Plural Nitrogens In The Hetero Ring Patents (Class 540/460)
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Patent number: 7192949Abstract: The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.Type: GrantFiled: April 24, 2006Date of Patent: March 20, 2007Assignee: Merck & Co., Inc.Inventors: Mark E. Fraley, Robert M. Garbaccio
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Patent number: 7189844Abstract: Disclosed is a process for preparing a compound of formula I comprising cyclizing a diene compound of formula III in the presence of a ruthenium catalyst in a suitable organic solvent, wherein the process is performed in a gaseous fluid at supercritical or near-supercritical conditions: The compounds of formula (I) are active agents for the treatment of hepatitis C viral (HCV) infections or are intermediates useful for the preparation of anti-HCV agents.Type: GrantFiled: September 9, 2005Date of Patent: March 13, 2007Assignee: Boehringer Ingelheim International GmbHInventors: Fabrice Gallou, Nathan Yee
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Patent number: 7183374Abstract: A process for diminishing the concentration of a metal complex from a solution containing said complex by the addition of an optionally fused and/or optionally substituted heterocyclic compound. The added compound is a solubility-enhancing compound that enhances the solubility of said complex in a second solution. Thereafter the solution containing said complex can be extracted with the second solution.Type: GrantFiled: November 18, 2004Date of Patent: February 27, 2007Assignee: Boehringer Ingelheim International GmbHInventors: Michael Brenner, Siegfried Meineck, Thomas Wirth
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Patent number: 7179908Abstract: Provided are cucurbituril derivatives having the formula (1), their preparation methods and uses: where X is O, S or NH; R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl groups of 1 to 30 carbon atoms, alkenyl groups of 1 to 30 carbon atoms, alkynyl groups of 1 to 30 carbon atoms, alkylthio groups of 1 to 30 carbon atoms, alkylcarboxyl groups of 1 to 30 carbon atoms, hydroxyalkyl groups of 1 to 30 carbon atoms, alkylsilyl groups of 1 to 30 carbon atoms, alkoxy groups of 1 to 30 carbon atoms, haloalkyl groups of 1 to 30 carbon atoms, nitro group, alkylamine groups of 1 to 30 carbon atoms, amine group, aminoalkyl groups of 1 to 30 carbon atoms, unsubstituted cycloalkyl groups of 5 to 30 carbon atoms, cycloalkyl groups of 4 to 30 carbon atoms with hetero atoms, unsubstituted aryl groups of 6 to 30 carbon atoms, and aryl groups of 6 to 30 carbon atoms with hetero atoms; and n and m are independently integers from 4 to 20 and from 1 to 7, respectively.Type: GrantFiled: July 3, 2002Date of Patent: February 20, 2007Assignee: Pohang University of Science and Technology FoundationInventors: Kimoon Kim, Jianzhang Zhao, Hee-Joon Kim, Soo-Young Kim, Jinho Oh
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Patent number: 7176208Abstract: The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.Type: GrantFiled: April 16, 2004Date of Patent: February 13, 2007Assignee: Enanta Pharmaceuticals, Inc.Inventors: Suanne Nakajima, Zhenwei Miao, Ying Sun, Datong Tang, Guoyou Xu, Brian Porter, Yat Sun Or, Zhe Wang
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Patent number: 7163935Abstract: Substituted 1,4,7-triazacyclononane-N,N?,N?-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.Type: GrantFiled: June 3, 2003Date of Patent: January 16, 2007Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Martin W. Brechbiel, Hyun-Soon Chong
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Patent number: 7160466Abstract: Uses of cucurbituril derivatives are disclosed.Type: GrantFiled: August 25, 2003Date of Patent: January 9, 2007Assignee: Pohang University of Science and Technology FoundationInventors: Kimoon Kim, Jaheon Kim, In-Sun Jung, Soo-Young Kim, Eunsung Lee, Jin-Koo Kang
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Patent number: 7151096Abstract: The invention provides a novel class of cyclic compounds, pharmaceutical compositions comprising such cyclic compounds and methods of using such compounds to treat or prevent diseases and disorders associated with cyclin-dependent kinases (CDKs) activity, particularly diseases associated with the activity of CDK2 and CDK5.Type: GrantFiled: March 5, 2004Date of Patent: December 19, 2006Assignee: IRM LLCInventors: Pingda Ren, Francisco Adrian, Nathanael S. Gray, Xia Wang
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Patent number: 7148347Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.Type: GrantFiled: April 6, 2004Date of Patent: December 12, 2006Assignee: Boehringer Ingelheim International GmbHInventors: Joerg Brandenburg, Kai Donsbach, Hans-Dieter Ecker, Rogelio Perez Frutos, Fabrice Gallou, Dieter Gutheil, Nizar Haddad, Robert Hagenkoetter, Dirk Kemmer, Jutta Kroeber, Thomas Nicola, Juergen Schnaubelt, Michael Schul, Robert Donald Simpson, Xudong Wei, Eric Winter, Yibo Xu, Nathan K. Yee
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Patent number: 7081452Abstract: Substituted 1,4,7-triazacyclononane-N,N?,N?-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.Type: GrantFiled: December 13, 2002Date of Patent: July 25, 2006Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Martin W. Brechbiel, Hyun-Soon Chong
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Patent number: 7064119Abstract: A novel fused bicyclic pyrimidine derivative or a salt thereof that acts as a tachykinin receptor antagonist and, in particular, as an NK1 receptor antagonist is represented by the following general formula (1): wherein the rings A and B are each a benzene ring having 1 to 3 substituents (any adjacent two of which may be bound to one another to form a ring); the ring C is a nitrogen-containing ring; R is a hydrogen atom, a C1 to C6 alkyl group, a C1 to C6 alkylcarbonyl group, or a C1 to C6 alkylsulfonyl group; m is 1 or 2; and n is 2 or 3.Type: GrantFiled: March 24, 2003Date of Patent: June 20, 2006Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Shigeki Seto, Asao Tanioka, Makoto Ikeda, Shigeru Izawa
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Patent number: 7060290Abstract: Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or unsubstituted alkyl, (ii) substituted or unsubstituted alkenyl, (iii) substituted or unsubstituted alkanoyl, (iv) substituted or unsubstituted alkenoyl wherein the double bond is cis, and (v) (ortho or para) carbonyl-substituted aryl; and wherein the subtituent is each an independent group or linked together thereby forming a ring; and wherein X is one or more substituted or unsubstituted group containing one or more O, N, or S atom and wherein the substituent is each an independent group or linked together thereby forming a ring; and wherein the therapeutic agent is an alcohol-containing water-insoluble steroids or another alcohol containing compounds and methods to prepare such compounds.Type: GrantFiled: February 16, 2000Date of Patent: June 13, 2006Assignee: Supergen, Inc.Inventors: Bruce H. Morimoto, Peter L. Barker
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Patent number: 7056912Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.Type: GrantFiled: November 14, 2003Date of Patent: June 6, 2006Assignee: Zentaris GmbHInventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
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Patent number: 7022717Abstract: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.Type: GrantFiled: November 7, 2003Date of Patent: April 4, 2006Assignee: AnorMED, Inc.Inventors: Gary James Bridger, Eva Maria Boehringer, Zhongren Wang, Dominique Schols, Renato Tony Skerlj, David Earl Bogucki
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Patent number: 7018850Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: GrantFiled: June 7, 2002Date of Patent: March 28, 2006Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
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Patent number: 6992184Abstract: The invention relates to a novel synthetic route for a group of ligands and to an improved catalyst containing the ligand. The invention also provides use of a ligand for inhibiting dye transfer.Type: GrantFiled: August 13, 2001Date of Patent: January 31, 2006Assignee: Carnegie Mellon UniversityInventors: Riccardo Filippo Carina, Carl Gibson
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Patent number: 6984734Abstract: The present invention provides an oxidative coupling procedure that allows efficient synthesis of novel cyclo[n]pyrrole macrocycles. Therefore, the present invention provides cyclo[n]pyrroles where n is 6, 7, 8, 9, 10, 11, or 12, and derivatives, multimers, isomers, and ion and neutral molecule complexes thereof as new compositions of matter. A protonated form of cyclo[n]pyrrole displays a gap of up to 700 nm between strong Soret and Q-like absorption bands in the electronic spectrum, demonstrating no significant ground state absorption in the visible portion of the electronic spectrum. Uses of cyclo[n]pyrroles as separation media, nonlinear optical materials, information storage media and infrared filters are provided.Type: GrantFiled: February 26, 2003Date of Patent: January 10, 2006Assignee: Board of Regents, The University of Texas SystemInventors: Jonathan L. Sessler, Daniel Seidel, Frederic R. Bolze, Thomas Koehler
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Patent number: 6962690Abstract: Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents for soft tissue cancers.Type: GrantFiled: October 22, 2002Date of Patent: November 8, 2005Assignees: Dow Global Technologies Inc., Texas Tech UniversityInventors: Garry E. Kiefer, Darryl J. Bornhop
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Patent number: 6946459Abstract: Two new crystalline forms of 1S-[1alpha(2S*, 3R*), 9alpha]6, 10-dioxo-N-(2-ethoxy-5-oxo-tetrahydro-3-furany1)-9 [[(1-isoquinolyl) carbony1]amino]octahydro-6H-pyridazino [1,2-a][1,2]diazepin-1-carboxamide (anhydrous or hydrated), their preparation process and the pharmaceutical compositions containing them.Type: GrantFiled: November 18, 2002Date of Patent: September 20, 2005Assignee: Aventis Pharma S. A.Inventors: Jean-Yves Godard, Valerie Rognon
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Patent number: 6943157Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R1, R2, R2a and R3 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of central nervous disorders. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.Type: GrantFiled: October 9, 2002Date of Patent: September 13, 2005Assignee: Myriad Genetics, Inc.Inventors: Gangadhar Nagula, Jan Urban, Hwa-Ok Kim, Christopher Lum, Hiroshi Nakanishi
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Patent number: 6924305Abstract: Compounds of the formula I, in which B1, B2, R1, R2, R6, R7, K1 and K2 are as defined in the description are novel effective tryp-tase inhibitors.Type: GrantFiled: January 26, 2002Date of Patent: August 2, 2005Assignee: Altana Pharma AGInventor: Wolf-Rüdiger Ulrich
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Patent number: 6916805Abstract: This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.Type: GrantFiled: January 4, 2002Date of Patent: July 12, 2005Assignee: Warner-Lambert Company LLCInventors: Danette Andrea Dudley, Jeremy John Edmunds
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Patent number: 6900222Abstract: The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein —Z1—Z2— is a bivalent radical; R1, R2 and R3 are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; or when R1 and R2 are on adjacent carbon atoms, R1 and R2 taken together may form a bivalent radical of formula; Alk is optionally substituted C1-6alkanediyl; the bivalent radical is a substituted piperidinyl, an optionally substituted pyrrolidinyl, homopiperidinyl, piperazinyl or tropyl; R5 is a radical of formula wherein n is 1 or 2; p1 is 0, and p2 is 1 or 2; or p1 is 1 or 2, and p2 is 0; X is oxygen, sulfur or ?NR9; Y is oxygen or sulfur; R7 is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R8 is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R9 is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R10 is hydrogen or C1-6alkyl; and Q is aType: GrantFiled: May 23, 2000Date of Patent: May 31, 2005Assignee: Janssen Pharmaceutica N.V.Inventors: Marcel Frans Leopold De Bruyn, Kristof Van Emelen, Piet Tom Bert Paul Wigerinck, Wim Gaston Verschueren
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Patent number: 6867208Abstract: The present invention relates to compounds of the formula I A—B—D—E—F—G??(I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.Type: GrantFiled: May 13, 2002Date of Patent: March 15, 2005Assignees: Hoechst Aktiengesellschaft, Genentech, Inc.Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Jochen Knolle, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
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Patent number: 6864103Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: GrantFiled: November 14, 2001Date of Patent: March 8, 2005Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Stephane Petoud, Seth M. Cohen, Jide Xu
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Publication number: 20040266988Abstract: The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4+ T cell immune responses by identifying compounds that block the interaction of CD4 and MHC, class II, gene products and a method of treatment which comprises administering such an identified compound. The compounds that inhibit undesired human CD4+ T cell immune responses can be used to treat disease such as multiple sclerosis and to prevent graft rejection and graft versus host disease. More specifically, the application concerns compounds having molecular weights between about 1400 and 400 that mimic three portions of the human CD4 lymphocyte cell surface antigen. The portions are residues 29-35, the C—C′ loop of the D1 domain; residues 317-323, the C—C′ loop of the D4 domain; and residues 346-353, the CDR3 or FG ridge of the D4 domain of the CD4 molecule. Specific examples of such compounds include cyclic peptides and peptidomimetic.Type: ApplicationFiled: May 7, 2004Publication date: December 30, 2004Applicant: Thomas Jefferson UniversityInventors: Robert Korngold, Ziwei Huang
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Patent number: 6818764Abstract: A method of manufacturing substance GM-95 having general formula [I], comprising (a) deprotecting a macrocyclic compound having general formula [II] (wherein, R1's are the same or different and each represents a lower alkyl group, and R2 represents a thiol protecting group) by removing acetal protecting groups (the R1's) thereof, and forming an oxazole ring through an intramolecular cyclization reaction between produced formyl group and an amide group, and (b) deprotecting a resulting macrocyclic compound having general formula [III] (wherein, R2 is as mentioned above) by removing the thiol protecting group (R2) thereof, and forming a thiazoline ring through an intramolecular cyclization reaction between a thiol group thus produced and an amide group.Type: GrantFiled: June 3, 2003Date of Patent: November 16, 2004Assignees: Taiho Pharmaceutical Co., Ltd., Sosei Co., Ltd.Inventors: Shozo Yamada, Kazuhiko Shigeno, Kazuhiro Kitagawa, Shigeo Okajima, Tetsuji Asao
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Patent number: 6793839Abstract: A method for producing cucurbit[n]urils, where n is from 4 to 12, comprising mixing substituted and/or unsubstituted glycoluril with an acid and a compound that can form methylene bridges between glycoluril units, and heating the mixture to a temperature of from 20° to 120° to thereby form cucurbit[n]. Novel cucurbit[n]urils, where n=4, 5, 7, 8, 9, 10, 11 and 12 and substituted cucurbit[s,u]urils, where s=number of substituted glycoluril units, u=number of unsubstituted units and s+u=4-12 are also described.Type: GrantFiled: January 7, 2002Date of Patent: September 21, 2004Assignee: Unisearch LimitedInventors: Anthony Ivan Day, Alan Peter Arnold, John Rodney Blanch
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Patent number: 6790954Abstract: A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and capable of growth under varied culture conditions, and methods of producing maytansinoid ansamitocins by culturing PF4-4 in a suitable growth medium.Type: GrantFiled: January 29, 2002Date of Patent: September 14, 2004Assignees: Immunogen, Inc., Genentech, Inc.Inventors: Johnson Chung, Graham S. Byng
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Publication number: 20040170866Abstract: The present invention relates to a cyclic tertiary amine compound represented by a formula (1) and an organic luminescent device.Type: ApplicationFiled: March 4, 2004Publication date: September 2, 2004Inventors: Wang Guofang, Manabu Uchida, Hajime Yokoi, Takaharu Nakano, Kenji Furukawa
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Publication number: 20040072762Abstract: Compounds of the formula I, in which B1, B2, R1, R2, R6, R7, K1 and K2 are as defined in the description are novel effective tryp-tase inhibitors.Type: ApplicationFiled: July 22, 2003Publication date: April 15, 2004Inventor: Wolf-Rudiger Ulrich
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Publication number: 20040029850Abstract: Compounds having the general formula 1Type: ApplicationFiled: March 26, 2003Publication date: February 12, 2004Inventor: Peter Bernstein
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Patent number: 6680311Abstract: The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.Type: GrantFiled: February 25, 1998Date of Patent: January 20, 2004Assignees: Eli Lilly and Company, Wayne State University, University of HawaiiInventors: Rima S Al-Awar, William J Ehlhardt, Subbaraju V Gottumukkala, Michael J Martinelli, Eric D Moher, Richard E Moore, John E Munroe, Bryan H Norman, Vinod F Patel, James E Ray, Chuan Shih, John E Toth, Venkatraghavan Vasudevan
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Patent number: 6673786Abstract: A compound of formula I in which M, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, B5, B6, K1, and K2 are defined herein and are novel effective tryptase-inhibitors.Type: GrantFiled: May 3, 2002Date of Patent: January 6, 2004Assignee: Altana Pharma AGInventor: Wolf-Rüdiger Ulrich
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Publication number: 20040002448Abstract: The present invention covers macrocyclic compounds of formula I active in-vitro and in cellular assays against the NS3 protease of the hepatitis C virus.Type: ApplicationFiled: February 5, 2003Publication date: January 1, 2004Applicant: Boehringer Ingelheim (Canada) Ltd.Inventors: Youla S. Tsantrizos, Dale R. Cameron, Anne-Marie Faucher, Elise Ghiro, Nathalie Goudreau, Teddy Halmos, Montse Llinas-Brunet
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Patent number: 6667320Abstract: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.Type: GrantFiled: December 15, 2000Date of Patent: December 23, 2003Assignee: AnormedInventors: Gary James Bridger, Eva Maria Boehringer, Zhongren Wang, Dominique Schols, Renato Tony Skerlj, David Earl Bogucki
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Publication number: 20030224977Abstract: Compounds of formula I: 1Type: ApplicationFiled: January 29, 2003Publication date: December 4, 2003Applicant: Boehringer Ingelheim (Canada) Ltd.Inventors: Montse Llinas-Brunet, Vida J. Gorys
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Patent number: 6656930Abstract: Certain aralkyl diazabicycloalkyl compounds are disclosed for treatment of CNS disorders, such as cerebral ischemia, psychosis, and convulsions.Type: GrantFiled: September 4, 2001Date of Patent: December 2, 2003Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Wayne D Bowen, Brian R. de Costa, Celia Dominguez, Xiao-Shu He, Kenner C. Rice
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Publication number: 20030216436Abstract: The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A-B, K, Q, X, Y, Z, R and R1 are as defined in claim 1. The present invention also provides processes for the preparation thereof, the use thereof in treating immune mediated disease and conditions, and pharmaceutical compositions for use in such therapy.Type: ApplicationFiled: March 13, 2003Publication date: November 20, 2003Inventors: Daniel Romo, Jun Liu, Nam Song Choi, Zonggao Shi
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Publication number: 20030212268Abstract: Provided are cucurbituril derivatives having the formula (1), their preparation methods and uses: 1Type: ApplicationFiled: March 4, 2003Publication date: November 13, 2003Inventors: Kimoon Kim, Jianzhang Zhao, Hee-Joon Kim, Soo-Young Kim, Jinho Oh
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Patent number: 6639069Abstract: Cucurbituril derivatives, their preparation methods and uses.Type: GrantFiled: March 8, 2002Date of Patent: October 28, 2003Assignee: Pohang University of Science and TechnologyInventors: Kimoon Kim, Jaheon Kim, In-Sun Jung, Soo-Young Kim, Eunsung Lee, Jin-Koo Kang
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Publication number: 20030199688Abstract: Macrocyclic module compositions are made from cyclic synthons. The macrocyclic module structures are prepared by stepwise or concerted schemes which couple synthons in a closed ring. The macrocyclic module structures may have a pore of nanometer dimensions.Type: ApplicationFiled: August 23, 2002Publication date: October 23, 2003Inventors: Josh Kriesel, Timothy B. Karpishin, Donald B. Bivin, Grant Merrill, Martin Stuart Edelstein, Thomas H. Smith, Jeffery A. Whiteford, Robert Thomas Jonas
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Publication number: 20030195228Abstract: Disclosed are pharmaceutical compositions of hepatitis C viral protease inhibitors having improved bioavailability, and methods of using these compositions for inhibiting the replication of the hepatitis C virus (HCV) and for the treatment of an HCV infection. These compositions include co-solvent systems, lipid based systems, solid dispersions and granulations, and all comprise the hepatitis C viral protease inhibitor, at least one pharmaceutically acceptable amine and optionally one or more additional ingredients.Type: ApplicationFiled: February 4, 2003Publication date: October 16, 2003Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Shirlynn Chen, Xiaohui Mei
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Publication number: 20030191053Abstract: The present invention aims to provide cyclic peptide derivatives having motilin receptor antagonist activity or the like and useful as pharmaceuticals.Type: ApplicationFiled: February 24, 2003Publication date: October 9, 2003Inventors: Hiroharu Matsuoka, Tsutomu Sato
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Publication number: 20030181363Abstract: Compounds of formula I: 1Type: ApplicationFiled: December 17, 2002Publication date: September 25, 2003Applicant: Boehringer Ingelheim (Canada) Ltd.Inventors: Montse Llinas-Brunet, Vida J. Gorys
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Publication number: 20030168630Abstract: The invention relates to a novel synthetic route for a group of ligands and to an improved catalyst containing the ligand. It provides a method for the synthesis of a ligand having the structure: (I) The invention also provides use of a ligand for inhibiting dye transfer.Type: ApplicationFiled: February 19, 2003Publication date: September 11, 2003Inventors: Riccardo Filippo Carina, Carl Gibson
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Publication number: 20030157669Abstract: Improved purification methods for ansamitocins are disclosed.Type: ApplicationFiled: March 4, 2003Publication date: August 21, 2003Applicant: SmithKline Beecham plcInventor: Mark Fulston
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Patent number: 6608027Abstract: The present invention covers macrocyclic compounds of formula I active in-vitro and in cellular assays against the NS3 protease of the hepatitis C virus. wherein W, R21, R22, R3, R4, D and A are as defined herein, or a pharmaceutically acceptable salts or ester thereof.Type: GrantFiled: January 16, 2001Date of Patent: August 19, 2003Assignee: Boehringer Ingelheim (Canada) LtdInventors: Youla S. Tsantrizos, Dale R. Cameron, Anne-Marie Faucher, Elise Ghiro, Nathalie Goudreau, Teddy Halmos, Montse Llinas-Brunet
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Publication number: 20030144260Abstract: The present invention provides according to a first of its aspects, new compounds that have a flexible scaffold with various degrees of conformational restriction and accordingly are useful as drug candidates. These compounds may be used to produce new combinatorial libraries that will permit to screen for and select drug candidates for a variety of uses in human medicine, veterinary medicine and in agriculture.Type: ApplicationFiled: January 3, 2002Publication date: July 31, 2003Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEMInventor: Chaim Gilon
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Publication number: 20030114420Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.Type: ApplicationFiled: December 19, 2001Publication date: June 19, 2003Inventors: Mark E. Salvati, James Aaron Balog, Weifang Shan, Soren Giese