The Cyclopentanohydrophenanthrene Ring System Shares A Spiro Atom With A Lactone Ring (i.e., -c(=x)-o- Is Part Of The Ring, Wherein X Is Chalcogen) Patents (Class 540/11)
  • Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
    Patent number: 8222237
    Abstract: Described herein are 3-(6,6-ethylene-17?-hydroxy-3-oxo-17?-pregna-4-ene-17?-yl)propionic acid ?-lactone derivatives having progestational and aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: July 17, 2012
    Assignee: Evestra, Inc.
    Inventors: Klaus Nickisch, Pemmaraju Rao, Kesavaram Narkunan, James Cessac
  • 13-alkyl-11beta-phenylgonanes
    Patent number: 5446036
    Abstract: There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH;R.sup.2 is alpha- or beta-position methyl or ethyl;R.sup.1 is selected from heteroaryl radicals, cycloalkyl radicals, cycloalkenyl radicals, aryl radicals, alkenyl radicals, and alkyl radicals where R.sup.2 is in the alpha-position and an ethyl radical where R.sup.2 is in the beta-position; andR.sup.3 and R.sup.4 are selected from one of two different groups of substituent pairs, the group from which the selection is made being determined by the position of R.sup.2.
    Type: Grant
    Filed: November 2, 1993
    Date of Patent: August 29, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Stefan Scholz, Eckhard Ottow, Guenter Neef, Walter Elger, Sybille Beier, Krzysztof Chwalisz
  • 2,2:6,6-diethylen-3-oxo-17alpha-pregn-4-ene-21,17alpha-carbolactones, process for their production & pharmaceutical preparations containing them
    Patent number: 4868166
    Abstract: 2,2;6,6-diethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactones of general formula I, ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group,R.sub.2 represents a methyl or ethyl group and ##STR2## process for their production and their pharmaceutical use.
    Type: Grant
    Filed: February 5, 1988
    Date of Patent: September 19, 1989
    Assignee: Schering Aktiengesellschaft
    Inventors: Dieter Bittler, Klaus Nickisch, Henry Laurent, Rudolf Wiechert, Martin Haberey