Abstract: Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.

Abstract: Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.

Abstract: The novel disazo dyestuffs of the formula (I) in which the substituents and indices have the meanings given in the description, are outstandingly suitable for dyeing cellulosic materials in red-violet to blue brilliant color shades.

Abstract: Disazo dyes of the formula ##STR1## where the ring A may be benzofused,X is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.1 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen, carboxyl, C.sub.1 -C.sub.4 -alkoxycarbonyl or hydroxysulfonyl,R.sup.2 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen, carboxyl or C.sub.1 -C.sub.4 -alkoxycarbonyl, or R.sup.1 and R.sup.2 together are a radical of the formula L--NZ--CO, where L is methylene or carbonyl and Z is substituted or unsubstituted C.sub.1 -C.sub.4 -alkyl or substituted or unsubstituted phenyl, andR.sup.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, phenoxy, C.sub.1 -C.sub.4 -alkanoyloxy or benzoyloxy,are useful for dyeing natural or synthetic substrates.

Abstract: Diaza-18-crown-6 compounds of the formula I: ##STR1## wherein X is a phenol, naphthol or quinolinol moiety selected from those of the formulae: ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from hydrogen, halo, cyano, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.8) acyl, acetamido, mercapto, alkyl or arylsulfonyl, trifluoromethyl, aryl, and substituted aryl wherein the aryl moiety is selected from phenyl and naphthyl and the aryl substituent is selected from halo, cyano, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.8) acyl, phenyl, acetamido, mercapto, alkyl or arylsulfonyl and trifluoromethyl; provided that when R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are hydrogen and X is phenol, R.sub.4 is not nitro; and provided that when X is phenol and R.sub.5 is hydrogen, R.sub.1 (or R.sub.2) and R.sub.4 are not both nitro.

Abstract: Anionic azo compounds which, in the free acid form, have the Formula (1): ##STR1## wherein: Ar and Ar.sup.1 are each independently aryl or substituted aryl providing at least one of Ar and Ar.sup.1 has at least one substituent selected from COOH and COSH;J and J.sup.1 are each independently of formula (2), (3) or (4): ##STR2## each R.sup.5 is independently selected from H, alkyl, substituted alkyl, alkoxy, halogen, CN, ureido and NHCOR.sup.6 ;R.sup.6 is H, alkyl, substituted alkyl, aryl, substituted aryl, aralkyl or substituted aralkyl;each T is independently alkyl;each W is independently selected from H, CN, CONR.sup.10 R.sup.11, pyridinium and COOH;each m is an alkylene chain having 2 to 8 carbon atoms;B is H, alkyl or COOH;R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.10 and R.sup.11 are each independently H, alkyl or substituted alkyl;L is a divalent organic linking group;n is 0 or 1;each X is independently carbonyl or a group of the Formula (5), (6) or (7): ##STR3## Z is OR.sup.7, SR.sup.7 or NR.sup.8 R.sup.

Abstract: Malonic acid dyes capable of forming polycondensation products have the formula ##STR1## where R.sup.1 and R.sup.2 are each independently of the other hydroxyl, C.sub.1 -C.sub.6 -alkoxy, chlorine or bromine,R.sup.3 is hydrogen or C.sub.1 -C.sub.6 -alkyl,A is C.sub.1 -C.sub.20 -alkylene which may be interrupted by oxygen atoms or by imino or C.sub.1 -C.sub.4 -alkylimino groups, andChr is the radical of a chromophore derived from an anthraquinone, perylene, disazo or trisazo dye or else, when R.sup.3 is C.sub.1 -C.sub.6 -alkyl, from a monoazo dye.

Abstract: The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and preferably .sup.123 I-labeled compounds to the patient and sensing radiation emitted from the organ or body area. Novel non-radioactive iodine substituted amyloid binding compounds and amyloid binding compounds which are readily iodinated are further aspects of the invention.

Abstract: Reactive dyes of the formula ##STR1## in which M is twice-coupled 1-amino-8-hydroxynaphthalene-3,6-disulfonic acid, 1-amino-8-hydroxynaphthalene-4,6-disulfonic acid, 1-amino-8-hydroxynaphthalene-4-sulfonic acid or 2-amino-5-hydroxynaphthalene-7-sulfonic acid, A and B, independently of each other, are each sulfophenylene or sulfonaphthylene which can be further substituted, and X.sub.1 and X.sub.2 are each a 2,4-difluoro-5-chloropyrimid-6-yl radical, subject to the condition that A and B together contain at least 3 sulfo groups, are particularly suitable for dyeing and printing cellulose-containing fibre materials and produce, in high dyeing yield, dyeings and prints having good fastness properties.