Porphyrins (including Hydrogenated; E.g., Chlorophyll, Etc.) Patents (Class 540/145)
  • Patent number: 10696702
    Abstract: Propyl-bridged diphosphine compounds, metal complexes of these compounds and the use thereof for alkoxycarbonylation.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: June 30, 2020
    Assignee: EVONIK OPERATIONS GMBH
    Inventors: Jiawang Liu, Kaiwu Dong, Robert Franke, Helfried Neumann, Ralf Jackstell, Matthias Beller
  • Patent number: 10556873
    Abstract: Substituted 1,4,7-triazacyclononane-N,N?,N?-triacetic acid and 1,4,7,10-tetraazacycicododecane-N,N?,N?,N??-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: February 11, 2020
    Assignee: ILLINOIS INSTITUTE OF TECHNOLOGY
    Inventor: Hyun-Soon Chong
  • Patent number: 10259913
    Abstract: Disclosed herein are nanoactuating rotaxanes comprising a threading component, the threading component comprising a oligoviologen, and at least two macrocylic components, wherein the oligoviologen is threaded through each of the macrocylic components. Also disclosed are methods for making and using the rotaxanes.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: April 16, 2019
    Assignees: Northwestern University, King Abdulaziz City for Science and Technology (KACST)
    Inventors: James Fraser Stoddart, Yuping Wang, Marco Frasconi, Junling Sun
  • Patent number: 9963474
    Abstract: The invention relates to compounds having Formula (1): A-L-B or pharmaceutically acceptable salts thereof, wherein: A is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; L is an optional linker moiety; and B is a mitochondrial targeting moiety. The invention also relates to pharmaceutical compositions containing such compounds and salts, and to the use of such compounds and salts for treating diabetes, preferably hyperglycemic diabetes. A mass spectrometry probe and to a method of labelling a biological molecule 1 for mass spectrometry detection are also described.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: May 8, 2018
    Assignee: Medical Research Council
    Inventors: Michael Patrick Murphy, Robin Andrew James Smith, Richard Charles Hartley
  • Patent number: 9757386
    Abstract: Disclosed herein are compositions comprising a targeted corrole nanoparticle; and an acceptable excipient. Also disclosed are compositions comprising a targeted corrole nanoparticle; and an acceptable carrier. Further, disclosed herein are methods of imaging a condition in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; administering an effective amount of the targeted corrole nanoparticle to the subject; and imaging the condition in the subject. In addition, disclosed herein are methods of treating cancer in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; and administering a therapeutically effective dosage of the targeted corrole nanoparticle to the subject.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 12, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventor: Lali K. Medina-Kauwe
  • Patent number: 9624144
    Abstract: The invention separating material and separation method make it possible to separate and collect 1,3-butadiene selectively from a mixed gas containing 1,3-butadiene and a C4 hydrocarbon other than 1,3-butadiene. A separating material capable of adsorbing 1,3-butadiene selectively includes: a dicarboxylic acid compound (I) represented by formula (I) (wherein R1, R2, R3 and R4 independently represent a hydrogen atom, an alkyl group or the like); a metal ion such as a zinc ion and a cobalt ion; and a metal complex having such a structure that multiple pseudo-diamondoid frameworks are intruded mutually, wherein each of the pseudo-diamondoid frameworks comprises an organic ligand (II) that is represented by formula (II) (wherein X represents —CH2—, —CH2—CH2—, —CH?CH— or the like; and R5, R6, R7, R8, R9, R10, R11 and R12 independently represent a hydrogen atom, an alkyl group or the like) and is capable of being bidentately coordinated with the metal ion.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: April 18, 2017
    Assignee: SHOWA DENKO K.K.
    Inventors: Keisuke Kishida, Yoshihiro Watanabe
  • Patent number: 9365722
    Abstract: Bacteriochlorin of Formula I: wherein R is H or silyl are described, along with compositions containing the same and methods of making and using the same.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: June 14, 2016
    Assignee: North Carolina State University
    Inventors: Jonathan S. Lindsey, Olga Mass
  • Patent number: 9155791
    Abstract: A compound in the form of a metallized tetrapyrollic photosensitizer linked to a fluorescent dye where the photosensitizer (PS), is linked by a structure that does not have detrimental radiation emittance or absorbing characteristics, to a fluorophore, usually a cyanine dye (CD). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins. The fluorophore is usually a cyanine dye with variable substituents. And, A method for determining effectiveness of PDT by comparing proportion of STAT-3 monomer with crosslinked STAT-3 dimer after PDT where the relative proportion of STAT-3 monomer to crosslinked STAT-3 directly correlates to efficacy of the PDT.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: October 13, 2015
    Assignee: Health Research, Inc.
    Inventors: Ravindra K. Pandey, Heinz Baumann, Yihui Chen, Penny Joshi, Nayan Patel
  • Patent number: 9113535
    Abstract: A compound that can be used as a donor material in organic photovoltaic devices comprising a non-activated porphyrin fused with one or more non-activated polycyclic aromatic rings or one or more non-activated heterocyclic rings can be obtained by a thermal fusion process. The compounds can include structures of Formula I: By heating the reaction mixture of non-activated porphyrins with non-activated polycyclic aromatic rings or heterocyclic rings to a fusion temperature and holding for a predetermined time, fusion of one or more polycyclic rings or heterocyclic rings to the non-activated porphyrin core in meso,? fashion is achieved resulting in hybrid structures containing a distorted porphyrin ring with annulated aromatic rings. The porphyrin core can be olygoporphyrins.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: August 18, 2015
    Assignees: The University of Southern California, The Regents of the University of Michigan
    Inventors: Mark E. Thompson, Viacheslav Diev, Kenneth Hanson, Stephen R. Forrest
  • Patent number: 9073937
    Abstract: Photoactive layers for use in a photovoltaic cell are described. The photoactive layers comprise at least one photoactive ion paired with another ion. This photoactive ion pair can be in the form of an ionic liquid, hydrogen bonded ion pair, cocrystal, or complex to allow for greater flexibility and portability. Also described are photovoltaic cells that contain the described photoactive layers sandwiched between two electrodes.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: July 7, 2015
    Assignee: Board of Trustees of The University of Alabama
    Inventors: Rachel M. Frazier, Daniel T. Daly, Scott K. Spear, Robin D. Rogers, Whitney Hough
  • Patent number: 9056089
    Abstract: The present invention discloses a process of preparing jambu extract that results in a jambu extract free from chlorophyll and derivatives of this compound. It is a method for isolating the components of interest in a simplified way, with quite high process yield, higher than 85%. The present invention further relates to the use of this extract in preparing cosmetic compositions, the cosmetic compositions comprising said extract, and to cosmetic products comprising said cosmetic compositions.
    Type: Grant
    Filed: March 21, 2006
    Date of Patent: June 16, 2015
    Assignee: Natura Cosmeticos S.A.
    Inventors: Sergio Delarcina, Jr., José Renato Cagnon, Alexandre Roberto Silva, Viviane Emi Nakano Fukusawa
  • Patent number: 9040687
    Abstract: The present invention provides novel porphyrin derivatives represented by the general formula 1 and/or pharmaceutically acceptable derivatives thereof as NIR sensitizers for photodynamic therapeutic and diagnostic, biological and industrial applications. These porphyrin derivatives possess absorption (400-700 nm) and emission (600-750 nm) in the regions where biological chromophores do not absorb and hence are ideal candidates for application as NIR PDT agents and fluorescence sensors for medicinal applications in biology. The substituents like hydroxyl and glycolic units on these dyes render them amphiphilicity thereby improving their solubility in the aqueous media and cellular uptake and localization. These dyes show no toxicity in the dark and are highly selective towards tumor cells and stain nucleus very rapidly. Accordingly, these porphyrin derivatives are extremely useful as NIR PDT fluorescence sensors in photodynamic therapeutic and diagnostic, biological and industrial applications.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: May 26, 2015
    Assignee: COUNCIL OF SCIENTIFIC AND IDUSTRIAL RESEARCH
    Inventors: Danaboyina Ramaiah, Suneesh C. Karunakaran, Jisha S. Vadakkancheril, Chandrashekar K. Tavarekere, Srinivasan Alagar, Madhavan Radhakrishna Pillai, Sivakumari Asha Nair, Saneesh Babu P. Saras, Mohan Chintalagiri Rao, Kunchala Sridhar Rao
  • Publication number: 20150133653
    Abstract: The invention provides compounds of Formula I: wherein b, D, R1, R2, G, Ra and Rb have meanings given in the description, or pharmaceutically-acceptable salts or solvates, or pharmaceutically functional derivatives thereof. The invention further provides process for conjugating the compounds to carrier molecules and uses of such compounds and conjugates in the treatment of disease.
    Type: Application
    Filed: November 20, 2014
    Publication date: May 14, 2015
    Inventors: Gokhan Yahioglu, Ioanna Stamati, Mahendra Deonarain
  • Patent number: 9026203
    Abstract: The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical internalization. Such salts may be formed from a pharmaceutically acceptable base, for example an organic amine such as an amino alcohol, or from a pharmaceutically acceptable acid, for example a sulphonic acid or a sulphonic acid derivative. Due to their increased water solubility, such salts are particularly suitable for use in the preparation of parenteral pharmaceutical preparations, e.g. for use as solutions for injection or infusion.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: May 5, 2015
    Assignee: PCI Biotech AS
    Inventors: Jo Klaveness, Anders Hogset
  • Patent number: 9017826
    Abstract: Porphyrin compounds are provided. The compounds may further comprise a fused polycyclic aromatic hydrocarbon or a fused heterocyclic aromatic. Fused polycyclic aromatic hydrocarbon s and fused heterocyclic aromatics may extend and broaden absorption, and modify the solubility, crystallinity, and film-forming properties of the porphyrin compounds. Additionally, devices comprising porphyrin compounds are also provided. The porphyrin compounds may be used in a donor/acceptor configuration with compounds, such as C60.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: April 28, 2015
    Assignees: The University of Southern California, The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Jeramy D. Zimmerman, Mark E. Thompson, Viacheslav Diev, Kenneth Hanson
  • Publication number: 20150099873
    Abstract: The present invention provides a crystalline form of HPPH (2-((1?-n-hexyloxy)ethyl)-2-divinyl-pyropheophorbide-a). The crystalline form can be characterized by an X-ray powder diffraction (XRD) pattern and differential scanning calorimeter (DSC) pattern. The present invention also provides a method for preparing the crystalline form of HPPH.
    Type: Application
    Filed: February 7, 2013
    Publication date: April 9, 2015
    Inventors: Zhenliang Chen, Fei Zheng, Yumei Wu, Tianmin Zhu, Hua Bai
  • Publication number: 20150096618
    Abstract: A porphyrin-based compound is represented by Chemical Formula 1 or 2. A dye for a dye-sensitized solar cell includes the porphyrin-based compound so that the dye has improved photoelectric conversion efficiency. A dye-sensitized solar cell includes a first electrode, a second electrode, and a dye layer formed between the first electrode and the second electrode, and the dye layer includes the porphyrin-based compound.
    Type: Application
    Filed: March 28, 2014
    Publication date: April 9, 2015
    Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hyojeong JO, Jungeun NAM, Daehwan KIM, Jinkyu KANG
  • Publication number: 20150090672
    Abstract: Methods, kits, cartridges and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of a manganese porphyrin catalyst or a manganese porphyrazine catalyst are described. Methods, kits, cartridges and compounds related to decomposed cyanide ions and hydrogen cyanide for water decontamination.
    Type: Application
    Filed: October 9, 2014
    Publication date: April 2, 2015
    Inventor: John T. Groves
  • Patent number: 8987439
    Abstract: The three-dimensional structure of the present invention is a three-dimensional structure formed on a base. This three-dimensional structure contains a plurality of porphyrins, a plurality of first metal ions, and a plurality of specific organic molecules. The porphyrin contains two or more functional groups. The first metal ion is a metal ion for linking the functional group of one porphyrin to the functional group of another porphyrin. The above specific organic molecule is an organic molecule that forms a coordinate bond with a metal ion contained in the two-dimensional structure and that has only one site to coordinate to the metal ion.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: March 24, 2015
    Assignee: Japan Science and Technology Agency
    Inventors: Rie Makiura, Hiroshi Kitagawa
  • Publication number: 20150079687
    Abstract: [Problem] To provide to a reagent composition used in quantitative measurement of lithium in aqueous solutions such as biological specimens and environmental liquid samples by a simple colorimeter or ultraviolet-visible light spectrophotometer immediately, a reagent composition which permits to measure a concentration of lithium by visual observation, and a method and apparatus for measuring lithium ion by using the reagent. [Solution] A reagent composition for measuring lithium comprising F28 tetraphenylporphyrin compound as chelating agent, including further a water-soluble organic solvent, a pH modifier and a stabilizer, and a method and apparatus for measuring lithium ion by using the reagent.
    Type: Application
    Filed: April 25, 2012
    Publication date: March 19, 2015
    Applicant: METALLOGENICS CO., LTD.
    Inventors: Takuya Iwabuchi, Tsugikatsu Odashima
  • Patent number: 8980565
    Abstract: The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A?-Z—B?—B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A? is a linker group or covalent bond; B? is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: March 17, 2015
    Assignee: North Carolina State University
    Inventor: Jonathan S. Lindsey
  • Publication number: 20150064120
    Abstract: The present invention relates to the cosmetic use, as an antidandruff agent, of catalytic oxidation compounds chosen from porphyrins, or of a cosmetic composition comprising the same.
    Type: Application
    Filed: February 22, 2013
    Publication date: March 5, 2015
    Inventor: Henri Samain
  • Patent number: 8962597
    Abstract: Disclosed herein is a dispersion comprising a liquid or semi-solid continuous phase, a dispersed solid phase comprising a plurality of organic, inorganic or inorganic-organic particles, and an alkyl ketal ester having the structure wherein a is 0 or an integer of 1 to 12, specifically 1 to 6, more specifically 1 to 4; b is 0 or 1; R2 is a divalent C1-8 group optionally substituted with up to 5 hydroxyl groups; and R1 is C1-6 alkyl, and wherein at least a portion of the alkyl ketal ester is present in the continuous phase, on a surface of at least some of the dispersed particles, or a combination thereof.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: February 24, 2015
    Inventors: Lee Richard Rieth, Dorie J. Yontz, Nicholas Morante
  • Patent number: 8962797
    Abstract: Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: February 24, 2015
    Assignee: Nanoquantum Sciences, Inc.
    Inventors: Gary W. Jones, Anatoliy L. Tatarets, Leonid D. Patsenker
  • Publication number: 20150048314
    Abstract: Coordinating additives are included in porphyrinoid-based materials to promote intermolecular organization and improve one or more photoelectric characteristics of the materials. The coordinating additives are selected from fullerene compounds and organic compounds having free electron pairs. Combinations of different coordinating additives can be used to tailor the characteristic properties of such porphyrinoid-based materials, including porphyrin oligomers. Bidentate ligands are one type of coordinating additive that can form coordination bonds with a central metal ion of two different porphyrinoid compounds to promote porphyrinoid alignment and/or pi-stacking. The coordinating additives can shift the absorption spectrum of a photoactive material toward higher wavelengths, increase the external quantum efficiency of the material, or both.
    Type: Application
    Filed: October 12, 2011
    Publication date: February 19, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Stephen R. Forrest, Jeramy Zimmerman, Eric K. Yu, Mark E. Thompson, Cong Trinh, Matthew Whited, Viacheslav Diev
  • Patent number: 8946202
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: February 3, 2015
    Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke University
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Publication number: 20150031854
    Abstract: The invention relates to novel hemin derivatives of general formula (I), preparing and use thereof as antibacterial and/or antiviral agents, including, as a component in a pharmaceutical compositions. Advantages of the novel antibacterial and antiviral agents based on the hemin derivatives are in their biocompatibility, biodegradability, a high efficacy against resistant bacteria and widespread viruses which are dangerous to humans, and the lack of toxicity.
    Type: Application
    Filed: November 15, 2012
    Publication date: January 29, 2015
    Applicant: OBSSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES"
    Inventors: Vladimir Evgenievich Nebolsin, Galina Alexandrovna Zheltukhina, Sergei Alexandrovich Okorochenkov
  • Patent number: 8940783
    Abstract: The present invention relates to a pheophorbide-? conjugate or its salt, solvate or hydrate. The pheophorbide-? conjugate of the present invention exhibiting fluorescence upon its introduction into cells and degradation inhibits the survival of various cancer cells. Especially, the conjugate of pheophorbide-? (1) and doxorubicin shows higher fluorescence intensity at lower pH (cancer environment). Therefore, the present composition for photodynamic therapy (PDT) of cancers is also very useful in detecting cancers. Interestingly, the anticancer effects of the present composition are dually exerted with help of both the photosensitizer and the anticancer drug of the present conjugates.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: January 27, 2015
    Assignee: Gwangju Institute of Science and Technology
    Inventors: Yong-Chul Kim, Hyo Jin Ko, Hyun You, Jung-Hoon Yoon, Hyo-Eun Yoon
  • Publication number: 20150011749
    Abstract: Metal-accumulating plants for preparing compositions including a metal catalyst derived from the plants. The composition is substantially devoid of organic matter. Also, carrying out chemical reactions with the compositions prepared from metal-accumulating plants.
    Type: Application
    Filed: March 5, 2013
    Publication date: January 8, 2015
    Applicants: UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Claude Grison, Vincent Escande
  • Publication number: 20150005490
    Abstract: Provided is a novel strain permitting genetic engineering of green sulfur bacteria that synthesize bacteriochlorophyll e. Isolated green sulfur bacterium Chlorobaculum limnaeum strain RK-j-1 with accession number NITE BP-1202; isolated transformed Chlorobaculum limnaeum strain obtained by transformation of strain RK-j-1, preferably Chlorobaculum limnaeum dbchU strain with accession number NITE BP-1203 wherein bchU gene is disrupted; a production method of bacteriochlorophyll f containing a step of cultivating Chlorobaculum limnaeum strain dbchU; and bacteriochlorophyll f obtained by the aforementioned production method.
    Type: Application
    Filed: February 12, 2013
    Publication date: January 1, 2015
    Inventors: Jiro Harada, Masato Noguchi, Hitoshi Tamiaki
  • Patent number: 8921608
    Abstract: Industrially relevant product selectivities and reaction rates are obtained from rhodium catalyzed hydroformylation of propylene via the use of a novel induction period in which the supramolecular ligand assembly, the rhodium precatalyst and an initial substrate are allowed to form a hydroformylation catalyst that is more selective toward branched aldehydes. Upon heating this incubated mixture and addition of propylene, iso-butyraldehyde is obtained in higher concentrations and rates that are otherwise unattainable.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 30, 2014
    Assignee: Eastman Chemical Company
    Inventors: David William Norman, Elaine Beatrice Mackenzie
  • Publication number: 20140371286
    Abstract: A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
    Type: Application
    Filed: January 23, 2014
    Publication date: December 18, 2014
    Applicant: North Carolina State University
    Inventors: Han-Je Kim, Jonathan S. Lindsey
  • Patent number: 8907081
    Abstract: A long wavelength absorbing porphyrin/metalloporphyrin molecule is provided, made up of a porphyrin macrocycle and an anchor group for attachment to a substrate. A molecular linking element is interposed between the porphyrin macrocycle and the anchor group. The porphyrin/metalloporphyrin molecule also includes an (aminophenyl)amine group, either N,N-(4-aminophenyl)amine or N-phenyl-N-(4-aminophenyl)amine, where an amino moiety of the 4-aminophenyl group is derivatized by an element such as hydrogen, haloalkanes, aromatic hydrocarbons, halogenated aromatic hydrocarbons, heteroarenes, halogenated heteroarenes, or combinations of the above-mentioned elements.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: December 9, 2014
    Assignee: Sharp Laboratories of America, Inc.
    Inventors: Sean Andrew Vail, David R. Evans, Wei Pan
  • Patent number: 8906897
    Abstract: The invention relates to novel antimicrobial, including antibacterial and antifungal, agents and compositions based on hemin derivatives of general formula (I), and also to the production of novel hemin derivatives. The advantages of antibacterial agents based on hemin derivatives are their biocompatibility, biodegradability, high effectiveness against resistant bacteria and widespread microfungi that are harmful to humans, and freedom from toxicity and side effects.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: December 9, 2014
    Assignee: Obschestvo S Ogranichennoi Otvetstvennostiyu “Pharmenterprises”
    Inventors: Vladimir Evgenievich Nebolsin, Galina Alexandrovna Zheltukhina
  • Patent number: 8901292
    Abstract: A method of mass production of tetrakis(p-nitrophenyl)porphyrins, by which successful isolation of the barely soluble product from meso-aryl nitration of tetraphenylporphyrin toward a remarkable yield of nearly 90% has been realized by means of a solid phase extraction technique. This is a simpler and more straight forward synthetic method, suitable production at an industrial scale with lower cost, shorter synthetic time and lower solvent consumption.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: December 2, 2014
    Assignee: The Hong Kong Polytechnic Univeristy
    Inventors: Kevin Ka Leung Cheuk, John Haozhong Xin, Priscilla Pui Sze Lee, Zhi Xue
  • Publication number: 20140330000
    Abstract: A compound of formula MOL-M-L, wherein M is a 5 or 6-coordinate metal, L is a bidentate ligand, and MOL is a compound of formula (II): (II) wherein X is C and R\ R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. In another embodiment, a system comprises a substrate and a compound of the present disclosure immobilized on the substrate. In still another embodiment, a method comprises introducing a reagent to a substrate presenting the compound of the present disclosure.
    Type: Application
    Filed: March 30, 2012
    Publication date: November 6, 2014
    Inventors: Michael D. Hopkins, Cameron P. Iverson, Wing-Yeung (Wayne) Lau
  • Patent number: 8871926
    Abstract: The present disclosure generally relates to self-assembly methods for generating porphyrin nanostructures. For example, in one embodiment a method is provided that includes preparing a porphyrin solution and a surfactant solution. The porphyrin solution is then mixed with the surfactant solution at a concentration sufficient for confinement of the porphyrin molecules by the surfactant molecules. In some embodiments, the concentration of the surfactant is at or above its critical micelle concentration (CMC), which allows the surfactant to template the growth of the nanostructure over time. The size and morphology of the nanostructures may be affected by the type of porphyrin molecules used, the type of surfactant used, the concentration of the porphyrin and surfactant the pH of the mixture of the solutions, and the order of adding the reagents to the mixture, to name a few variables.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: October 28, 2014
    Assignee: Sandia Corporation
    Inventors: Hongyou Fan, Feng Bai
  • Patent number: 8865890
    Abstract: A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive surface and carrying a redox-active layer structure. The redox-active layer structure may be a monolayer or a multi-layer structure and is configured to have at least one predetermined electronic property including at least one of electrodensity and oxidation state. The electronic property of the layer structure defines an optical property of the structure thereby determining an optical response of the structure to certain incident light. This at least one electronic property is changeable by subjecting the redox-active layer structure to an electric field or to a redox-active material. The device thus enables effecting a change in said electronic property that results in a detectable change in the optical response of the layer structure.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: October 21, 2014
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Milko E. Van Der Boom, Atindra D. Shukla, David Rosenblatt, Tarkeshwar Guptar
  • Patent number: 8859760
    Abstract: Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: October 14, 2014
    Assignee: Frontier Scientific, Inc.
    Inventors: Glenn Prestwich, Jerry C. Bommer, Charles Testa
  • Publication number: 20140301937
    Abstract: Provided herein are compositions useful in the separation of fullerenes from a mixture comprising fullerenes. Also provided herein are methods of making the compositions, as well as methods of using the compositions for fullerene separation.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 9, 2014
    Inventors: Wei Zhang, Qi Wang, Chenxi Zhang
  • Publication number: 20140296511
    Abstract: Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.
    Type: Application
    Filed: May 5, 2014
    Publication date: October 2, 2014
    Applicant: NANOQUANTUM SCIENCES, INC.
    Inventors: Gary W. Jones, Anatoliy L. Tatarets, Leonid D. Patsenker
  • Patent number: 8846904
    Abstract: The present invention provides a porphyrin derivative having improved water solubility, desirably having both water solubility and lipophilicity. Specifically, the present invention provides a water-soluble porphyrin consisting of a tetraphenylporphyrin derivative represented by Formula (1): wherein m represents an integer of 1 to 30; n represents an integer of 2 to 4; R represents a hydrogen atom or an optionally substituted alkyl or aromatic group; Ph represents an optionally substituted phenyl group; and X? is a counterion and represents a halide ion, PF6?, or BF4?.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: September 30, 2014
    Assignee: University of Miyazaki
    Inventors: Masahide Yasuda, Tsutomu Shiragami, Jin Matsumoto
  • Patent number: 8846905
    Abstract: An object of the present invention is to provide a novel porphyrin complex having excellent light collection characteristics and a dye-sensitized solar cell using the porphyrin complex as a sensitizing dye. The porphyrin complex of the present invention as a means for achieving the object is characterized by comprising a porphyrin derivative and a metal atom. The porphyrin derivative has a carboxyaryl group, which is optionally substituted on the aryl ring, attached to at least one of four meso positions of a porphyrin ring optionally substituted at the ?-position and also has a diarylamino group, which is optionally substituted on one or both of the aryl rings, attached to at least either of a meso position adjacent thereto and a meso position opposite thereto.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: September 30, 2014
    Assignee: Kyoto University
    Inventor: Hiroshi Imahori
  • Patent number: 8841443
    Abstract: A silafluorene metalloporphyrin- benzene organic semiconductor material and preparing method and uses thereof are provided. The structure of the silafluorene metalloporphyrin- benzene organic semiconductor material is defined by structure formula (I): wherein: n is an integer between 1 and 100, R1, R2, R3, R4 are H, alkyl with C1-C32, phenyl, alkyl benzene or alkoxyl benzene containing one or more C1-C32, M is a metal ion. The silafluorene metalloporphyrin- benzene organic semiconductor material has good solubility, high carrier mobility, strong absorbance, wide absorbent range to light and elevated utilization ratio of solar light. Besides, the process of the preparing method is simple and easy to operate and control.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: September 23, 2014
    Assignee: Ocean's King Lighting & Science Technology Co., Ltd.
    Inventors: Mingjie Zhou, Jie Huang, Yijin Liu
  • Publication number: 20140261647
    Abstract: A novel compound represented by general formula (1), a support supporting this novel compound, and a photoelectric transduction element using this support. (In the formula, Y is an optionally substituted hydrocarbon group having 1-20 carbon atoms having —CO—NR4- or —SO2—NR4- in the group; Z is a group of a conjugated system; R1, R2, and R3 represent optionally substituted hydrocarbon groups or optionally substituted hydrocarbon-oxy groups; at least one of R1, R2, and R3 is an optionally substituted hydrocarbon-oxy group; R4 represents a hydrogen atom or an optionally substituted hydrocarbon group having 1-20 carbon atoms; R4 and Z may join together to form a ring. However, Y excludes groups represented by partial structural formulas (Y-11) and (Y-12).
    Type: Application
    Filed: August 21, 2012
    Publication date: September 18, 2014
    Applicant: ADEKA CORPORATION
    Inventors: Yohei Aoyama, Kazuyuki Noda, Hiroyuki Osada
  • Patent number: 8835416
    Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: September 16, 2014
    Assignee: Infacare Pharmaceutical Corporation
    Inventors: George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
  • Patent number: 8829183
    Abstract: A nanostructured molecular unit and method for forming is described where a cationic porphyrin having an ethanolic substituent species and a metal in the porphyrin cavity is combined with an anionic porphyrin having a sulfonate substituent species and a metal in the porphyrin cavity to form by self-assembly a nanostructured molecular unit with a morphology comprising four dendritic elements connected at a central node.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: September 9, 2014
    Assignee: Sandia Corporation
    Inventors: John A. Shelnutt, Kathleen E. Martin, Zhongchun Wang, Craig J. Medforth
  • Patent number: 8822677
    Abstract: An improved two stage reaction process for production of mono-L-aspartyl chlorin e6. In a first stage, the activation reaction between chlorin e6 and a carbodiimide produces a previously unknown anhydride in an activation reaction product (Formula I). This reaction product is purified to remove a significant proportion of the precursors of di-L-aspartyl chlorin e6. The purified activation reaction product contains a higher concentration of the previously unknown anhydride. This purified reaction product is used in a second stage: a coupling reaction of the purified activation reaction product with aspartate. The coupling reaction produces a coupling reaction product that has significantly reduced di-L-aspartyl chlorin e6 concentration. This reduced di-L-aspartyl chlorin e6 concentration facilitates purification of mono-L-aspartyl chlorin e6 from the coupling reaction mixture.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: September 2, 2014
    Assignee: Purdue Pharmaceutical Products L.P.
    Inventors: Leon Xu, Alexander J. Pallenberg
  • Publication number: 20140231775
    Abstract: A dendrimer compound characterized by comprising a core represented by the following formula (1-1), (1-2), (1-3), or (1-4) and at least one kind of dendritic structure selected among dendritic structures represented by the following formulae (3) and (4).
    Type: Application
    Filed: April 9, 2014
    Publication date: August 21, 2014
    Inventors: Makoto KITANO, Yoshiaki TSUBATA
  • Publication number: 20140227196
    Abstract: Water soluble porphyrin compounds useful in the field of magnetic resonance imaging (MRI) as contrast agents. Particular compounds include manganese.
    Type: Application
    Filed: February 12, 2013
    Publication date: August 14, 2014
    Applicants: THE HOSPITAL FOR SICK CHILDREN, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Xiao-an ZHANG, Wei Ran CHENG, Inga HAEDICKE, Hai-Ling CHENG