Binds Specifically-identified Amino Acid Sequence Patents (Class 530/387.9)
  • Patent number: 11987627
    Abstract: The present disclosure relates to the technical field of antibody drugs, and in particular, to an anti-CD47 antibody or an antigen-binding fragment thereof, a pharmaceutical composition comprising the anti-CD47 antibody or the antigen-binding fragment thereof, and applications thereof. The anti-CD47 antibody or the antigen-binding fragment thereof has significant antitumor activity and high affinity with human CD47 protein, can eliminate the capability of SIRPa to bind to CD47 on a surface of a cell, and does not have significant hemoagglutination activity and thus can be applied to the preparation of an anti-tumor drug.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: May 21, 2024
    Assignee: NANJING SANHOME PHARMACEUTICAL CO., LTD.
    Inventors: Yong Wang, Liwen Zhao, Qifeng Song, Yongqiang Zhu, Yanan Zhang, Luwei Han, Liang Jin, Wenming Wu
  • Patent number: 11912763
    Abstract: Provided is an antibody targeting CLDN18.2. The antibody targeting CLDN118.2 comprises VL and/or VH; the VL comprises the following CDR sequences: a VL CDR1 amino acid sequence as shown in SEQ ID NO: 11 or SEQ ID NO: 12; a VL CDR2 amino acid sequence as shown in SEQ ID NO: 13; and a VL CDR3 amino acid sequence as shown in SEQ ID NO: 14; and the VH comprises the following CDR sequences; a VH CDR1 amino acid sequence as shown in SEQ ID NO: 15; a VH CDR2 amino acid sequence as shown in SEQ ID NO: 16; and a VH CDR3 amino acid sequence as shown in SEQ ID NO: 17. Further disclosed are a bispecific antibody targeting CLDN18.2, a conjugates of the antibody, a CAR molecule targeting CLDN18.2 and a cell comprising same, and applications thereof.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: February 27, 2024
    Assignee: L & L BIOPHARMA CO., LTD.
    Inventor: Jiajian Liu
  • Patent number: 11786511
    Abstract: Disclosed herein are methods for increasing circulating mesenchymal stem cells by administering a compound having the general formula 1 as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: October 17, 2023
    Assignee: University of Southern California
    Inventors: Kevin J. Gaffney, Kathleen E. Rodgers, Maira Soto, Michael Weinberg
  • Patent number: 11732037
    Abstract: Obesity and/or diabetes are treated by partially inhibiting circulating leptin in a person in need thereof.
    Type: Grant
    Filed: December 16, 2020
    Date of Patent: August 22, 2023
    Assignee: Board of Regents, The University of Texas Svstem
    Inventors: Philipp E. Scherer, Shangang Zhao
  • Patent number: 11732051
    Abstract: The present invention relates to subcutaneous formulations of anti-CD38 antibodies and their uses.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: August 22, 2023
    Assignee: JANSSEN BIOTECH, INC.
    Inventors: Richard Jansson, Vineet Kumar
  • Patent number: 11655306
    Abstract: A fusion protein for cancer treatment and a use thereof is disclosed. The fusion protein for preventing or treating cancer of the present invention includes a fusion polypeptide including: an antibody or fragment thereof binding to a tumor-associated antigen; a linker; and a NK cell-inducing protein of CXCL16, wherein a co-administration of the fusion polypeptide along with the NK cells, an immunocyte therapeutic agent, greatly increases an influx of the NK cells into cancer expressing a certain antigen, thereby having a remarkable effect on preventing or treating cancer.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: May 23, 2023
    Inventors: Seok Ho Kim, Jaemin Lee, Duck Cho
  • Patent number: 11541070
    Abstract: The present invention relates to methods of treating ovarian cancer in a subject by administering to the subject by evaluating the subject's expression levels of specific biomarkers or angiogenic an anti-activin-A compound, such as an anti-activin-A antibody or an activin-A-binding receptor. In some embodiments, at least two compounds are administered to the subject, where the first compound is an anti-activin A compound, and the second compound is a chemotherapeutic compound, for example capecitabine. The invention further relates to methods of identifying subjects for treatment factors.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: January 3, 2023
    Assignee: Atara Biotherapeutics, Inc.
    Inventors: Huiquan Han, Christopher Michael Haqq, Isaac Ciechanover, Xiaolan Zhou, John Zhao-Nian Lu
  • Patent number: 11535681
    Abstract: The invention generally provides improved anti-sickled-globin antibodies and fragments thereof. In particular embodiments, the antibody or antigen binding fragment thereof recognizes the ?s, Glu6Val mutation. In various embodiments, the invention provides a conjugate comprising an anti-?s-globin antibody or antigen binding fragment thereof and a detectable label. In particular embodiments, a hybridoma comprising an anti-?s-globin antibody contemplated herein is provided.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: December 27, 2022
    Assignee: Bluebird Bio, Inc.
    Inventor: Olivier Negre
  • Patent number: 11497796
    Abstract: Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent may include blocking the cis interaction between RGMa and Neogenin and/or disrupting lipid rafts. In turn, this promotes neuronal cell survival and axon growth and/or regeneration. Also disclosed herein is a method of treating a disease in a subject in need thereof. The method may include administering the agent to the subject. Further disclosed herein is a method of identifying an agent that modulates the cis interaction between RGMa and Neogenin.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: November 15, 2022
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Philippe P. Monnier, Nardos G. Tassew
  • Patent number: 11479608
    Abstract: The present invention belongs to the fields of tumor therapy and molecular immunology. The present invention relates to an anti-CTLA4 antibody, pharmaceutical composition and use thereof. The anti-CTLA4 antibody of the present invention can specifically bind CTLA4, and can very effectively block the binding of CLTA4 to B7.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: October 25, 2022
    Assignee: Akeso Biopharma, Inc.
    Inventors: Baiyong Li, Yu Xia, Peng Zhang, Xinghua Pang, Zhongmin Wang
  • Patent number: 11435354
    Abstract: There is provided a simple and minimally invasive adenocarcinoma detection method. The adenocarcinoma detection method of the present invention includes a step of detecting in vitro a presence or absence of an abnormal cleavage in a specific protein in a test subject-derived sample. The abnormal cleavage in the specific protein is, for example, a cleavage resulting in one or more breaks in a peptide bond in the specific protein and/or a cleavage resulting in a deletion of one or two more amino acid residues at one or more sites of the specific protein. The adenocarcinoma detection method of the present invention includes a step of detecting a presence or amount of a protein having the abnormal cleavage or a decrease in an amount of a normal protein.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 6, 2022
    Assignees: UNIVERSITY OF MIYAZAKI, OSAKA UNIVERSITY
    Inventors: Masamitsu Nakazato, Nobuhiro Matsumoto, Yasuji Arimura, Hironobu Tsubouchi, Toshifumi Takao, Nobuaki Okumura, Masafumi Fukuda
  • Patent number: 11402383
    Abstract: The present invention belongs to the field of immunology and molecular biology, which relates to an anti-PCSK9 antibody, the pharmaceutical composition and method of use thereof. In particular, the present invention relates to the monoclonal antibody, which can bind PCSK9 specifically, block association of PCSK9 with LDLR, upregulate the amount of LDLR on cell surface, heighten the metabolism of LDL cholesterol and/or triglycerides, and prevent/treat cardiovascular diseases caused by hypercholesterolemia.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: August 2, 2022
    Assignee: AD Pharmaceutical Co., Inc.
    Inventors: Baiyong Li, Zhongmin Wang, Yu Xia, Peng Zhang, Wuxian Ren, Jinan Jiao, Yuanyuan Xu, Dongsheng Dai
  • Patent number: 11285199
    Abstract: The present invention relates to a vaccine composition comprising a Staphylococcus aureus attenuated enterotoxin protein and cytotoxin protein, and more particularly to a Staphylococcus aureus enterotoxin protein, a Staphylococcus aureus cytotoxin protein, a vaccine composition for prevention of bovine mastitis, comprising the Staphylococcus aureus enterotoxin protein and Staphylococcus aureus cytotoxin protein and a method for preventing bovine mastitis comprising administering the vaccine composition to a bovine.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: March 29, 2022
    Assignees: Mississippi State University
    Inventors: Dong Chan Moon, Suk Kyung Lim, Keum Chan Jang, Suk Chan Jung, Hee Soo Lee, Bang Hun Hyun, Hyang Mi Nam, Heui Jin Kim, Keun Seok Seo
  • Patent number: 11130801
    Abstract: A method of modulating growth factor responses of cells expressing C3a receptor (C3aR) and C5a receptor (C5aR) and at least one growth factor receptor includes administering to the cells at least one agent that modulates C3aR and/or C5aR signaling of the cells.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: September 28, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: M. Edward Medof, Michael G. Strainic, Elliot Pohlmann, Ming-Shih Hwang
  • Patent number: 11103139
    Abstract: Described herein are embodiments of systems and methods that utilize images of a user's face to detect fever and intoxication. One embodiment of a system to detect fever includes first and second inward-facing head-mounted cameras that are located less than 5 cm from a user's face, are sensitive to wavelengths below 1050 nanometer, and are configured to capture images of respective first and second regions on the user's face. The system also includes a computer that calculates, based on baseline images captured with the cameras while the user did not have a fever, a baseline pattern of hemoglobin concentrations at regions on the face. The computer also calculates, based on a current set of images captured with the cameras, a current pattern of hemoglobin concentrations at the regions, and detects whether the user has a fever based on a deviation of the current pattern from the baseline pattern.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: August 31, 2021
    Assignee: Facense Ltd.
    Inventors: Ari M Frank, Arie Tzvieli, Ori Tzvieli, Gil Thieberger
  • Patent number: 11099195
    Abstract: The present invention provides methods and systems to accurately detect and measure levels of endogenous antibodies, for examples endogenous IgA, to particular antigens in a biological sample from a companion animal, which is useful to diagnose inflammatory conditions, including bowel disease (IBD), gastrointestinal infections, and food sensitivities in companion animals, e.g., dogs or cats, and to distinguish among such gastrointestinal disorders. Such methods and systems identify whether a sample from the patient is associated with an inflammatory condition, infection, and/or food sensitivity condition, by using non-invasive means, thus conveniently providing information useful for guiding treatment decisions.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 24, 2021
    Assignee: VETICA LABS, INC.
    Inventors: Juan Estruch, Genevieve Hansen
  • Patent number: 10591490
    Abstract: Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: March 17, 2020
    Assignee: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH
    Inventors: Harald Althaus, Tobias Obser, Juergen Patzke, Reinhard Schneppenheim
  • Patent number: 10526631
    Abstract: The present invention relates to a method of reducing serine for asparagine misincorporation in a protein produced by a culture of cells in a cell culture method, the method comprising the addition of asparagine and iron to the cell culture medium.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: January 7, 2020
    Assignee: ARES TRADING S.A.
    Inventors: Thomas Solacroup, Matthieu Stettler, Hervé Broly
  • Patent number: 10227411
    Abstract: The present invention relates to methods and compositions for modulating T cells. The modulation includes suppressing or inducing regulatory T cells or cytotoxic T cells.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: March 12, 2019
    Assignee: Xencor, Inc.
    Inventors: Matthew Bernett, Seung Chu, Dilki Wickramarachichi, John Desjarlais
  • Patent number: 9869683
    Abstract: Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: January 16, 2018
    Assignee: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH
    Inventors: Harald Althaus, Tobias Obser, Juergen Patzke, Reinhard Schneppenheim
  • Patent number: 9829494
    Abstract: The ratio of concentrations of pro-adrenomedullin (pro-ADM)/pro-endothelin (pro-END) immunoreactivity in body fluids of critically ill patients is used as for the diagnosis, course control and prognosis, including an assessment of the mortality risk, of severe life threatening diseases. Further, a treatment of critically ill patients having high levels of pro-ADM but insufficient levels of pro-END immunoreactivities with a medicament comprising vasoconstrictive endothelin or its precursors, and/or endothelin agonists or adrenomedullin antagonists is provided.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: November 28, 2017
    Assignee: ADRENOMED AG
    Inventors: Andreas Bergmann, Joachim Struck, Nils G. Morgenthaler
  • Patent number: 9758591
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 12, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • Patent number: 9663567
    Abstract: The invention relates to monoclonal antibodies (mAbs) that bind to serotransferrin (TF), hybridoma lines that secrete these antibodies or fragments thereof, and the use of these antibodies to detect TF antigens. Methods and uses for detecting prostate cancer, as well as methods and uses for distinguishing early and late stage prostate cancer are encompassed.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: May 30, 2017
    Assignee: ALPER BIOTECH LLC
    Inventor: Özge Alper
  • Patent number: 9655899
    Abstract: The instant invention relates to methods for the treatment of WEE1 kinase associated cancer by administering a WEE1 inhibitor, wherein the WEE1 inhibitor is WEE1-1 or a pharmaceutically acceptable salt thereof, or WEE1-2 or a pharmaceutically acceptable salt thereof. In another embodiment, the invention relates to a method for treating a WEE1 kinase associated cancer patient, comprising administering a WEE1 inhibitor, wherein the cancer cells of said patient to be treated are characterized by low expression levels of PKMYT1.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: May 23, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Stuart Denham Shumway
  • Patent number: 9512231
    Abstract: The disclosure relates to a polypeptide comprising at least four domains specifically binding to a certain MHC peptide complex, the domains separated by linker amino acid sequences, thereby providing each domain with the capability to bind a separate MHC peptide complex, to a nucleic acid encoding for such a polypeptide, to a vector comprising such a nucleic acid, to a host cell for expression of such a polypeptide, to a pharmaceutical composition comprising such a polypeptide, and to a kit of parts comprising at least two polypeptides according to the disclosure.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: December 6, 2016
    Assignee: APO-T B.V.
    Inventors: Ralph Alexander Willemsen, Maria Johanna J. E. Van Driel
  • Patent number: 9365647
    Abstract: The invention relates to a method of modulating concentration of Alzheimer's Disease (AD) relevant proteins amyloid precursor protein (APP), beta (?) and gamma (?) secretases and amyloid beta peptide (A?), and also relates to a method of reducing A? shedding. Furthermore, this invention extends to a compound for use in the treatment of AD, and also to a method of treating AD.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: June 14, 2016
    Assignee: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
    Inventors: Stefan Franz Thomas Weiss, Katarina Jovanovic, Danielle Gonsavles, Bianca Da Costa Dias, Stefan Knackmuss, Uwe Reusch, Melvyn Little, Marc Saul Weinberg
  • Patent number: 9347957
    Abstract: The present invention provides a reagent for assaying D-dimer which includes carriers sensitized to first and second monoclonal antibodies which react with D-dimer, but have different reactivity to D-dimer in which the first monoclonal antibody reacts with high- and low-molecular fractions of D-dimer, the second monoclonal antibody reacts with the high-molecular fraction, but reactivity of the second monoclonal antibody with the low-molecular fraction is different from that of the first monoclonal antibody and a kit of reagent for assaying D-dimer.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: May 24, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Keisuke Nagai, Kazuaki Yamashita, Susumu Hoshiko, Takeshi Suzuki
  • Patent number: 9285371
    Abstract: Provided is a method of screening a target-specific antibody for an antigen that undergoes structural change in a particular physiological condition.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: March 15, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Min-Kyung Kim, Jae-Il Lee
  • Patent number: 9201068
    Abstract: The present invention is directed to a method and apparatus that satisfies the need for a bioelectronic tongue for food allergy detection. The method of detecting concentration of food allergen incorporates antibodies into an electronic tongue to create a bioelectronic tongue. Additionally the method uses impedance, capacitance, and/or other related electrochemical methods for detecting analyte in complex media. Furthermore the method additionally includes methods to subtract out non-specific interactions. The method also subtracts non-specific interactions. The device/apparatus is a Bioelectronic Tongue for detecting allergen in diluted food samples. The device includes: a sensor array; an impedance or capacitance analyzer; a preprocessor; a feature extractor; a pattern recognizer; and an output device indicating an allergen concentration.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: December 1, 2015
    Assignee: CLARKSON UNIVERSITY
    Inventors: Ian Ivar Suni, Yin Huang, Stephanie Ann Caswell Schuckers
  • Patent number: 9175073
    Abstract: The inventors discovered that the adhesion molecule CAR, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified CARL, a novel CAR ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in Th1 cells. In addition, they found that anti-CAR antibodies could inhibit the adhesion of activated lymphocytes to CAR molecules. Thus, the present invention provides methods for detecting Th1 cells using CAR or anti-CARL antibodies, and methods of screening for inhibitors suppressing the adhesion of Th1 cells using the binding between CAR and CARL as an index. Furthermore, the present invention relates to methods of screening for inhibitors of the binding between CAR and CARL, antibodies that inhibit the binding between CAR and CARL, and therapeutic compositions comprising these antibodies.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 3, 2015
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Keiko Yamaguchi, Toshio Imai, Kenzo Muramoto
  • Patent number: 9150658
    Abstract: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: October 6, 2015
    Assignee: GENMAB A/S
    Inventors: Sandra Verploegen, David P. E. Satijn, Rene Hoet, Paul Parren, Jan Van De Winkel, Vibeke Miller Breinholt, Eva Ehrnrooth, Ole Baadsgaard, Tom Vink, Willem Karel Bleeker, Mischa Houtkamp, Maroeska Oudshoorn, Rob N. De Jong
  • Patent number: 9073998
    Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: July 7, 2015
    Assignee: Amgen Fremont Inc.
    Inventors: Richard Weber, Xiao Feng, Orit Foord, Larry Green, Jean M. Gudas, Bruce Keyt, Ying Liu, Palaniswami Rathanaswami, Robert Raya, Xiao Dong Yang, Jose Corvalan, Ian Foltz, Xiao-Chi Jia, Jaspal S. Kang, Chadwick T. King, Scott L. Klakamp, Qiaojuan Jane Su
  • Publication number: 20150147333
    Abstract: Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.
    Type: Application
    Filed: October 17, 2014
    Publication date: May 28, 2015
    Applicant: GENENTECH, INC.
    Inventors: Elaine Storm, Frederic J. de Sauvage, Jeremy M. Murray, Cameron L. Noland, Yan Wu, Christine Tan, Jo-Anne Hongo, Yongmei Chen
  • Publication number: 20150147334
    Abstract: The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease.
    Type: Application
    Filed: February 6, 2015
    Publication date: May 28, 2015
    Applicant: NEW YORK UNIVERSITY
    Inventors: Thomas M. Wisniewski, Fernando Goni
  • Publication number: 20150147784
    Abstract: Two universally conserved sequences from influenza type A neuraminidases were identified by large scale sequence analysis then chemically modified and conjugated to carrier proteins to generate mono-specific and monoclonal antibodies. The two antibodies, one targeting the N-terminus of the type A neuraminidase and the other sequence close to enzymatic active site, were capable of binding to all 9 subtypes of neuraminidase while demonstrating remarkable specificity against the viral neuraminidase sequences since no cross-reactivity against allantoic proteins was observed. Quantitative analyses of NA using slot blot suggest that the antibodies can be used for NA antigen quantitation in vaccines. These represent the first time the antibody-based immunoassay can be used for NA quantitative determination.
    Type: Application
    Filed: December 1, 2014
    Publication date: May 28, 2015
    Inventors: Xuguang Li, Runtao He, Gary Van Domselaar
  • Publication number: 20150147332
    Abstract: An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: September 26, 2014
    Publication date: May 28, 2015
    Inventors: Rajendar K. Deora, Meenu Mishra, Neelima Sukumar
  • Publication number: 20150147330
    Abstract: Described herein is the identification of a panel of high affinity monoclonal antibodies that bind GPC3. The disclosed antibodies recognize native GPC3 on the surface of cancer cells, as well as soluble GPC3. The highest affinity antibody (YP7) was further characterized and shown to be highly sensitive in that it was capable of detecting cancer cells with low expression of GPC3. YP7 also exhibited significant HCC tumor growth inhibition in vivo. Immunotoxins comprising the antibodies disclosed herein fused to PE38 exhibited very high binding affinity for GPC3-expressing cells and significantly inhibited GPC3-expressing cancer cell growth. Thus, the high-affinity monoclonal antibodies disclosed herein can be used for the diagnosis and treatment of GPC3-expressing cancers.
    Type: Application
    Filed: May 31, 2013
    Publication date: May 28, 2015
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Service
    Inventors: Mitchell Ho, Yen T. Phung, Wei Gao, Yifan Zhang
  • Publication number: 20150147316
    Abstract: The invention provides murine, chimeric, and humanized antibodies that specifically bind to CD33. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting CD33.
    Type: Application
    Filed: May 15, 2013
    Publication date: May 28, 2015
    Applicant: SEATTLE GENETICS, INC.
    Inventors: May Kung Sutherland, Maureen Ryan, Django Sussman, Patrick Burke, Scott Jeffrey
  • Publication number: 20150147763
    Abstract: The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN18.2.
    Type: Application
    Filed: May 6, 2013
    Publication date: May 28, 2015
    Inventors: Ugur Sahin, Özlem Türeci, Rita Mitnacht-Kraus, Stefan Wöll
  • Publication number: 20150147329
    Abstract: The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.
    Type: Application
    Filed: July 25, 2014
    Publication date: May 28, 2015
    Inventors: Rahul Raman, Xiaoying Koh, Karthik Viswanathan, Ram Sasisekharan, Aarthi Chandrasekaran
  • Publication number: 20150147762
    Abstract: Pancreatic cancer can be detected using a monoclonal antibody which binds to pancreatic RNase 1 when a site in pancreatic RNase 1 capable of being modified with an N-glycan chain is not linked to a glycan chain, but which does not bind to pancreatic RNase 1 when an N-glycan chain is linked to the site. Also provided is a monoclonal antibody which can bind to pancreatic RNase 1 simultaneously with the binding of the aforementioned antibody to pancreatic RNase 1, and determining the ratio of A to B using the antibodies, wherein A represents the amount of the site located in the pancreatic RNase 1 capable of being modified with an N-glycan chain, wherein an N-glycan chain is linked or not linked to the site; and B represents the amount of the site located in the pancreatic RNase 1 capable of being modified with an N-glycan chain.
    Type: Application
    Filed: June 6, 2013
    Publication date: May 28, 2015
    Applicant: TOSOH CORPORATION
    Inventor: Daisuke Nakatani
  • Publication number: 20150147274
    Abstract: Antibodies which are antagonists of the human HGF receptor (MET), wherein the antibodies specifically bind to amino acid residues 568-741 of human MET (SEQ ID No: 1) with high affinity.
    Type: Application
    Filed: November 30, 2012
    Publication date: May 28, 2015
    Inventors: Danielle Marie Di Cara, John McCafferty, Ermanno Gherardi, Anthony Richard Pope
  • Patent number: 9040669
    Abstract: Antigen binding proteins with T cell receptor-like paratopes, that is, with an antigen binding region specific for an human leukocyte antigen-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab?)2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: May 26, 2015
    Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Nai-Kong Cheung, Dimiter Tassev, Jian Hu
  • Publication number: 20150143584
    Abstract: This invention relates generally to nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to Arabidopsis thaliana, Brassica napus, Glycine max and Oryza sativa nucleic acid sequences encoding sugar and lipid metabolism regulator proteins and the use of these sequences in transgenic plants. In particular, the invention is directed to methods fir manipulating sugar-related compounds and for increasing oil level and altering the fatty acid composition in plants and seeds. The invention further relates to methods of using these novel plant polypeptides to stimulate plant growth and/or to increase yield and/or composition of seed storage compounds.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 21, 2015
    Applicant: BASF PLANT SCIENCE GMBH
    Inventors: Heiko A. Haertel, Garima Bhatt
  • Publication number: 20150143574
    Abstract: The invention relates to a new gene that is able to provide plants with resistance against pathogens, more preferably Verticillium, Ralstonia or Fusarium. Said gene is typical for Brassicaceae and encodes for a proteins having a sequence as depicted in FIG. 7 or FIG. 2A. Also provided are methods for enhancing the pathogen resistance of plants, wherein said plants preferably are Brassicaceae, but wherein the resistance also is functional in other plants. Further provided are host cells with a nucleotide construct encoding said protein.
    Type: Application
    Filed: May 24, 2013
    Publication date: May 21, 2015
    Inventors: Bart Pierre Hélène Joseph Thomma, Koste Abdissa Yadeta
  • Publication number: 20150141287
    Abstract: Genetic markers associated with intellectual disability as well as compositions, methods and kits for screening for genetic markers of intellectual disability, diagnosing intellectual disability and identifying individuals with a predisposition for offspring suffering from intellectual disability are provided.
    Type: Application
    Filed: January 22, 2015
    Publication date: May 21, 2015
    Inventor: John B. Vincent
  • Publication number: 20150140003
    Abstract: The invention provides anti-human alpha-synuclein antibodies and methods of using the same.
    Type: Application
    Filed: November 20, 2014
    Publication date: May 21, 2015
    Inventors: Klaus Kaluza, Olaf Mundigl, Thomas Kremer, Markus Britschgi, Sylwia Huber
  • Publication number: 20150141528
    Abstract: An in vitro diagnostic (IVD) device is used to detect the presence of and/or severity of neural injuries or neuronal disorders in a subject. The IVD device relies on an immunoassay which identifies biomarkers that are diagnostic of neural injury and/or neuronal disorders in a biological sample, such as whole blood, plasma, serum, and/or cerebrospinal fluid (CSF). An IVD device may measure one or more of several neural specific markers in a biological sample and output the results to a machine readable format, either to a display device or to a storage device internal or external to the IVD.
    Type: Application
    Filed: June 2, 2014
    Publication date: May 21, 2015
    Applicant: BANYAN BIOMARKERS, INC.
    Inventor: Stephen Larner
  • Publication number: 20150140001
    Abstract: Provided is an antibody specifically binding to the CTLD (C-type lectin like domain) of clecl4a (C-type lectin domain family 14, member A), a method for preparing the antibody, a composition for suppressing angiogenesis comprising the antibody, a method for suppressing angiogenesis by administering the antibody or the composition, a composition for preventing or treating cancer comprising the antibody, a method for treating cancer by administering the antibody or the composition, a composition for diagnosing cancer comprising the antibody, a kit for diagnosing cancer comprising the composition, a method for diagnosing cancer using the composition, a composition for suppressing angiogenesis comprising a material for inhibiting expression of clecl4a, a kit for angiogenesis comprising the composition, a method for suppressing angiogenesis or treating cancer using the composition, and the use of the CTLD of clecl4a as an epitope for an antibody suppressive of angiogenesis.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 21, 2015
    Applicant: SCRIPPS KOREA ANTIBODY INSTITUTE
    Inventors: Suk Mook Lee, Min kyoung Ki, Mee Hyun Jeoung, Jong Rip Choi
  • Publication number: 20150139999
    Abstract: Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the invention relates to antagonists of interferon proteins and associated methods of use as well as methods to develop neutralizing antibodies against IFN antagonists to treat viral infections.
    Type: Application
    Filed: June 5, 2014
    Publication date: May 21, 2015
    Inventors: Sergei V. Kotenko, Geoffrey L. Smith