Abstract: Sodium amoxycillin, of use for example by parenteral administration, is prepared by:(a) suspending amoxycillin trihydrate in a mixture comprising an aprotic organic solvent and a lower alcohol;(b) solubilizing the amoxycillin trihydrate by the addition of a low molecular weight amine of the group of cyclic or heterocyclic aliphatics;(c) adding to such solution the sodium salt of diethyloxalacetic acid, agitating the reaction mixture at a temperature of from -10.degree. C. to ambient temperature and finally isolating the sodium amoxycillin by filtration after its precipitation in the reaction medium by the addition of an aprotic organic solvent.
Type:
Grant
Filed:
October 21, 1986
Date of Patent:
April 12, 1988
Assignee:
Antibioticos S.A.
Inventors:
Augustin Perez-Aranda Ortega, Santiago C. Ruzafa, Fernando R. Serra
Abstract: A sound generating device for a jogger has a generator circuit for generating pace signals the frequencies of which are different from each other in correspondence with different tempos and for generating reference clock pulses, a time counter for receiving and counting the reference clock pulses, and circuits for selectively supplying pace signals the frequencies of which are different from each other and which are supplied from the generator circuit. In response to an instruction signal generated by a switching operation, the time counter starts counting. Simultaneously, based on a selected pace signal from the generator circuit, a desired pace sound can be produced.