Keratin Patents (Class 530/357)
  • Patent number: 9045600
    Abstract: Molded articles of pure keratin protein, keratin copolymers or crosslinked keratin proteins are produced from a wetted protein powder by application of compression and optionally heat. Stabile materials can be molded or machined.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: June 2, 2015
    Assignee: Keraplast Technologies, Ltd.
    Inventors: Robert James Kelly, Clive Marsh
  • Publication number: 20150144563
    Abstract: Articles containing soil adsorbing polymers, and more particularly, articles, for example nonwovens, such as paper towels, wovens, and/or sponges and/or article-forming components thereof that comprise a durably bonded soil adsorbing polymer, article-forming components used to make such articles, and processes for making same are provided.
    Type: Application
    Filed: November 20, 2014
    Publication date: May 28, 2015
    Inventors: Robin Lynn McKIERNAN, Robert Joseph McCHAIN, Steven Daryl SMITH
  • Publication number: 20150080552
    Abstract: Described herein are methods to produce keratin protein-based biomaterials, the parameters required to achieve improved extraction, the parameters required to improve isolation, the parameters of lyophilization and the grinding process to achieve consistent particulate sizes of protein materials.
    Type: Application
    Filed: August 16, 2012
    Publication date: March 19, 2015
    Applicant: Keranetics LLC
    Inventors: Luke Burnett, Sarah Ann Boyd
  • Publication number: 20150065686
    Abstract: A method for making natural fibre products comprising embrittling natural fibres and breaking the embrittled fibres into nanoparticles, forming a suspension of the fibre nanoparticles in a spinnable liquid, and spinning fibre from the suspension. The method may be used to make fibres having the dimensions and properties of cashmere.
    Type: Application
    Filed: April 2, 2013
    Publication date: March 5, 2015
    Inventor: George Stylios
  • Patent number: 8901017
    Abstract: Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second crosslinking compound that includes two or more primary amine groups. The first and second crosslinking compounds may be individually crosslinkable with each other and with the protein. Also described are fiber products that may include inorganic or organic fibers and a cured thermoset binder prepared from a protein and at least two crosslinking compounds. Additionally, methods of making fiber products are described that include providing inorganic or organic fibers, and applying a liquid binder composition to the fibers to form a fiber-binder amalgam. The liquid binder composition may include a protein and at least two crosslinking compounds that include a carbohydrate and an organic amine with two or more primary amines. The amalgam may be heated to a curing temperature to form the fiber product.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: December 2, 2014
    Assignee: Johns Manville
    Inventors: Mingfu Zhang, Jawed Asrar, Uranchimeg Lester
  • Publication number: 20140326165
    Abstract: Disclosed is a process for preparing proteinaceous materials. The process comprises solubilising fibrous protein by contacting it with an alkaline solution, ageing the resulting mixture to form a homogenous solution, and coagulating the resulting solution to form the proteinaceous material. The proteinaceous materials may be produced as, for example, fibres, films, sheets, coatings, particles, shapes, foams or composites.
    Type: Application
    Filed: August 17, 2012
    Publication date: November 6, 2014
    Applicant: FARMCORP WOOLS LIMITED
    Inventor: Mirshahin Seyed Saleh
  • Publication number: 20140322720
    Abstract: There is provided a composition for diagnosing, treating, and preventing an age-related macular degeneration and a method for diagnosing an age-related macular degeneration.
    Type: Application
    Filed: December 4, 2013
    Publication date: October 30, 2014
    Applicant: KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP.
    Inventors: Hyewon CHUNG, Hyung-Soon PARK, Gum-Yong KANG
  • Publication number: 20140295484
    Abstract: The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides the necessary information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through one or more metabolic pathways of interest.
    Type: Application
    Filed: March 7, 2014
    Publication date: October 2, 2014
    Applicant: The Regents of the University of California
    Inventor: Marc K. HELLERSTEIN
  • Publication number: 20140235824
    Abstract: A method to wash wool containing lanolin and impurities includes the steps of providing a volume of an aqueous liquid at a temperature below a melting temperature of the lanolin, soaking the wool in the volume of the liquid, creating air bubbles in the liquid and allowing the air bubbles to pass through the wool to attach the impurities, removing the air bubbles and attached impurities from the volume, and separating lanolin from wool containing lanolin and impurities, along with the wool and lanolin obtainable by this method.
    Type: Application
    Filed: October 5, 2012
    Publication date: August 21, 2014
    Inventor: Christiaan Matthias Hubertus Gerard Reutelingsperger
  • Patent number: 8785595
    Abstract: Reagents and methods for functionalizing polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalizing reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalizing reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: July 22, 2014
    Assignee: Glythera Limited
    Inventors: Andrew Graham Watts, Terrence Kantner, Amanda Barbara MacKenzie
  • Patent number: 8785370
    Abstract: A formulation is disclosed comprising a reactive keratin derivative. Also described are methods of making the formulation and hair treatment methods and systems that include use of the formulation. The hair treatment methods may be useful, for example, in straightening or revitalizing hair.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: July 22, 2014
    Assignee: Keratin Complex Holdings, Inc.
    Inventors: Peter Coppola, Vito C. Bucario
  • Publication number: 20140170097
    Abstract: The invention provides compositions and methods for reversible covalent binding of benefit agents to keratinous substrates through the reaction of a dicarbonyl functional group on the surface of a benefit agent with reactive amines on keratinous surfaces. The deposits formed are durable and resistant to transfer, but are readily removed by contacting the deposit with an amine-containing solution.
    Type: Application
    Filed: December 18, 2012
    Publication date: June 19, 2014
    Applicant: AVON PRODUCTS, INC.
    Inventors: Sung Bin Shin, Sen Yang
  • Publication number: 20140134906
    Abstract: Embodiment of the present disclosure can include a compound, a structure bonded to the compound, and the like. In an embodiment, the compound can be a linker between an agent and a structure, where the agent can be a dye or a pigment and the structure can be a fiber, hair, or another structure.
    Type: Application
    Filed: July 12, 2012
    Publication date: May 15, 2014
    Inventor: Jason J. Locklin
  • Patent number: 8715701
    Abstract: Protein preparations containing biologically active compounds and the application of the protein preparations obtained, particularly as a component of medicinal and cosmetic preparations as protective substances or in the regeneration of cells and tissues of the human organism, and which can comprise a component of culture media for dermal or hepatic tissues, or for stem cells destined for use in the regeneration of cells and tissues in the human organism.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: May 6, 2014
    Assignee: Instytut Medycyny Doswiadczalnej I Klinicznej
    Inventors: Andrzej Lipkowski, Anna Grabowska, Katarzyna Kurzepa, Aleksandra Szczucinska
  • Publication number: 20140114053
    Abstract: An improved method of separating a macromolecule by isoelectric focusing comprising subjecting the macromolecule to electrophoresis in an isoelectric-focusing medium including a substantially thiol-free reducing agent, preferably a trivalent phosphorous compound and more preferably tributyl phosphine, the improvement being the solubility and focusing of the macromolecule is enhanced compared to isoelectric focusing of the same macromolecule in a similar isoelectric-focusing medium containing a thiol-reducing agent.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 24, 2014
    Inventors: Ben Herbert, Andrew Arthur Gooley, Keith Leslie Williams
  • Patent number: 8628593
    Abstract: The process described in the instant invention has the steps of dissolving the lipid-containing biomass in an ionic liquid, whereby a lipid phase and a hydrophilic phase are formed. The lipid phase contains primarily triglycerides, which can be converted to biodiesel by transesterification to, e.g., methyl esters. The hydrophilic phase comprises dissolved biopolymers, such as cellulose, hemicellulose, and protein. The biopolymers are converted in situ to compounds that are insoluble in the molten inorganic salt hydrate. The molten inorganic salt hydrates regenerated by removing insolubles, such as lignin, ash from the biomass, and water.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: January 14, 2014
    Assignee: BOleCON International Holding N.V.
    Inventors: Jacob A. Moulijn, Sjoerd Daamen, Paul O'Connor, Rob Van Der Meij
  • Patent number: 8575313
    Abstract: The present invention relates to a process for extracting keratin from poultry feather, and provides a quicker process thus allowing large-scale productions of the keratin production to be carried out in timely manner thus increasing the productivity and efficiency of such process.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: November 5, 2013
    Assignee: Universiti Malaysia Pahang
    Inventors: Arun Gupta, Ramanan Perumal
  • Patent number: 8530626
    Abstract: Methods to produce keratin elastomer, involving: (A)(1) reacting a diisocyanate with a blocking agent to form a diisocyanate with one —NCO group blocked by the blocking agent and one —NCO group unblocked, (2) reacting the diisocyanate with one —NCO group blocked by the blocking agent and one —NCO group unblocked with keratin at about 100° to about 120° C. to form keratin urethane with —NCO group functionality (i.e., with one —NCO group unblocked), (3) optionally reacting the keratin urethane with —NCO group functionality with a compound capable of reacting with the —NCO group; (B) reacting a diisocyanate with keratin to form keratin elastomer; or (C) reacting a monoisocyanate with keratin to form keratin elastomer.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: September 10, 2013
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventor: Jeanette M. Cardamone
  • Publication number: 20130231023
    Abstract: Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second crosslinking compound that includes two or more primary amine groups. The first and second crosslinking compounds may be individually crosslinkable with each other and with the protein. Also described are fiber products that may include inorganic or organic fibers and a cured thermoset binder prepared from a protein and at least two crosslinking compounds. Additionally, methods of making fiber products are described that include providing inorganic or organic fibers, and applying a liquid binder composition to the fibers to form a fiber-binder amalgam. The liquid binder composition may include a protein and at least two crosslinking compounds that include a carbohydrate and an organic amine with two or more primary amines. The amalgam may be heated to a curing temperature to form the fiber product.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 5, 2013
    Inventors: Mingfu Zhang, Jawed Asrar, Uranchimeg Lester
  • Patent number: 8524493
    Abstract: The present invention is directed to methods of detecting viable epithelial cells in a sample. The method includes isolating the sample comprising cells from a patient and culturing the cells for a time sufficient for an epithelial cell-specific marker to be released from the cells. The marker includes a substantially full-length cytokeratin. The method further includes detecting the released marker. Detection of the marker indicates the presence of disseminated epithelial cells. Methods are also directed to identifying disseminated epithelial tumor cells.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: September 3, 2013
    Assignee: Centre Hospitalier Universitaire de Montpellier
    Inventors: Catherine Panabières, Klaus Pantel, Jean-Pierre Vendrell
  • Patent number: 8486688
    Abstract: The use or process of use of a sequencing batch reactor for eliminating prion in specified risk materials and for measuring the efficacy of a sequencing batch reactor to degrade prior proteins in specified risk materials are disclosed. The specified risk material is fed to a sequencing batch reactor containing a layer of acclimatized anaerobic sludge, and the specified risk material reacts with the sludge at a temperature below 25° C. so as to allow degradation of the prion protein.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: July 16, 2013
    Assignee: Bio-Terre Systems Inc.
    Inventors: Daniel Y. Masse, Yun Xia
  • Publication number: 20130137595
    Abstract: A biomarker, method, test kit, and diagnostic system for detecting the presence of lymphoma in a person are disclosed. The lymphoma may be Hodgkin's lymphoma or non-Hodgkin's lymphoma. The person may be a high-risk subject. In one embodiment, a plasma sample from a person is obtained. The level of at least one protein listed in Table S3 in the plasma sample is measured. The level of at least one protein in the plasma sample is compared with the level in a normal or healthy subject. The lymphoma is diagnosed based upon the level of the at least one protein in the plasma sample in comparison to the normal or healthy level.
    Type: Application
    Filed: November 30, 2012
    Publication date: May 30, 2013
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventor: BATTELLE MEMORIAL INSTITUTE
  • Patent number: 8361723
    Abstract: Keratin 8 and 18 (K8/K18) mutations are shown to be associated with a predisposition to liver or biliary tract disease, particularly noncryptogenic hepatobiliary disease. Unique K8/K18 mutations are shown in patients with diseases including but without limitation to viral hepatitis, biliary atresia, alcoholic cirrhosis and other acute or chronic toxic liver injury, cryptogenic cirrhosis, acute fulminant hepatitis, autoimmune liver disease, cystic fibrosis, primary biliary cirrhosis, primary sclerosing cholangitis, diseases that are linked with cryptogenic cirrhosis, such as nonalcoholic steatohepatitis, and the like. Livers with keratin mutations had increased incidence of cytoplasmic filamentous deposits. Therefore, K8/K18 are susceptibility genes for developing cryptogenic and noncryptogenic forms of liver disease. Mutant alleles are associated with disease susceptibility, and their detection is used in the diagnosis of a predisposition to these conditions.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: January 29, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: M. Bishr Omary, Nam-On Ku
  • Patent number: 8263526
    Abstract: The combination of keratin hydrolysate with viable cells or infectious propagules of a fungal biological control agent such as Paecilomyces species, Metarhizium species, Beauveria species, and/or Verticillium species, provides effective control of soil-dwelling or subterranean insects, including termites, and particularly those belonging to the family Rhinotermitidae, such as the Formosan subterranean termite and native North American subterranean termites. In use, a foam-forming composition comprising the keratin hydrolysate and an insecticidally effective amount of the fungus are applied to the insects, the locus of the insects, to material susceptible to infestation by said insects, or to the locus of material susceptible to infestation by said insects.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: September 11, 2012
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Christopher A. Dunlap, Mark A. Jackson, Maureen S. Wright
  • Publication number: 20120219667
    Abstract: Nutritional supplements comprising keratin protein either in powder or liquid form as well as novel methods of producing soluble keratin proteins by oxidation are provided. In one embodiment of the disclosure, a soluble keratin protein product can be produced by treating an insoluble keratin source in an oxidizing solution at low pH and heat for a sufficient time to oxidize essentially all of the cysteine residues in the protein. By then raising the pH to the pKa of the proteins, or to the point at which the protein is present in the salt form, a solution of high molecular weight proteins that are in a low salt solution can be obtained. This solution is essentially free of peptides and salts that have an adverse effect on flavor and palatability, and maintains a high proportion of sulfur amino acids for beneficial health effects. The resulting protein product can be dissolved into water, juice, or a nutritional drink, or sprinkled on food. Alternatively, the protein can be provided as a liquid supplement.
    Type: Application
    Filed: July 1, 2010
    Publication date: August 30, 2012
    Applicant: Keraplast Technologies, Ltd.
    Inventors: Robert James McClelland Kelly, Clive Marsh
  • Publication number: 20120130048
    Abstract: The present invention relates to a process for extracting keratin from poultry feather, and provides a quicker process thus allowing large-scale productions of the keratin production to be carried out in timely manner thus increasing the productivity and efficiency of such process.
    Type: Application
    Filed: August 30, 2011
    Publication date: May 24, 2012
    Applicant: UNIVERSITI MALAYSIA PAHANG
    Inventors: Arun GUPTA, Ramanan PERUMAL
  • Publication number: 20120104656
    Abstract: Molded articles of pure keratin protein, keratin copolymers or crosslinked keratin proteins are produced from a wetted protein powder by application of compression and optionally heat. Stabile materials can be molded or machined.
    Type: Application
    Filed: May 13, 2010
    Publication date: May 3, 2012
    Inventors: Robert James Kelly, Clive Marsh
  • Patent number: 8124735
    Abstract: The invention relates to a porous keratin construct material comprising keratin protein for use in wound healing applications. The porous keratin construct is capable of bio-absorbing into a wound to promote wound healing. The rate at which the construct bio-absorbs into the wound may be controlled altered by controlling the degree of disulfide cross-linking between the keratin proteins in the porous keratin construct. The invention is also related to a method of making the porous keratin construct.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: February 28, 2012
    Assignee: Keraplast Technologies, Ltd.
    Inventors: Robert James Kelly, Clive Marsh, Mohammad Azam Ali, Gudmunder Fertram Sigurjonsson
  • Patent number: 8101202
    Abstract: Useful materials are produced from keratin containing raw materials by a process that includes gentle lanthionization of cystine disulfide bonds. Hydratable materials are produced for use in medical and cosmetic applications.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: January 24, 2012
    Assignee: Keraplast Technologies, Ltd
    Inventors: Keith Edward Branham, James Perry English, Donald R. Cowsar
  • Publication number: 20120009237
    Abstract: Disclosed are keratin preparations for use in medical applications. Methods of treating wounds are provided, wherein keratin preparations are applied to the wound in a treatment effective amount. Methods of treating burn wounds are also provided. Surgical or paramedic aids are provided, comprising a substrate with keratin preparations provided thereon. Kits comprising keratin derivatives packaged in sterile form are also provided.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 12, 2012
    Inventor: Mark E. Van Dyke
  • Patent number: 8048989
    Abstract: A biodegradable biopolymer material consists of silk fibroin from domesticated silkworm; silk fibroin from wild silkworm; a composite material comprising silk fibroin from domesticated silkworm and silk fibroin from wild silkworm; or a composite material comprising either silk fibroin from domesticated silkworm or silk fibroin from wild silkworm and at least one secondary substance selected from the group consisting of cellulose, chitin, chitosan, chitosan derivatives, keratin from wool and polyvinyl alcohol. The material may be prepared by, for instance, casting an aqueous solution of domesticated silkworm silk fibroin on the surface of a substrate and then cast drying the applied solution. The biodegradable biopolymer material is effectively used as, for instance, a metal ion-adsorbing material, a sustained release substrate for a useful substance such as a medicine, a biological cell-growth substrate and a biodegradable water-absorbing material.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: November 1, 2011
    Assignee: National Institute of Agrobiological Sciences
    Inventors: Masuhiro Tsukada, Takayuki Arai
  • Patent number: 8044177
    Abstract: The present invention provides a novel water-soluble keratin derivative and applications thereof. Water-soluble keratin produced by the alkali treatment of feathers, and modified keratin, gives the following useful materials: (1) a high energy wave absorber, (2) a luminescent substrate, (3) a material weatherproofness improver, (4) a water repellant, and (5) a foaming agent.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: October 25, 2011
    Assignees: Umeda Jimusho Ltd., Institute of Rheological Function of Food Co., Ltd., Asai Germanium Research Institute Co., Ltd.
    Inventors: Keiji Umeda, Yositaka Nadachi, Katsunobu Sakai, Yukitaka Nogami, Masahiko Sudo
  • Publication number: 20110237484
    Abstract: The present invention relates to a washing machine comprising an electrochemical cell, to a process for electrochemical cleaning of fibers, to laundry detergents for electrochemical cleaning of fibers and to the fibers thus cleaned.
    Type: Application
    Filed: March 24, 2011
    Publication date: September 29, 2011
    Applicant: BASF SE
    Inventors: Ulrich GRIESBACH, Steffen Maas, Florian Stecker, Andreas Fischer
  • Patent number: 8008439
    Abstract: A biodegradable biopolymer material consists of silk fibroin from domesticated silkworm; silk fibroin from wild silkworm; a composite material comprising silk fibroin from domesticated silkworm and silk fibroin from wild silkworm; or a composite material comprising either silk fibroin from domesticated silkworm or silk fibroin from wild silkworm and at least one secondary substance selected from the group consisting of cellulose, chitin, chitosan, chitosan derivatives, keratin from wool and polyvinyl alcohol. The material may be prepared by, for instance, casting an aqueous solution of domesticated silkworm silk fibroin on the surface of a substrate and then cast drying the applied solution. The biodegradable biopolymer material is effectively used as, for instance, a metal ion-adsorbing material, a sustained release substrate for a useful substance such as a medicine, a biological cell-growth substrate and a biodegradable water-absorbing material.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: August 30, 2011
    Assignee: National Institute of Agrobiological Sciences
    Inventors: Masuhiro Tsukada, Takayuki Arai
  • Publication number: 20110196129
    Abstract: Keratin hydratable absorbents and films are fabricated with simple, repeatable processes. Freeze drying produces a material with instantaneous water absorption to over 20 times its weight in water. Films produced are flexible and uniform with water absorption 7-8 times the original weight.
    Type: Application
    Filed: May 4, 2006
    Publication date: August 11, 2011
    Inventors: Chunyong Wu, Jun Li, Douglas Wicks, Sarah Morgan, Robert Allen Smith
  • Publication number: 20110190813
    Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial.
    Type: Application
    Filed: August 14, 2008
    Publication date: August 4, 2011
    Inventors: Alan George Brownlee, Christopher Malcolm Elvin, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Charles Mark Lindall
  • Patent number: 7972788
    Abstract: It is an object of the present invention to find substances that can be used as skin aging markers, and the present invention provides a method for determining the degree of skin aging, including measurement of expression of secretory proteins and/or intracellular proteins and/or their genes in skin cells and/or skin tissues, wherein the secretory proteins and/or intracellular proteins change their expression with aging of skin. The present invention also provides a kit for determining the degree of skin aging and a method for identifying substances effective in the prevention of skin aging.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: July 5, 2011
    Assignees: Fancl Corporation, Yokohama City University, Kihara Memorial Yokohama Foundation for the Advancement of Life Sciences, Kirin Holdings Kabushiki Kaisha
    Inventors: Satoshi Miyata, Kaoru Miyazaki, Chie Yasuda, Akihiro Iwamatsu
  • Publication number: 20110142910
    Abstract: Disclosed are optimized keratin preparations for use in medical applications. Methods to produce optimized keratin preparations are provided for use in biomedical applications, particularly for the treatment of bleeding, and for the treatment of wounds. Also disclosed are surgical or paramedic aids comprising a substrate with keratin preparations provided thereon, and kits comprising keratin derivatives packaged in sterile form.
    Type: Application
    Filed: February 16, 2007
    Publication date: June 16, 2011
    Inventor: Mark E. Van Dyke
  • Publication number: 20110117167
    Abstract: Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
    Type: Application
    Filed: November 18, 2010
    Publication date: May 19, 2011
    Applicant: AFFINERGY, INC.
    Inventors: Isaac Gilliam Sanford, Michelle Steffen Jansen, Paul Theodore Hamilton, Jonathan Allen Hodges, Shrikumar Ambujakshan Nair, Yuchen Chen, Martyn Kerry Darby, Hanne Gron, Ganesan Sathya
  • Publication number: 20110117168
    Abstract: Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
    Type: Application
    Filed: November 18, 2010
    Publication date: May 19, 2011
    Applicant: AFFINERGY, INC.
    Inventors: Ganesan Sathya, Michelle Steffen Jansen, Paul Theodore Hamilton, Jonathan Allen Hodges, Shrikumar Ambujakshan Nair, Hanne Gron
  • Publication number: 20110082282
    Abstract: Processes using Allium tissue homogenates and extracts in a simple and cost-effective manner to maximize the yields and recovery of thiosulfinates from Allium tissues and related organisms possessing alliinase, LF synthase and/or S-alk(en)yl-L-cysteine sulfoxides are disclosed.
    Type: Application
    Filed: October 5, 2010
    Publication date: April 7, 2011
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Kirk L. Parkin, Guodong Zhang
  • Publication number: 20110053156
    Abstract: The invention relates generally to the field of cancer detection, diagnosis, subtyping, staging, prognosis, treatment and prevention. More particularly, the present invention relates to methods for the detection, and/or diagnosing and/or subtyping and/or staging of lung cancer in a patient. Based on a particular panel of biomarkers, the present invention provides methods to detect, diagnose at an early stage and/or differentiate small cell lung cancer (SCLC) from non-small cell lung cancer (NSCLC) and within NSCLC to differentiate between squamous cell carcinomas (SCC), adenocarcinomas (AC), within SCC to discriminate G2 and G3 stage and within lung cancer to differentiate for lung cancers with or without neuroendocrine origin. It further provides the use of said panel of biomarkers in monitoring disease progression in a patient, including both in vitro and in vivo imaging techniques.
    Type: Application
    Filed: February 19, 2009
    Publication date: March 3, 2011
    Applicant: MUBIO PRODUCTS BV
    Inventors: Ann Vander Borght, Franciscus Charles Servatius Ramaekers, Stefan Maarten Van Den Eijnde, Marjan Harmsma, Frank Walter Falkenberg, Kaï Stühler, Gereon Poschmann, Helmut Erich Meyer, Günter Kloppel
  • Patent number: 7892572
    Abstract: The invention provides a biocompatible material derived from keratin that is useful for many aspects of medical treatment of bone. The keratin material is preferably S-sulfonated and enriched in intermediate filament proteins of high molecular weight. The keratin material may be porous for use as a bone replacement and augmentation product but also provided is the use of dense keratin materials in bone treatment for use as an internal fixation appliance in the treatment of bone fractures and bone regeneration, and a method for preparing the keratin material for use in the preservation, restoration and development of form and function of bone.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: February 22, 2011
    Assignee: Keraplast Technologies, Ltd.
    Inventors: Philip Victor Peplow, Subasinghe Nisanke George Premalal Jayantha Dias, Alisa Dawn Roddick-Lanzilotta, Robert James Kelly
  • Publication number: 20110021701
    Abstract: The invention relates to a material comprising cellulose in association with a support selected from a polymer and/or a fibre, wherein said cellulose is produced by a micro-organism. The cellulose-reinforced material is provided for incorporation into a composite.
    Type: Application
    Filed: August 14, 2007
    Publication date: January 27, 2011
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventors: Alexander Bismarck, Julasak Juntaro, Athanasios Mantalaris, Marion Pommet, Milo S.P. Shaffer
  • Publication number: 20100330019
    Abstract: Soluble keratin derivatives are disclosed. The soluble keratin derivatives may include a soluble keratin protein having at least one substituted chemical group at a lysine group, terminal amine group and/or hydroxyl amino acid group of a soluble keratin protein. Soluble keratin derivatives may be formed by succinylation or quaternisation, or by reaction with fatty acid derivatives. The soluble keratin derivatives may be used in personal care formulations, and may also comprise mixtures of several different soluble keratin derivatives.
    Type: Application
    Filed: October 31, 2008
    Publication date: December 30, 2010
    Inventors: Robert James Kelly, Sonya Mary Scott, Alisa Dawn Roddick-Lanzilotta, Steven Geoffrey Aitken
  • Patent number: 7838217
    Abstract: Keratin 8 and 18 (K8/K18) mutations are shown to be associated with a predisposition to liver or biliary tract disease, particularly noncryptogenic hepatobiliary disease. Unique K8/K18 mutations are shown in patients with diseases including but without limitation to viral hepatitis, biliary atresia, alcoholic cirrhosis and other acute or chronic toxic liver injury, cryptogenic cirrhosis, acute fulminant hepatitis, autoimmune liver disease, cystic fibrosis, primary biliary cirrhosis, primary sclerosing cholangitis, diseases that are linked with cryptogenic cirrhosis, such as nonalcoholic steatohepatitis, and the like. Livers with keratin mutations had increased incidence of cytoplasmic filamentous deposits. Therefore, K8/K18 are susceptibility genes for developing cryptogenic and noncryptogenic forms of liver disease. Mutant alleles are associated with disease susceptibility, and their detection is used in the diagnosis of a predisposition to these conditions.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: November 23, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: M. Bishr Omary, Nam-On Ku
  • Publication number: 20100196302
    Abstract: This present invention provides a process for keratin hydrolysis by means of microbiological and/or enzymatic processes. In particular, the keratin is derived from feathers of animals, such as chicken and are submitted to hydrolysis by a strain of Bacillus sp. The hydrolysates have molecular weight lower than 500 Da, which makes them ideal for cosmetic applications, particularly for applications in compositions for treatment of hair fiber re-building.
    Type: Application
    Filed: June 30, 2008
    Publication date: August 5, 2010
    Inventors: Alane Beatriz Vermelho, Ana Lúcia Vazquez Villa, Ana Maria Mazotto de Almeida, Edilma Paraguai de Souza Dias, Elizabete Pereira dos Santos
  • Patent number: 7763715
    Abstract: Methods for using ionic liquids to extract and separate a biopolymer from a biomass containing the biopolymer are disclosed. Methods for dissolving a biopolymer in an ionic liquid are also disclosed. A recovery solvent is used to reduce the solubility of the biopolymer in the ionic liquid and conventional separation techniques are used to recover the biopolymer. Biopolymers encompassed by this invention include chitin, chitosan, elastin, collagen, keratin and polyhydroxyalkanoate.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: July 27, 2010
    Assignee: The Procter & Gamble Company
    Inventors: Stacie Ellen Hecht, Raymond Louis Niehoff, Karunakaran Narasimhan, Charles William Neal, Paul Arlen Forshey, Dean Van Phan, Anju Deepali Massey Brooker, Katherine Helen Combs
  • Patent number: 7732574
    Abstract: The invention relates to a would care product that provides a biochemical environment around a wound to promote wound healing. The wound care product includes a keratin protein fraction material in which the protein fraction is intact, is from the intermediate filament protein family or the high sulfur protein family and in which the protein fraction is S-sulfonated. The invention also described a method of making a wound care product.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: June 8, 2010
    Assignee: Keraplast Technologies, Ltd.
    Inventors: Robert James Kelly, Alisa Dawn Roddick-Lanzilotta, Mohammad Azam Ali
  • Publication number: 20100069612
    Abstract: The present invention provides a novel water-soluble keratin derivative and applications thereof. Water-soluble keratin produced by the alkali treatment of feathers, and modified keratin, gives the following useful materials: (1) a high energy wave absorber, (2) a luminescent substrate, (3) a material weatherproofness improver, (4) a water repellant, and (5) a foaming agent.
    Type: Application
    Filed: September 15, 2009
    Publication date: March 18, 2010
    Applicants: UMEDA JIMUSHO LTD., INSTITUTE OF RHEOLOGICAL FUNCTION OF FOOD CO., LTD., ASAI GERMANIUM RESEARCH INSTITUTE CO., LTD.
    Inventors: Keiji UMEDA, Yositaka NADACHI, Katsunobu SAKAI, Yukitaka NOGAMI, Masahiko SUDO