The Cyclopentanohydrophenanthrene Ring System Is Fully Saturated Patents (Class 540/39)
  • Synthesis of aryl serines
    Patent number: 6057473
    Abstract: Anthraquinone chiral ligands (AQN) are used in asymmetric aminohydroxylation addition reactions of cinnamate based olefins for synthesizing aryl serines. The anthraquinones impart a reverse regioselectivity as compared to the commonly employed phalazine chiral ligands (PHAL). Carbamates are employed as the oxidant nitrogen source. The yields and enantiomeric efficiencies are Excellent. .beta.-Hydroxyamines are obtained by deprotecting the corresponding .beta.-hydroxycarbamate.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: May 2, 2000
    Assignee: The Scripps Research Institute
    Inventors: K. Barry Sharpless, Beata Tao, Gunther Schlingloff