Chalcogen Bonded Directly To The Spiro Hetero Ring Patents (Class 540/33)
  • Teeth whitening methods, visually perceptible signals and compositions therefor
    Patent number: 10610475
    Abstract: Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: April 7, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Zhiqiang Liu, Long Pan, Shaotang Yuan, Jairajh Mattai, James Masters
  • Methods for the purification of deoxycholic acid
    Patent number: 10005813
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-?-hydroxysteroids from ?-9,11-ene, 11-keto or 11-hydroxy-?-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: June 26, 2018
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Achampeta Rathan Prasad, John Gregory Reid, Roy A. Swaringen, Jr.
  • Process and new intermediates for the preparation of steroids with a progestogen activity
    Patent number: 7667056
    Abstract: The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of Desogestrel of formula (I). Said process is characterized by the regioselective reduction of the compound of formula (II) to give the intermediate of formula (III).
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: February 23, 2010
    Assignee: Poli Industria Chimica S.p.A.
    Inventors: Paride Grisenti, Fabio Pecora, Elisa Verza, Massimo Leoni, Laura Bossi
  • 11.beta.-aryl-17, 17-spirothiolane-substituted steroids
    Patent number: 6043235
    Abstract: The invention is directed to 11.beta.-aryl-17,17-spirothiolane substituted steroid compounds of formula (I) exhibiting binding to the progestin receptor. ##STR1## Also disclosed are methods of using and process of making the compounds.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: March 28, 2000
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, Rupa S. Shetty, John A. Kepler, David Y.-W. Lee
  • Conversion of steroidal 17-cyanohydrins to corticoids
    Patent number: 5003063
    Abstract: The invention involves a two step chemical transformation of a steroidal 17-cyanohydrin (II) ##STR1## to a 17.alpha.-hydroxy-21-halo-20-keto steroid (IV) ##STR2## intermediate which can readily be converted to pharmaceutically useful corticoids.
    Type: Grant
    Filed: January 30, 1990
    Date of Patent: March 26, 1991
    Assignee: The Upjohn Company
    Inventor: John G. Reid
  • 11a-hydroxy steroid diester
    Patent number: 4948533
    Abstract: The present invention relates to 21-(3-carboxy-1-oxopropoxy) -17.alpha.-hydroxy-11.alpha.-(3,3-dimethyl-1-oxobutoxy)pregna-1,4-diene-3, 20 dione and pharmaceutically acceptable salts thereof which are useful steroid prodrugs.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: August 14, 1990
    Assignee: The Upjohn Company
    Inventors: John M. Braughler, Edward D. Hall, Wendell Wierenga, John M. McCall
  • Novel 11 .beta.-alkynylphenyl-10-nor-steroids
    Patent number: 4912097
    Abstract: Novel 11.beta.-alkynylphenyl-19-nor-steroids of the formula ##STR1## wherein R.sub.1 is alkynyl of 2 to 8 carbon atoms optionally substituted with at least one member of the group consisting of --OH halogen, trialkylsilyl of 1 to 6 alkyl carbon atoms, alkoxy and alkylthio of 1 to 6 carbon atoms and dialkylamino of 1 to 6 alkyl carbon atoms having remarkably antiprogestomimetic and antiglucocorticoidal activity.
    Type: Grant
    Filed: April 30, 1987
    Date of Patent: March 27, 1990
    Assignee: Roussel Uclaf
    Inventors: Jean-Georges Teutsch, Michel Klich, Daniel Philibert