Abstract: The 6-(spirocyclopropyl)-penicillanic acid 4,4-dioxides of the general Formula (I):
as defined herein above which exhibit beta-lactamase inhibiting activity, use of such compounds in combination with beta-lactam antibiotics for inhibiting beta-lactamases, pharmaceutical compositions and processes for preparing such compounds.
Type:
Grant
Filed:
January 26, 2001
Date of Patent:
December 3, 2002
Assignee:
American Cyanamid Company
Inventors:
Vincent P. Sandanayaka, Amarnauth S. Prashad