Abstract: Compositions and methods for sealing, coating and adhering tissues are provided that utilize a polymeric system comprising at least a Polymer and a crosslinking agent; and, optionally, (i) a Gelation Disrupting Agent, (ii) an Augmentative Polymer or Monomer, (iii) an Adjunct Compound (iv) an Antimicrobial Agent (v) an Adhesion Enhancer, (vi) a Crosslink Augmentating Agent or any combination thereof. Additionally, a Therapeutic Agent may be incorporated.

Abstract: A method for demonstrating the comparative break-though strengths of at least two tissue products is disclosed. The steps include: a) providing a break-through test apparatus b) providing the tissue products; c) observing a first condition of each tissue product; d) disposing a first of the tissue products between a lower platen and an upper platen in a face-to-face-to-face relationship between coextensive apertures disposed within the lower and upper platen; e) providing a simulated mucous composition; f) directing a first portion of the simulated mucous composition toward the first tissue product; g) observing a second condition of the first tissue product; h) disposing a second tissue product between the coextensive apertures; i) directing a second portion of the simulated mucous composition toward the second tissue product; j) observing a second condition of the second tissue product; and, k) comparing the second condition of the first tissue product and the second condition of the second tissue product.

Abstract: A method for testing the break-through strength of a tissue product is disclosed. The method entails the steps of: a) observing a first condition of the tissue product; b) disposing the tissue product between a lower platen and an upper platen; c) disposing at least a portion of the tissue product within an aperture disposed within the lower platen and an aperture disposed within the upper platen; d) providing a simulated mucous composition; e) directing the simulated mucous composition toward the tissue product disposed within the aperture disposed within the lower platen and the aperture disposed within the upper platen; f) after step d), observing a second condition of the tissue product; and, g) comparing the first and the second conditions of the tissue product.

Abstract: Method for treatment of inflammatory and fibrotic conditions in vivo using pure rhUG is disclosed. Method for treating or preventing inflammatory or fibrotic conditions characterized by a deficiency of endogenous functional UG is also disclosed. Compositions containing pure rhUG, optionally also containing lung surfactant, and assay procedures for detection of UG-fibronectin complexes, are also provided.

Abstract: A monoclonal antibody which binds preferentially to colonic glycoproteins of cells of persons having ulcerative colitis, compared to colonic glycoproteins of cells of persons not having ulcerative colitis, and diagnostic and therapeutic uses thereof.

Abstract: A carbohydrate-free polypeptide coded for by a human DNA sequence of 309 nucleotides is immunologically reactive with monoclonal antibody against the human DF3 breast carcinoma-associated antigen. The nucleotide sequence is also useful as a probe to reveal restriction fragment length polymorphisms in human DNA.