Azodioxy Patents (Class 534/568)
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Patent number: 7259250Abstract: A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. When the compound is obtained from a carbon acid with a pKa less than about 10, it provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to about 20, vascular relaxing effect is obtained at nanomolar concentrations without glutathione. In another embodiment, a biocompatible polymer incorporates a C-nitroso moiety.Type: GrantFiled: February 8, 2005Date of Patent: August 21, 2007Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone
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Patent number: 7122529Abstract: Chemical compounds which release nitric oxide in a controlled manner upon photolysis with light are provided. These compounds are O2-benzyl, O2-naphthylmethyl and O2-naphthylallyl substituted diazeniumdiolates. Also provided are methods of preparing these novel compounds in high chemical yields as well as methods of using these compounds.Type: GrantFiled: July 12, 2002Date of Patent: October 17, 2006Assignee: The Johns Hopkins UniversityInventors: Patrick H. Ruane, John P. Toscano
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Publication number: 20040180863Abstract: The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates via the direct reaction of nitric oxide with amidines and enamines, and to a method of converting amines into such compounds.Type: ApplicationFiled: March 23, 2004Publication date: September 16, 2004Applicant: Govt. of the USA, rep. by the Secretary, Dept. of Health & Human Servs., Office of Tech. TransferInventors: Joseph A. Hrabie, Larry K. Keefer
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Publication number: 20040092484Abstract: The invention provides NO- or NO−-releasing imidate, thioimidate, and amide diazeniumdiolates, in which the N2O2− functional group is bonded to a carbon atom. The invention also provides compositions comprising such diazeniumdiolate compounds, and methods of using such compounds and compositions. The invention further provides a method of preparing NO- or NO−-releasing imidate, thioimidate, and amide diazeniumdiolates.Type: ApplicationFiled: November 6, 2003Publication date: May 13, 2004Applicant: Government of the United States of America, represented by the Secretary, Department of HealthInventors: Ernst V. Arnold, Larry K. Keefer, Joseph A. Hrabie
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Patent number: 6538116Abstract: A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. In another case, the C-nitroso compound contains the moiety where X is S, O or NR. One embodiment is directed to COX-2 inhibitors where a tertiary carbon atom and/or an oxygen atom and/or a sulfur atom is nitrosylated.Type: GrantFiled: December 13, 2001Date of Patent: March 25, 2003Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone
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Patent number: 6359182Abstract: A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. When the compound is obtained from a carbon acid with a pKa less than about 10, it provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to about 20, vascular relaxing effect is obtained at nanomolar concentrations without glutathione. The compound is preferably water-soluble and preferably contains a carbon alpha to the nitrosylated carbon which is part of a ketone group.Type: GrantFiled: October 26, 2000Date of Patent: March 19, 2002Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone
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Patent number: 5434251Abstract: Symmetric azo dyestuffs of the formula ##STR1## wherein the substituents have the meaning given in the description, produce improved dyeings or prints on wool and cellulose materials.Type: GrantFiled: April 2, 1993Date of Patent: July 18, 1995Assignee: Bayer AktiengesellschaftInventor: Karl-Josef Herd
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Patent number: 5393874Abstract: The preparation of N-hydroxy-N'-diazenium oxides of the general formula I ##STR1## where R is an aliphatic or cycloaliphatic radical, by reacting a hydroxylamine of the general formula IIR--NH--OH IIor its salt with nitrosyl chloride or nitrosylsulfuric acid in aqueous solution is described.The process products are intermediates for fine chemicals and are used in the form of their metal salts as wood preservatives.Type: GrantFiled: September 14, 1993Date of Patent: February 28, 1995Assignee: BASF AktiengesellschaftInventors: Klemens Massonne, Martin Fischer