The Cyclopentanohydrophenanthrene Ring System Shares Spiro Atoms With Two Hetero Rings, Each Of Which Contains Two Oxygens (e.g., 3,17-bis-ketals, Etc.) Patents (Class 540/10)
Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
Type:
Grant
Filed:
September 12, 2012
Date of Patent:
December 15, 2015
Assignee:
Life Technologies Corporation
Inventors:
Robert H. Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
Abstract: The present disclosure is generally directed to neuroactive 13,17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
Abstract: The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
Type:
Grant
Filed:
August 17, 1999
Date of Patent:
August 8, 2000
Assignee:
Novo Nordisk A/S
Inventors:
Knud Erik Andersen, Tine Krogh J.o slashed.rgensen, Rolf Hohlweg, Erik Fischer, Uffe Bang Olsen, Zdenek Polivka, Karel Sindelar, Vladimir Valenta
Abstract: Novel 3-keto-19-nor-.DELTA..sup.4,9 -steroids of the formula ##STR1## and their non-toxic, pharmaceutically acceptable acid addition salts possessing a remarkable antiglucocorticoidal activity.
Type:
Grant
Filed:
September 10, 1991
Date of Patent:
January 26, 1993
Assignee:
Roussel Ulcaf
Inventors:
Daniel Philibert, Jean G. Teutsch, Germain Costerousse, Roger Deraedt
Abstract: The present invention relates to 21-(3-carboxy-1-oxopropoxy) -17.alpha.-hydroxy-11.alpha.-(3,3-dimethyl-1-oxobutoxy)pregna-1,4-diene-3, 20 dione and pharmaceutically acceptable salts thereof which are useful steroid prodrugs.
Type:
Grant
Filed:
February 16, 1989
Date of Patent:
August 14, 1990
Assignee:
The Upjohn Company
Inventors:
John M. Braughler, Edward D. Hall, Wendell Wierenga, John M. McCall