Two Of The Cyclos Share At Least Three Ring Members Or A Ring Member Is Shared By Three Of The Cyclos (e.g., Bridged, Peri-fused, Etc.) Patents (Class 540/556)
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Patent number: 6552017Abstract: The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.Type: GrantFiled: June 15, 2000Date of Patent: April 22, 2003Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Albert J. Robichaud, Taekyu Lee, Wei Deng, Ian S. Mitchell, Michael Guang Yang, Simon Haydar, Wenting Chen, Christopher D. Mc Clung, Emilie J. B. Calvello, David M. Zawrotny
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Patent number: 6552012Abstract: The present invention relates to novel heteroaryl diazabicycloalkane derivatives represented by general formula (I), any of its enantiomers or any mixture thereof, an N oxide thereof, a pharmaceutically acceptable salt thereof, in a labelled or un-labelled form, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.Type: GrantFiled: August 22, 2001Date of Patent: April 22, 2003Assignee: Neurosearch A/SInventors: Dan Peters, Simon Feldbaek Nielsen, Gunnar M. Olsen, Elsebet Ostergaard Nielsen
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Patent number: 6548493Abstract: The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.Type: GrantFiled: June 15, 2000Date of Patent: April 15, 2003Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Albert J. Robichaud, Taekyu Lee, Wei Deng, Ian S. Mitchell, Wenting Chen, Christopher D. McClung, Emilie J. B. Calvello, David M. Zawrotny
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Patent number: 6503900Abstract: This invention provides [1,4]diazepino[6,7,1-jk]carbazole compounds of the formula: wherein: R1 and R2 are H, alkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, phenoyl or thiophenoyl; R3, R4, R5 and R6 are H, alkyl, cycloalkyl, alkoxy or cycloalkoxy; R7 is H or alkyl; R8 is H or alkyl; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, as well as methods and pharmaceutical compositions utilizing them for the treatment or prevention of disorders such as obsessive-compulsive disorder, depression, anxiety, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.Type: GrantFiled: November 2, 2001Date of Patent: January 7, 2003Assignee: WyethInventors: Annmarie Louise Sabb, Gregory Scott Welmaker, Robert Lewis Vogel, Joan Eileen Sabalski
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Patent number: 6472525Abstract: Disclosed is an acyl group-containing hexaazaisowurtzitane derivative represented by the following formula (I): W At Q(6−t), wherein t represents an integer of from 4 to 6, A independently represents an acyl group having 1 to 10 carbon atoms, each Q independently represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms, and W represents a hexavalent hexaazaisowurtzitane residue represented by the following formula (II): Also disclosed is a method for producing the above-mentioned acyl group-containing hexaazaisowurtzitane derivative. The acyl group-containing hexaazaisowurtzitane derivative of the present invention is useful as a precursor of a polynitrohexaazaisowurtzitane derivative which can be used not only as a material for explosives but also as an additive for propellants and explosives.Type: GrantFiled: May 16, 1997Date of Patent: October 29, 2002Assignee: Asahi Kasei Kabushiki KaishaInventors: Tamotsu Kodama, Masahiro Tojo, Masanori Ikeda
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Patent number: 6468998Abstract: The present invention provides a pyrrolidine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof and a pharmaceutically acceptable salt thereof. The present invention further provides a pharmaceutical composition containing a compound of the formula (I), an optically active compound thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable additive. The compound of the present invention has a serotonin 2 receptor antagonistic action along with a platelet aggregation suppressive action, a peripheral circulation improving action and a lacrimation promoting action. Therefore, the compound of the present invention can be a useful medicine showing effect against thrombotic embolism, dry eye and the like.Type: GrantFiled: May 1, 2001Date of Patent: October 22, 2002Assignee: Mitsubishi Pharma CorporationInventors: Takanobu Kuroita, Masakazu Fujio, Haruto Nakagawa
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Publication number: 20020143008Abstract: Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke.Type: ApplicationFiled: December 20, 2001Publication date: October 3, 2002Applicant: Neurocrine Biosciences, Inc.Inventors: Mustapha Haddach, Zhiqiang Guo, James R. McCarthy
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Publication number: 20020128261Abstract: This invention provides compounds of the formula: 1Type: ApplicationFiled: November 2, 2001Publication date: September 12, 2002Applicant: American Home Products CorporationInventors: Annmarie L. Sabb, Robert L. Vogel
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Publication number: 20020119966Abstract: This invention provides compounds of formula I having the structure 1Type: ApplicationFiled: November 2, 2001Publication date: August 29, 2002Applicant: American Home Products CorporationInventors: Annmarie Louise Sabb, Robert Lewis Vogel
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Patent number: 6436989Abstract: The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions.Type: GrantFiled: December 24, 1997Date of Patent: August 20, 2002Assignee: Vertex Pharmaceuticals, IncorporatedInventors: Michael R. Hale, Roger D. Tung, Christopher T. Baker, Andrew Spaltenstein
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Publication number: 20020107242Abstract: This invention provides compounds of the formulae: 1Type: ApplicationFiled: November 2, 2001Publication date: August 8, 2002Applicant: American Home Products CorporationInventors: Annmarie L. Sabb, Robert L. Vogel, James A. Nelson, Sharon J. Rosenzweig-Lipson, Gregory S. Welmaker, Joan E. Sabalski
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Publication number: 20020107237Abstract: The present invention relates to novel N12, N13-bridged sugar derivatives of indolylopyrrolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.Type: ApplicationFiled: September 27, 2001Publication date: August 8, 2002Inventors: Mark G. Saulnier, Edward H. Ruediger, Neelakantan Balasubramanian, Mikael Mahler, Francis Beaulieu, Carol Bachand, David B. Frennesson
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Patent number: 6420357Abstract: Disclosed are the compounds Asamarine A and B, novel cytotoxic diterpene-alkaloids, that have been isolated from the sponge Raspailia sp. The structure of these compounds have been established on the basis of NMR data and confirmed by X-ray analysis. Also disclosed are compounds (I) and (II), wherein wherein R1 represents hydrogen or lower alkyl or lower alkanoyl; R2 represents hydrogen or lower alkyl; R3 is either an alkyl or a cycloalkyl group containing one or more isoprene units, or a monoterpene or a sesquiterpene or a sesquiterpene or a diterpene group; R4 or R5 represent hydrogen or lower alkyl; R6 represents lower alkyl; and X represents F or Cl or Br or I.Type: GrantFiled: June 22, 2001Date of Patent: July 16, 2002Assignee: Instituto Biomar, S.A.Inventors: Yoel Kashman, Amira Rudi, Tesfamariam Yosief, Dolores G. Gravalos
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Publication number: 20020086860Abstract: This invention provides [1,4]diazepino[6,7,1-jk]carbazole compounds of the formula: 1Type: ApplicationFiled: November 2, 2001Publication date: July 4, 2002Applicant: American Home Products CorporationInventors: Annmarie L. Sabb, Gregory S. Welmaker, Robert L. Vogel, Joan E. Sabalski
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Publication number: 20020062022Abstract: This invention provides processes for synthesizing compounds of formula I: 1Type: ApplicationFiled: November 2, 2001Publication date: May 23, 2002Applicant: American Home Products CorporationInventors: Annmarie L. Sabb, Robert L. Vogel, Madelene M. Antane, Panolil Raveendranath, Sreenivasulu Megati, Michael D. Smith, James A. Nelson
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Publication number: 20020055504Abstract: This invention provides a process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino[6, 7, 1-hi]indole derivatives of the general formula: 1Type: ApplicationFiled: November 2, 2001Publication date: May 9, 2002Inventor: Anita W-Y. Chan
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Publication number: 20020055630Abstract: The present invention provides processes for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b][1, 4]diazepino[6, 7, 1-hi]indole derivatives of the general formula: 1Type: ApplicationFiled: November 2, 2001Publication date: May 9, 2002Applicant: American Home Products CorporationInventors: Gregory S. Welmaker, Joan E. Sabalski
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Publication number: 20020037893Abstract: The present invention relates to novel heteroaryl diazabicycloalkane derivatives represented by general formula (I), any of its enantiomers or any mixture thereof, an N oxide thereof, a pharmaceutically acceptable salt thereof, in a labelled or un-labelled form, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.Type: ApplicationFiled: August 22, 2001Publication date: March 28, 2002Inventors: Dan Peters, Simon Feldbaek Nielsen, Gunnar M. Olsen, Elsebet Ostergaard Nielsen
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Patent number: 6359130Abstract: The present invention is directed to novel fused aryl and heteroaryl bridged indenopyrrolocarbazoles which are useful, inter alia, as therapeutic agents. The invention is also directed to methods for making and using the bridged indenopyrrolocarbazoles.Type: GrantFiled: May 17, 2000Date of Patent: March 19, 2002Assignee: Cephalon, Inc.Inventors: Jasbir Singh, Robert L. Hudkins, John P. Mallamo, Theodore L. Underiner, Rabindranath Tripathy
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Patent number: 6352983Abstract: Novel compounds of the formula wherein the substituents are defined as in the application having antibiotic properties.Type: GrantFiled: October 8, 1999Date of Patent: March 5, 2002Assignee: Aventis Pharma S.A.Inventors: Constantin Agouridas, Francois Bretin, Alexis Denis, Claude Fromentin
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Patent number: 6297372Abstract: A nitro group-containing hexaazaisowurtzitane derivative represented by the following general formula (I): W An N(6−n) (I) wherein n is an integer of 4 or 5, A is an acyl group having 1-10 carbon atoms with each acyl group being the same as or different from one or more of the others, N is a nitro group and W is a hexavalent hexaazaisowurtzitane residue represented by the following formula (II): a nitroso group-containing hexaazaisowurtzitane derivative represented by the following general formula (III): W An NS(6−n) (III) wherein n is an integer of 4 or 5, A is an acyl group having 1-10 carbon atoms with each acyl group being the same as or different from one or more of the others, NS is a nitroso group and W is a hexavalent hexaazaisowurtzitane residue of formula (II) above, and an acyl group-containing hexaazaisowurtzitane derivative represented by the following general formula (IV): W Am H(6−m) (IV) wherein N is an integer of 4-6,Type: GrantFiled: September 30, 1999Date of Patent: October 2, 2001Assignee: Asahi Kasei Kabushiki KaishaInventors: Shuji Kawabe, Hiroshi Miya, Tamotsu Kodama, Nobuhisa Miyake
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Patent number: 6297373Abstract: A method for acylating a hexakis (arylmethyl) hexaazaisowurtzitane (WB6) by reductively removing the arylmethyl groups in the presence of an acylating agent, characterized by contacting a WB6 (a) with a heterogeneous system reduction catalyst (b) in the presence of an acylating agent (c) and a reducing agent (d) in a solvent (e) for the WB6 (a) to reductively remove the arylmethyl groups from the WB6 (a) and acylate the same, and by preventing the WB6 (a) and the catalyst (b) from being contacted with each other when at least either of the acylating agent (c) and the reducing agent (d) is not present. In this method, the decomposition of the WB6 skeleton, which readily occurs in the beginning of the acylation of the WB6 as a starting material, can be highly effectively inhibited. This method can hence stably produce a tetraacylhexaazaisowurtzitane derivative in a high yield and is industrially advantageous.Type: GrantFiled: March 14, 2000Date of Patent: October 2, 2001Assignee: Asahi Kasei Kabushiki KaishaInventors: Tamotsu Kodama, Naoko Ishihara, Haruyuki Minoura, Nobuhisa Miyake, Setsuo Yamamatsu
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Patent number: 6160113Abstract: Processes and compositions for nitration of N-substituted isowurtzitane compounds with concentrated nitric acid at elevated temperatures to form HNIW and recovery thereof with high yields and purities. Polymorphic conversions to the epsilon HNIW crystal form at quanititative yields are also described.Type: GrantFiled: April 28, 1999Date of Patent: December 12, 2000Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Raja Duddu, Paritosh R. Dave
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Patent number: 6153749Abstract: Disclosed is a method for producing an acyl group-containing hexaazaisowurtzitane derivative represented by the following formula (1),WA.sub.n H.sub.(6-n) (1)wherein n represents an integer of 4 or 6, each A independently represents an acyl group having 1 to 10 carbon atoms, H represents a hydrogen atom, and W represents a hexavalent hexaazaisowurtzitane residue represented by the following formula (2): ##STR1## which comprises: providing a composition system comprising a mixed solvent of a first solvent and a second solvent respectively having high and low dissolving abilities for the desired compound, wherein the mixed solvent has the desired compound dissolved therein; and removing the first solvent having a high dissolving ability from the composition system to thereby deposit crystals of the desired compound. The desired compound, which is useful as a precursor of high performance explosive additive, i.e.Type: GrantFiled: January 11, 1999Date of Patent: November 28, 2000Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Tamotsu Kodama, Haruyuki Minoura, Nobuhisa Miyake, Setsuo Yamamatsu, Tsutomu Katsumata
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Patent number: 6153608Abstract: The invention relates to a compound of the following general formula [I] or a medicinally acceptable salt thereof, or a solvate thereof, ##STR1## wherein R.sup.1 represents alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, or halogen; R.sup.2 represents hydrogen, hydroxy, or halogen; R.sup.3 represents hydrogen, alkyl, or amidino; Ring A represents a 5 to 11-membered cyclic amino group which may be substituted, which cyclic amino group may be bridged between two carbon atoms in optional positions. The compound of this invention is useful for the prevention or treatment of cerebral tissue impairment due to the vasospasm following cerebral hemorrhage.Type: GrantFiled: July 29, 1998Date of Patent: November 28, 2000Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiroyoshi Hidaka, Akira Matsuura, Takushi Matsuzaki
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Patent number: 6147209Abstract: Hexabenzylhexaazaisowurtzitane is converted to tetracetyl, dibenzyl azaisowurtzitane. The benzyl groups are removed by catalytic transfer hydrogenolysis leaving a pair of available nitrogens. The available nitrogens are acetylated, and the resulting intermediate is converted to CL-20 with a strong nitrating agent.Type: GrantFiled: December 8, 1992Date of Patent: November 14, 2000Assignee: Cordant Technologies Inc.Inventors: Robert B. Wardle, Jerald C. Hinshaw
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Patent number: 6130330Abstract: What is claimed is a process for preparing macropolycyclic polyamines of the formula ##STR1## where A.sup.1, A.sup.2, A.sup.3 and A.sup.4 are as defined in the description. These compounds are prepared by a novel improved process by reacting a cyclic amine of the formula ##STR2## with a compound of the formula X--A.sup.2 --Y or X--A.sup.3 --Y where A.sup.1, A.sup.2, A.sup.3 and A.sup.4 are as defined in the description and X and Y are a leaving group.Type: GrantFiled: March 4, 1999Date of Patent: October 10, 2000Assignee: Clariant GmbHInventors: Bernd Nestler, Michael Seebach
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Patent number: 6127362Abstract: 9,10-DIAZATRICYCLO[4,4,1,1.sup.2,5 ]DECANE (la) AND 2,7-DIAZATRICYCLO[4,4,0,0.sup.3,8 ]DECANE (1b) DERIVATIVES HAVING ANALGESIC ACTIVITY.Type: GrantFiled: December 2, 1999Date of Patent: October 3, 2000Assignee: Neuroscienze S.C.A.R.L.Inventors: Giorgio Cignarella, Paola Vianello
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Patent number: 6015898Abstract: Processes and compositions for nitration of N-substituted isowurtzitane compounds with concentrated nitric acid at elevated temperatures to form HNIW and recovery of gamma HNIW with high yields and purities. Polymorphic conversion of HNIW crystals to epsilon HNIW crystals is also disclosed.Type: GrantFiled: May 1, 1998Date of Patent: January 18, 2000Assignee: The United States of America, as represented by the Secretary of the ArmyInventors: Raja G. Duddu, Paritosh R. Dave
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Patent number: 6013646Abstract: Novel indolocarbazole derivatives potentially useful for the treatment of dementias characterized by tau hyperphosphorylation [Alzheimer's disease (AD), frontal lobe degeneration (FLD), argyrophilic grains disease, subacute sclerotizing panencephalitis (SSPE) as a late complication of viral infections in the CNS], and cancer.Type: GrantFiled: July 2, 1998Date of Patent: January 11, 2000Assignee: Bayer CorporationInventors: Hanno Roder, Timothy B. Lowinger, David R. Brittelli, Michael C. VanZandt
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Patent number: 5892035Abstract: A process for preparing a N,N'-difluorodiazoniabicycloalkane salt of the formula: ##STR1## by reacting a corresponding diazabicycloalkane or diazabicycloalkane Br.o slashed.nsted acid salt and fluorine in the presence of a Br.o slashed.nsted acid or in the presene or absence of a base, by reacting a corresponding N,N'-difluorodiazoniabicycloalkane salt and an acid or salt, by reacting a corresponding diazabicycloalkane and fluorine in the presence of a Br.o slashed.nsted acid and then reacting an intermediate product and an acid or salt, or by reacting a corresponding diazabicycloalkane Br.o slashed.nsted acid salt and fluorine in the presence or absence of a base and then reacting an intermediate product and an acid or salt.Type: GrantFiled: May 15, 1997Date of Patent: April 6, 1999Assignee: Daikin Industries Ltd.Inventors: Teruo Umemoto, Masayuki Nagayoshi, Ginjiro Tomizawa, Kenji Adachi
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Patent number: 5880281Abstract: A process for the preparation of tetraazamacrocycles of general formula (I) ##STR1## wherein n, p and q can independently be 0 or 1, comprising the following steps:a): condensation of polyamines with a glyoxal derivative;b): condensation of the resulting compound with an alkylating agent;c): oxidation of the resulting compound with an oxidizing agent, to give a mixture of oxidated products which is submitted tod): hydrolysis in acid aqueous solution, to give the compound of formula (I).Type: GrantFiled: June 19, 1997Date of Patent: March 9, 1999Assignee: Dibra S.p.A.Inventors: Maria Argese, Giorgio Ripa, Alessandro Scala, Vittorio Valle
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Patent number: 5854239Abstract: The present invention relates to diazabicyclic compounds and, specifically, to compounds of the formula ##STR1## wherein A, G, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are as defined in the specification. The compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.Type: GrantFiled: June 20, 1996Date of Patent: December 29, 1998Assignee: Pfizer Inc.Inventors: Harry R. Howard, Kevin D. Shenk
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Patent number: 5723604Abstract: A process of synthesizing HBIW using a mineral acid, such as perchloric acid, as the acid catalyst is disclosed. According to the process, glyoxal, adjusted to a pH from 4 to 7, and benzylamine are reacted in the presence of the mineral acid for sufficient time to form HBIW. The resulting HBIW is then isolated according to conventional separation techniques.Type: GrantFiled: June 22, 1995Date of Patent: March 3, 1998Assignee: Thiokol CorporationInventors: Louis F. Cannizzo, William W. Edwards, Robert B. Wardle, Thomas K. Highsmith
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Patent number: 5693794Abstract: A new compound, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo?5.5.0.0.sup.5,9.0 3,11 !dodecane) is disclosed and a method of preparation thereof. The new compound is useful as a high energy, high density explosive.Type: GrantFiled: September 30, 1988Date of Patent: December 2, 1997Assignee: The United States of America as represented by the Secretary of the NavyInventor: Arnold T. Nielsen
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Patent number: 5679673Abstract: Certain aralkyl diazabicycloalkyl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each of R, R.sup.1, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently selected from hydrido, lower-alkyl, benzyl, and haloloweralkyl; wherein each of R.sup.2, R.sup.3 and R.sup.10 through R.sup.13 is independently selected from hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; wherein each of R.sup.8 and R.sup.Type: GrantFiled: November 21, 1994Date of Patent: October 21, 1997Assignee: The United States of America, represented by the Department of Health and Human ServicesInventors: Wayne Bowen, Brian R. de Costa, Celia Dominguez, Xiao-Shu He, Kenner C. Rice
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Patent number: 5589476Abstract: A compound of formula (I): ##STR1## in which R.sub.1 represents a hydrogen atom or a straight or branched (C.sub.1 -C.sub.4)alkyl group; andA represents a 5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl group, a 4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-methyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-phenylmethyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 5-methyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 5,6-dihydro-4H-imidazo[1,5,4-de]quinoxalin-2-yl group, a 6-oxo-5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl group, or a 5-methyl-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2-yl group which may be unsubstituted or substituted in the 6-position by a phenylmethyl group;or an addition salt thereof with a pharmaceutically acceptable acid.Type: GrantFiled: October 3, 1994Date of Patent: December 31, 1996Assignee: SynthelaboInventors: Samir Jegham, G erard Defosse, Thomas A. Purcell, Luc Even
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Patent number: 5587476Abstract: The invention relates to an addition compound which is obtainable by reaction of a diamine of the formula I, ##STR1## where R.sup.1 is (C.sub.2 -C.sub.4)-alkylene or 1,2- or 1,3-cyclo-(C.sub.3 -C.sub.7)-alkylene andR.sup.2 and R.sup.3, which are identical or different, are (C.sub.1 -C.sub.3)-alkyl or hydrogen orR.sup.2 and R.sup.3 together are (C.sub.2 -C.sub.4)-alkylene, with fullerenes C.sub.60 and/or C.sub.70. The fullerene derivatives are useful as electrically conducting materials.Type: GrantFiled: February 15, 1995Date of Patent: December 24, 1996Assignee: Hoechst AktiengesellschaftInventors: Klaus-Dieter Kampe, Hans-Ulrich ter Meer, Norbert K. Egger, Martin A. Vogel
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Patent number: 5512679Abstract: 2-aryl-ethane-sulphonic acids of the formulaAr.sup.1 --CH.sub.2 --CH.sub.2 --SO.sub.3 H (I),in whichAr.sup.1 denotes a carbocyclic or heterocyclic aromatic radical which can be bound to an anellated benzene nucleus,can be obtained by reaction of the underlying vinyl aromatic compound with sulphurous acid, if the reaction is carried out in the presence of an amine of the formulaN(R.sup.1,R.sup.2,R.sup.3 (III),in whichR.sup.1, R.sup.2 and R.sup.3 have the meaning mentioned in the description.Type: GrantFiled: September 8, 1994Date of Patent: April 30, 1996Assignee: Bayer AktiengesellschaftInventors: Jurgen-Dietrich Meier, Christian Munster, Volker Kass, Horst Siffrin
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Patent number: 5473065Abstract: The present invention relates to novel N,N'-difluorinated diazabicycloalkane derivatives which are useful as electrophilic fluorinating agents, processes for preparing such N,N'-difluorinated diazabicycloalkane derivatives and methods of using such compounds as fluorinating agents. The invention also presents novel N-fluorinated azaazoniabicycloalkane-Lewis acid adduct intermediates which are formed in the processes for preparing such N,N'-difluorinated diazabicycloalkane derivatives.Type: GrantFiled: December 7, 1993Date of Patent: December 5, 1995Assignee: Air Products and Chemicals, Inc.Inventor: Ronald E. Banks
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Patent number: 5463049Abstract: Process for preparing enantiomerically pure imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thiones of formula ##STR1## starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) ##STR2## Novel enantiomerically pure intermediates of formula (III) and (IV) prepared in the course of the present process.Type: GrantFiled: February 15, 1994Date of Patent: October 31, 1995Assignee: Janssen Pharmaceutica N.V.Inventors: Alfons G. M. De Knaep, Luc J. R. Moens, Eduard J. C. Vreysen
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Patent number: 5461048Abstract: The invention relates to novel cholecystokinin antagonists of the formula ##STR1## wherein R.sup.1 is aryl or substituted aryl, and a pharmaceutically acceptable salt thereof useful as cholecystokinin antagonists.Type: GrantFiled: November 30, 1994Date of Patent: October 24, 1995Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshinari Sato, Teruaki Matuo, Takatomo Ogahara
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Patent number: 5438050Abstract: New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the inhibition of protein kinases, such as protein kinase C, for the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension, or for inflammatory processes, allergies, cancers, viral diseases, and certain degenerative damages of the central nervous system are disclosed.Type: GrantFiled: January 21, 1994Date of Patent: August 1, 1995Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Johannes Hartenstein, Hubert Barth, Christoph Schachtele, Claus Rudolph, Gunter Weinheimer, Hartmut Osswald
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Patent number: 5367071Abstract: The invention is a process for preparing 1,4-diazoniabicycloalkanes of Formula I wherein the corresponding 1-hydro-4-aza-1-azoniabi-cycloalkane salt of the 1,4-diazabicycloalkane is fluorinated in the presence of an alkali metal salt under reaction conditions sufficient to form the desired 1,4-diazoniabicycloalkane. ##STR1## wherein n represents 0, 1 or 2;each R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 independently represents hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, C.sub.1 -C.sub.6 alkyl-substituted aryl or aryl-substituted C.sub.1 -C.sub.6 alkyl; andeach X.sup.- represents a counterion or 2X.sup.- represents a single divalent counterion.Type: GrantFiled: December 7, 1993Date of Patent: November 22, 1994Assignee: Air Products and Chemicals, Inc.Inventor: Robert G. Syvret
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Patent number: 5324723Abstract: 1,3-Oxazole and 1,3-thiazole compounds of formula I, and their pharmaceutically acceptable salts and prodrugs: ##STR1## wherein X represents oxygen or sulphur;R.sup.1 represents a non-aromatic azacyclic or azabicyclic ring system.Type: GrantFiled: July 1, 1993Date of Patent: June 28, 1994Assignee: Merck Sharpe & Dohme Ltd.Inventors: Raymond Baker, John Saunders, Roger J. Snow, Graham A. Showell
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Patent number: 5308842Abstract: Conformationally constrained tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds and ring homologs thereof are topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma associated therewith.Type: GrantFiled: May 10, 1993Date of Patent: May 3, 1994Assignee: Merck & Co., Inc.Inventors: John J. Baldwin, Gerald S. Ponticello
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Patent number: 5270464Abstract: Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing anti-HIV-1 activity, compositions containing these compounds as active ingredients, and methods of treating subjects suffering from HIV-1 infection by administering these compounds.Type: GrantFiled: April 5, 1993Date of Patent: December 14, 1993Assignee: Janssen Pharmaceutica N.V.Inventors: Michael J. Kukla, Henry J. Breslin, Alfons H. M. Raeymaekers, Josephus L. H. Van Gelder, Paul A. J. Janssen
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Patent number: 5254685Abstract: A tricyclic compound represented by the general formula (1) and salts thereof. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are also disclosed.Type: GrantFiled: August 7, 1991Date of Patent: October 19, 1993Assignees: Wakunaga Seiyaku Kabushiki Kaisha, Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaharu Yokomoto, Akira Yazaki, Norihiro Hayashi, Shunso Hatono, Satoshi Inoue, Yasuhiro Kuramoto
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Patent number: 5204342Abstract: Novel hydrogenated heterocyclic compounds, containing two nitrogen atoms, of the formula ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.5 and Rhd 7 are each, independently of the others, hydrogen or lower alkyl, m is 2 or 3, n is 1 or 2, and either R.sub.4 and R.sub.6 are each hydrogen or R.sub.4 and R.sub.6 together form an additional bond, in free form or in form of a salt, can be used as pharmaceutical active ingredients and can be manufactured in a manner known per se.Type: GrantFiled: March 31, 1992Date of Patent: April 20, 1993Assignee: Ciba-Geigy CorporationInventors: Wolfgang Frostl, Cesare Mondadori, Dietrich Strub, Armin Zust
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Patent number: 5189161Abstract: Novel benzo[b]pyrrolo[3,2,1-jk]benzodiazepines, intermediates and processes for the preparation thereof, and methods for alleviating pain utilizing the compounds or compositions thereof are disclosed.Type: GrantFiled: March 4, 1991Date of Patent: February 23, 1993Assignee: Hoechst Roussel Pharmaceuticals Inc.Inventors: Edward J. Glamkowski, Barbara E. Kurys