Rare Earth Containing (at. No. 21, 39, 57-60 Or 62-71) Patents (Class 534/15)
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Patent number: 7060636Abstract: The present invention is directed toward a tunable dielectric device comprising: a substrate and an endohedral fullerene encapsulating trimetallic nitride template compound disposed on the substrate. The endohedral fullerene encapsulating trimetallic nitride template compound has a dipole moment that is oriented when a voltage of less than about 5 volts is applied thereto causing a change in the orientation of the dipole moment of the compound. The physical dimension of the compound is essentially unchanged.Type: GrantFiled: October 7, 2004Date of Patent: June 13, 2006Assignee: Luna Innovations IncorporatedInventors: Janice P. Phillips, Bryan E. Koene, Steven A. Stevenson, Daniela M. Topasna, Martin E. Rogers
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Patent number: 7052541Abstract: The present invention includes a paint or coating composition comprising an organic pigment or dye complexed to the surface of a layered or fibrous inorganic clay. A wide variety of paint colors can be obtained by varying the pH during the preparation as well as by varying the synthesis conditions and changing particle size of the clay. The paint has unprecedented stability.Type: GrantFiled: February 18, 2003Date of Patent: May 30, 2006Assignee: Board of Regents, The University of Texas SystemInventors: Russell Chianelli, Lori A. Polette
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Patent number: 7053210Abstract: A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1?-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, with a base, followed by heating to give pyropheophorbide a, which is converted to HPPH by treatment with acid, followed by hexyl alcohol under basic conditions.Type: GrantFiled: July 2, 2003Date of Patent: May 30, 2006Assignee: Health Research, Inc.Inventors: Ravindra K. Pandey, Thomas J. Dougherty, Alexander J. Pallenberg
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Patent number: 7045116Abstract: This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharmaceuticals to the site of osteomyelitis.Type: GrantFiled: December 11, 2002Date of Patent: May 16, 2006Assignee: Dow Global Technologies Inc.Inventors: Dana W. Simon, Alan D. Strickland, Jaime Simon, Daniel J. Macey, R. Keith Frank, Kenneth McMillan
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Patent number: 7038041Abstract: An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti estrogen portion, tether or linker portion and a porphyrin portion. The method of invention exploits an active process that involves strong and specific interactions between nuclear receptor and its cognate ligand.Type: GrantFiled: April 12, 2001Date of Patent: May 2, 2006Assignee: The Trustees of Boston UniversityInventors: Rahul Ray, Scott C. Mohr, Narasimha Swamy
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Patent number: 7034149Abstract: The present invention relates to a cyan dye mixture, an ink composition containing the mixture and a method of ink-jet recording with the ink composition. The print obtained by the method is characterized by discoloring or fading little even when allowed to stand in a well ventilated shade or in an ozone gas. The cyan dye mixture comprises compounds which are obtained by chlorosulfonating, as a starting material, copper phthalocyanine or a sulfonated copper phthalocyanine and then aminating the chlorosulfonation product with an aminating agent used in an amount of at least 2.5 mol per mol of the starting material, and which are represented by the following formula (1): wherein M represents a proton, alkali metal ion, alkaline earth metal ion, onium ion of an organic amine, or ammonium ion; m is an integer of 1 to 4; and n is an integer of 0 to 3; provided that m+n is an integer of 1 to 4.Type: GrantFiled: July 25, 2001Date of Patent: April 25, 2006Assignee: Nippon Kayaku Kabushiki KaishaInventors: Kitayama Hirokazu, Shinichi Namba, Takafumi Fujii, Junji Otani, Junko Yoshioka, Yasuo Shirasaki
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Patent number: 7030105Abstract: The invention provides a method for preparing glutathionylcobalamin (GluSCbl) which involves running the reaction in an aqueous solvent with a relatively small excess of glutathione, i.e. GluSH, specifically from one to less than four molar equivalents of GluSH. The formed GluSCbl is precipitated from the aqueous solvent, preferably by the addition of a precipitate inducing solvent. This provides GluSCbl in acceptable purity without the need for an additional chromatographic purification step. Additionally, it has been found that the reaction can be run to an acceptable level of purity by using very high concentrations of the reactants, i.e. around saturation concentrations for aquocobalamin. This has the advantage of eliminating the need for air-free conditions.Type: GrantFiled: May 6, 2003Date of Patent: April 18, 2006Assignee: Kent State UniversityInventors: Nicola E. Brasch, Ling Xia
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Patent number: 7026347Abstract: Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conjugate compounds are also disclosed.Type: GrantFiled: June 24, 2003Date of Patent: April 11, 2006Assignee: CellGate, Inc.Inventors: Benjamin Frydman, Aldonia L. Valasinas, Venodhar K. Reddy, Hirak S. Basu, Aparajita Sarkar, Subhra Bhattacharya, Yu Wang, Laurence J. Marton, Andrei V. Blokhin
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Patent number: 7022840Abstract: A porphyrin array exhibiting a large two-photon absorption property, and being linked with an acetylenic bond(s), represented by the following formulas: wherein R1 represents an alkyl or aryl group, M1 represents a metal ion capable of serving as a core metal and forming a coordinate bond with Im, M2 represents two protons or a metal ion incapable of forming a coordinate bond with Im, R2 and R3 represent a group selected from a porphyrin residue or porphyrin metal complex residue, a cyclic diimide residue, a dialkylviologen residue, a benzoquinone residue, an N-methylpyrrolidine-fullerene derivative residue and a ferrocene residue, Im is represented by Im1 or Im2: (R8 represents methyl or H), L1 represents —(—C?C—)m— (m=1 to 3); n represents an integer of 1 or more; R9 represents one of R1, R2, R3 and Im.Type: GrantFiled: November 19, 2003Date of Patent: April 4, 2006Assignee: Nara Institute of Science and TechnologyInventors: Yoshiaki Kobuke, Kazuya Ogawa
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Patent number: 7019132Abstract: The present invention is related to novel photopyrin compounds and the pharmaceutically acceptable salt thereof useful as an anticancer or photodynamic diagnostic agent by way of reproducing singlet state oxygen radical and the inventive compounds have superior advantages such as excellent photon yield to produce singlet oxygen, good physical stability and potent cell cytotoxicity to conventional photosensitizer. The present invention also provides a pharmaceutical composition comprising a novel photopyrin compound of formula (I) to (VII) or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating various cancers such as stomach cancer, liver cancer, lung cancer, cervical cancer and breast cancer in human or mammal together with a pharmaceutically acceptable carrier.Type: GrantFiled: November 20, 2003Date of Patent: March 28, 2006Assignee: Kostarworld Co., Ltd.Inventors: Nam-Tae Woo, Min-Suk Kang, Won-Young Lee, Chang-Hee Lee, Yong-Rok Kim, Dai-Woon Lee, Dong-Hoon Won, Si-Hwan Ko
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Patent number: 7018851Abstract: This invention relates to a luminescent lanthanide chelate comprising a lanthanide ion and a chelating ligand of formula (I) wherein R1 is selected from the group consisting H, —COOH, —COO?, —CH2COOH and —CH2COO?; G1 is a group consisting of one or two moieties each moiety being selected from the group consisting of ethynediyl, ethenylene, phenylene, biphenylene, naphthylene, pyridylene, pyrazinylene, pyrimidinylene, pyridazinylene, furylene, thienylene, pyrrolylene, imidazolylene, pyrazolylene, thiazolylene, isothiazolylene, oxazolylene, isoxazolylene, fyrazanylene, 1,2,4-triazol-3,5-ylene and oxadiazolylene; G2 for coupling to a biospecific binding reactant is selected from the group consisting of amino, aminooxy, carbonyl, aldehyde or mercapto groups and activated forms made of them; Z is selected from the group consisting of carboxyalkyl amine, ether, thioether, carbonyl and unsubstituted or substitute methyl (—CR2—) wherein group R2 is selected from the group consisting of H, methyl, ethyl and carboType: GrantFiled: February 13, 2003Date of Patent: March 28, 2006Assignee: Innotrac Diagnostics OyInventors: Harri Takalo, Jaana Rosenberg
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Patent number: 7012140Abstract: The present invention is directed, in general, to a contrast agent comprising a tetraazacyclododecane ligand and comprising a macrocyclic ring and a paramagnetic metal ion coordinated to the tetraazacyclododecane ligand. Pendent arms R, R?, R? and R?? attached to a ring nitrogen. The pendent arms have the general formula: ?C?HR1R2 and for three or more of the pendant arms a chirality of the carbon atoms C? are identical for each of three or more of the pendant arms. The R1 group is larger than hydrogen and R2 is selected from the group consisting of: an alcohol, amides, a carboxylate, phosphinates and a phosphonate. One or more substituents R6 is a group larger than a methyl group and is located on one or more ring carbons.Type: GrantFiled: July 14, 2003Date of Patent: March 14, 2006Assignees: Board of Regents, The University of Texas System, MacrocyclicsInventors: A. Dean Sherry, Mark Woods, Zoltan Kovacs
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Patent number: 7008742Abstract: A process for forming a cocrystalline mixture of titanyl phthalocyanine (TiOPc) and titanyl fluorophthalocyanine (TiOFPc) includes: dry milling a mixture of crude TiOPc and crude TiOFPc, thereby forming an amorphous pigment mixture of TiOPc and TiOFPc; and heating the amorphous pigment mixture at a temperature effective to form a cocrystalline composition comprising titanyl phthalocyanine (TiOPc) and titanyl fluorophthalocyanine (TiOFPc), the cocrystalline composition being characterized by an X-ray diffraction spectrum exhibiting intensity peaks at 7.2°, 12.9°, 16.3°, 22.3°, 24.6°, 26.2°, and 28.8° with respect to X-rays of Cu K?at a wavelength of 1.54 1 ? of the Bragg angle 2?.Type: GrantFiled: December 21, 2004Date of Patent: March 7, 2006Assignee: Eastman Kodak CompanyInventor: Michel F. Molaire
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Patent number: 7008937Abstract: The present invention provides a class of porphyrins and metal chelated porphyrins for use as inhibitors of heme iron uptake. The porphyrin/metal chelated porphyrin molecules of the invention are tetra-positively charged porphyrins based on meso-tetra(4-pyridyl)porphines. Several such agents are shown herein to cause inhibition of iron uptake in vivo and in vitro. The invention further provides therapeutic compositions including the porphyrins and/or metalloporphyrins of the invention. In addition, methods of inhibition of heme iron uptake in vivo are taught, as well as methods of treatment of diseases characterized by iron-overload. These methods include the administration of a porphyrin or metalloporphyrin in a therapeutic composition of the invention to prevent uptake of heme iron, thus preventing replenishment of a patient's iron stores.Type: GrantFiled: June 3, 2004Date of Patent: March 7, 2006Assignee: Frontier Scientific, Inc.Inventor: Jerry C. Bommer
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Patent number: 7005392Abstract: A CVD Method of forming gate dielectric thin films on a substrate using metalloamide compounds of the formula M(NR1R2)x, wherein M is selected from the group consisting of: Zr, Hf, Y, La, Lanthanide series elements, Ta, Ti, Al; N is nitrogen; each of R1 and R2 is same or different and is independently selected from the group consisting of H, aryl, perfluoroaryl, C1–C8 alkyl, C1–C8 perfluoroalkyl, alkylsilyl and x is the oxidation state on metal M; and an aminosilane compound of the formula HxSi(NR1R2)4-x, wherein H is hydrogen; x is from 0 to 3; Si is silicon; N is nitrogen; each of R1 and R2 is same or different and is independently selected from the group consisting of H, aryl, perfluoroaryl, C1–C8 alkyl, and C1–C8 perfluoroalkyl. By comparison with the standard SiO2 gate dielectric materials, these gate dielectric materials provide low levels of carbon and halide impurity.Type: GrantFiled: March 30, 2001Date of Patent: February 28, 2006Assignee: Advanced Technology Materials, Inc.Inventors: Thomas H. Baum, Chongying Xu, Bryan C. Hendrix, Jeffrey F. Roeder
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Patent number: 7005519Abstract: This invention relates to a method of preparing a compound of formula (I): The method includes reacting one or more compounds of formula (II): in the presence of a base and a halogenating agent. In formulas (I) and (II) above, each A, independently, is aryl or heteroaryl; each n, independently, is 0–3; and each R1, independently, is C1–C10 alkyl, C3–C20 cycloalkyl, C3–C20 heterocycloalkyl, aryl, heteroaryl, halo, cyano, nitro, ORa, NRaRb, SiRaRbRc, COORa, OC(O)Ra, C(O)NRaRb, N(Ra)—C(O)Rb, or SO3Ra; wherein each of Ra, Rb, and Rc, independently, is H, C1–C10 alkyl, C3–C20 cycloalkyl, C3–C20 heterocycloalkyl, aryl, or heteroaryl; thereby producing the compound of formula (I) in a one-pot reaction. This invention also relates to the compounds prepared by the method described above.Type: GrantFiled: August 18, 2004Date of Patent: February 28, 2006Assignee: Academia SinicaInventors: Chin-Ti Chen, Hsiu-Chih Yeh
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Patent number: 7005518Abstract: Fluorescent dyes are disclosed which are useful as reporter groups for labeling biomolecules. The silicon phthalocyanine dyes disclosed are preferably water soluble, isomericly pure, possess high quantum yield, and are useful in bioassays.Type: GrantFiled: October 23, 2003Date of Patent: February 28, 2006Assignee: Li-Cor, Inc.Inventors: Xinzhan Peng, Daniel R. Draney, Jiyan Chen
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Patent number: 7002031Abstract: A process for obtaining silicon-bridged metallocene compounds comprising the following steps: a) reacting, at a temperature of between ?10° C. and 70° C., the starting ligand with about 2 molar equivalents of an alkylating agent; b) after the reaction has been completed, adding at least 2 molar equivalents of an alkylating agent that can be also different from the first one; and c) reacting, at a temperature of between ?10° C. and 70° C., the product obtained from step b) with at least 1 molar equivalent of a compound of formula ML?s, wherein M is a transition metal; s is an integer corresponding to the oxidation state of the metal; and L? is an halogen atom selected from chlorine, bromine and iodine.Type: GrantFiled: December 30, 2002Date of Patent: February 21, 2006Assignee: Basell Polyolefine GmbHInventors: Luigi Resconi, Simona Guidotti, Davide Balboni
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Patent number: 7001588Abstract: Expanded porphyrin comprising substitutions for at least two NH groups by S, Se or Te are non-photoactive and are selective for binding G-quadruplexes characteristic of the c-MYC control region. Accordingly, these expanded porphyrins are useful to modulate the expression of genes controlled by the formation of c-MYC type G-quadruplexes, such as c-MYC itself.Type: GrantFiled: September 12, 2003Date of Patent: February 21, 2006Assignee: Cylene PharmaceuticalsInventor: Laurence H. Hurley
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Patent number: 6998497Abstract: A metal bis-triflimide compound having the formula: [Mx]n+[(N(SO2CF3)2)(nx?yz)](nx?yz)?[Ly]z? where M is a metal selected from the metals in groups 5 to 10, 12 and 14 to 16 and Cu, Au, Ca, Sr, Ba, Ra, Y, La, Ac, Hf, Rf, Ga, In, Tl, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Lu and the actinides; L is a negative or neutral ligand; n is 2,3,4,5,6,7 or 8; x is greater than or equal to 1 y is 0,1,2,3,4,5,6,7 or 8; and z is 0,1,2,3 or 4.Type: GrantFiled: March 12, 2002Date of Patent: February 14, 2006Assignee: The Queen's University of BelfastInventors: Martyn J. Earle, Barry Joseph Mcauley, Alwar Ramani, Kenneth Richard Seddon, Jillian M. Thomson
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Patent number: 6995260Abstract: The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.Type: GrantFiled: May 20, 2004Date of Patent: February 7, 2006Assignee: Brookhaven Science Associates, LLCInventors: Haitao Wu, Michiko Miura
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Patent number: 6989443Abstract: The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head, neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.Type: GrantFiled: June 28, 2004Date of Patent: January 24, 2006Assignee: Brookhaven Science Associates, LLCInventors: Haitao Wu, Michiko Miura
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Patent number: 6984722Abstract: A cationic Group 3 or Lanthanide metal complex for coordination polymerization of olefins is disclosed. The precursor metal complex is stabilized by a monoanionic bidentate ancillary ligand and two monoanionic ligands. The ancillary ligand and the transition metal form a metallocycle having at least five primary atoms, counting any ?-bound cyclopentadienyl group in the metallocycle as two primary atoms. Olefin polymerization is exemplified.Type: GrantFiled: November 29, 2001Date of Patent: January 10, 2006Assignee: ExxonMobil Chemical Patents Inc.Inventors: Joseph N Christopher, Kevin R. Squire, Jo Ann M. Canich, Timothy D. Shaffer
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Patent number: 6984743Abstract: The present invention relates to a process for preparing a metallocene, which comprises reacting a ligand starting compound with an adduct of the formula (I), M1XnDa ??(I) where M1 is a metal of group III, IV, V or VI of the Periodic Table of the Elements or an element of the lanthanide or actinide series, preferably titanium, zirconium or hafnium, particularly preferably zirconium, X are identical or different and are each halogen, C1–C10-alkoxy, C6–C10-aryloxy, C1–C10-alkylsulfonate such as mesylate, triflate, nonaflate, C6–C10-arylsulfonate such as tosylate, benzenesulfonate, C1–C10-alkylcarboxylate such as acetate, formate, oxalate or 1,3-dicarbonylate such as acetylacetonate or fluorinated 1,3-dicarbonylate, in particular chlorine, bromine, particularly preferably chlorine, n is an integer and is 2,3,4,5 or 6 and corresponds to the oxidation number of the metal M1, a is an integer or fraction and 0<a?4 and a is preferably in the range from 0.5 to 2.5 and is in particular 1, 1.Type: GrantFiled: September 3, 1998Date of Patent: January 10, 2006Assignee: Basell Polyolefine GmbHInventors: Carsten Bingel, Berthold Schiemenz, Markus Göres
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Patent number: 6984602Abstract: Polydentate substituted pyrrole based chelants, metal complexes containing the same, olefin polymerization catalyst compositions, and polymerization processes using the same.Type: GrantFiled: April 25, 2002Date of Patent: January 10, 2006Assignee: Univation Technologies, LLCInventors: Jessica Cook, Inna Shulman, John Joseph Bielak
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Patent number: 6982324Abstract: Novel degradable macromolecular magnetic resonance imaging contrast agents for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are disclosed. The macromolecule contrast agents disclosed in various aspects of this invention are degradable gadolinium compounds which show prolonged plasma retention, and enhanced permeability and retention in solid tumors, but are still capable of being rapidly cleared from the body.Type: GrantFiled: November 5, 2002Date of Patent: January 3, 2006Assignee: University of Utah Research FoundationInventors: Zheng-Rong Lu, Jindrich Kopecek, Dennis L. Parker
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Patent number: 6969765Abstract: The invention relates to medicine and concerns a photosensitizer for detecting and curing tumors. The inventive photosensitizer is embodied in the form of a composition containing chlorin in the form of salt and alkali metals. The chlorin is composed of 80-90% of chlorin e6, 5-20 of purpurin 5 and the rest being purpurin 18 -chlorin p6. Said photosensitizer is produced by extracting Spirulina biomass with the aid of acetone. Afterwards said biomass is exposed to acid treatment, neutralization, hydrolysis, extraction of pheophorbide a, dissolution in acetone, addition of a strong base, neutralization and reprecipitation of chlorin e6.Type: GrantFiled: October 4, 2001Date of Patent: November 29, 2005Assignee: Obschestvo s Ogranichennoi Otvetstvennostiju “Rada-Pharma”Inventors: Andrei Valentinovich Reshetnikov, Igor Dmitrievich Zalevsky, Jury Viktorovich Kemov, Andrei Valentinovich Ivanov, Artashes Vacheevich Karmenyan, Alexandr Tikhonovich Gradjushko, Vladimir Petrovich Laptev, Nataliya Petrovna Neugodova, Olga Yurievna Abakumova, Valery Alexeevich Privalov, Alexandr Vladimirovich Lappa, Vladimir Alexandrovich Romanov
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Patent number: 6951640Abstract: The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.Type: GrantFiled: February 27, 2003Date of Patent: October 4, 2005Assignee: Brookhaven Science Associates, LLCInventors: Michiko Miura, Daniel N. Slatkin
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Patent number: 6936700Abstract: The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds.Type: GrantFiled: January 17, 2003Date of Patent: August 30, 2005Assignee: NeoRx CorporationInventor: Sudhakar Kasina
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Patent number: 6930193Abstract: An isoreticular metal-organic framework (IRMOF) and method for systematically forming the same. The method comprises the steps of dissolving at least one source of metal cations and at least one organic linking compound in a solvent to form a solution; and crystallizing the solution under predetermined conditions to form a predetermined IRMOF. At least one of functionality, dimension, pore size and free volume of the IRMOF is substantially determined by the organic linking compound.Type: GrantFiled: April 30, 2002Date of Patent: August 16, 2005Assignee: The Regents of the University of MichiganInventors: Omar M. Yaghi, Mohamed Eddaoudi, Hailian Li, Jaheon Kim, Nathaniel Rosi
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Patent number: 6930177Abstract: The invention provides true La(OiPr)3 preferable as a starting material for an asymmetric synthesis catalyst and a process for producing the same. In this process, anhydrous lanthanum chloride LaCl3 is reacted with potassium isopropoxide K(OiPr) in a mixed solvent of isopropanol and toluene, then the isopropanol is distilled away to replace all the solvent by toluene, then the reaction solution is left, decanted and filtered to give a transparent filtrate, and the solvent is distilled away from the filtrate which is then vacuum-dried under heating, whereby high-purity La(OiPr)3 is obtained in 77% yield. In this high-purity La(OiPr)3, the La content is 97 to 103% of the theoretical content, impurity K is 0.3% or less, (Li+Na) is 0.01% or less, Cl is 0.2% or less, and the degree of association thereof is 5.5 to 6.5.Type: GrantFiled: August 7, 2002Date of Patent: August 16, 2005Assignee: Kabushikikaisha Kojundokagaku KenkyushoInventors: Hidekimi Kadokura, Masamichi Matsumoto, Tadashi Ishii, Yumie Okuhara, Yoshinori Kuboshima, Hiroshi Matsumoto
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Patent number: 6919327Abstract: Novel coordination polymers, their pharmaceutical formulations, useful for treating atheroma, tumors and other neoplastic tissue, as well as other conditions that are responsive to the induction of targeted oxidative stress, are disclosed.Type: GrantFiled: November 16, 2001Date of Patent: July 19, 2005Assignee: Pharmacyclics, Inc.Inventors: Darren Magda, Dale Miles, Nikolay Gerasimchuk, Cheryl Lepp
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Patent number: 6869638Abstract: A CVD Method of forming gate dielectric thin films on a substrate using metalloamide compounds of the formula M(NR1R2)x, or wherein M is Zr, Hf, Y, La, Lanthanide series elements, Ta, Ti, or Al; N is nitrogen; each of R1 and R2 is same or different and is independently selected from H, aryl, perfluoroaryl, C1-C8 alkyl, C1-C8 perfluoroalkyl, alkylsilyl; and x is the oxidation state on metal M; and an aminosilane compound of the formula HxSiAy(NR1R2)4-x-y or wherein H is hydrogen; x is from 0 to 3; Si is silicon; A is a halogen; Y is from 0 to 3; N is nitrogen; each of R1 and R2 is same or different and is independently selected from the group consisting of H, aryl, perfluoroaryl, C1-C8 alkyl, and C1-C8 perfluoroalkyl; and n is from 1-6. By comparison with the standard SiO2 gate dielectric materials, these gate dielectric materials provide low levels of carbon and halide impurity.Type: GrantFiled: September 18, 2001Date of Patent: March 22, 2005Assignee: Advanced Tehnology Materials, Inc.Inventors: Thomas H. Baum, Chongying Xu, Bryan C. Hendrix, Jeffrey F. Roeder
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Patent number: 6852842Abstract: Small dendrimer-based MRI contrast agents are disclosed to accumulate in renal tubules. The accumulation enables visualization of renal structure and function, permitting assessment of structural and functional damage to the kidneys. In a disclosed embodiment, six, small dendrimer-based MRI contrast agents were synthesized, and their pharmacokinetics, whole body retention, and renal MRI images were evaluated in mice. Surprisingly, despite having unequal renal clearance properties, all of the dendrimer agents clearly visualized the renal anatomy and proximal straight tubules of the mice better than Gd-[DTPA]-dimeglumine. Dendrimer conjugate contrast agents prepared from PAMAM-G2D, DAB-G3D, and DAB-G2D dendrimers were excreted rapidly and may be acceptable for use in clinical applications.Type: GrantFiled: August 26, 2002Date of Patent: February 8, 2005Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Martin W. Brechbiel, Robert A. Star, Hisataka Kobayashi
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Patent number: 6852843Abstract: The present invention relates to novel complexes of (transition) metals containing ligands having phosphorus centers supporting a carbene atom or heteroalkane radical bonded to the (transition) metal.Type: GrantFiled: February 3, 2003Date of Patent: February 8, 2005Assignee: The Governors of the University of AlbertaInventors: Ronald G. Cavell, Ruppa P. Kamalesh Babu, Aparna Kasani
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Patent number: 6849730Abstract: The present invention provides methods of making porphyrins and related compounds such as chlorins by condensing suitable starting materials (e.g., a dipyrromethane-dicarbinol plus dipyrromethane) in a polar solvent in the presence of a Lewis acid. The reactions are preferably carried out in a manner that minimizes rearrangement of the reaction product.Type: GrantFiled: September 25, 2001Date of Patent: February 1, 2005Assignee: North Carolina State UniversityInventors: Jonathan S. Lindsey, G. Richard Geier, III, Lianhe Yu
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Patent number: 6849752Abstract: The invention relates to a process for synthesizing an ionic metal complex represented by the general formula (1) or (5). This process includes reacting in an organic solvent a compound (corresponding to ligand of the complex) represented by the general formula (2) or (6) with a halogen-containing compound represented by the general formula (3) or (4), in the presence of a reaction aid containing an element selected from the group consisting of elements of groups 1-4 and 11-14 of the periodic table. It is possible by this process to easily and efficiently synthesize the ionic metal complex, which can be used as a supporting electrolyte for electrochemical devices, a polymerization catalyst of polyolefins and so forth, or a catalyst for organic synthesis.Type: GrantFiled: November 1, 2002Date of Patent: February 1, 2005Assignee: Central Glass Company, Ltd.Inventors: Shoichi Tsujioka, Hironari Takase, Mikihiro Takahashi, Yoshimi Isono
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Patent number: 6846432Abstract: Methods and compositions for removing phosphate from swimming pool waters are disclosed. The compositions include both soluble and substantially insoluble lanthanide carboxylates, preferred examples being lanthanum glycolate and lactate. The methods include the addition of the lanthanide compounds to the bulk of the pool water, but preferably involve the loading of the pool filter with the composition and the circulation of pool water through the filter to effect the removal of dissolved phosphate in the water.Type: GrantFiled: July 12, 2002Date of Patent: January 25, 2005Assignees: Innovez Pty Ltd.Inventor: Dudley John Mills
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Patent number: 6846915Abstract: The present invention provides hydroxypyridinone and hydroxypyrimidone chelating agents. Also provides are Gd(III) complexes of these agents, which are useful as contrast enhancing agents for magnetic resonance imaging. The invention also provides methods of preparing the compounds of the invention, as well as methods of using the compounds in magnetic resonance imaging applications.Type: GrantFiled: July 12, 2002Date of Patent: January 25, 2005Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Daniel M. J. Doble, Christopher J. Sunderland, Marlon Thompson
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Publication number: 20040265237Abstract: The present invention provides an inclusion compound having a cucurbituril derivative of the formula 1 as a host molecule and a metal complex of the formula 2 as a guest molecule. A pharmaceutical composition having an anticancer effect can be obtained by using the inclusion compound according to the present invention. The pharmaceutical composition can prevent effective components from being biologically degraded in vivo and can exhibit continuous drug effect for a long time just by a single dosage by controlling the release time of the platinum complex once it reaches target tumor cells.Type: ApplicationFiled: March 18, 2004Publication date: December 30, 2004Inventors: Kimoon Kim, Young Jin Jeon, Soo Young Kim, Young Ho Ko
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Publication number: 20040258619Abstract: The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal99mTc, are useful as radiopharmaceuticals.Type: ApplicationFiled: June 21, 2004Publication date: December 23, 2004Inventors: Colin Mill Archer, Harry John Wadsworth, Torgrim Engell
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Publication number: 20040256743Abstract: A method for producing an organic compound having Q, the method including a step of reacting a compound represented by general formula (2) with an organic starting material having at least one halogen atom bonded to a carbon atom having four &sgr; bonds so as to replace the halogen atom in the organic starting material with Q:Type: ApplicationFiled: June 10, 2004Publication date: December 23, 2004Applicant: Mitsui Chemicals, Inc.Inventors: Setsuko Funaki, Yoshiteru Taniguchi, Tadahito Nobori, Yoshihiro Yamamoto, Isao Hara, Takaomi Hayashi, Kazumi Mizutani, Shinji Kiyono
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Patent number: 6833442Abstract: There is provided a complex having a specified chemical structure and an asymmetric catalyst using such a complex. Further, an epoxidation of amine or ketone is enantioselectively conducted by using such an asymmetric catalyst.Type: GrantFiled: August 5, 2002Date of Patent: December 21, 2004Assignee: The University of TokyoInventors: Masakatsu Shibasaki, Takashi Ohshima, Tetsuhiro Nemoto
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Publication number: 20040248728Abstract: A compound of formula I: 1Type: ApplicationFiled: August 19, 2003Publication date: December 9, 2004Inventors: Michael Chi-Wang Chan, Chi-Fai Kui
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Patent number: 6828439Abstract: Disclosed are novel compounds, compositions, and methods that are particularly useful in photodynamic therapy. In particular, the inventive compounds, compositions, and methods relate to the formation of cytotoxic radical species in the presence of light. Significantly, the compounds, compositions, and methods of the present invention do not require the presence of oxygen in the photodynamic therapy and, as such, rely on a unimolecular mechanism for producing the radicals. The inventive compounds, compositions, and methods can be used, for example, in the treatment of cancers as well as infections caused by microorganisms such as protozoa, fungi, bacteria, and viruses.Type: GrantFiled: August 20, 2001Date of Patent: December 7, 2004Assignee: Advanced Research and Technology Institute, Inc.Inventors: Jeffrey M. Zaleski, Diwan Singh Rawat
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Patent number: 6821921Abstract: The present invention relates to catalyst systems, processes for making such catalysts, intermediates for such catalysts, and olefin polymerization processes using such catalysts wherein such catalyst includes a component represented by the following formula IA: wherein R and R′ independently represent a hydrogen atom, or a substituted or unsubstituted, branched or unbranched hydrocarbyl or organosilyl radical; R1, R2, and R3 independently represent a hydrogen atom, or a substituted or unsubstituted, branched or unbranched hydrocarbyl radical; M is a group IIIB, IVB, VB, VIB, VIIB or VIII transition metal; T independently represents a univalent anionic ligand such as a hydrogen atom, or a substituted or unsubstituted hydrocarbyl, halogeno, aryloxido, arylorganosilyl, alkylorganosilyl, amido, arylamido, phosphido, or arylphosphido group, or two T groups taken together represent an alkylidene or a cyclometallated hydrocarbyl bidentate ligand; L independently represents a sigma donorType: GrantFiled: December 16, 2002Date of Patent: November 23, 2004Assignee: Chevron Chemical Co.Inventors: Klaus H. Theopold, Woo-Kyu Kim, Leonard A. MacAdams, John M. Power, Javier M. Mora, Albert P. Masino
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Publication number: 20040223915Abstract: The invention relates to cerium compounds having general formulas (I) Rni+Yin− and (II) Rb+Yb+ and their application as medicaments in the prophylaxis and/or treatment of cancer diseases.Type: ApplicationFiled: February 6, 2004Publication date: November 11, 2004Applicant: Faustus Forschungs Cie. Translational Cancer Research GmbHInventor: Bernhard Keppler
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Patent number: 6812343Abstract: A porphyrin ring-fusion polymer which consists of two or more Zn(II)-porphyrin rings fused in a single direction and in which any two porphyrin rings adjacent to each other are fused by three covalent bonds, that is, one meso-meso carbon bond (i.e., one bond between meso-position carbon atoms) and two &bgr;—&bgr; carbon bonds (i.e., two bonds between &bgr;-position carbon atoms adjacent to the meso-position carbon atoms); a process for preparing the porphyrin ring-fusion polymer regioselectively by conducing the fusion reaction in an aromatic hydrocarbon solvent in the presence of a quinoline and Lewis acid containing rare earth element under reflux; and fused-ring porphyrin compound obtained by subjecting the porphyrin ring-fusion polymer to demetallization or replacement of the Zn atoms by other metal atoms.Type: GrantFiled: February 6, 2003Date of Patent: November 2, 2004Assignee: Japan Science & Technology AgencyInventor: Atsuhiro Osuka
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Publication number: 20040215000Abstract: Organometallic complexes comprising a trivalent lanthanide metal ion complexed with one or more polydentate ligands containing one or more pyrazolyl-derived groups, such as trispyrazolyl borate species, are useful in light emitting materials e.g., in electroluminescent flat panel displays. In the complexes, several classes of which are novel, a coordinate bond is formed between the metal and one of the nitrogen atoms of the pyrazolyl rings.Type: ApplicationFiled: May 18, 2004Publication date: October 28, 2004Applicant: Isis Innovation LimitedInventor: Victor Christou
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Patent number: 6809059Abstract: A catalyst and method for performing a Michael addition reaction between a &bgr;-dicarbonyl compound with a cyclic or acyclic enone, where the catalyst comprises a substituted or unsubstituted lanthanum-linked BINOL complex, e.g. a (R,R)-La-linked-BINOL complex (I), are described. The catalyst is stable in air, is readily separated from the reaction mixtures and may be reused if desired.Type: GrantFiled: July 26, 2001Date of Patent: October 26, 2004Assignee: Johnson Matthey PLCInventor: Masakatsu Shibasaki