Lower Fungi, E.g., Mold, Etc. Patents (Class 530/823)
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Patent number: 8765147Abstract: The present disclosure relates to endophytic fungi from higher plants such as a Pteromischum sp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.Type: GrantFiled: November 14, 2011Date of Patent: July 1, 2014Assignee: The Regents of the University of CaliforniaInventors: Gary A. Strobel, Yuhao Ren, David B. Teplow
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Patent number: 8715698Abstract: The present invention relates to an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same. The present invention also relates to a composition comprising an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same.Type: GrantFiled: September 19, 2008Date of Patent: May 6, 2014Assignees: Pevion Biotech, AG, Istituto Superiore di SanitaInventors: Rinaldo Zurbriggen, Flavia de Bernardis, Antonio Cassone, Silvia Rasi
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Patent number: 8211830Abstract: The present invention discloses fungal isolates of Phoma spp. or extracts obtained therefrom, useful for the control of broad leaf weeds, including Canada thistle, perennial sowthistle, dandelion, scentless chamomile, false cleavers, chickweed, wild buckwheat, and field bindweed. Te present invention also discloses biological control compositions comprising fungal isolates formulated in a growth medium for maintaining the viability of the fungal isolates when the biological control composition is applies to soil.Type: GrantFiled: May 30, 2002Date of Patent: July 3, 2012Assignee: Her Majesty the Queen in Right of Canada, as represented by the Minister of Agriculture and Agri-Food CanadaInventors: Karen L. Bailey, JoAnne Derby
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Patent number: 8080256Abstract: The present disclosure relates to endophytic fungi from higher plants such as a Pteromischum sp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.Type: GrantFiled: November 6, 2008Date of Patent: December 20, 2011Assignee: Regents of the University of CaliforniaInventors: Gary A. Strobel, Yuhao Ren, David B. Teplow
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Patent number: 8003114Abstract: The invention relates to the abfB-2 gene of Penicillium funiculosum that codes for a type B ?-L-arabinofuranosidase and has a cellulose binding domain. This enzyme ?-L-arabinofuranosidase can be incorporated in nutritional additives or in foods for animals for which it improves the digestibility and thus the nutritional value.Type: GrantFiled: May 3, 2006Date of Patent: August 23, 2011Assignee: Adisseo France S.A.S.Inventors: Jean Marie Francois, Jean-Luc Parrou, Olivier Tourrasse, Olivier Nore
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Patent number: 7968106Abstract: The invention relates to the abfB-1 gene of Penicillium funiculosum that codes for a type B ?-L-arabinofuranosidase. This enzyme ?-L-arabinofuranosidase can be incorporated in nutritional additives or in foods for animals for which it improves the digestibility and thus the nutritional value.Type: GrantFiled: May 3, 2006Date of Patent: June 28, 2011Assignee: Adisseo France S.A.S.Inventors: Jean Marie Francois, Jean-Luc G. Parrou, Olivier Tourrasse, Olivier Nore
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Patent number: 7815918Abstract: A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-length Pneumocystis kexin, or a full length Streptococcus pneumoniae pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a patient.Type: GrantFiled: December 31, 2004Date of Patent: October 19, 2010Assignee: University of RochesterInventors: Francis Gigliotti, Terry W. Wright, Constantine G. Haidaris, Patricia J. Simpsonhaidaris, Jesse Wells
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Patent number: 7550426Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group, and an acetyl group. These agents are useful in treating cancer, especially prostate cancer.Type: GrantFiled: May 18, 2005Date of Patent: June 23, 2009Assignee: GHC Research Development CorporationInventors: Thomas E. Wagner, Xianzhong Yu
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Patent number: 7425535Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group. These agents are useful in treating cancer, especially prostate cancer.Type: GrantFiled: May 6, 2005Date of Patent: September 16, 2008Assignee: GHC Research Development CorporationInventors: Xianzhong Yu, Thomas E. Wagner
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Patent number: 7094750Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group. These agents are useful in treating cancer, especially prostate cancer.Type: GrantFiled: May 9, 2001Date of Patent: August 22, 2006Assignee: Greenville Hospital SystemInventors: Xianxhang Yu, Thomas E. Wagner
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Patent number: 6482601Abstract: A homogeneous assay for determining the fumonisin content in grains uses the technique of fluorescence polarization. A grain extract is prepared by shaking a crushed grain sample with a solvent. A mixture is prepared by combining the grain extract with a tracer and with monoclonal antibodies specific to fumonisin. The tracer is able to bind to the monoclonal antibodies to produce a detectable change in fluorescence polarization. The tracer is prepared by conjugating fumonisin to a suitable fluorophore. The fluorescence polarization of the mixture is measured. The fumonisin concentration of the mixture may be calculated using a standard curve obtained by measuring the fluorescence polarization of a series of fumonisin solutions of known concentration.Type: GrantFiled: September 11, 2000Date of Patent: November 19, 2002Assignee: Diachemix LLCInventors: Mohammad Sarwar Nasir, Michael E. Jolley
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Patent number: 6403362Abstract: An expressing system which enables a large amount of production of a protein in Humicola, in particular, Humicola insolens, and particularly host-vector systems and a process for producing a protein using the systems, wherein an expression vector comprising the regulator sequences, i.e., the promoter, the signal sequence, and the terminator, of the cellulase NCE1 gene or NCE2 gene derived from Humicola insolens is constructed and used. The expression vector enables highly efficient production of cellulase NCE4, for example, in Humicola insolens at a rate as high as about 4.5 g or more per one liter of culture.Type: GrantFiled: March 3, 1999Date of Patent: June 11, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tatsuki Moriya, Kouichirou Murashima, Kaoru Aoyagi, Naomi Sumida, Manabu Watanabe, Toru Hamaya, Jinichiro Koga, Toshiaki Kono, Takeshi Murakami
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Patent number: 6228615Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrD are also provided. The invention further provides assays which utilize these transformed host cells.Type: GrantFiled: June 8, 1999Date of Patent: May 8, 2001Assignee: Eli Lilly and CompanyInventors: Paul Luther Skatrud, Maarten A. de Waard, Alan C. Andrade, Robert Brown Peery
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Patent number: 6030618Abstract: The present invention relates to immunogenic complexes of heat shock proteins (hsp) noncovalently bound to exogenous antigenic molecules which when administered to an individual elicit specific immunological responses in the host. Methods of prevention and treatment of cancer and infectious disease are provided.Type: GrantFiled: September 10, 1996Date of Patent: February 29, 2000Assignee: Fordham UniversityInventor: Pramod K. Srivastava
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Patent number: 5928898Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrD are also provided. The invention further provides assays which utilize these transformed host cells.Type: GrantFiled: December 23, 1997Date of Patent: July 27, 1999Assignee: Eli Lilly and CompanyInventors: Paul Luther Skatrud, Maarten A. de Waard, Alan C. Andrade, Robert Brown Peery
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Patent number: 5908760Abstract: A method of preparing .varies.-glucan lyase enzymes is described. The method comprises isolating the enzymes from a culture of fungus wherein the culture is substantially free of any other organisms. Also described are the amino acid sequences for the enzymes and their coding sequences.Type: GrantFiled: July 8, 1996Date of Patent: June 1, 1999Assignee: Danisco A/SInventors: Kirsten Bojsen, Shukun Yu, Karsten Kragh, Tove Christensen, Jan Marcussen
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Patent number: 5849868Abstract: The nucleic acid and amino acid sequences for proteinaceous elicitors of the plant defense reaction known as the hypersensitive response are described along with methods for preparation and processes for inactivation.Type: GrantFiled: February 23, 1994Date of Patent: December 15, 1998Assignee: Cornell Research Foundation, Inc.Inventors: Steven V. Beer, Zhong-Min Wei, David W. Bauer, Alan Collmer, Sheng-Yang He, Ron Laby
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Patent number: 5801034Abstract: This invention provides a method for killing cells in fermentation mixtures in order to prepare the fermentation mixture for processing to recover or extract a desired product from the fermentation mixture. A preferred method of this invention comprises in either order, adjusting the pH of the fermentation mixture to a value equal to or less than about two pH units below the pK.sub.a of the compatible organic acid using a mineral acid, and adding a sufficient amount of a compatible organic acid and/or organic acid salt to the mixture to effect a substantially complete cell kill. The method of this invention is useful for killing microorganisms such as yeast, bacteria or fungi in any culture or fermentation mixture and is particularly useful in systems where it is desired to kill the cells without lysing them.Type: GrantFiled: December 14, 1994Date of Patent: September 1, 1998Assignee: Genencor InternationalInventors: Virgil B. Lawlis, Jr., Henry G. Heinsohn, Enrique F. Baliu
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Patent number: 5589624Abstract: The polypeptide with the sequence (SEQ ID NO: 1)______________________________________ Ala--Thr--Tyr--Asn--Gly--Lys--Cys--Tyr--Lys--Lys--Asp-- Asn--Ile--Cys--Lys--Tyr--Lys--Ala--Gln--Ser--Gly--Lys-- Thr--Ala--Ile--Cys--Lys--Cys--Tyr--Val--Lys--Lys--Cys-- Pro--Arg--Asp--Gly--Ala--Lys--Cys--Glu--Phe--Asp--Ser-- Tyr--Lys--Gly--Lys--Cys--Tyr--Cys ______________________________________can be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.Type: GrantFiled: January 13, 1995Date of Patent: December 31, 1996Assignee: Hoechst AktiengesellschaftInventors: Norbert Ulbrich, Rolf Hilgenfeld, Heinz Hanel, Burkhard Sachse, Peter Braun, Joachim Wink, Peter Eckes, Jurgen Logemann, Jozef Schell
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Patent number: 5421839Abstract: Antifungal polypeptide and process for its productionThe polypeptide with the sequence (SEQ ID NO: 1)Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln -Ser-Gly-Lys-Thr-Ala-Ile-Cys- Lys-Cys-Tyr-Val-Lys-Lys-Cys-Pro-Arg-Asp-Gly-Ala-Lys-Cys-Glu-Phe-Asp-Ser-Ty r-Lys-Gly-Lys-Cys-Tyr-Cyscan be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.Type: GrantFiled: October 30, 1992Date of Patent: June 6, 1995Assignee: Hoechst AktiengesellschaftInventors: Norbert Ulbrich, Rolf Hilgenfeld, Heinz Hanel, Burkhard Sachse, Peter Braun, Joachim Wink, Peter Eckes, Jurgen Logemann, Jozef Schell
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Patent number: 5378621Abstract: This invention provides a method for killing fungal cells without lysing in fermentation processes in order to prepare the fermentation mixture for processing to recover or extract an extracellularly expressed enzyme from the fermentation mixture. A preferred method of this invention comprises adjusting the pH of the fermentation mixture to less than 2.79 using a mineral acid, then adding sufficient acetic acid to the mixture to affect a substantially complete cell kill in mixture. A salt of the acetic acid can be used. The organic acid or salt can be added, then the pH adjusted to the desired level. Other organic acids can be used, in which case the pH of the mixture is adjusted to the pK.sub.a of the selected organic acid before the organic acid is added to the mixture.Type: GrantFiled: May 7, 1993Date of Patent: January 3, 1995Assignee: Genencor, Inc.Inventors: Virgil B. Lawlis, Jr., Henry G. Heinsohn, Enrique F. Baliu
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Patent number: 5374714Abstract: A method of obtaining a novel polypeptide from a crude extraction product of polysaccharide peptide Coriolus versicolor comprising: a) boiling a water soluble powder of polysaccharide peptide Coriolus versicolor; b) centrifuging a boiled product from step a); c) filtering a centrifuged product from step b); d) purifying a solution from step c) by gel filtration chromatography; e) subjecting the purified material from step d) to HPLC using a reversed-phase at ambient temperature, wherein a solvent composition is at an acidic Ph and further includes KCl solvent, and wherein an elution system consists of a linear gradient of about 80% methanol applied at a rate of from between 0-40 minutes to obtain chromatographic peaks; f) analyzing the chromatographic peaks by monitoring for absorbance at about 230 nm, 1.0 AUFS for protein analysis and about 620 nm, 0.Type: GrantFiled: November 30, 1992Date of Patent: December 20, 1994Inventors: Mable M. P. Yang, George Chen
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Patent number: 5334704Abstract: Disclosed herein is a novel glycoprotein derived from Ganoderma mycelia. The glycoprotein is free of human hemagglutination ability, and has immunosuppressive activities and a molecular weight of 16,000-18,000 as measured by SDS gel electrophoresis or 12,000-16,000 as measured by tricin-SDS gel electrophoresis. The glycoprotein is produced by culturing Ganoderma mycelia, extracting the resultant Ganoderma mycelia with an aqueous solvent, and then purifying the resultant extract. An immunosuppressive agent containing an effective amount of the glycoprotein is also disclosed.Type: GrantFiled: April 28, 1988Date of Patent: August 2, 1994Assignee: Meiji Milk Products Co., Ltd.Inventors: Hajime Tsunoo, Kousuke Kino, Akio Yamashita
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Patent number: 5288639Abstract: A polypeptide sequence from Candida albicans is described which has significant sequence homology with known stress proteins from other organisms, particularly the heat shock protein hsp 90 of Sacchromyces cerevisiae. Corresponding DNA sequences are also described, together with antibodies raised against fragments of the sequence. The polypeptide and DNA sequences and antibodies provide separate means for the diagnosis and/or treatment of fungal, particularly Candida, infections.Type: GrantFiled: March 14, 1991Date of Patent: February 22, 1994Assignee: The Victoria University of ManchesterInventors: James P. Burnie, Ruth C. Matthews
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Patent number: 5173419Abstract: Two chitinases from Trichoderma harzianum P1 (ATCC 74058) show chitin-containing-fungus- and insect-inhibiting activity. The first is an endochitinase having a molecular weight of 36 kDa and an isoelectric point of 5.3.+-.0.2. The second is an exochitinase having a molecular weight of 36 kDa an an isoelectric point of 4.4.+-.0.2. The chitinases can be applied in contact with chitin-containing fungus or insect as an inhibitor thereof. The chitinases can be applied to plants or to soil around plants which need production from a chitinase-containing pest. The chitinases can also be used to isolate genes coding for them which can be inserted into a genome of a plant needing protection from a chitinase-containing pest or into the genome of a microorganism to provide transgenic microorganism useful to produce enzyme or as a biocontrol agent.Type: GrantFiled: June 17, 1991Date of Patent: December 22, 1992Assignee: Cornell Research Foundation, Inc.Inventors: Gary E. Harman, Roxanne M. Broadway, Arne Tronsmo, Matteo Lorito
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Patent number: 4701442Abstract: A process for preparing nucleoproteic material which comprises immersing organic material into a suitable solvent for a sufficient time to extract nucleoproteins from said material, adding a sufficient amount of an acid to form a precipitate of nucleoproteic material, and recovering said nucleoproteic material precipitate. A composition of nucleoproteic material produced according to this process. A method for alleviating symptoms of neoplastic diseases which comprises sterilizing the composition of nucleoproteic material, preparing a formulation comprising an effective amount of said sterilized composition, and administering said formulation to a patient having symptoms of a neoplastic disease.Type: GrantFiled: June 13, 1985Date of Patent: October 20, 1987Assignee: Elena AvramInventor: Emanuel Revici
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Patent number: 4675400Abstract: Bifunctional derivatives of a 3-carboxhydrazide of an antineoplastic dimeric indole-dihydroindole alkaloids, useful both in forming conjugates with immunoglobulins and as anti-tumor agents.Type: GrantFiled: June 17, 1985Date of Patent: June 23, 1987Assignee: Eli Lilly and CompanyInventor: George J. Cullinan