Abstract: A method of preventing or treating infection by human rotavirus by administering an enteral nutritional product containing either bovine .kappa.-casein or human .kappa.-casein at a concentration greater than that found in human or bovine milk and sufficient to inhibit infection of mammalian cells by human rotavirus.

Abstract: The infection of mammalian cells by RSV may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of respiratory tract infection in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.

Abstract: The invention provides biodegradable, thermoplastic compositions made of the reaction product of soybean protein and a carbohydrate filler, a reducing agent, a plasticizer, water, and optional additives as desired. The composition has a high degree of flowability for processing by extrusion and injection molding into solid articles that are biodegradable with a high degree of tensile strength and water resistance.

Abstract: The infection of mammalian cells by RSV may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of respiratory tract infection in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.

Abstract: A protein which inhibits milk secretion by lactating cows and which is present in the second (2A) significant peak when a nominally 10-30 KDa fraction of the whey proteins of the milk is resolved on a "Mono Q" anion exchange column using 10 mM imidazole buffer, pH 7.0 and a sodium chloride elution gradient. Its pI by isoelectric focussing in a gel tube is 4.8 to 5.0.

Abstract: A method of producing denatured bovine serum albumin (BSA) milk products is disclosed which provides a container for containing the milk products and a source of heating the container for a period of time and within a certain temperature range sufficient for producing the denatured BSA milk products without substantially diminishing either the flavor or the nutritional value of the milk products. It appears that the consumption of denatured BSA milk products, as opposed to consumption of non-denatured BSA milk products, will tend to reduce the likelihood of a person acquiring Insulin Dependent Diabetes Mellitus (IDDM), atherosclerotic vascular disease, myasthenia gravis, multiple sclerosis, pernicious anemia, and other human autoimmune diseases.

Abstract: Organofunctional silicone chains having an organic moiety on at least one end of the chains, are covalently linked to free amino groups of proteins by the organic moieties to provide a useful ingredient for cosmetic formulations.

Abstract: A cDNA sequence encoding human .kappa.-casein.

Abstract: The present invention provides solid pharmaceutical compositions in dosage form containing an active ingredient or principle, preferably memantine, which exhibit an extended two-phase release profile and which are characterized by the presence of both a water-soluble and a water-insoluble salt of casein, preferably sodium and calcium caseinate, in the matrix thereof, in broad proportions and in a total amount between 5 and 98% by weight of the composition, and with a process for the production thereof.

Abstract: Disclosed herein is an infection protectant which is excellent in infection protective effects and is also safe. .kappa.-Casein, a sialic-acid-conjugated protein derived from cow milk, and a glycomacropeptide derived from .kappa.-casein, each of which is useful as an active ingredient in this invention, have been found to be effective for the prevention of adhesion of E. coli on cells and also for the inhibition of transformation of lymphocytes by EBV and also to have strong HI activity against virus. The infection protectant of this invention is hence believed to exhibit marked effects for the prevention of occurrence of infectious diarrhea, for mass protection against spreading of influenza, and also against canceration of lymphocytes. Since the active ingredient of the infection protectant is a substance derived from cow milk, it is free of any problem from the viewpoint of safety. Moreover, it is absolutely tasteless and odorless. It can therefore be added to foods for its application.

Abstract: New protein hydrolyzates are produced by treating an aqueous solution of a protein hydrolyzate with an adsorptive resin functional to remove from the protein hydrolyzate bitter taste components, color and odor components and aromatic amino acids. The treated protein hydrolyzate solutions can be concentrated and dried if desired to powder form.

Abstract: A method of inhibiting dental calculus by applying to the teeth an oral composition containing a dental calculus inhibiting amount of one or more of the phosphopeptides SEQ.ID NO:1 to SEQ.ID NO:9, especially in the form of a zinc/phosphopeptide complex or aggregate.

Abstract: An agent for tyrosinase inhibition which contains the effective quantity of enzymatic hydrolyzates of milk proteins, having a decomposition rate from 6% to 55% as expressed by the percentage of formol nitrogen to total nitrogen.

Abstract: Kappa-caseino-glycomacropeptide (CGMP) is industrially produced from a whey product concentrated in proteins partly freed from lactose by selective precipitation of the residual whey proteins with ethanol from the supernatant collected after separation of the flocculate obtained by heat treatment in acidic medium.

Abstract: Reformed casein micelles are produced from an aqueous solution or dispersion of commercially available processed casein by the sequential addition, over an extended period of time, of calcium ions and a soluble phosphate salt, after which the aqueous reaction medium is concentrated such as by ultrafiltration or diafiltration, to increase the level of casein micelles thereon and remove excess salts. The reformed casein micelles are used as a complete or partial replacement for fat in a variety of food products, particularly coffee whiteners. Coffee whiteners containing reformed casein micelles as a replacement for the fat component have functional and organoleptic properties equivalent to conventional coffee whiteners.

Abstract: A topical use pharmaceutical composition and a process for its preparation, comprising an improved enzyme-modified casein sol. Prior to being enzyme-modified, the casein is solubilized and neutralized by an alkali solution containing a molar weight percent ratio in the range of from 90:10 to 100:0, potassium hydroxide to sodium hydroxide. Said neutralization occurring for a time in the range of 5 to 35 minutes to allow for complete neutralization of the casein. The neutralized casein is then hydrolyzed or modified by enzymatic digestion by a proteolytic enzyme for a time sufficient to achieve a weight ratio of protein nitrogen to amino nitrogen in the range from 7:1 to 9:1. The improved enzyme-modified casein sol may then be mixed with stabilizing and pressuring agents, such as carrageenan, polyvinyl pyrrolidone, methyl paraben or propyl paraben.

Abstract: Disclosed herein is an infection protectant which is excellent in infection protective effects and is also safe. .kappa.-Casein, a sialic-acid-conjugated protein derived from cow milk, and a glycomacropeptide derived from .kappa.-casein, each of which is useful as an active ingredient in this invention, have been found to be effective for the prevention of adhesion of E. coli on cells and also for the inhibition of transformation of lymphocytes by EBV and also to have strong HI activity against virus. The infection protectant of this invention is hence believed to exhibit marked effects for the prevention of occurrence of infectious diarrhea, for mass protection against spreading of influenza, and also against canceration of lymphocytes. Since the active ingredient of the infection protectant is a substance derived from cow milk, it is free of any problem from the viewpoint of safety. Moreover, it is absolutely tasteless and odorless. It can therefore be added to foods for its application.

Abstract: Method for oxidative folding of peptide and protein substrates to form disulfide bonds using dimethyl sulfoxide and other equivalent sulfoxides as mild oxidizing agents.

Abstract: A dentifrice composition useful in inhibiting caries and ginivitis comprising a caries and gingivitis inhibiting amount of a material selected from the group consisting of a water soluble salt of a whole caseinate, a water soluble salt of alpha.sub.s -caseinate, a water soluble salt of beta-casinate and a digest of a whole caseinate, alpha.sub.s -caseinate or beta-caseinate and mixtures thereof is disclosed.

Abstract: Chemically modified proteins obtainable by reacting casein, collagen, gelatin, albumin or mixtures thereof(a) with 0.5 to 15% by weight of chlorine or of a compound which liberates chlorine under the reaction conditions, in an aqueous medium at a pH of from 0 to 7 or(b) with 0.5 to 50% by weight of a non-aromatic mono- or disulfonic acid which contains in its organic radical one or more groups or structural features which react with nucleophiles, in an aqueous medium at a pH of from 6 to 14,are used as dispersants in colorant formulations.

Abstract: A process for producing .kappa.-casein glycomacropeptides which comprises adjusting the pH of a solution of milk starting materials containing the .kappa.-casein glycomacropeptides to below 4, treating the solution by ultrafiltration with a membrane having a fraction molecular weight of 10,000-50,000, and concentrating the obtained filtrate with a membrane having a fraction molecular weight of 50,000 or less.

Abstract: High molecular weight protein/fatty acid condensation products obtained by reaction of one mole of a protein hydrolysate of average molecular mass 3,000 to 7,000 with 0.5 to 3, preferably 2 to 2.5, moles of a C.sub.12 -C.sub.18 -fatty acid chloride in aqueous medium at a pH of 7 to 12. These protein/fatty acid condensation products are distinguished by eliciting no mucosal irritation whatever. They are therefore outstandingly suitable as surfactants for mild washing and cleansing agents.

Abstract: The present invention provides an agent utilizing for immunological assays in medical fields for blocking nonspecific adsorption, a process for preparing thereof and a method of blocking nonspecific adsorption.The agent contains a combination of milk protein as an effective constituent and a buffer solution containing one or more principal constituents selected from the group of organic acids and their salts.

Abstract: A phosphopeptide or a salt thereof the phosphopeptide having from 5 to 30 amino acids including the sequenceA-B-C-D-Ewhere A, B, C, D and E are independently phosphoserine, phosphothreonine, phosphotyrosine, phosphohistidine, glutamate and aspartate and compositions particularly compositions to teeth including same.

Abstract: Therapeutic produced based on an organic derivative of silicon, notably of silanol complexed with an amino acid, with a pharmaceutically acceptable salt of such an acid, or with a protide. The produce is suitable for the preparation of medicaments for activation and regulation of metabolism and of growth and of multiplication of cells, in particular those which are involved in the immuno-processes or in the formation of conjunctive and bone tissue.

Abstract: The method consists in subjecting the raw material (milk or retentate) to enzymatic hydrolysis by means of at least one proteolytic enzyme able to reproduce the proteic digestion occuring in vivo in the human body; recovering the thus obtained hydrolyzate; subjecting the latter to at least one ultrafiltration step on membranes able to retaining the phosphopeptides while letting the peptides pass therethrough, the ultrafiltrate thus containing the non phosphorylated peptides; recovering the ultrafiltration retentate; disaggregating the phosphopeptides in the retentate; and subjecting the latter to at least one further ultrafiltration step on membranes which do not retain the phosphopeptides, these being thus separated from the enzyme and available to be recovered as product. The resulting products are useful as dietetic aliments, therapeutic nutriments or medicaments.

Abstract: A novel compound having the formula (I): ##STR1## or a reactive derivative or functional equivalent thereof, wherein m is an integer from 1 to 4, and R.sub.1 and R.sub.2 are same or different and selected from hydrogen and 1-4C alkyl; a fluorescent conjugate having the formula (III): ##STR2## wherein m R.sub.1 and R.sub.2 have the meaning given in claim 1, and R.sub.4 is a substituent attached to the keto group of formula (III) by a covalen bond. The new compounds and conjugates are usefual as fluorescent labelling agents.

Abstract: A medicinal composition, particularly but not exclusively for use in fluids for medical dialysis, contains, as an agent for maintaining the osmolality of the fluid, a protein hydrolysate resulting from the action of a proteolytic enzyme on the sodium caseinate fraction of milk protein. The enzyme is preferably trypsin but other proteolytic enzymes and enzyme mixtures may be used, examples being chymotrypsin, pancreatin and pronase.The method of production involves treating the sodium caseinate in aqueous medium with the enzyme at the appropriate pH and temperature for optimum enzyme activity. The product of the enzymic hydrolysis, after filtration through a bacterial filter, adjustment of the osmolality to an appropriate level of around 300 mOsm/Kg and the pH to physiological level of about 6.6 and addition of physiological salt levels, constitutes the final product.

Abstract: This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system comprising the mammal's casein promoter which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desired recombinant protein in or along with its milk. This invention also relates to the transgenic mammal that produces the desired recombinant product in its milk.

Abstract: This invention relates to a hydrated adhesive gel using a product which is obtained by reacting an aqueous solution consisting essentially of protein having amino groups at the side chains thereof, a gelling retarder, and a hydrophilic tackifier with a N-hydroxyimidoester compound.

Abstract: An agent is disclosed that is useful for treating liquid media, e.g., dechlorinating aqueous media. The agent contains at least one salt from the sulfur oxide family, such as sodium sulfite. In the agent, the salt is in mixture with an organic gel forming binder. The mixed material is especially adapted for preparing self-supporting, discrete particles of solid compacted material, e.g., tableted composition. The composition can provide such compacted material not only of desirable strength and hardness, but also of desirably controlled dissolution rate.

Abstract: A casein-soluble protein complex is prepared by raising the pH of an aqueous medium containing casein and soluble protein to within the range of 7.0 to 8.0, heating to a temperature in the range of about 65.6.degree. C. to 85.0.degree. C. and holding for a time sufficient to form the complex. Precipitation of the complex is then carried out by adjusting the temperature to within the range of 32.2.degree. C. to 76.7.degree. C. and lower the pH to within the range of 4.2 to 5.5 whereby the complex precipitates. The resultant precipitated complex is unique and can be used in making processed and imitation cheeses.

Abstract: Derivatized polymers containing glycoside side chains linked to the polymer by ether, sulfide, or amine linkages are prepared by reacting a polymer containing alcohol, thiol, and/or amine groups with a glycidyl glycoside having the formula ##STR1## where (SAC).sub.n represents a saccharide residue with n being 1-20. Typical polymers include poly(vinyl) alcohol, poly(ethyleneimine), poly(dimethylaminopropyl methacrylamide), and proteins such as caseinate or gluten. Typical glycosides are glycoside of glucose and maltodextrin-10.

Abstract: A process for preparing a milk protein resistent to acids and bases which comprises subjecting an aqueous solution or dispersion containing casein and 0.5-30 parts of an acidic polysaccharide per 100 parts of casein at pH of 7.3-10.5 and at a temperature of 70.degree. C. or higher for 3 minutes or more. When the heat treatment is carried out in the presence of calcium or magnesium ion in an amount of up to 1.4 parts by weight per 100 parts of casein, thickening activity of the milk protein is further improved.

Abstract: A method for the continuous production of a purified immunoglobulin preparation wherein the antibodies are substantially enriched by means of a selective two-step ammonium sulfate fractionation procedure employing centrifugation and ion depletion processes. The purified immunoglobulins are subsequently commingled with condensed skim milk and spray dried. The resulting product for example is employed in the formulation of milk replacers for artificial rearing of neonatal pigs to provide the passive immunity to disease normally provided by sows' colostrum and later milk.

Abstract: In a process for preparing caseinates comprising the introduction of a mixture of casein, lyes and/or basic salts and water into a baking extruding device, in order to achieve a uniform product flow discharge and an end product with good water solubility, following on from a product feed zone of the baking extruding device, the mixture is supplied to a plasticizing zone with return elements and accompanied by pressure and temperature increases, and then to a discharge zone, it being expanded after discharge from the nozzle.