Polycyclo Ring System Which Contains The Hetero Ring As One Of The Cyclos Patents (Class 540/476)
  • Patent number: 4843081
    Abstract: A and A' are each hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or aryloxy;X is cyano, nitro, COOR, SR, SOR or SOOR;R is H, C.sub.1-6 alkyl or aryl;n n' and n" are each 0 to 4; andm, m' and m" are each 1 to 4, have calcium channel blocking activity.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: June 27, 1989
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: John R. Regan, Jeffrey N. Barton, John T. Suh, Jerry W. Skiles
  • Patent number: 4831132
    Abstract: Novel ortho-(mono-substituted amino)phenylimines being intermediates to psychotropic drugs and other drugs are economically and industrially prepared by reacting anilines with nitriles in the presence of a boron trifluoride ether adduct and a halide-type Lewis acid, if necessary together with an organic base. Furthermore, the imines can be hydrolyzed with an acid to afford the corresponding ketones.
    Type: Grant
    Filed: December 30, 1986
    Date of Patent: May 16, 1989
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tsutomu Sugasawa, Kazuyuki Sasakura
  • Patent number: 4824472
    Abstract: Novel herbicidal 1-cyclyl or polycyclyl substituted 1H-imidazole-5-carboxylic acid derivatives, compositions containing these compounds as active ingredients, and a method for controlling weeds, preferably selectively in crops of useful plants. Processes for making these novel compounds.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: April 25, 1989
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Guy R. E. Van Lommen, Victor Sipido, Wim G. Verschueren, William R. Lutz
  • Patent number: 4797397
    Abstract: Certain .alpha.-[(2-nitro-1H-imidazol-1-yl)methyl]-aziridinylethanols and the corresponding aziridine-ring opened analogs are useful as radiation sensitizers for X-irradiation therapy of tumors.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: January 10, 1989
    Assignee: Warner-Lambert Company
    Inventors: Mark J. Suto, Leslie M. Werbel
  • Patent number: 4769452
    Abstract: A method of extracting benzo-c-phenanthridine alkaloids from plants of the families Papaveraceae, Fumariaceae, and Berberidaceae, comprising grinding the plant, extracting the ground plant with acidulated methanol or acidulated ethanol, precipitating the extract with an acid salt soluble in the solvent used, redissolving the precipitated salt in water, adding sufficient acid to form a precipitate, and collecting the precipitate so formed.
    Type: Grant
    Filed: June 18, 1987
    Date of Patent: September 6, 1988
    Assignee: Vipont Laboratories, Inc.
    Inventor: Richard T. Boulware
  • Patent number: 4728645
    Abstract: Disclosed are compounds of formula I ##STR1## wherein R.sub.1 represents hydrogen, lower alkyl, substituted lower alkyl, nitro, halogen, free, etherified or esterified hydroxy, free, etherified, oxidized etherified or esterified mercapto, unsubstituted, mono- or disubstituted amino, ammonio, free or functionally modified sulfo, free or functionally modified formyl, C.sub.2 -C.sub.20 -acyl, cyano, free or functionally modified carboxy; and R.sub.2 represents hydrogen, lower alkyl, substituted lower alkyl, halogen; free, etherified or esterified hydroxy; free, etherified, oxidized etherified or esterified mercapto; free or functionally modified carboxy, or acyl; the 7,8-dihydro derivatives thereof; and compounds of the formula I* ##STR2## wherein n denotes 0, 1, 2, 3 or 4, and R.sub.1 and R.sub.2 are as defined above under formula I and salts thereof; e.g. as aromatase inhibitors; pharmaceutical compositions containing these compounds; the use of these compounds for the treatment of conditions responsive to e.
    Type: Grant
    Filed: February 4, 1986
    Date of Patent: March 1, 1988
    Assignee: Ciba-Geigy Corporation
    Inventor: Leslie J. Browne
  • Patent number: 4680284
    Abstract: The invention relates to renin inhibiting compounds of the formula: ##STR1## wherein R.sub.2 is loweralkyl or arylalkyl; R.sub.3 is loweralkyl; X is ##STR2## wherein A is hydrogen or an N-protecting group, R.sub.1 is loweralkyl or arylalkyl, m is 1-3, n is 1-3, p is 1-3, q is 1-3, s is 1-3, and t is 0-2.
    Type: Grant
    Filed: January 16, 1986
    Date of Patent: July 14, 1987
    Assignee: Abbott Laboratories
    Inventors: Jay R. Luly, Jacob J. Plattner, Anthony K. Fung
  • Patent number: 4619784
    Abstract: There are disclosed diffusion transfer color processes and products which employ novel image dye-providing materials which provide image dyes having the chromophoric system represented by the formula ##STR1## X is H, alkyl, aryl or substituted aryl; W is H or alkyl, R is H or alkyl; m and n are each integers of from 2 to 6.The image dye-providing material includes a diffusion control moiety such as a hydroquinonyl group and may be diffusible or nondiffusible as a function of the diffusion control moiety.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: October 28, 1986
    Assignee: Polaroid Corporation, Patent Dept.
    Inventors: Louis Locatell, Jr., Charles M. Zepp, Ronald F. Cieciuch