Bicyclo Carbocyclic Ring System Consisting Of A Six-membered Ring And A Five-membered Ring (e.g., Indane, Etc.) Patents (Class 534/659)
  • Patent number: 8617827
    Abstract: The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1=O, A2=N, A3=C; G2: A1=S, A2=N, A3=C; G3: A1=O, A2=O, A3=N; G4: A1=S, A2=O, A3=N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420 nm) generate fluorescent rhodamine or carbopyronine derivatives and small non-toxic fragments such as N2 or N2O. The invention also relates to methods for preparing such compounds and to the use of these compounds for optical microscopy and imaging techniques.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: December 31, 2013
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Stefan W. Hell, Vladimir N. Belov, Vadim P. Boyarskiy, Christian A. Wurm, Stefan Jakobs, Claudia Geisler
  • Patent number: 8394860
    Abstract: The present invention relates generally to methods and related compositions using flavonoids and/or indanes extracted from the stems and leaves of C. quadrangularis to reduce weight and inhibit lipase, ?-amylase and ?-glucosidase activity in mammals. By example and not by way of limitation, embodiments of the present disclosure, a composition and related methods for reducing body weight and/or inhibiting any combination of lipase, ?-amylase and ?-glucosidase is provided. The composition contains an effective amount of one or more flavonoids or indanes selected from 3-O-rhamnopyranosylkaempferol, 3-(4-hydroxybenzylidene)-2-(2,5-dihydroxyphenyl)-1-(4-hydroxyphenyl)indane-4,6-diol, quercitrin, rhamnitrin, rhamnocitrin, quercitrin-3-O?-acetate and parthenocissin A.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: March 12, 2013
    Assignee: Gateway Health Alliances, Inc.
    Inventor: Julius Enyong Oben
  • Patent number: 8362090
    Abstract: The present invention relates generally to methods and related compositions using flavonoids and/or indanes extracted from the stems and leaves of C. quadrangularis to reduce weight and inhibit lipase, ?-amylase and ?-glucosidase activity in mammals. By example and not by way of limitation, embodiments of the present disclosure, a composition and related methods for reducing body weight and/or inhibiting any combination of lipase, ?-amylase and ?-glucosidase is provided. The composition contains an effective amount of one or more flavonoids or indanes selected from 3-O-rhamnopyranosylkaempferol, 3-(4-hydroxybenzylidene)-2-(2,5-dihydroxyphenyl)-1-(4-hydroxyphenyl)indane-4,6-diol, quercitrin, rhamnitrin, rhamnocitrin, quercitrin-3-O?-acetate and parthenocissin A.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: January 29, 2013
    Assignee: Gateway Health Alliances, Inc.
    Inventor: Julius Enyong Oben
  • Publication number: 20120202216
    Abstract: The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1=O, A2=N, A3=C; G2: A1=S, A2=N, A3=C; G3: A1=O, A2=O, A3=N; G4: A1=S, A2=O, A3=N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420 nm) generate fluorescent rhodamine or carbopyronine derivatives and small non-toxic fragments such as N2 or N2O. The invention also relates to methods for preparing such compounds and to the use of these compounds for optical microscopy and imaging techniques.
    Type: Application
    Filed: September 10, 2009
    Publication date: August 9, 2012
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Stefan W. Hell, Vladimir N. Belov, Vadim P. Boyarskiy, Christian A. Wurm, Stefan Jakobs, Claudia Geisler
  • Publication number: 20110230651
    Abstract: The present invention is related to derivatives of benzenesulfonamide represented by formula (I), and the pharmaceutical composition thereof. In addition, the benzenesulfonamide derivatives disclosed in the present invention can serve as potential cell cycle inhibitors, and thereby these benzenesulfonamide derivatives and the pharmaceutical composition thereof can be antitumor drug candidates, which might aim at cell cycle. Particularly, the benzenesulfonamide derivatives disclosed in the present invention may function as antitumor drugs to treat solid cancers.
    Type: Application
    Filed: February 23, 2011
    Publication date: September 22, 2011
    Applicant: Purzer Pharmaceutical Co., LTD.
    Inventors: Ji-Wang Chern, Grace Shiahuy Chen, Pei-Teh Chang, Kuan-Yu Chen, Meng-Ling Chen, Hsueh-Yun Lee, Chiung Hua Huang, Chun-Tang Chiou
  • Patent number: 7659313
    Abstract: The present invention relates generally to methods and related compositions using flavonoids and/or indanes extracted from the stems and leaves of C. quadrangularis to reduce weight and inhibit lipase, ?-amylase and ?-glucosidase activity in mammals. By example and not by way of limitation, embodiments of the present disclosure, a composition and related methods for reducing body weight and/or inhibiting any combination of lipase, ?-amylase and ?-glucosidase is provided. The composition contains an effective amount of one or more flavonoids or indanes selected from 3-O-rhamnopyranosylkaempferol, 3-(4-hydroxybenzylidene)-2-(2,5-dihydroxyphenyl)-1-(4-hydroxyphenyl)indane-4,6-diol, quercitrin, rhamnitrin, rhamnocitrin, quercitrin-3-O?-acetate and parthenocissin A.
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: February 9, 2010
    Assignee: Gateway Health Alliances, Inc.
    Inventor: Julius Enyong Oben
  • Patent number: 6075131
    Abstract: Compounds of Formula (1) have utility as dyes for ink-jet printing where Formula (1) comprises:T.sub.q --W Formula (1)which includes all acceptable forms of such compounds selected from one or more of the following (including mixtures thereof and combinations thereof in the same species): stereoisomers, zwitterions, polymorphs, solvates, isotopic forms; and all suitable salts thereof; in which:q represents from 1 to 4 inclusive;W comprises an optionally substituted hydrocarbyl group (preferably an optionally substituted aromatic group, or an optionally substituted aliphatic group); andeach T independently comprises a group of the Formula (2):B--N.dbd.N--J--Y-- Formula (2)in which:B comprises an optionally substituted indanyl group;Y comprises a carbonyl group or a sulphonyl group; andJ comprises a group of Formula (3): ##STR1## in which: R.sup.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: June 13, 2000
    Assignee: Zeneca Limited
    Inventors: Neil Anthony Tallant, Paul Wight, Peter Gregory
  • Patent number: 5462694
    Abstract: A mesomorphic compound of the formula (I) according to claim 1 characterized by having at least one cyclic group selected from .beta. class including, e.g., thiazole-2,5-diyl, benzoxazole-2,5-diyl, indan-2,5-diyl, and quinoxaline-2,6-diyl and also having a linkage of Y.sup.1 (CH.sub.2).sub.m Y.sup.2, where Y.sup.1 and Y.sup.2 are --CH.sub.2 --, --O--, --COO-- or --OCO-- and m is 1-16, is suitable as a component for a liquid crystal composition providing improved response characteristics. A liquid crystal device is constituted by disposing the liquid crystal composition between a pair of substrates. The liquid crystal device is used as a display panel constituting a liquid crystal apparatus providing good display characteristics.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: October 31, 1995
    Assignee: Canon Kabushiki Kaisha
    Inventors: Yoko Kosaka, Takao Takiguchi, Takashi Iwaki, Takeshi Togano, Shinichi Nakamura, Ikuo Nakazawa
  • Patent number: 5162545
    Abstract: Malonic acid dyes capable of forming polycondensation products have the formula ##STR1## where R.sup.1 and R.sup.2 are each independently of the other hydroxyl, C.sub.1 -C.sub.6 -alkoxy, chlorine or bromine,R.sup.3 is hydrogen or C.sub.1 -C.sub.6 -alkyl,A is C.sub.1 -C.sub.20 -alkylene which may be interrupted by oxygen atoms or by imino or C.sub.1 -C.sub.4 -alkylimino groups, andChr is the radical of a chromophore derived from an anthraquinone, perylene, disazo or trisazo dye or else, when R.sup.3 is C.sub.1 -C.sub.6 -alkyl, from a monoazo dye.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: November 10, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl-Heinz Etzbach, Karin H. Beck, Gerhard Wagenblast
  • Patent number: 5145953
    Abstract: A biscyclobutarene monomer is prepared having two cyclobutarene moieties bridged by a divalent radical having at least one azo linkage. The monomers can be polymerized to form polymers exhibiting outstanding thermooxidative stability at high temperatures for prolonged time periods.
    Type: Grant
    Filed: February 2, 1988
    Date of Patent: September 8, 1992
    Assignee: The Dow Chemical Company
    Inventors: Robert A. Kirchhoff, Alan K. Schrock