The Additional Chalcogen Is Bonded Directly To The Ring Nitrogen Patents (Class 540/355)
  • O-sulfated spiro .beta.-lactam hydroxamic acids
    Patent number: 4638060
    Abstract: Antibacterial activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: January 20, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, William H. Koster, Robert Zahler
  • 3-acylamino-2-oxo-1-azetidinesulfonic acids
    Patent number: 4632985
    Abstract: Antibacterial activity is exhibited by 2-azetidinones activated in the 1-position with an --SO.sub.
    Type: Grant
    Filed: June 3, 1985
    Date of Patent: December 30, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: David Kronenthal
  • Process for preparing (s)-3-amino-2-oxo-1-azetidinesulfonic acid salts
    Patent number: 4625022
    Abstract: The process of this invention provides for the conversion of amino acid amides having the formula ##STR1## to 3-amino-2-oxo-1-azetidinesulfonic acid salts having the formula ##STR2## wherein one of R.sub.2 and R.sub.3 is hydrogen and the other is hydrogen, alkyl, cycloalkyl, phenyl or substituted phenyl and M.sup..sym. is hydrogen or a cation.
    Type: Grant
    Filed: November 15, 1985
    Date of Patent: November 25, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David M. Floyd, Alan W. Fritz, Christopher M. Cimarusti
  • Process for preparing azetidinone derivatives
    Patent number: 4622178
    Abstract: A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 represents a straight-chain or branched-chain lower alkyl group, substituted or unsubstituted aryl group, substituted or unsubstituted phenylmethyl group or substituted or unsubstituted phenyloxymethyl group, R.sup.2 represents hydrogen atom, an optionally substituted hydrocarbon residue or protective group for amino group selected from the class consisting of acyl, silyl, sulfonyl and phosphonyl derived from organic or inorganic acid, and R.sup.3 represents a substituted or unsubstituted aryl group or the residue of substituted or unsubstituted heterocyclic ring.
    Type: Grant
    Filed: May 1, 1984
    Date of Patent: November 11, 1986
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Shigeru Torii, Hideo Tanaka, Junzo Nogami, Michio Sasaoka, Norio Saito, Takashi Shiroi
  • Hydrazide derivatives of monocyclic beta-lactam antibiotics
    Patent number: 4610824
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: September 9, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Truner