Chalcogen Bonded Directly At The 11-position Of The Cyclopentanohydrophenanthrene Ring System Patents (Class 540/43)
  • Anti Mineralocorticoid Therapy of Infection
    Publication number: 20090053294
    Abstract: Antimineralocorticoid compounds are disclosed for use in the prophylaxis and therapy of viral infections, especially the retroviral infection by HIV. These compounds can be administered alone or in combination with conventional anti-viral agents or anti-sense mineralocorticoid Steroid ReceptorNA or DNA mutants of heat shock proteins.
    Type: Application
    Filed: October 31, 2006
    Publication date: February 26, 2009
    Inventor: Patrick T. Prendergast
  • 7?-Hydroxyacetyl and 7?-Hydroperoxyacetyl-substituted steroid compounds
    Patent number: 7417140
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 26, 2008
  • 7 ?-Enedione-substituted steroid compounds
    Patent number: 7414127
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 19, 2008
  • 7?-biscarbonyl-substituted steroid compounds
    Patent number: 7411062
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 12, 2008
  • Crystal form
    Patent number: 7112670
    Abstract: The present invention involves a novel crystal form of 17?-hydroxy-7?-(5?-methyl-2?-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, ?-lactone, having the formula which is an intermediate useful in preparation of an important pharmaceutical, eplerenone.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: September 26, 2006
    Assignee: Pharmacia Corporation
    Inventors: Bruce Allen Pearlman, Frederick J. Antosz
  • Processes for preparation of 9,11- epoxy steroids and intermediates useful therein
    Publication number: 20020016455
    Abstract: Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I 1
    Type: Application
    Filed: April 3, 2001
    Publication date: February 7, 2002
    Inventors: John S. Ng, Ping T. Wang, Julio A. Baez, Chin Liu, Dennis K. Anderson, Jon P. Lawson, Bernhard Erb, Joseph Wieczorek, Gennaro Mucciariello, Fortunato Vanzanella, Sastry A. Kunda, Leo J. Letendre, Mark J. Pozzo, Yuen-Lung L. Sing, Edward E. Yonan
  • Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
    Patent number: 6180780
    Abstract: Multiple reaction schemes, process steps and intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I wherein the variables are as defined by the specification.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: January 30, 2001
    Assignee: G.D. Searle & Co.
    Inventors: John S. Ng, Ping T. Wang, Julio A. Baez, Chin Liu, Dennis K. Anderson, Jon P. Lawson, Bernhard Erb, Joseph Wieczorek, Gennaro Mucciariello, Fortunato Vanzanella, Sastry A. Kunda, Leo J. Letendre, Mark J. Pozzo, Yuen-Lung L. Sing, Edward E. Yonan
  • Microbial 11.alpha.-hydroxylation of steroids
    Patent number: 6046023
    Abstract: The invention relates to a microbial method of in vitro transformation of a steroid into its corresponding 11.alpha.-hydroxy analogue using oxygen and a microorganism selected from the Aspergillus ochraceus, Aspergillus niger, Rhizopus stolonifer, Rhizopus nigricans, Rhizopus arrhizus, and strains of Pestelotia, using as substrate a steroid having a purity of less than 97% and more than 90% at a concentration greater than 10 g/l.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: April 4, 2000
    Assignee: Akzo Nobel, N.V.
    Inventors: Marten Wiersma, Peter van der Meijden
  • Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
    Patent number: 5981744
    Abstract: Multiple reaction schemes, process steps and intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other 9,11-epoxy-steroids.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: November 9, 1999
    Assignee: G. D. Searle and Co.
    Inventors: John S. Ng, Ping T. Wang, Julio A. Baez, Chin Liu, Dennis K. Anderson, Jon P. Lawson, Bernhard Erb, Joseph Wieczorek, Sastry A. Kunda, Leo J. Letendre, Mark J. Pozzo, Yuen-Lung L. Sing, Edward E. Yonan