Nitrogen Containing Ring Or Ring System Attached By Carbon Or Acyclic Carbon Chain To The -c(=x)- Group Patents (Class 540/328)
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Patent number: 6642377Abstract: A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: wherein the ring A means the basic antibiotic; R10 means a protected functional group used in organic synthesis; Ak—E means the alkali earth metal; and B means the inorganic acid, respectively.Type: GrantFiled: January 14, 2002Date of Patent: November 4, 2003Assignee: Eisai Co., Ltd.Inventors: Akio Kayano, Hiroyuki Chiba, Taiju Nakamura, Shin Sakurai, Hiroyuki Ishizuka, Hiroyuki Saito, Yuuki Komatsu, Manabu Sasho, Nobuaki Sato, Shigeto Negi
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Patent number: 6207668Abstract: The present invention relates to novel substituted pyridines/pyrimidines of the formula I where A is CH or N; X is NH, oxygen or S(O)q where q is 0, 1 or 2; Y is a direct bond or CH2; Z is oxygen, NR7 or S(O)m is 0, 1 or 2, and the radicals R1, R2, R3, R4, R5, R6 and R7 are as defined in the description, to processes for their preparation, and to their use as pesticides, fungicides, ovicides or as veterinary medicaments.Type: GrantFiled: April 1, 1997Date of Patent: March 27, 2001Assignee: Hoechst ScheringInventors: Ralf Braun, Wolfgang Schaper, Werner Knauf, Ulrich Sanft, Manfred Kern, Werner Bonin
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Patent number: 5126335Abstract: Compounds of formula (I) and pharmaceutically acceptable salts and in-vivo hydrolysable esters thereof: ##STR1## wherein X is hydrogen or a group NHR.sup.1, wherein R.sup.1 is hydrogen or an amino protecting group, and R is an optionally substituted 5-membered or 6-membered saturated heterocyclic group containing 1 or 2 heteroatoms selected from oxygen, sulphur or nitrogen, are useful in the treatment of bacterial infections in humans and animals.Type: GrantFiled: March 21, 1990Date of Patent: June 30, 1992Assignee: Beecham Group p.l.c.Inventors: Roger J. Ponsford, Andrew V. Stachulski
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Patent number: 4954489Abstract: Compounds of formula (I) and their salts and esters: ##STR1## wherein X is hydrogen or a group NHR.sup.1, wherein R.sup.1 is hydrogen or an amino protecting group, and R is optionally substituted C.sub.5-8 cycloalkyl or cycloalkenyl, are useful in the treatment of bacterial infections.Type: GrantFiled: April 5, 1989Date of Patent: September 4, 1990Assignee: Beecham Group p.l.c.Inventors: Roger J. Ponsford, Andrew V. Stachulski
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Patent number: 4918067Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or in-vivo hydrolysable ester thereof: ##STR1## wherein R.sup.1 is a 5 or 6 membered sulphur and/or nitrogen containing heterocyclic group substituted by an optionally protected amino group, with the proviso that R.sup.1 is not 2-aminothiazol-4-yl, and R is hydrogen; optionally substituted C.sub.1-12 alkyl; optionally substituted C.sub.2-12 alkenyl or alkynyl; carbocyclyl; aryl or heterocyclyl.These compounds have antibacterial properties, and therefore are of use in the treatment of bacterial infections in humans and animals caused by a wide range of organizations.Type: GrantFiled: July 22, 1987Date of Patent: April 17, 1990Assignee: Beecham Group p.l.c.Inventors: Brian C. Gasson, Michael J. Pearson
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Patent number: 4816452Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or in-vivo hydrolysable ester thereof: ##STR1## wherein R.sup.1 is hydrogen or an amino protecting group and R is substituted methyl; optionally substituted C.sub.2-12 alkyl, alkenyl or alkynyl; carbocyclyl; aryl or heterocyclyl. These compounds have antibacterial properties, and therefore are of use in the treatment of bacterial infections in humans and animals caused by a wide range of organisms.Type: GrantFiled: July 25, 1986Date of Patent: March 28, 1989Assignee: Beecham Group P.L.C.Inventors: Michael J. Pearson, Richard L. Elliott
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Patent number: 4748163Abstract: Antibacterially active and animal growth-promoting novel .beta.-lactam compounds of the formula ##STR1## in which R.sup.1 represents the radical ##STR2## Y representing N or CR.sup.9, or Y--R.sup.7 representing >C.dbd.O or >C.dbd.N--R.sup.7,Z representing O, S, or NR.sup.10, andR.sup.2 represents hydrogen or a protective group.Type: GrantFiled: February 21, 1986Date of Patent: May 31, 1988Assignee: Bayer AktiengesellschaftInventors: Gunter Schmidt, Hans-Joachim Zeiler, Karl G. Metzger
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Patent number: 4734407Abstract: Antibacterially active and animal growth-regulating novel .beta.-lactam compounds of the formula ##STR1## in which R.sup.1 represents an optionally substituted radical of the formula ##STR2## Z represents oxygen, sulphur or --N--R.sup.Type: GrantFiled: March 10, 1986Date of Patent: March 29, 1988Assignee: Bayer AktiengesellschaftInventors: Gunter Schmidt, Hans-Joachim Zeiler, Karl G. Metzger
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Patent number: 4711956Abstract: The invention relates to penicillin derivatives of Formula I, and a method of synthesis; the derivatives having high antimicrobial activity against gram-positive and gram-negative microorganisms. ##STR1## R is selected from the group consisting of ##STR2## R.sub.1 is selected from the group consisting of hydrogen and a hydroxyl group;R.sub.2 is selected from the group consisting of hydrogen, an alkaline metal, and a carboxy protective group;R.sub.3 is selected from the group consisting of hydrogen, a lower alkyl, and a phenyl residue;R.sub.4, R.sub.5, and R.sub.6 are each selected from the group consisting of hydrogen, a halogen, a lower alkyd, and a lower alkoxy group;A is selected from the group consisting of oxygen and a N-(lower alkyl) residue; andn is 0 or 1.Type: GrantFiled: July 17, 1985Date of Patent: December 8, 1987Assignee: TPO "Pharmachim"Inventors: Ivanka A. Atanassova, Marieta A. Haimova, Vesselina B Chavdarova, Anton I. Nakov, Nedelcho G. Petkov, Ruska S. Avramova
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Patent number: 4684639Abstract: A compound having the partial structure (I) ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each is hydrogen or a group --COR.sup.5 or --CO--OR.sup.5 wherein R.sup.5 represents an optionally substituted hydrocarbon group; R.sup.3 is halogen and R.sup.4 is hydrogen, methoxy, hydroxymethyl or formamido.These compounds are suitably bicyclic .beta.-lactam antibiotics.Type: GrantFiled: July 5, 1984Date of Patent: August 4, 1987Assignee: Beecham GroupInventors: George Burton, Desmond J. Best
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Patent number: 4670431Abstract: A compound having the partial structure (A): ##STR1## wherein n is 1 or 2.Type: GrantFiled: January 19, 1984Date of Patent: June 2, 1987Assignee: Beecham Group p.l.c.Inventor: Peter H. Milner
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Patent number: 4666835Abstract: 6.beta.-(L-.alpha.-Aminoadipoyl)-2.alpha.-vinyl-2.beta.-methylpenam-3-carbo xylic acid is provided in an enzymatic process converting .delta.-(L-.alpha.-aminoadipoyl)-L-cysteinyl-D-.gamma.,.delta.-didehydrois oleucine with isopenicillin N synthetase. The 2.alpha.-vinylpenam product is converted by known methods to the 6.beta.-amino-2.alpha.-vinyl-2.beta.-methylpenam-3-carboxylic acid nucleus and the latter is N-acylated to provide corresponding 6.beta.-acylaminopenams.Type: GrantFiled: April 29, 1986Date of Patent: May 19, 1987Inventor: Jack E. Baldwin
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Patent number: RE33948Abstract: Antibacterially active and animal growth-promoting novel .beta.-lactam compounds of the formula ##STR1## in which R.sup.1 represents the radical ##STR2## Y representing N or CR.sup.9, or Y--R.sup.7 representing ##STR3## Z representing O, S, or NR.sup.10, and R.sup.2 represents hydrogen or a protective group.Type: GrantFiled: August 29, 1989Date of Patent: June 2, 1992Assignee: Bayer AktiengesellschaftInventors: Gunter Schmidt, Hans-Joachim Zeiler, Karl G. Metzger