Technetium Containing (at. No. 43; Tc) Patents (Class 534/14)
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Patent number: 5783171Abstract: Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies as well as proteinaceous and non-proteinaceous ligands and anti-ligands. The radiolabeled antibodies, ligands or anti-ligands, or catabolites thereof, demonstrate improved biodistribution properties, including reduced localization within the intestines.Type: GrantFiled: March 11, 1996Date of Patent: July 21, 1998Assignee: NeoRx CorporationInventors: Linda M. Gustavson, Sudhakar Kasina, Alan R. Fritzberg
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Patent number: 5780007Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 14, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5780006Abstract: For use in imaging sites of diagnostic interest within the body, the present invention provides radionuclide chelators, optionally coupled to targeting molecules such as peptides of the formula: ##STR1##Type: GrantFiled: August 28, 1996Date of Patent: July 14, 1998Assignee: Resolution Pharmaceuticals Inc.Inventors: Alfred Pollak, Anne Goodbody
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Patent number: 5777087Abstract: The present invention provides novel aryl diphosphines having the formula ##STR1## wherein X, Y, R.sub.1-18, m, m' and n are defined herein, and which can be complexed with a transition metal to form a novel catalyst useful in such applications as hydroformylation.Type: GrantFiled: April 18, 1996Date of Patent: July 7, 1998Assignee: Celanese International CorporationInventors: Christian W. Kohlpaintner, Brian E. Hanson, Hao Ding
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Patent number: 5776428Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 7, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5772981Abstract: A method of radiolabeling a protein with a radionuclide including contacting the protein with a protected tertiary thiol-containing bifunctional chelating agent that is capable of reacting with the protein at one end of the agent and is capable of complexing with a radionuclide at the other end of the agent, to form a protein-acetyl-t-thiol-containing conjugate. The protein-acetyl-t- thiol-containing conjugate then is deprotected and admixed with a reducing agent for the radionuclide, where the radionuclide is added in a subsequent step, to form a mixture of reducing agent and protein-t-thiol-containing conjugate. This mixture then is reacted with a radionuclide whereby the radionuclide reacts with pendant sulfhydryl groups present on the protein-t-thiol-containing conjugate. Methods of radioimmunotherapy and diagnostic kits suitable for forming a composition to be administered to a human patient also are disclosed.Type: GrantFiled: January 8, 1997Date of Patent: June 30, 1998Assignee: Immunomedics, Inc.Inventors: Seregulam V. Govindan, Ruth Grebenau, Gary L. Griffiths, Hans J. Hansen
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Patent number: 5770178Abstract: The invention provides a metal chelate forming peptide having an amino acid sequence of three amino acid residues represented by: X1-X2-Cys, wherein X1 represents an amino acid residue other than Cys residue; X2 represents an amino acid residue other than Cys residue and Pro residue; functional groups at the N-terminus, C-terminus and side chain may be substituted with protecting groups; and each of the amino acid residues may be any of D-form and L-form. Further, the invention provides a complex of the peptide with a physiologically active peptide, protein or other substance; a labeled reagent obtained by labeling the peptide or the complex with a metal radionuclide; and a radiodiagnostic and radiotherapeutic composition comprising the metal radionuclide-labeled reagent.Type: GrantFiled: December 20, 1995Date of Patent: June 23, 1998Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Yoshitoshi Itaya, Ikuya Seki, Koichi Hanaoka, Yoshifumi Shirakami
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Patent number: 5760191Abstract: A metal chelate comprising a compound having the following formula and one or more metal ions which metal ions are a radionucleotide or a paramagnetic metal ion: ##STR1##Type: GrantFiled: February 22, 1995Date of Patent: June 2, 1998Assignee: Nycomed Imaging ASInventors: Robert A. Snow, Daniel J. Delecki, Chandra R. Shah
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Patent number: 5760216Abstract: A method for the systematic and efficient synthetic preparation and identification of metabolites of a pharmaceutical product in order to study possible toxic and/or otherwise biologically-active metabolites of such pharmaceutical products as early and conveniently as possible in the very expensive drug development process, comprising adding samples of the pharmaceutical product to a series of combinations of a synthetic metalloporphyrin (SMP) with a synthetic metalloporphyrin-co-oxidizing reagent in the presence of a suitable solvent, under specified conditions, in a manner such that each sample of pharmaceutical product is reacted with a different combination of synthetic metalloporphyrin, SMP-co-oxidizing reagent and solvent, followed by separation and isolation of the resulting oxidative products, then confirmation of the identity of metabolites from the pre-identified oxidative products by appropriate animal model studies, and subjecting the actual metabolites prepared in larger quantities by the above mType: GrantFiled: September 12, 1995Date of Patent: June 2, 1998Assignee: Abbott LaboratoriesInventors: Mukund S. Chorghade, David H. Dolphin, David R. Hill, Fumio Hino, Elaine C. Lee
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Patent number: 5759518Abstract: The invention relates to new metal complexes of dendrimeric macromolecules that contain 8 to 64 ions of an element of atomic numbers 21-129, 39, 42-44, or 57-83 and a polymeric, complexing ligand of formula IA--(X).sub.b (I)in which A, X and b have different meanings, agents that contain these compounds as well as the use of the latter in diagnosis. The invention further relates to a process for the production of the complexes and agents.Type: GrantFiled: October 3, 1996Date of Patent: June 2, 1998Assignee: Schering AktiengesellschaftInventors: Heribert Schmitt-Willich, Johannes Platzek, Andreas Muhler, Thomas Frenzel
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Patent number: 5756726Abstract: Novel texaphyrin compounds having improved functionalization are described. Metal complexes of these compounds are active as photosensitizers for the generation of singlet oxygen and thus are potentially useful for treatments performed with singlet oxygen. Several of the metallotexaphyrin complexes absorb light in the physiologically important range of 690-880 nm. The complexes form long-lived triplet states and thus may act as efficient photosensitizers for generation of singlet oxygen.Type: GrantFiled: June 6, 1995Date of Patent: May 26, 1998Assignees: Pharmacyclics, Inc., Board of Regents, The University of Texas SystemInventors: Gregory W. Hemmi, Jonathan L. Sessler, Tarak D. Mody
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Patent number: 5756825Abstract: The present disclosure details the preparation of hydroxamic-acid based bifunctional chelators and their use in conjugating metal ions to proteins and nucleic acids for tumor or tissue imaging or therapy purposes. Some preferred aspects of the disclosure involve the preparation of trisuccin, chemical name N-?tris(2-N- benzyloxyaminocarbonylethyl)! methylsuccinamic acid, which is a hydroxamic acid/succinate based structure that is particularly useful for binding radionuclides such as .sup.99m Tc, .sup.186 Re and .sup.67 Cu.Type: GrantFiled: April 16, 1993Date of Patent: May 26, 1998Inventors: Ahmad Safavy, Donald J. Buchsbaum, Mohammad Bagher Kazaeli
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Patent number: 5753206Abstract: Peptide derivatives of leutenizing hormone releasing hormone that are capable of binding radionuclides are provided. The peptide derivatives are readily labeled with isotopes of rhenium or technetium, while retaining their ability to tightly bind LHRH receptors. Methods for preparing the labeled peptides and their use in methods of radiodiagnosis and radiotherapy are described.Type: GrantFiled: June 7, 1995Date of Patent: May 19, 1998Assignee: Immunomedics, Inc.Inventors: William J. McBride, Habibe Karacay, Gary L. Griffiths
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Patent number: 5753205Abstract: A diagnostic composition suitable for administration to a warm-blooded animal comprising somatostatin or a molecule capable of interacting with the somatostatin receptor labeled with a radionuclide by means of a chelate ligand capable of administration to an animal to produce reliable visual imaging of tumors or therapeutic effects on tumors.Type: GrantFiled: January 13, 1995Date of Patent: May 19, 1998Assignee: Mallinckrodt Medical, Inc.Inventors: Leon R. Lyle, Raghavan Rajagopalan, Karen Deutsch
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Patent number: 5753520Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.Type: GrantFiled: February 6, 1995Date of Patent: May 19, 1998Assignee: Johnson Matthey Inc.Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giandomenico, Jon A. Zubieta
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Patent number: 5750660Abstract: Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an antibody, antibody fragment or other biologically active molecule to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes.Type: GrantFiled: July 15, 1996Date of Patent: May 12, 1998Assignee: The Dow Chemical CompanyInventors: Garry E. Kiefer, Jaime Simon, Joseph R. Garlich
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Patent number: 5744120Abstract: This invention provides novel radiopharmaceuticals which are useful as imaging agents for the diagnosis of cardiovascular disorders, infectious disease and cancer. The radiopharmaceuticals are comprised of phosphine or arsine ligated technetium-99m labeled hydrazino or diazino modified biologically active molecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. This invention also provides methods for using the radiopharmaceuticals and kits comprising radiopharmaceutical precursors. The radiopharmaceuticals of this invention have the structure:?(Q).sub.d' L.sub.n --C.sub.h' !.sub.x --M.sub.t (A.sub.L1).sub.y (A.sub.L2).sub.z ;wherein the variables are as defined herein.Type: GrantFiled: April 3, 1995Date of Patent: April 28, 1998Assignee: The DuPont Merick Pharmaceutical CompanyInventors: David Scott Edwards, Shuang Liu
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Patent number: 5741912Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: April 21, 1998Assignee: Bracco International B.V.Inventors: Kondareddiar Ramalingam, Natarajan Raju
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Patent number: 5738838Abstract: Peptides useful for lung imaging, and preferably containing a biological-function domain which includes the sequence Ile-Lys-Val-Ala-Val (IKVAV) (SEQ. ID NO. 1) and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in a variety of diseases and pathologic conditions, and particularly diagnostic imaging of diseases and pathologic conditions of the lung.Type: GrantFiled: December 30, 1992Date of Patent: April 14, 1998Assignee: Rhomed IncorporatedInventor: Paul O. Zamora
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Patent number: 5736122Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides, and methods for using such peptides labeled with technetium-99m via a radiolabel-binding moiety covalently linked to the peptide to image thrombus sites in a mammalian body.Type: GrantFiled: June 7, 1995Date of Patent: April 7, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5736120Abstract: A method for radiolabelling peptides using polyaminocarboxylate ligands having suitable protecting groups such that they can be added to peptides by standard solid phase or solution phase peptide synthetic chemistry and can be deproteced using standard cleavage/deprotection reagents and produce the peptide/chelate conjugate as a high purity monoaddition product is provided. The cleaved and deprotected ligand-peptide molecules can then be labeled with lanthanide or actinide radionuclides. The protected polyaminocarboxylate ligands form mono-anhydrides or mono-active esters under solid phase or solution phase conditions and permit only the desired monoaddition chelate-peptide conjugate to be formed.Type: GrantFiled: June 7, 1996Date of Patent: April 7, 1998Inventor: Ananthachari Srinivasan
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Patent number: 5726304Abstract: Compounds of the formula ##STR1## and the metalated forms and salts thereof; wherein n is an integer of 1-4; andwherein each P.sub.i is independently a pyrrole residue of the formula ##STR2## wherein each R.sub.ia and R.sub.ib is independently a noninterfering substituent, andwherein each Z.sub.i is independently a covalent bond; or isa meso bridging group of the formula ##STR3## or is an N-meso bridging group of the formula.dbd.N--.revreaction.--N.dbd.; or isa CC linkage of the formula ##STR4## or is a CNCCNC linkage of the formula ##STR5## wherein each R.sub.ic, R.sub.id, R.sub.ie, R.sub.if and R.sub.ig is independently a noninterfering substituent; or isa CNC linkage of the formula--CH.dbd.N--CH.dbd..revreaction..dbd.CH--N.dbd.CH--wherein at least one Z.sub.i is said CNC linkage, are disclosed. These compounds are useful in photodynamic therapy and diagnosis. The metalated forms when the metal is paramagnetic are useful as MRI contrast agents.Type: GrantFiled: April 26, 1994Date of Patent: March 10, 1998Assignee: The University of British ColumbiaInventors: Hang Tang, Lily Y. Xie, Tilak Wijesekera, David Dolphin, Ross W. Boyle
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Patent number: 5716594Abstract: Novel biotin amide analogs that are useful for targeting therapeutic and imaging agents to sites of infection and tumors in vivo are disclosed.Type: GrantFiled: October 2, 1996Date of Patent: February 10, 1998Assignee: The JMDE TrustInventors: David R. Elmaleh, Alan J. Fischman, Timothy M. Shoup, John W. Babich
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Patent number: 5714579Abstract: This invention relates to compositions that are radiolabeled scintigraphic imaging agents, comprising a polybasic compound covalently linked to a radiolabel binding moiety and the composition further comprising a polysulfated glycan. The invention also provides methods for producing and using such compositions. Specifically, the invention relates to compositions comprised of technetium-99m (Tc-99m) labeled scintigraphic imaging agents comprising a polybasic compound having at least 5 chemical functionalities that are basic at physiological pH and a radiolabel-binding moiety, the composition further comprising a polysulfated glycan, the composition being capable of specifically binding to inflammatory sites in vivo. Methods and kits for making such compositions, and methods for using such compositions to image sites of infection and inflammation in a mammalian body, are also provided.Type: GrantFiled: June 5, 1995Date of Patent: February 3, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Brian R. Moyer
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Patent number: 5711931Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.Type: GrantFiled: June 7, 1995Date of Patent: January 27, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram
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Patent number: 5707603Abstract: The invention provides targeting radioactive immunoreagents comprising a metal radionuclide ion, a complexing agent having structure A-I, as defined in the specification, and an immunoreactive group covalently bonded to the complexing agent. The present invention also provides novel complexing agents having the structure A-I, as defined in the specification. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.Type: GrantFiled: January 19, 1995Date of Patent: January 13, 1998Assignee: Nycomed Imaging ASInventors: John L. Toner, David A. Hilborn, Bruce J. Murray, Timothy Z. Hossain, Robert A. Snow, Ashis K. Saha, Richard Philion, Clyde W. Shearman, Chandra Shah
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Dimeric DTPA derivatives, their metal complexes and pharmaceutical agents containing these complexes
Patent number: 5695737Abstract: The invention relates to new dimeric DTPA derivatives, their metal complexes, containing at least one ion of an element of atomic numbers 21-32, 37-39, 42-51 and 57-83, agents containing these complexes, their use in NMR diagnosis and/or diagnostic radiology, radiodiagnosis and radiotherapy, as well as process for their production.Type: GrantFiled: June 7, 1995Date of Patent: December 9, 1997Assignee: Schering AktiengesellschaftInventors: Werner Krause, Franz Karl Maier, Michael Bauer, Gabriele Schuhmann-Giampieri, Wolf Press, Johannes Platzek, Heribert Schmitt-Willich -
Patent number: 5693324Abstract: Tris(isonitrile) copper(I) sulfate complexes and their use in synthetic methods for making radionuclide isonitrile coordination complexes such as ?.sup.99m Tc(1-isocyano-2-methoxy-2-methylpropane).sub.6 !.sup.+. The coordination complexes are useful as radiopharmaceutical imaging agents.Type: GrantFiled: February 21, 1995Date of Patent: December 2, 1997Assignee: The DuPont Merck Pharmaceutical CompanyInventor: David Scott Edwards
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Patent number: 5690904Abstract: Tetradentate ligands are used to form neutral 99m-technetium complexes which may be useful as radiopharmaceuticals e.g. as brain imaging agents. The ligands have the structure ##STR1## where n is 2 or 3, m is 0-4, R is H or substituted or unsubstituted C.sub.1 -C.sub.6 alkyl, provided that one CR.sub.2 group adjacent the starred nitrogen atom represents CO and forms with the adjacent N atom, a --CONH-- amide group,Y is unsubstituted or substituted C.sub.1 -C.sub.6 alkyl, and one of X and X' represents H or a labile thiol protecting group while the other is unsubstituted or substituted C.sub.1 -C.sub.6 alkyl, alkenyl or alkynyl.Type: GrantFiled: April 28, 1995Date of Patent: November 25, 1997Assignee: Amersham International plcInventors: Susan E. MacWhorter, Tiann-long Wu, Douglas S. White
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Patent number: 5688485Abstract: This invention relates to compounds and methods for use in determining renal function by means of scintigraphic urography. More specifically, this invention relates to radionuclide complexes of ester-substituted diaminethiols, radiopharmaceutical compositions comprising said complexes, kits for the preparation of said compositions, and a method of using said compositions for examining renal function. Compounds of this invention have the formula: ##STR1## wherein the various groups are as defined herein.Type: GrantFiled: December 31, 1992Date of Patent: November 18, 1997Assignee: The DuPont Merck Pharmaceutical CompanyInventor: Thomas David Harris
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Patent number: 5688489Abstract: Detectably labelled non-receptor mediated cell-associating compounds are provided for use in the diagnostic imaging of target sites in a mammal. Cell-associating compounds may be directly labelled, or labelled via a chelating compound to form a conjugate. Such cell-associating compounds are particularly useful to image target sites such as tumour sites and sites of infection.Type: GrantFiled: September 15, 1995Date of Patent: November 18, 1997Assignee: Resolution Pharmaceuticals, Inc.Inventors: Susan H. Peers, Anne Goodbody, Alfred Pollak, John Thornback
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Patent number: 5684137Abstract: Novel chelating compounds and the corresponding radionuclide metal chelates are useful for radiolabeling proteins such as antibodies, ligands such as biotin and anti-ligands such as streptavidin with radionuclide metals such as .sup.99m Tc, .sup.186 Re, and .sup.188 Re. The radiolabeled proteins, ligands and anti-ligands have diagnostic or therapeutic use, depending on the radionuclide metal chosen.Type: GrantFiled: February 22, 1995Date of Patent: November 4, 1997Assignee: NeoRx CorporationInventors: Sudhakar Kasina, Linda M. Gustavson
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Patent number: 5681974Abstract: Mo adsorbent for .sup.99 Mo-.sup.99m Tc generators has a skeleton structure having mainly repeating units represented by the general formula; ##STR1## wherein X is a halogen atom or alkoxide group having one to six carbon atoms, 10% or more of X is halogen, R is an alkylene, polymethylene, or carbon chain having unsaturated bond, repeating unit (D) is bonded to any one of repeating units (A), (B), and (C), the branch structure is controlled by the content of repeating units (A), (B), and (C), the adsorbent is insoluble in water and adsorbs selectively only Mo from an aqueous solution containing Mo, and elutes .sup.99m Tc generated from a radioactive isotope .sup.99 Mo. This Mo adsorbent uses .sup.99 Mo obtained from natural Mo by (n, .gamma.) method, therefore, a generator having the same size as conventional .sup.99m Tc generators is realized.Type: GrantFiled: May 20, 1996Date of Patent: October 28, 1997Assignees: Kaken Co., Ltd., Japan Atomic Energy Research InstituteInventors: Yoshio Hasegawa, Mizuka Nishino, Taketoshi Takeuchi, Katsuyoshi Tatenuma, Masakazu Tanase, Kiyoyuki Kurosawa
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Patent number: 5679778Abstract: A compound of formula I ##STR1## in which E is an alkenyl group or represents H.sub.2 in which case the compound is in acid addition salt form, J is selected from --CO--NH--, --CO--O--, --CO--S-- and --NH--CO--, T is an alkylene chain, or, if J is --CO--NH--, T is the residue of an amino acid moiety, Q is a hydrophilic or cleavable moiety, and Z is an amine- and/or thiol-reactive moiety. Conjugates formed by reacting such compound with a macromolecule, e.g. an immunoglobulin, and labelled macromolecules comprising a metal atom bound to such conjugate are also disclosed.Type: GrantFiled: June 30, 1995Date of Patent: October 21, 1997Assignee: Johnson Matthey Public Limited CompanyInventors: Michael J. Abrams, Gary J. Bridger, David A. Schwartz, Sreenivasan Padmanabhan, Michael E. Ultee
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Patent number: 5676923Abstract: Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.Type: GrantFiled: June 7, 1995Date of Patent: October 14, 1997Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Ulrich Niedballa, Peter Mareski, Bernd Raduchel, Hanns-Joachim Weinmann, Andreas Muhler, Bernd Misselwitz
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Patent number: 5670132Abstract: PEG-modified-Tc-99m-radiolabeled antibody fragments are useful for radioimmunodetection of tumors and infectious lesions and display striking reductions in renal uptake and retention of radioisotope compared to non-PEG-modified fragments.Type: GrantFiled: September 20, 1994Date of Patent: September 23, 1997Assignee: Immunomedics, Inc.Inventors: Gary L. Griffiths, Hans J. Hansen, Habibe Karacay
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Patent number: 5663307Abstract: Novel compounds of the formula ##STR1## where G.sup.1 and G.sup.2 are each independently --OH or --N(R.sup.2).sub.2, provided that at least one of G.sup.1 and G.sup.2 is --N(R.sup.2).sub.2, where each R.sup.2 is independently hydrogen, alkyl, aryl, acyl or --(A).sub.p --R.sup.a and the other variables are as defined in the specification and claims, and novel complexes of these compounds with metals are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: September 2, 1997Assignee: Bracco International B.V.Inventors: David P. Nowotnik, Palaniappa Nanjappan
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Patent number: 5662885Abstract: For use in imaging sites of diagnostic interest within the body, the present invention provides radionuclide chelators, optionally coupled to targeting molecules such as peptides of the formula: ##STR1##Type: GrantFiled: July 22, 1994Date of Patent: September 2, 1997Assignee: Resolution Pharmaceuticals Inc.Inventors: Alfred Pollak, Anne Goodbody
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Patent number: 5660811Abstract: An isotopic tracer composition and methods of making and using same for radiological evaluation of body functions and diseases in a subject and for radiological therapy. The isotopic tracer composition comprises a protein carrier agent such as fibrinogen, antibodies, enzymes or portions thereof, bound to a radioisotope which has been reduced to a lower oxidation state by stannous phosphate at a pH of greater than 7. Some suitable radioisotopes are isotopes of technetium, rhenium and ruthenium.Type: GrantFiled: May 30, 1995Date of Patent: August 26, 1997Assignee: The Board of Regents of the University of OklahomaInventor: Stanley L. Mills
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Patent number: 5659041Abstract: Radionuclide chelating compounds are provided for conjugation to targeting molecules such as proteins, peptides or antibodies. The resulting labeled targeting molecules may be used in diagnosis and therapy.Type: GrantFiled: September 2, 1994Date of Patent: August 19, 1997Assignee: Resolution Pharmaceuticals, Inc.Inventors: Alfred Pollak, Robert A. Kirby, Robert Dunn-Dufault
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Patent number: 5653958Abstract: The present invention relates particularly to novel imidazole based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: April 10, 1995Date of Patent: August 5, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Raghavan Rajagopalan, Ananthachari Srinivasan
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Patent number: 5650134Abstract: Somatostatin peptides bearing a chelating group selected from a bifunctional N.sub.4 -chelating group particularly suitable for Tc, Rh, Cu, Co or Re-labelling, and a bifunctional polyamino-polycarboxylic acid chelating group are complexed with a .alpha.-, .beta.-, .gamma.- or positron-emitting nuclide or a nuclide with Auger-e.sup.- -cascades and are useful as radiopharmaceuticals.Type: GrantFiled: July 12, 1995Date of Patent: July 22, 1997Assignee: Novartis AG (formerly Sandoz Ltd.)Inventors: Rainer Albert, Helmut Macke
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Patent number: 5648060Abstract: The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: May 26, 1995Date of Patent: July 15, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Raghavan Rajagopalan, William L. Neumann, Dennis L. Nosco
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Patent number: 5645815Abstract: This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.Type: GrantFiled: May 12, 1995Date of Patent: July 8, 1997Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James, Edgar R. Civitello
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Patent number: 5645814Abstract: The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: April 18, 1994Date of Patent: July 8, 1997Assignee: Mallinckrodt Medical, Inc.,Inventors: Steven R. Woulfe, Raghavan Rajagopalan
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Patent number: 5639879Abstract: A simple method for the synthesis of 1,4,7, 10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7, 10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.Type: GrantFiled: February 2, 1995Date of Patent: June 17, 1997Assignee: Associated Universities, Inc.Inventors: Ronnie C. Mease, Leonard F. Mausner, Suresh C. Srivastava
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Patent number: 5635157Abstract: Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.Type: GrantFiled: October 6, 1993Date of Patent: June 3, 1997Inventors: Ronnie C. Mease, Kathryn L. Kolsky, Leonard F. Mausner, Suresh C. Srivastava
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Patent number: 5635158Abstract: The peptides described are modified with the phosphine group and are useful for marking with .sup.99m Tc and .sup.186-188 Re or paramagnetic agents for use in diagnosis and radiotherapy; in particular chelating compounds having the co-ordinating sets PN.sub.2 X, where X is --S, --O, COO--, PN.sub.3, P.sub.2 N.sub.3 and P.sub.2 N.sub.2 are described.Type: GrantFiled: June 23, 1995Date of Patent: June 3, 1997Assignee: Sorin Radiofarmaci SRLInventors: Ulderico Mazzi, Fabio Lunghi
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Patent number: 5632969Abstract: Novel N.sub.3 S.sub.2 chelating ligands can be chelated to a radiodetectable element, Tc or Re, and are useful for radiolabeling peptides. A group of peptides especially useful are somatostatin derivatives which are valuable of the selective detection or treatment of tumors with somatostatin receptors.Type: GrantFiled: October 13, 1994Date of Patent: May 27, 1997Assignee: Merck & Co., Inc.Inventors: Richard J. Flanagan, Jean-Marc Dufour, Keith T. Hogan
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Patent number: 5627286Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: May 6, 1997Assignee: Bracco International B.V.Inventors: Kondareddiar Ramalingam, Natarajan Raju