Derived From Leafy Green Plants, E.g., Alfalfa Pollen, Etc. Patents (Class 530/379)
  • Patent number: 9040054
    Abstract: The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v 1a.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: May 26, 2015
    Assignee: BIOMAY AG
    Inventors: Michael Wallner, Barbara Bohle, Martin Himly, Nicole Wopfner, Gabriele Gadermaier, Matthias Egger, Peter Lackner, Fatima Ferreira, Michael Hauser
  • Publication number: 20150080553
    Abstract: The invention provides methods for reducing the levels of alfa (1,3)-fucosylated N-glycans on glycoproteins produced in plants or plant cells. In addition, the invention provides alfa(1,3)-fucosyltransferase genes from Nicotiana benthamiana, and mutant N. benthamiana plants in which the levels of alfa(1,3)-fucosylated N-glycans are reduced.
    Type: Application
    Filed: October 4, 2012
    Publication date: March 19, 2015
    Inventors: Koen Weterings, Gerben Van Eldik
  • Publication number: 20150079120
    Abstract: The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Applicant: Merck Patent GmbH
    Inventors: Helmut FIEBIG, Andreas NANDY, Roland SUCK, Oliver CROMWELL, Arnd PETERSEN, Wolf-Meinhard BECKER
  • Publication number: 20140364589
    Abstract: A BrTCP24 gene for controlling the growth of Chinese cabbage and its applications. The BrTCP24 gene has the nucleotide sequence shown in SEQ ID No. 1, the whole length of which is 1221 bp. The gene is useful for improving the production of economic crop. As indicated by experimental results, the gene serves as a controlling gene for plant growth and has the function of down-regulating the plant growth. Through overexpressing the gene, a transgenic plant smaller than the wild one can be obtained. The gene of the invention can provide theory basis and gene source for breeding new varieties of crops.
    Type: Application
    Filed: August 19, 2013
    Publication date: December 11, 2014
    Applicant: VEGETABLE RESEARCH INSTITUTE OF SHANDONG, ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Jianwei Gao, Fengde Wang, Yihui Zhang, Lifeng Liu, Huayin Li, Libin Li, Lihua Wang, Cuihua Wang
  • Patent number: 8828658
    Abstract: The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes to change conformation upon exposure to appropriate light conditions, and to bind in a conformation-dependent manner to cognate proteins called phytochrome-interacting factors. The invention comprises a method of regulating interaction between a first protein of interest and second protein within a cell by light. Such a method optionally comprises providing in the cell (1) a first protein construct which comprises the first protein, a phytochrome domain (PHD), and (2) providing in the cell a second protein construct which comprises the second protein and a phytochrome domain-interacting peptide (PIP) that can bind selectively to the Pfr state, but not to the Pr state, of the phytochrome domain.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: September 9, 2014
    Assignee: The Regents of the University of California
    Inventors: Christopher A. Voigt, Anselm Levskaya, Wendell Lim
  • Publication number: 20140223596
    Abstract: The present invention provides use of a plant gene JAZ5a for improving drought-resistance of a plant. It further provides a method for improving the drought-resistance of a plant, comprising enhancing the expression or activity of Jaz5A in said plant.
    Type: Application
    Filed: July 5, 2012
    Publication date: August 7, 2014
    Inventor: Adrianus Johannes Van Tunen
  • Publication number: 20140150138
    Abstract: A novel Beta vulgaris serine proteinase inhibitor gene (BvSTI) and its protein are identified in response to insect feeding on B. vulgaris seedlings. BvSTI is cloned into an expression vector with constitutive promoter and transformed into Nicotiana benthamiana plants to assess BvSTI's ability to impart resistance to lepidopteran insect pests. A reporter gene GUS is also cloned into an expression vector under control of the BvSTI gene promoter and transformed into N. benthamiana plants to determine if the promoter induces expression of the gene upon wounding and insect feeding. BvSTI DNA and amino acid sequences and the promoter sequences from various strains of B. vulgaris are obtained. Transformation of BvSTI cDNA under control of constitutive promoter or an inducible promoter into economically valuable plants is useful for effective control of insect pests that feed on the economically valuable plants and utilize serine proteases for digestion.
    Type: Application
    Filed: November 26, 2012
    Publication date: May 29, 2014
    Applicant: United States as Represented by the Secretary of Agriculture
    Inventor: United States as Represented by the Secretary of
  • Publication number: 20140137294
    Abstract: Methods and means to alter the glucosinolate (GSL) content in plants, in particular in specific plant parts, by modifying glucosinolate transporter protein (GTR) activity in plants or parts thereof are herein described. In particular, methods are provided to decrease GSL content of plant seed and meal thereof, as well as methods to increase GSL content in green plant tissue, of Brassicales plants.
    Type: Application
    Filed: July 6, 2011
    Publication date: May 15, 2014
    Applicants: UNIVERSITY OF COPENHAGEN, BAYER CROPSCIENCE NV
    Inventors: Peter Denolf, Christiane Opsomer, Barbara Ann Halkier, Hussam Hassan Nour-Eldin Auis, Tonni Grube Andersen, Svend Roesen Madsen, Morten Egevang Jørgensen
  • Publication number: 20140037663
    Abstract: The present invention provides mutant polypeptides useful as hypoallergens. More specifically the present invention provides mutant Bet v 1 proteins and the use of such polypeptides as hypoallergens for desensitizing against birch pollen allergies. Furthermore, the invention provides vaccine formulations comprising such polypeptides; the use of such formulations; and to methods of vaccination against birch pollen allergy.
    Type: Application
    Filed: April 18, 2012
    Publication date: February 6, 2014
    Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTT
    Inventors: Kristiina Takkinen, Marja-Leena Laukkanen, Hans Söderlund, Sirpa Jylhä, Heidi Holkeri, Merja Niemi, Janne Jänis, Juha Rouvinen
  • Patent number: 8603755
    Abstract: The invention provides methods of identifying herbicidal auxins. The invention further provides auxin-herbicide-resistant plants and genes conferring auxin-herbicide resistance. This invention also provides a method of identifying other proteins that bind picolinate auxins from additional plant species. The invention further provides a method to identify the molecular binding site for picolinate auxins. The invention also includes the use of the picolinate herbicidal auxin target site proteins, and methods of discovering new compounds with herbicidal or plant growth regulatory activity. The invention also includes methods for producing plants that are resistant to picolinate herbicidal auxins. Specific examples of novel proteins associated with herbicide binding include AFB5, AFB4, and SGT1b.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: December 10, 2013
    Assignee: Dow AgroSciences, LLC.
    Inventors: Terence A. Walsh, Glenn Hicks, Mary Honma, John P. Davies
  • Publication number: 20130276167
    Abstract: This invention relates to an isolated nucleic acid fragment encoding a transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of accumulated oil in a transformed host cell.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 17, 2013
    Inventors: Rebecca E. Cahoon, Theodore Mitchell Klein
  • Publication number: 20130224251
    Abstract: The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
    Type: Application
    Filed: December 17, 2010
    Publication date: August 29, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Martin Wald, Andreas Nandy, Helmut Fiebig, Bernhard Weber, Helga Kahlert, Gerald Reese, Oliver Cromwell
  • Publication number: 20130165626
    Abstract: An objective of the present invention is to provide an antifreeze protein which is capable of being efficiently produced on an industrial level at low cost and which is safe and has an excellent antifreezing activity for use on a practical level. Also, an objective of the present invention is to provide a polypeptide that corresponds to the active part of the antifreeze protein; a composition, a food, a biological sample protectant and a cosmetic containing the antifreeze protein or the polypeptide; and an antibody that specifically reacts with the antifreeze protein or the polypeptide. The antifreeze protein according to the present invention is characterized in being derived from a plant and having a specific amino acid sequence or being a plant seed protein.
    Type: Application
    Filed: April 28, 2011
    Publication date: June 27, 2013
    Inventors: Joichi Fukuoka, Hidehisa Kawahara, Hideaki Kegasa, Naoki Arai, Jun Tomono, Shinichi Yokota
  • Patent number: 8470972
    Abstract: Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modifying the genome of non-nuclear organelles are also provided.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: June 25, 2013
    Assignee: Gencia Corporation
    Inventor: Shaharyar Khan
  • Publication number: 20130029844
    Abstract: The invention provides novel cyclotide polypeptides, and variants and fragments thereof, obtained from Butterfly pea and having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant-parasitic pests such as nematodes and insects.
    Type: Application
    Filed: April 4, 2012
    Publication date: January 31, 2013
    Applicant: PIONEER HI BRED INTERNATIONAL INC.
    Inventors: Daniel J. Altier, Xuehua Hu, Daniel L. Siehl, Jun-Zhi Wei, Gusui Wu
  • Patent number: 8357509
    Abstract: Disclosed herein are recombinant tobacco osmotin polypeptides and methods for expressing tobacco osmotin polypeptides in microbial host cells. The recombinant tobacco osmotin polypeptides produced by the methods disclosed herein may be utilized as biocides or as therapeutic agents in medicaments.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: January 22, 2013
    Assignee: Auburn University
    Inventors: Tung-Shi Huang, Ywh-Min Tzou, Narendra Slngh, Bryan A. Chin
  • Patent number: 8354504
    Abstract: Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: January 15, 2013
    Assignee: The Board of Trustees of The University of Kentucky
    Inventors: Joseph Chappell, Kyoungwhan Back
  • Patent number: 8329992
    Abstract: Polynucleotides encode polypeptides for increasing the rate of growth of plants. Introduction of the polynucleotides into plants produces plants having altered characteristics, such as increased growth, increased leaf area and reduced fertility. Expression of polypeptides in plants or plant cells promotes cell division. Expression of the polynucleotides in plants in the antisense orientation produces plants that are sterile or have smaller leaves.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: December 11, 2012
    Assignees: The State of Oregon Acting by and Through The State Board of Higher Education on Behalf of Oregon State University, Michigan Technological University
    Inventors: Victor B. Busov, Steven H. Strauss
  • Publication number: 20120263741
    Abstract: The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterised in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.
    Type: Application
    Filed: March 22, 2010
    Publication date: October 18, 2012
    Inventors: Roland SUCK, Helmut Fiebig, Oliver Cromwell
  • Publication number: 20120142033
    Abstract: Extraction and purification of recombinant proteins rendered difficult to extract from transgenic plants by using an extraction solution containing reducing agents and surfactants or an extraction solution containing reducing agents and organic solvents.
    Type: Application
    Filed: September 20, 2011
    Publication date: June 7, 2012
    Applicants: PrevenTec, Inc., National Institute of Agrobiological Science
    Inventors: Yoshihiro Fujiwara, Kenji Sekikawa, Yasuhiko Aiki, Fumio Takaiwa, Lijun Yang
  • Publication number: 20120141648
    Abstract: A process of extracting at least one target component from a plant material is provided. The process includes homogenizing a plant material in the presence of an extraction solvent to reduce the plant material to a plant liquid component and a plant pulp component. Each of the components may be further processed to extract specific components therefrom. Specifically, the plant liquid component can be processed to extract a plant-derived starch material, plant-derived proteins, plant-derived sugars, plant-derived sugars, and the like. The plant pulp material can be processed to extract pectin and cellulose. An associated system is also provided.
    Type: Application
    Filed: March 25, 2011
    Publication date: June 7, 2012
    Inventors: Joshua D. Morton, Steven D. Hume, Barry Bratcher
  • Publication number: 20120128597
    Abstract: A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass.
    Type: Application
    Filed: August 14, 2009
    Publication date: May 24, 2012
    Applicants: Forschungszentrum Borstel, Protectimmun GmbH
    Inventors: Marcus Peters, Marion Kauth, Albrecht Bufe, Otto Holt
  • Publication number: 20120095189
    Abstract: The invention relates to a method for recovering a stress protein from a plant, comprising: obtaining a liquid comprising the stress protein from the plant; precipitating one or more components other than the stress protein from the liquid; adding a fibrous filter aid and a mineral powder to the liquid; then subjecting the liquid comprising the stress protein, precipitated component(s), the fibrous filter aid and the mineral powder to a first filtration step over a filter, thereby separating the precipitate, fibrous filter aid and mineral powder from the filtrate comprising the stress protein; thereafter subjecting the filtrate to a further filtration step; and thereafter purifying the stress protein.
    Type: Application
    Filed: April 9, 2010
    Publication date: April 19, 2012
    Applicant: Alfa Biogene International B.V.
    Inventors: Friedrich C. Seifarth, Julia Lax
  • Publication number: 20120058497
    Abstract: The present invention provides a reagent and a method of safely, conveniently, and specifically diagnosing Crohn's disease. Provided are a diagnostic method for Crohn's disease in a subject, including measuring antibodies against one kind or more of dietary components selected from the group consisting of grapefruit, alfalfa, avocado, cabbage, green pepper, lettuce, onion, potato (white), spinach, tomato, oat, pecan, yeast, cane sugar, celery, buckwheat, corn, rice and soy, and a diagnostic reagent or kit for Crohn's disease, containing the above-mentioned preparation of a dietary component.
    Type: Application
    Filed: September 2, 2011
    Publication date: March 8, 2012
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yasuyo SUGA, Maiko MORI, Masaki HASHIMOTO, Manabu SUZUKI, Tomomi MORIGUCHI, Takaaki KAWAGUCHI, Keiko SAITO, Masakazu TAKAZOE
  • Publication number: 20120030811
    Abstract: The invention relates to the soybean variety designated A1024092. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024092. Also provided by the invention are tissue cultures of the soybean variety A1024092 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024092 with itself or another soybean variety and plants produced by such methods.
    Type: Application
    Filed: February 7, 2011
    Publication date: February 2, 2012
    Inventors: Thomas Floyd, Barbara Schweigert
  • Publication number: 20120021971
    Abstract: The invention relates to a heat shock protein from alfalfa and/or a hydrolysate of a heat shock protein from alfalfa in the manufacture of a food product for the prophylactic or therapeutic treatment of a chronic inflammatory disorder. Further, the invention relates to a clinical food product comprising heat shock protein from alfalfa and/or a hydrolysate of a heat shock protein from alfalfa.
    Type: Application
    Filed: July 29, 2011
    Publication date: January 26, 2012
    Applicant: Alfa Biogene International B.V.
    Inventor: Julia Lax
  • Publication number: 20120009210
    Abstract: Hypoallergenic mosaic antigens assembled from naturally-occurring allergens are disclosed herein. Also disclosed are methods of making such hypoallergenic mosaic antigens, particularly those derived from plant allergens such as timothy grass pollen (Phl p 1 and Phl p 2) and birch pollen (Bet v 1). In a particularly preferred embodiment, the method of making the hypoallergenic mosaic antigen involves the steps of (a) cleaving a naturally-occurring allergen into at least two, preferably at least three non-overlapping peptide fragments and (b) recombining the peptide fragments such that the mosaic antigen includes all or substantially all of the amino acids of the original naturally-occurring allergen, though in a different order.
    Type: Application
    Filed: July 8, 2011
    Publication date: January 12, 2012
    Applicant: BIOMAY AG
    Inventors: Raffaela Campana, Rudolf Valenta, Susanne Vrtala, Ines Swoboda, Anna Gieras, Susanne Spitzauer, Peter Valent, Katharina Blatt, Margarete Focke-Tejkl, Birgit Linhart, Dietrich Kraft
  • Patent number: 8092794
    Abstract: The present invention relates to pharmaceutical compositions adapted for pharmaceutical administration comprising at least one superoxide dismutase and at least one prolamine based peptide fragment. The invention also relates to certain superoxide dismutases and prolamine based peptide fragments.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: January 10, 2012
    Assignee: Isocell Pharma S.A.
    Inventor: Alphonse Calenda
  • Publication number: 20120005776
    Abstract: Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modifying the genome of non-nuclear organelles are also provided.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 5, 2012
    Inventor: SHAHARYAR KHAN
  • Publication number: 20120005783
    Abstract: The present invention relates to nucleic acids or nucleic acid fragments encoding amino acid sequences for polypeptides involved in tolerance to freezing and/or low temperature stress in plants. More particularly, the present invention relates to nucleic acids or nucleic acid fragments encoding amino acid sequences for ice recrystallisation inhibition proteins (IRIPs) in plants, and the use thereof for the modification of plant response to freezing and/or low temperature stress. Even more particularly, the present invention relates to polypeptides involved in tolerance to freezing and/or low temperature stress in Deschampsia and Festuca species.
    Type: Application
    Filed: May 10, 2011
    Publication date: January 5, 2012
    Inventors: German Spangenberg, Ulrik Peter John, Renata Martina Polotonianka
  • Publication number: 20110321201
    Abstract: Disclosed herein is the novel plant-specific transcription factor gene CaWRKYd that can be induced by interaction with TMV-P0 and that plays an important role in regulating plant defense responses through a CaMK1 cascade induced and acts as a positive regulator imparting disease resistance to plants. Also, a transgenic plant anchoring the gene therein is provided. Therefore, the gene allows the production of plants resistant to diseases and can be very effectively used in studying defense response mechanisms of plants.
    Type: Application
    Filed: April 13, 2011
    Publication date: December 29, 2011
    Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Kyung-Hee PAEK, La Mee CHOI, Gil-Je LEE, Jee Hyuck LIM
  • Patent number: 8067542
    Abstract: The present invention relates to an antifungal protein, AlfAFP1, which is a modified form of an antifungal protein isolated from Medicago plants, the modified form exhibiting enhanced anti-fungal activity for controlling fungal pathogenesis in plants. A method for inhibiting fungal colonization of plants is described which includes preparation of nucleotide sequences encoding the modified antifungal protein, preparation of vectors containing the nucleotide coding sequence, and methods for transforming plants with the nucleotide sequences. The polypeptide can be formulated into compositions useful in controlling plant pathogenic fungi.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: November 29, 2011
    Assignee: Monsanto Technology LLC
    Inventors: Jeffrey W Seale, Paul B. Vordtriede
  • Publication number: 20110289621
    Abstract: A series of independent human-induced, non-transgenic mutations found in at least one non-ripening (NOR) gene of tomato; tomato plants having these mutations in at least one of their NOR genes; and a method of creating and identifying similar and/or additional mutations in the NOR gene by screening pooled and/or individual tomato plants. The tomato plants of the present invention exhibit fruit that ripen more slowly, rot more slowly, are firmer, and have a longer shelf life post-harvest as a result of non-transgenic mutations in at least one of their NOR genes.
    Type: Application
    Filed: October 9, 2009
    Publication date: November 24, 2011
    Applicant: ARCADIA BIOSCIENCES, INC.
    Inventors: Susan R. Hurst, Dayna L. Loeffler, Michael N. Steine
  • Publication number: 20110274797
    Abstract: A pulse protein product, which may be an isolate, produces heat-stable solutions at low pH values and is useful for the fortification of soft drinks and sports drinks without precipitation of protein. The pulse protein product is obtained by extracting a pulse protein source material with an aqueous calcium salt solution to form an aqueous pulse protein solution, separating the aqueous pulse protein solution from residual pulse protein source, adjusting the pH of the aqueous pulse protein solution to a pH of about 1.5 to about 4.4 to produce an acidified pulse protein solution, which may be dried, following optional concentration and diafiltration, to provide the pulse protein product.
    Type: Application
    Filed: May 9, 2011
    Publication date: November 10, 2011
    Inventors: Kevin I. Segall, Martin Schweizer
  • Publication number: 20110172290
    Abstract: The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.
    Type: Application
    Filed: December 9, 2010
    Publication date: July 14, 2011
    Inventors: John E. Thompson, Tzann-Wei Wang, Dongen Lily Lu
  • Publication number: 20110173715
    Abstract: This invention relates generally to nucleic acid sequences encoding proteins that are associated with abiotic stress responses and abiotic stress tolerance in plants. In particular, this invention relates to nucleic acid sequences encoding proteins that confer drought, heat, cold, and/or salt tolerance to plants.
    Type: Application
    Filed: September 23, 2005
    Publication date: July 14, 2011
    Applicant: BASF PLANT SCIENCE GMBH
    Inventors: Piotr Puzio, Agnes Chardonnens, Harry Wild, Gunnar Plesch, Bryan McKersie
  • Publication number: 20110144021
    Abstract: The invention refers to compositions that comprise the protein preparation, obtained from the latex of Hevea brasiliensis, in a low concentration. Additionally, the invention refers to the use of the protein preparation or the composition described herein, for the preparation of a medicine to treat chronic inflammatory diseases, and to the method of treating same that uses the aforementioned composition or the protein preparation.
    Type: Application
    Filed: June 26, 2009
    Publication date: June 16, 2011
    Inventor: Fatima Mrue
  • Publication number: 20110093970
    Abstract: This invention relates to the field of agriculture, more specifically to the use of molecular biology techniques to alter fiber-producing plants, particularly cotton plants, and/or accelerate breeding of such fiber-producing plants. Methods and means are provided to alter fiber qualities, such as increasing fiber strength. Methods are also provided to identify molecular markers associated with fiber strength in a population of cotton varieties and related progenitor plants.
    Type: Application
    Filed: May 25, 2009
    Publication date: April 21, 2011
    Inventors: Tony Arioli, Steven Engelen, John Jacobs, Michel Van Thournout, Stephane Bourot
  • Publication number: 20110014238
    Abstract: The present invention relates generally to novel recombinant polypeptides of Bahia grass pollen and to genetic sequences encoding same. More particularly, the present invention is directed to Pas n 1 polypeptides and derivatives, and fragments thereof and genetic sequences encoding same. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications including, but not limited to, applications in the context of conditions characterised by an aberrant, inappropriate or otherwise unwanted immune response to the Bahia grass pollen.
    Type: Application
    Filed: October 21, 2008
    Publication date: January 20, 2011
    Applicant: COOPERATIVE RESEARCH CENTRE FOR ASTHMA
    Inventors: Robyn O'Hehir, Janet Davies, Jennifer Rolland
  • Publication number: 20100319086
    Abstract: The present invention provides LEC1 variants. The LEC1 variants comprise a LEC1 A domain, a LEC1 B domain and a LEC1 C domain, where the LEC1 B domain has at least one mutation and/or is chimeric with respect to the LEC1 A or C domain. The invention also includes methods of preparing such LEC 1 variants, and methods of using such LEC1 variants to modulate the level or activity of LEC1 variants in a plant cell. Modulation of LEC1 activity or levels can be used for different purposes such as increasing embryo oil concentration, oil content of a seed or altering oil phenotype in a plant.
    Type: Application
    Filed: December 30, 2009
    Publication date: December 16, 2010
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: BO SHEN, MITCHELL C. TARCZYNSKI, CHANGJIANG LI, KIMBERLY F. GLASSMAN, ARAGULA GURURAJ RAO, WUAS SHAANALEYZ
  • Publication number: 20100310472
    Abstract: The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
    Type: Application
    Filed: July 9, 2010
    Publication date: December 9, 2010
    Inventors: Andreas NANDY, Helmut FIEBIG, Oliver CROMWELL
  • Publication number: 20100310590
    Abstract: The invention provides hypoallergenic variants of Bet v 2 major allergen from Betula verrucosa plant pollen and the use thereof for the preventive or therapeutic treatment of allergic diseases.
    Type: Application
    Filed: September 16, 2008
    Publication date: December 9, 2010
    Applicant: LOFARMA S.p.A.
    Inventors: Giovanni Mistrello, Stefania Zanotta, Daniela Roncarolo, Paolo Falagiani
  • Publication number: 20100281583
    Abstract: The present invention relates to boron transporters and, in particular, to boron transporters derived from plants. The present invention also relates to methods that utilise boron transporters, such as methods for modulating boron transport in cells and methods for determining the level or rate of boron transport in a cell or organism on the basis of the expression level of one or more boron transporters.
    Type: Application
    Filed: January 11, 2008
    Publication date: November 4, 2010
    Applicant: Australian Centre for Plant Functional Genomics Pty Ltd
    Inventors: Tim Sutton, Ute Baumann, Julie Hayes, Peter Langridge
  • Publication number: 20100281576
    Abstract: The present invention relates to cytochrome P450 protein originating from Arabidopsis thaliana which can be used for increasing seed size or storage protein content in seed or for increasing water stress resistance of plant, a gene encoding said protein, a recombinant plant expression vector comprising said gene, a method of increasing seed size or storage protein content in seed and a method of increasing water stress resistance of plant by using said vector, plants produced by said method and transgenic seed of said plants. According to the present invention, by using cytochrome P450 gene of the present invention, seed size or storage protein content in seed can be increased or water stress resistance of plant can be increased.
    Type: Application
    Filed: January 15, 2008
    Publication date: November 4, 2010
    Applicant: Myongji University Industry and Academia Cooperation
    Inventors: Ho Bang Kim, Sang Bong Choi
  • Publication number: 20100267608
    Abstract: The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to use them to treat mammals suffering from various conditions related to the pharmacologic activities. Modifications of the cupredoxin derived peptides include amino acid sequence variants and structural derivations that increase the plasma half-life of the peptide, increase the specific activity of the pharmacologic activity, decrease immunogenicity, and decrease the biotransformation of the peptides. The modified cupredoxin derived peptides can be used in methods to treat mammals for cancer, conditions related to inappropriate angiogenesis, viral and bacterial infections, and specifically HIV and malaria, conditions related to ephrin signaling, and to deliver cargo compounds, including diagnostic compounds, to cancer cells.
    Type: Application
    Filed: September 11, 2007
    Publication date: October 21, 2010
    Inventors: Tapas Das Gupta, Ananda Chakrabarty
  • Publication number: 20100175150
    Abstract: Methods and compositions are provided to improve nitrogen use efficiency in plants or plant parts, increase carbon fixation in a plant or plant part, increase grain yield or biomass production of the plant, and/or increase the stress tolerance of the plant. The compositions and methods of the invention modulate these various phenotypes by modulating the level of at least one Dof (for DNA binding with one finger) polypeptide having a Dof domain or a biologically active variant or fragment of a Dof domain.
    Type: Application
    Filed: March 17, 2010
    Publication date: July 8, 2010
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Rajeev Gupta, Juan Liu, Kanwarpal S. Dhugga, Carl R. Simmons
  • Publication number: 20100175146
    Abstract: Compositions and methods for modulating flower organ development, leaf formation, phototropism, apical dominance, fruit development, initiation of roots, and for increasing yield in a plant are provided. The compositions include a ZMM28 sequence. Compositions of the invention comprise amino acid sequences and nucleotide sequences selected from SEQ ID NOS: 1-2 as well as variants and fragments thereof. Nucleotide sequences encoding the ZMM28 sequences are provided in DNA constructs for expression in a plant of interest are provided for modulating the level of a ZMM28 sequence in a plant or a plant part are provided. The methods comprise introducing into a plant or plant part a heterologous polynucleotide comprising a ZMM28 sequence of the invention. The level of the ZMM28 polypeptide can be increased or decreased. Such method can be used to increase the yield in plants; in one embodiment, the method is used to increase grain yield in cereals.
    Type: Application
    Filed: June 6, 2008
    Publication date: July 8, 2010
    Applicant: CropDesign N.V.
    Inventors: Wesley B. Bruce, Olga N. Danilevskaya
  • Publication number: 20100158955
    Abstract: The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.
    Type: Application
    Filed: May 6, 2004
    Publication date: June 24, 2010
    Inventors: Martin Wald, Oliver Cromwell, Andreas Nandy, Helga Kahlert, Bernhard Weber, Helmut Fiebig
  • Publication number: 20090324501
    Abstract: The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
    Type: Application
    Filed: June 11, 2007
    Publication date: December 31, 2009
    Applicant: Biomay AG
    Inventors: Rudolf Valenta, Margarete Focke-Tejkl, Birgit Linhart, Susanne Vrtala, Peter Valent, Renat Reininger, Susanne Spitzauer, Ines Swoboda, Marianne Van Hage, Hans Grönlund, Johanna Tinhofer, Kerstin Westritschnig, Theresia Popow-Kraupp
  • Publication number: 20090312525
    Abstract: The invention relates to an isolated aquaporin having a bound ligand, wherein said ligand close the conformation of said aquaporin and inhibit and/or reduce water transport of said aquaporin, and/or a high resolution structure of an isolated aquaporin in a closed conformation characterised by the coordinates deposited at the Protein Data Bank ID:1Z98, a crystal of said isolated aquaporin as well as the coordinates defining said crystal and the use of said aquaporin, and the use of the high-resolution structure as defined by the coordinates deposited at PDB ID:1Z98, and a method to produce said aquaporin.
    Type: Application
    Filed: September 8, 2006
    Publication date: December 17, 2009
    Inventors: Per Kjellbom, Kristina Hedfalk, Susanna Törnroth, Maria Karlsson, Urban Johansson, Richard Neutze