including the following steps: (1) a step of subjecting a collagen solution obtained by mixing collagen and a solvent to stirring and deaeration treatment; (2) a step of subjecting the collagen solution to freeze-dry treatment; and (3) a step of subjecting a dried collagen product after the freeze-dry treatment to insoluble treatment.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: January 24, 2023
    Inventors: Ken Nakata, Gaku Kanno
  • Patent number: 11523982
    Abstract: Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts. Production of collagen, elastin and hyaluronic acid are increased after application of the compositions.
    Type: Grant
    Filed: September 13, 2020
    Date of Patent: December 13, 2022
    Assignee: Marine Biology & Environmental Technologies, LLC
    Inventor: Eric Lewis
  • Patent number: 11439727
    Abstract: Collagen compositions, methods for preparing those collagen compositions, and 3D constructs formed from those collagen compositions are provided. In particular, methods of isolating collagen that exhibits an enhanced rate of gelling, such collagen compositions, and 3D constructs formed from such collagen compositions are provided.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: September 13, 2022
    Assignee: TDBT IP INC.
    Inventors: Daniel L. Cohen, Chris Pelletier
  • Patent number: 11312968
    Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: April 26, 2022
    Assignee: MODERN MEADOW, INC.
    Inventors: Lixin Dai, Julia Borden, Jeffrey Nelson, Kristin Ruebling-Jass
  • Patent number: 11273235
    Abstract: Materials and methods are provided to direct the formation of new lymphatics and to reconnect the disrupted lymphatic network. These materials and methods enable to improve survival of lymph nodes and lymph node fragments and their integration into a lymphatic network, following lymph node and lymph node fragments transplantation. The treatment or prevention of lymphedema is also addressed. In certain embodiments, a bundle of fibers or fibrils presented in the composition is effective to stimulate and direct the formation of new lymphatic and blood vessels. The bundle of fibers or fibrils presented in the composition is effective to promote survival of the lymph node or lymph node fragments and integration of the lymph node or lymph node fragments into a lymphatic network in the mammalian subject, at the site of transfer or transplantation.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: March 15, 2022
    Assignee: Fibralign Corporation
    Inventors: Catarina Hadamitzky, Tatiana Zaitseva, Michael V. Paukshto
  • Patent number: 11213613
    Abstract: Provided is a three dimensional tissue scaffold comprising a stem cell attracting element associated with a matrix, and fusion protein of stem cell attracting factor and collagen-binding domain, and methods of uses thereof.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: January 4, 2022
    Inventors: Jianwu Dai, Jie Sun, Bing Chen, Zhifeng Xiao
  • Patent number: 11090412
    Abstract: A biocompatible material for bone repair is described. The bone repair composition includes a mixture of a type I collagen, a type I collagen-glycosaminoglycan coprecipitate, tricalcium phosphate; and bioactive glass. Methods of using the composition for bone repair, and a kit for the bone repair composition are also described.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: August 17, 2021
    Inventors: Jeffrey Johnson, Nels Lauritzen, Brent Mitchell
  • Patent number: 11008379
    Abstract: A method of preparing a purified collagen solution from porcine skin may include receiving and inspecting the porcine skin; treating the porcine skin with a sodium hydroxide treatment, resulting in a sodium hydroxide processed skin; treating the sodium hydroxide processed skin with an ethanol treatment, resulting in ethanol treated processed skin; producing liquid collagen from the ethanol treated processed skin; clarifying the liquid collagen; and concentrating the clarified liquid collagen.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: May 18, 2021
    Assignee: Sigmagraft, Inc.
    Inventors: Qi Wang, Dae Kyu Chang
  • Patent number: 10973952
    Abstract: Disclosed are a matrix for restoring soft tissue and a method of producing the same, the method including: forming a sheet-type absorption layer (11) on one side of a double layer using biocompatible neutral collagen; forming a film-type support layer (12) on the remaining surface of the double layer by mixing collagen with a water-soluble polymer and a natural material; and forming a double layer-structured matrix (10) for restoring soft tissue by attaching the absorption layer (11) and the support layer (12) so as to treat damage to soft tissue of a mammal other than a human or restore damaged soft tissue. This invention pertains to the treatment of damage to soft tissue such as tendons, ligaments, and rotator cuffs or the restoration of damaged soft tissue, whereby the quality and reliability of products can be remarkably improved, thus satisfying various needs of consumers, who are the users thereof, and exhibiting a good effect.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: April 13, 2021
    Inventors: Ki Soo Kim, Ji Chui Yoo, Se Ken Yeo, Sang Bum Choi, Chang Kwon Ko, Dong Sam Suh, Cheong Ho Chang
  • Patent number: 10966822
    Abstract: A method for manufacturing a heart valve using bioprosthetic tissue that exhibits reduced in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: April 6, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Jeffrey S. Dove, Darin P. Dobler, James A. Davidson, Gregory A. Wright
  • Patent number: 10939690
    Abstract: A method for producing a collagenous material in particle form, includes: extracting a collagen- and fat-containing animal raw material using an aqueous extraction solution; optionally separating at least one part of the aqueous phase from the extraction residue; separating the extraction residue into a collagenous solid phase, an aqueous phase, and a fat phase; mixing at least one part of the collagenous solid phase with at least one part of the aqueous phase; at least partly drying the mixed phases; and comminuting the dried phases in order to obtain the collagenous material in particle form.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: March 9, 2021
    Assignee: Gelita AG
    Inventors: Thomas Meisner, Arend Willem Sloot
  • Patent number: 10882885
    Abstract: Described herein are novel synthetic molecules, polymers, and compositions comprising silica-binding peptides, and their methods of production. Also described herein are methods of synthesizing structurally and chemically complex silica-based materials using the synthetic molecules, polymers, and compositions.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: January 5, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Andrea Kimi Wallace, Maiko Furubayashi, Christopher A. Voigt
  • Patent number: 10493134
    Abstract: A composition of matter is disclosed which comprises crosslinked collagen, platelet rich plasma (PRP) and an inorganic salt. Methods of generating same and uses thereof are also disclosed.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: December 3, 2019
    Assignee: CollPlant Ltd.
    Inventors: Racheli Gueta, Oded Shoseyov, Frida Grynspan Gotlieb, Ofer Levy
  • Patent number: 10487135
    Abstract: A method for preparing low endotoxin collagen is disclosed. The method includes the following steps: providing an animal skin, removing residual adipose tissues and muscle tissues, swelling the animal skin by alkaline solution, peeling the upper and lower surfaces of the animal skin, hydrolyzing the animal skin by a solution including hydrolase, salting out the low endotoxin collagen by salt solutions, and washing the low endotoxin collagen by alcohols.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: November 26, 2019
    Inventors: Chen-Chih Tsai, Kuan-Yen Tung
  • Patent number: 10456500
    Abstract: A new preparation for regenerating tissues or healing wounds, which can be administered to a patient, which comprises serum and globin being insoluble at physiological pH, said preparation being obtained by adding said serum to said globin being insoluble at physiological pH.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: October 29, 2019
    Assignee: KHORIONYX
    Inventors: Jean-Louis Tayot, Jean Bernasconi
  • Patent number: 10413636
    Abstract: Tissue scaffolds are described herein. Also described are devices for treating wounds and methods of treating wounds using tissue scaffolds.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: September 17, 2019
    Assignee: KCI LICENSING, INC.
    Inventors: Hugo Pedrozo, Edward S. Griffey, Christopher R. Kaufmann
  • Patent number: 10086079
    Abstract: In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: October 2, 2018
    Assignee: Fibralign Corporation
    Inventors: Mikhail Vitoldovich Paukshto, David Harwood McMurtry, George R. Martin, Tatiana Zaitseva
  • Patent number: 9962254
    Abstract: Methods and devices for management of fluids during skin graft transplantation are disclosed. In one aspect of the invention, absorbent substrates for transplanting skin grafts are disclosed having a surface adapted to contact at least one excised skin graft and engage said graft for removal from a donor site; a sealing member at least partially surrounding an absorbent material disposed within the enclosure; wherein at least a portion of the skin-contacting surface is porous and in fluid communication with the absorbent layer to capture fluids.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 8, 2018
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Timothy Mark Robinson, John R. Harper
  • Patent number: 9855372
    Abstract: Implants for tissue repair/regeneration include a porous layer combined with dry materials that are activated to form a hydrogel upon contact with aqueous physiological fluids.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: January 2, 2018
    Inventor: Sébastien Ladet
  • Patent number: 9827323
    Abstract: Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: November 28, 2017
    Inventors: Anthony Harris, Johnathan Thompson, Rebecca Rone, Sheila Grant, David Grant
  • Patent number: 9701937
    Abstract: A carrier for cell cultivation having stress of 10-30 kPa at 10% load, preparing a material, which has physical property similar to cartilage tissue of vivo, by lyophilization using high concentrated collagen dispersion, solution or mixture thereof as a starting material, then performing insolubilizing treatment to regulate physical strength and absorption speed in a living body.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: July 11, 2017
    Inventors: Ken Nakata, Kanae Kasai
  • Patent number: 9694106
    Abstract: Cosmetic threads for reducing wrinkle size include at least one synthetic collagen fiber that wells after placement under the skin.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: July 4, 2017
    Assignee: MiMedx Group, Inc.
    Inventors: Rebeccah Brown, Thomas J. Koob
  • Patent number: 9682173
    Abstract: The present invention provides for solutions and methods of preparing a decellularized tissue for recellularization. The solutions provide collagen conditioning to restore collagen triple helix structure, strengthening of the collagen structure of the tissue, and biologically preparing the decellularized tissue by placing it in an environment that promotes recellularization. Methods and solutions for recellularization of a decellularized tissue, in accordance with the present invention, are also provided.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: June 20, 2017
    Assignee: The Children's Mercy Hospital
    Inventor: Richard Hopkins
  • Patent number: 9649341
    Abstract: The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: May 16, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Abdulhafez A. Selem, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • Patent number: 9637841
    Abstract: A fiber for artificial hair that has an improved appearance with a suppressed gloss is obtained by combining regenerated collagen fibers having different shapes in cross section. An artificial hair product using the same is provided. The fiber for artificial hair according to the present invention is obtained by combining fibers having different shapes in cross section. The fiber for artificial hair includes regenerated collagen fibers, and the regenerated collagens fibers include at least two types of regenerated collagen fibers whose cross-sectional shapes are selected from the group consisting of shapes including an elliptical shape, a circular shape, and a multifoil shape. The artificial hair product of the present invention includes the above-described fiber for artificial hair.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: May 2, 2017
    Inventors: Yoshitomo Matsumoto, Shin Sudo, Mitsuru Furukawa, Kazuaki Fujiwara, Masahiko Mihoichi
  • Patent number: 9518106
    Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: December 13, 2016
    Assignee: Northeastern University
    Inventors: Nima Saeidi, Jeffrey W. Ruberti
  • Patent number: 9415022
    Abstract: According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: August 16, 2016
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Jianmin Li, Michael Madden
  • Patent number: 9382310
    Abstract: Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translational modifications and which may incorporate one or more functional domains of biological or structural importance. The polymers are capable of high-yield production for a variety of applications.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: July 5, 2016
    Inventors: Oleg Mirochnitchenko, Masayori Inouye, Barbara Brodsky, John Ramshaw
  • Patent number: 9315561
    Abstract: The present invention relates to the newly identified timerization initiating and stagger determining capacity of the NC2 domain of collagen IX. The invention further relates to a hexavalent molecular building block wherein the linkage of additional moieties to the amino and carboxyl terminals of monomers comprising the NC2 domain of collagen IX promotes the directed association of those moieties via the trimerization initiating and stagger determining capacity of the NC2 domain of collagen IX.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: April 19, 2016
    Inventors: Hans Peter Bachinger, Sergey P. Budko
  • Patent number: 9192696
    Abstract: An artifact for osseous repair includes a bioresorbable porous cage defining an internal space, and a biocompatible composite which includes a plurality of mineralized collagen-mimic fibrils filled in the internal space of the bioresorbable porous cage.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: November 24, 2015
    Inventors: Jo-Ling Wang, Hui-Wan Chen
  • Patent number: 9186377
    Abstract: Articles for increasing lubrication of a joint are described herein. The articles include resorbable, biocompatible particles having a glass transition temperature within a joint of less than about 37° C. and capable of increasing fluid movement within the joint compared to synovial fluid, viscosupplemental fluid, or combinations thereof. A composition for increasing lubrication of a joint is also disclosed. The composition includes the resorbable, biocompatible particles and a carrier fluid. Methods of lubricating a joint and treating disease affecting the joint such as osteoarthritis are also described herein. The methods include introducing the resorbable, biocompatible particles into a joint.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: November 17, 2015
    Assignee: Maguire Abbey, LLC
    Inventor: Joseph P. Laico
  • Patent number: 9181404
    Abstract: Polymer blends and/or adducts obtainable from protein hydrolysates and/or gelatins used as raw material for the manufacture of regenerated leather and fabrics. Polymer adducts and/or blends conveniently prepared, tanned and finished can replace natural leather or fabric in the manufacture of clothing and consumer articles with particular technological properties.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: November 10, 2015
    Assignee: SICIT CHEMITECH S.P.A.
    Inventors: Massimo Costantino Neresini, Luciana Sartore, Manuela Cinzia Candido, Marco Fogato
  • Patent number: 9162006
    Abstract: The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 20, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Joris Hoefinghoff, Hans Christian Hedrich
  • Patent number: 9157070
    Abstract: A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having cells applied thereto under conditions suitable for cell culture. The combination comprises eukaryotic cells and a cell scaffold material. The cell scaffold material comprises a polymer of a spider silk protein.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: October 13, 2015
    Inventors: Jan Johansson, Anna Rising, My Hedhammar, Ulrika Johansson, Mona Widhe
  • Patent number: 9155818
    Abstract: The present invention relates to a multilayer structure (1) including a first upper layer (2) consisting of an organic matrix including collagen and at least a lower layer (3, 4, . . . 10) consisting of a composite matrix including hydroxylapatite and collagen. Furthermore, the present invention relates to a cartilaginous substitute including said multilayer structure (1) as well as an osteochondral substitute including said multilayer structure (1). Finally, the present invention relates to the use of said multilayer structure (1) for the preparation of said cartilaginous substitute and said osteochondral substitute for the treatment of cartilaginous defects and osteochondral defects or for the neo-formation of a cartilaginous tissue and/or a subchondral bone tissue.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: October 13, 2015
    Inventors: Anna Tampieri, Daniele Pressato, Claudio De Luca, Sergio Di Fede, Elena Landi
  • Patent number: 9096743
    Abstract: Disclosed is a process for forming films, fibers, and beads comprising a chitinous mass, for example, chitin, chitosan obtained from one or more biomasses. The disclosed process can be used to prepare films, fibers, and beads comprising only polymers, i.e., chitin, obtained from a suitable biomass, or the films, fibers, and beads can comprise a mixture of polymers obtained from a suitable biomass and a naturally occurring and/or synthetic polymer. Disclosed herein are the films, fibers, and beads obtained from the disclosed process. This Abstract is presented solely to aid in searching the subject matter disclosed herein and is not intended to define, limit, or otherwise provide the full scope of the disclosed subject matter.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: August 4, 2015
    Assignee: The Board of Trustees of the University of Alabama
    Inventors: Ying Qin, Robin D. Rogers, Daniel T. Daly
  • Patent number: 9096826
    Abstract: A culture substrate made of ceramics of any one or more of titania, alumina, zirconia, yttria, and carbon is used where minute pores having a pore diameter of from 0.1 ?m to 10 ?m are provided at least for a place to which a cell is seeded, and an undifferentiated cell is seeded to at least one place of a surface of the culture substrate, whereby a culture substrate and a culture method for efficiently culturing the undifferentiated cell to be formed into a 3-dimensional cell block shape without causing immune rejection, and an undifferentiated cultured cell.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: August 4, 2015
    Inventors: Fumihiko Kitagawa, Takafumi Imaizumi, Katsunori Sasaki
  • Patent number: 9095569
    Abstract: A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: August 4, 2015
    Assignee: CollPlant Ltd.
    Inventors: Oded Shoseyov, Or Dgany, Daniel L. Siegel
  • Patent number: 9040665
    Abstract: A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20×) can be added to the solution until the volume ratio of PBS buffer (20×) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: May 26, 2015
    Assignee: Case Western Reserve University
    Inventors: Gary Wnek, Linghui Meng
  • Publication number: 20150139991
    Abstract: The invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XVIII protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes.
    Type: Application
    Filed: October 17, 2011
    Publication date: May 21, 2015
    Applicant: LEADARTIS, S.L.
    Inventors: Luis Álvarez Vallina, Ángel Cuesta Martinez, Noelia Sainz Pastor, Laura Sanz Alcober
  • Publication number: 20150141619
    Abstract: The disclosure describes collagen constructs comprising anticancer agents, preferably, platinum, and related methods.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 21, 2015
    Inventor: Thomas J. Koob
  • Patent number: 9018355
    Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: April 28, 2015
    Assignee: Northeastern University
    Inventors: Nima Saeidi, Jeffrey W. Ruberti
  • Patent number: 9018354
    Abstract: An objective of the present invention is to provide methods of producing human collagen molecules that are easy to isolate and purify and that have a structure substantially equivalent to that of a natural collagen molecule, wherein host cells that are transduced with a collagen gene synthesize large amounts of human collagen protein derived from a gene introduced into a high exogenous gene expression vector. Another objective of the present invention is to provide collagen molecules produced by the production methods. The present inventors discovered that a large amount of human collagen hardly contaminated with host cell-derived collagen could be produced, by selecting from various mammalian cells a host cell that has low collagen expression and introducing a collagen gene construct into a vector capable of high exogenous gene expression.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: April 28, 2015
    Assignees: Fuso Pharmaceutical Industries, Ltd., Osaka Prefectural Government
    Inventors: Tetsuo Kase, Akio Kimura, Hiroshi Ueyama, Mizuki Nishihara, Yoko Kisaki, Aya Keshi
  • Publication number: 20150105323
    Abstract: The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 16, 2015
    Inventors: Tyler NOVAK, Kevin BLUM, Corey NEU, Sherry VOYTIK-HARBIN
  • Patent number: 9006182
    Abstract: A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: April 14, 2015
    Assignee: Conversion Energy Enterprises, Inc.
    Inventors: Barbara A. Soltz, Robert Soltz
  • Publication number: 20150094452
    Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventors: Oded SHOSEYOV, Shaul Lapidot, Sigal Meirovitch, Daniel L Siegel