Phenoxazines (including Hydrogenated) Patents (Class 544/102)
  • Patent number: 10745366
    Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: August 18, 2020
    Assignee: ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Nishant P Visavadiya
  • Patent number: 9997722
    Abstract: An organic light-emitting device includes: a first electrode; a second electrode facing the first electrode; and an organic layer between the first electrode and the second electrode, the organic layer including an emission layer, wherein the organic layer includes the compound represented by Formula 1: The organic light-emitting device according to embodiments of the present disclosure may have high efficiency and long lifespan characteristics.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: June 12, 2018
    Assignee: Samsung Display Co., Ltd.
    Inventor: Jungsub Lee
  • Patent number: 9932319
    Abstract: Disclosed are antioxidative, natural compounds, their salts, chelates and cleavage derivatives that exhibit a superior combination of properties. The compounds can be used for a variety of purposes, including stabilizing foods, cosmetics, beverages and nutritional supplement. The compounds can be prepared by substantially cleaving a humic acid of formula I to provide at least one antioxidant compounds of formula II, formula III, formula IV, formula V, formula VI, salts, or chelates thereof.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: April 3, 2018
    Assignee: Empire Technology Development LLC
    Inventors: Georgius Abidal Adam, Scott Andrew Needham
  • Patent number: 9670170
    Abstract: Disclosed herein are resorufin derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 6, 2017
    Assignee: BIOELECTRON TECHNOLOGY CORPORATION
    Inventors: Andrew W. Hinman, Dana Davis, William D. Shrader
  • Patent number: 9590190
    Abstract: The present invention provides a thermally activated delayed fluorescence material, a method of synthesizing the same and an OLED device using the same. The thermally activated delayed fluorescence material includes a structure formula 1 as wherein the group Ar1 is identical to or different from the group Ar2, and the group Ar1 and the group Ar2 are consisted of carbazole and/or phenothiazine. The thermally activated delayed fluorescence material has a higher glass transition temperature, high thermal stability and excellent luminous efficiency. The method of synthesizing the same has simplified steps, easily purified product, high yield, and luminous and thermal properties of the product can be adjusted by connecting to differentiated functional groups. The OLED device using the same has a light emitting layer of high fluorescence efficiency and long-term stability, so that luminous efficiency and service life of the OLED device can meet practical demand.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: March 7, 2017
    Assignee: Shenzhen China Star Optoelectronics Technology Co., Ltd
    Inventors: Shidang Xu, Zhenguo Chi, Yi Zhang, Jiarui Xu, Yifan Wang, Qinghua Zou
  • Patent number: 9556134
    Abstract: Disclosed are antioxidative natural compounds, their salts, chelates and cleavage derivatives that exhibit a superior combination of properties. The compounds can be used for a variety of purposes, including the stabilization of polymers. The compounds can be prepared by substantially cleaving a humic acid of formula I followed by esterification to provide at least one antioxidant compounds of formula V, formula VI, formula VII, formula VIII, salts thereof, or chelates thereof.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: January 31, 2017
    Assignee: Empire Technology Development LLC
    Inventors: Georgius Abidal Adam, Anita Needham
  • Patent number: 9296712
    Abstract: Disclosed herein are resorufin derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 29, 2016
    Assignee: Edison Pharmaceuticals, Inc.
    Inventors: Andrew W. Hinman, Dana Davis, William D. Shrader
  • Publication number: 20150141642
    Abstract: A light-emitting material containing a compound represented by the following general formula in a light-emitting layer has high light emission efficiency. In the following general formula, R1 to R10 represent a hydrogen atom or a substituent, provided that at least one of R1 to R10 represents an aryl group, a diarylamino group or a 9-carbazolyl group.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 21, 2015
    Applicant: KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION
    Inventors: Chihaya Adachi, QiSheng Zhang, Kei Sakanoue, Shuzo Hirata
  • Patent number: 8969339
    Abstract: The present disclosure is directed to methods of identifying a compound that binds to or interacts with a protein receptor involved in bone formation. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 and/or frizzled receptor and interfering with receptor binding to other proteins in a Wnt pathway. The present disclosure is further directed to methods and compositions that comprise an identified compound for treating or preventing a disease in a mammal in which Wnt pathway suppression plays a role.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: March 3, 2015
    Assignee: Enzo Biochem, Inc.
    Inventors: Dianqing (Dan) Wu, Dakai Liu, James J. Donegan
  • Patent number: 8962158
    Abstract: Provided is an organic electroluminescent device (organic EL device), which has improved luminous efficiency, has sufficient driving stability, and has a simple construction. The organic EL device of the present invention is an organic electroluminescent device, including a light-emitting layer and a hole-transporting layer between an anode and a cathode laminated on a substrate, in which the light-emitting layer contains a phosphorescent light-emitting dopant and an indolocarbazole compound that serves as a host material, or alternatively, the hole-transporting layer contains an indolocarbazole compound. The indolocarbazole compound is represented by the following formula (1). In the formula: A1's each represent an aromatic hydrocarbon group or an aromatic heterocyclic group, provided that at least one of A1's has a fused ring structure; and R1's each represent a hydrogen atom, an alkyl group, an alkoxy group, or an acyl group.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: February 24, 2015
    Assignee: Nippon Steel & Sumikin Chemical Co., Ltd.
    Inventors: Masaki Komori, Takahiro Kai, Toshihiro Yamamoto
  • Publication number: 20150041784
    Abstract: A compound represented by the general formula (1) is useful as a light-emitting material. In the general formula (1), Ar1 to Ar3 represent an aryl group, provided that at least one thereof represents an aryl group substituted by a group represented by the general formula (2). In the general formula (2), R1 to R8 represent a hydrogen atom or a substituent; Z represents O, S, O?C or Ar4—N; and Ar4 represents an aryl group.
    Type: Application
    Filed: May 10, 2013
    Publication date: February 12, 2015
    Inventors: Katsuyuki Shizu, Hiroyuki Tanaka, Hajime Nakanotani, Chihaya Adachi
  • Publication number: 20150010938
    Abstract: Probes for selectively detecting compounds comprising a thiol group and an amino group (“thiols”) are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as “” is a single or double bond; R1, R3-R6 and R8 independently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; R2 is an ?,?-unsaturated aliphatic ester; R7 is oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or R7 and R8 together form a cycloalkyl or aryl ring; X1 is CH2, S, NH, O, Se, Si(CH3)2, Ge(CH3)2, Sn(CH3)2, or C(CH3)2; and X2 is CH, CH2, N, NH, or CR9 where R9 is aryl.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 8, 2015
    Applicant: Oregon State Board of Higher Education on Behalf of Portland State University
    Inventors: Robert M. Strongin, Yixing Guo, Lovemore Hakuna, Mark Allen Lowry, Jorge Omar Escobedo Córdova
  • Publication number: 20140374733
    Abstract: An object of the present invention is to provide a photoelectric conversion element having a photoelectric conversion film which exhibits heat resistance, a high photoelectric conversion efficiency, a low level of dark currents, rapid response, and sensitivity characteristics to red and can be produced by a vapor deposition processing that is continuously performed under a high-temperature condition. The photoelectric conversion element of the present invention is a photoelectric conversion element in which a conductive film, a photoelectric conversion film containing a photoelectric conversion material, and a transparent conductive film are laminated on one another in this order, wherein the photoelectric conversion material includes a compound represented by Formula (1).
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Applicant: FUJIFILM Corporation
    Inventors: Yuki HIRAI, Yosuke YAMAMOTO, Tomoaki YOSHIOKA, Eiji FUKUZAKI, Katsuyuki YOFU, Masaaki TSUKASE, Mitsumasa HAMANO, Takahiko ICHIKI
  • Patent number: 8900725
    Abstract: A dendrimer and an organic light-emitting device including an organic layer having the dendrimer.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: December 2, 2014
    Assignee: Samsung Display Co., Ltd.
    Inventors: Yoon-Hyun Kwak, Jeoung-In Yi, Seung-Gak Yang, Hee-Yeon Kim, Jae-Yong Lee
  • Publication number: 20140308317
    Abstract: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.
    Type: Application
    Filed: December 9, 2013
    Publication date: October 16, 2014
    Applicant: CELLCEUTIX CORPORATION
    Inventors: Xiaodong Fan, Yongjiang Xu, Dahui Liu, Michael J. Costanzo
  • Publication number: 20140275054
    Abstract: Disclosed herein are resorufin derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: Edison Pharmaceuticals, Inc.
    Inventors: Andrew W. HINMAN, Dana Davis, William D. Shrader
  • Publication number: 20140243313
    Abstract: The invention disclosed herein is direct to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in treating neurodegenerative diseases and promoting the generation or survival of neurons in the mammalian brain. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula I or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to a method of promoting the generation or survival of neurons in a patient in need thereof in neurodegenerative and related diseases.
    Type: Application
    Filed: September 19, 2012
    Publication date: August 28, 2014
    Inventors: Austin Chih-Yu Chen, Jill Melissa Baccei, Brian Andrew Stearns, Nicholas Simon Stock, Yen Pham Truong
  • Publication number: 20140225083
    Abstract: A compound for an organic optoelectronic device represented by Chemical Formula 1 wherein groups R1-R4, Ar1, Ar2, L1, L2, X, n1, and n2 are described in the specification.
    Type: Application
    Filed: October 15, 2013
    Publication date: August 14, 2014
    Applicants: Cheil Industries Inc., Samsung Electronics Co., Ltd.
    Inventors: Sang Mo KIM, Jhun Mo SON, Ho Suk KANG, Yong Sik JUNG, Hyeon Ho CHOI, Kyu Young HWANG
  • Publication number: 20140221647
    Abstract: The present invention encompasses phenoxazine derivatives and methods of use thereof.
    Type: Application
    Filed: April 11, 2014
    Publication date: August 7, 2014
    Inventors: Gregory Zipfel, Byung Han, Robert Mach, Wenhua Chu
  • Publication number: 20140220612
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert BATCHELOR, Yue GE, Iain JOHNSON, Wai-Yee LEUNG, Jixiang LIU, Brian PATCH, Peter SMALLEY, Thomas STEINBERG, Kyle GEE
  • Publication number: 20140203216
    Abstract: The present invention relates to a compound of the formula (I), (II) or (III), to the use of the compound in an electronic device, and to an electronic device comprising a compound of the formula (I), (II) or (III). The present invention furthermore relates to a process for the preparation of a compound of the formula (I), (II) or (III) and to a formulation comprising one or more compounds of the formula (I), (II) or (III).
    Type: Application
    Filed: July 5, 2012
    Publication date: July 24, 2014
    Applicant: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Arne Buesing, Christof Pflumm, Teresa Mujica-Fernaud, Philipp Stoessel, Thomas Elberle, Frank Voges
  • Patent number: 8766001
    Abstract: The present invention relates to the improvement in organic electroluminescent devices by using compounds of the formula (1), in particular as hole-injection or hole-transport materials in a hole-injection or hole-transport layer.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: July 1, 2014
    Assignee: Merck Patent GmbH
    Inventors: Christof Pflumm, Arne Buesing, Amir Hossain Parham, Rocco Fortte, Holger Heil, Philipp Stoessel
  • Publication number: 20140158999
    Abstract: Disclosed are a compound for an organic optoelectronic device, an organic light emitting diode including the same, and a display device including the organic light emitting diode. A compound for an organic optoelectronic device represented by Chemical Formula 1 provides an organic optoelectronic device having an excellent life-span and improved luminous efficiency at a low driving voltage due to excellent electrochemical and thermal stability.
    Type: Application
    Filed: July 11, 2013
    Publication date: June 12, 2014
    Inventors: Yong Sik JUNG, Ho Suk KANG, Hyeon Ho CHOI, Sang Mo KIM, Jhun Mo SON, Kyu Young HWANG
  • Publication number: 20140155592
    Abstract: An arylamine compound is represented by Formula 1. where R, X, Y, and n are further defined.
    Type: Application
    Filed: November 27, 2013
    Publication date: June 5, 2014
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventor: Ichinori TAKADA
  • Patent number: 8735575
    Abstract: The present invention encompasses phenoxazine derivatives and methods of use thereof.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: May 27, 2014
    Assignee: Washington University
    Inventors: Gregory Zipfel, Byung Han, Robert Mach, Wenhau Chu
  • Publication number: 20140142301
    Abstract: The organic EL material is represented by Formula (1): where X1 to X4 are each independently a nitrogen (N) atom or a carbon atom that is monovalently bonded to R1(C—R1), R1 is a hydrogen atom, a halogen atom, an aryl group having 6 to 18 carbon atoms, a hetero aryl group having 6 to 18 carbon atoms, or an alkyl group having 1-12 carbon atoms, R2 to R10 are each independently hydrogen, an aryl group having 6 to 30 carbon atoms, or hetero aryl group having 6 to 30 carbon atoms, and at least one of X1 to X4 is a nitrogen atom.
    Type: Application
    Filed: November 20, 2013
    Publication date: May 22, 2014
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventor: Hiroaki ITOI
  • Patent number: 8723017
    Abstract: The present invention pertains to an electrode layer comprising a porous film made of oxide semiconductor fine particles sensitized with certain methin dyes. Moreover the present invention pertains to a photoelectric conversion device comprising said electrode layer, a dye sensitized solar cell comprising said photoelectric conversion device and to novel methin dyes.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: May 13, 2014
    Assignee: BASF SE
    Inventors: Kazuhiko Kunimoto, Hiroshi Yamamoto, Shinji Nakamichi, Ryuichi Takahashi, Junichi Tanabe
  • Publication number: 20140124756
    Abstract: A compound having an indolocarbazole ring structure is represented by the following general formula (1), and is used as a material for forming a highly efficient and highly durable organic electroluminescent device. The compound features excellent hole injection/transport capability, has electron blocking power and is highly stable in the form of a thin film. wherein, A is a divalent aromatic hydrocarbon group or aromatic heterocyclic group, Ar1 to Ar4 are monovalent aromatic hydrocarbon groups or aromatic heterocyclic groups, and R1 to R9 are hydrogen atoms, deuterium atoms, fluorine atoms, chlorine atoms, cyano groups, nitro groups, alkyl groups, cycloalkyl groups, alkenyl groups, alkyloxy groups, cycloalkyloxy groups, aromatic hydrocarbon groups, aromatic heterocyclic groups or aryloxy groups.
    Type: Application
    Filed: February 14, 2012
    Publication date: May 8, 2014
    Applicant: HODOGAYA CHEMICAL CO., LTD.
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Sawa Izumi, Hiroshi Ookuma, Shuichi Hayashi
  • Publication number: 20140114063
    Abstract: An organic electroluminescence (EL) material and an organic EL device including the same, the organic electroluminescence (EL) material being represented by following Chemical Formula 1:
    Type: Application
    Filed: October 18, 2013
    Publication date: April 24, 2014
    Applicant: Samsung Display Co., Ltd.
    Inventor: Hiroaki ITOI
  • Publication number: 20140070146
    Abstract: The present application relates to a compound of a formula (I), to the use of this compound in an electronic device, and to an electronic device comprising one or more compounds of the formula (I). The invention furthermore relates to the preparation of the compound of the formula (I) and to a formulation comprising one or more compounds of the formula (I).
    Type: Application
    Filed: April 12, 2012
    Publication date: March 13, 2014
    Applicant: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Arne Buesing, Christof Pflumm, Teresa Mujica-Fernaud, Philipp Stoessel, Thomas Eberle
  • Publication number: 20140061548
    Abstract: The present invention relates to a compound of the formula (I), to the use of the compound in an electronic device, and to an electronic device comprising a compound of the formula (I). The present invention furthermore relates to a process for the preparation of a compound of the formula (I) and to a formulation comprising one or more compounds of the formula (I).
    Type: Application
    Filed: April 14, 2012
    Publication date: March 6, 2014
    Applicant: Merck Patent CmbH
    Inventors: Elvira Montenegro, Arne Buesing, Frank Voges, Christof Pflumm
  • Patent number: 8653261
    Abstract: Actinomysin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided. The actinomysin-based near IR emitting compounds have the structure: wherein R is H or NH2; R1, R2, R3, and R4 are independently a moiety comprising 1-30 atoms selected from H, O, C, and N, wherein the atoms are in a linear, branched, or cyclic configuration; R3 and/or R4 comprise a quaternary nitrogen atom; and R5 is H, F, or Cl.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: February 18, 2014
    Assignee: Life Technologies Corporation
    Inventors: Stephen Yue, Jixiang Liu, Jolene Bradford
  • Publication number: 20140042370
    Abstract: The present invention relates to compounds of the formula (1) and formula (2), which are suitable for use in electronic devices, in particular in organic electroluminescent devices.
    Type: Application
    Filed: March 26, 2012
    Publication date: February 13, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Irina Martynova, Christof Pflumm, Amir Hossain Parham, Christof Pflumm, Rémi Manouk Anémian, Teresa Mujica-Fernaud, Claire De Nonancourt
  • Publication number: 20140042412
    Abstract: A compound for an organic optoelectronic device is represented by the following Chemical Formula 1:
    Type: Application
    Filed: October 11, 2013
    Publication date: February 13, 2014
    Inventors: Dong-Wan RYU, Sung-Hyun JUNG, Dal-Ho HUH, Jin-Seok HONG, Gi-Wook KANG, Mi-Young CHAE
  • Publication number: 20140018355
    Abstract: The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.
    Type: Application
    Filed: June 27, 2013
    Publication date: January 16, 2014
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Timothy L. MACDONALD, Jerry L. NADLER, Peng CUI
  • Publication number: 20140001443
    Abstract: Embodiments of the present invention are directed to a compound represented by Formula 1 below and an organic light-emitting device including the compound.
    Type: Application
    Filed: November 13, 2012
    Publication date: January 2, 2014
    Applicant: Samsung Display Co. Ltd.
    Inventors: Jung-Sub Lee, Seung-Gak Yang
  • Publication number: 20130315825
    Abstract: Derivatives of phenothiazine, phenoxazine, and phenazine compounds and their use as ?-synuclein ligands are described. Also described are methods of using these compounds and their radiolabeled analogs for the detection, monitoring, and treatment of synucleinopathies, including Parkinson's disease.
    Type: Application
    Filed: May 3, 2013
    Publication date: November 28, 2013
    Applicant: Washington University
    Inventors: Zhude Tu, Robert Mach, Lihai Yu, Paul Kotzbauer
  • Publication number: 20130313532
    Abstract: [Problem] To provide a charge transporting material which allows for a low driving voltage and is superior in luminous efficiency and durability. [Means for resolution] A charge transporting material comprising a compound represented by any one of the following general formula (1-1) to general formula (1-3): wherein R111 to R114, R121 to R125 and R131 to R135 each independently represent a hydrogen atom or a substituent, and may be bound together to form a ring; L111 to L113 each independently represent O or S; L121 to L123 each independently represent a single bond or a divalent linking group; and Ar111 to Ar113 each independently represent an aryl group or a heteroaryl group.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 28, 2013
    Applicant: UDC IRELAND LIMITED
    Inventors: Kousuke WATANABE, Yosuke YAMAMOTO, Wataru SOTOYAMA
  • Publication number: 20130126856
    Abstract: An organic compound with excellent characteristics excelling in hole-injecting/transporting performance and having electron blocking ability, high stability in a thin-film state and high luminous efficiency is provided as material for an organic electroluminescent device. The compound of a general formula (1) having an indenocarbazole ring structure is used as a constituent material of at least one organic layer in the organic electroluminescent device that includes a pair of electrodes and one or more organic layers sandwiched between the pair of electrodes.
    Type: Application
    Filed: July 29, 2011
    Publication date: May 23, 2013
    Applicant: HODOGAYA CHEMICAL CO., LTD.
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi, Kouki Kase, Eiji Takahashi
  • Publication number: 20130126350
    Abstract: A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.
    Type: Application
    Filed: December 17, 2012
    Publication date: May 23, 2013
    Applicant: BAYER HEALTHCARE LLC
    Inventor: Bayer Healthcare LLC
  • Publication number: 20130122276
    Abstract: A photoelectric conversion device comprising a transparent electrically conductive film, a photoelectric conversion film and an electrically conductive film in this order, wherein the photoelectric conversion film comprises a photoelectric conversion layer, and an electron blocking layer, wherein the electron blocking layer contains a compound represented by the specific formula.
    Type: Application
    Filed: January 3, 2013
    Publication date: May 16, 2013
    Applicant: FUJIFILM CORPORATION
    Inventor: FUJIFILM Corporation
  • Publication number: 20130102014
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 25, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Harley Batchelor, Yue Ge, Iain D. Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg
  • Patent number: 8367822
    Abstract: The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors' transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: February 5, 2013
    Assignee: Enzo Therapeutics, Inc.
    Inventors: Dianqing (Dan) Wu, Dakai Liu, James J. Donegan
  • Publication number: 20120322717
    Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.
    Type: Application
    Filed: May 22, 2009
    Publication date: December 20, 2012
    Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
  • Publication number: 20120280221
    Abstract: A material for an organic photoelectric device, the material including a compound including a pyridine ( ) moiety, the compound being a bipolar organic compound including both a hole transporting unit and an electron transporting unit, the compound being represented by the following Formula 1:
    Type: Application
    Filed: July 17, 2012
    Publication date: November 8, 2012
    Inventors: Eun-Sun YU, Nam-Soo KIM, Young-Hoon KIM, Mi-Young CHAE, Eui-Su KANG
  • Publication number: 20120217485
    Abstract: Provided are novel organic electroluminescent compounds and organic electroluminescent devices using the same. Since the organic electroluminescent compound exhibits good luminous efficiency and excellent life property compared to the existing material, it may be used to manufacture OLED devices having superior operation life and consuming less power due to improved power efficiency.
    Type: Application
    Filed: July 30, 2010
    Publication date: August 30, 2012
    Applicant: ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.
    Inventors: Hyo Jung Lee, Young Jun Cho, Sung Jin Eum, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
  • Patent number: 8231690
    Abstract: The present invention relates to a composition for the coloring of keratin fibres, notably hair, that comprises a phenoxazinone dye of formula (I) as well as the use of this dye for hair coloring. The invention thus makes it possible to obtain coloration that respects the nature of the hair and offers strong shades, which are resistant and have low selectivity.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: July 31, 2012
    Assignee: L'Oreal
    Inventors: Boris Lalleman, Patrick Choisy, Alain Lagrange
  • Publication number: 20120178747
    Abstract: The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors' transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm.
    Type: Application
    Filed: November 14, 2006
    Publication date: July 12, 2012
    Inventors: Dianqing (Dan) Wu, Dakai Liu, James J. Donegan
  • Publication number: 20120175599
    Abstract: [Problem] An organic compound of excellent characteristics is provided that exhibits excellent hole-injecting/transporting performance with electron blocking ability, and that has high stability in the thin-film state and high luminous efficiency, the organic compound being provided as material for an organic electroluminescent device having high efficiency and high durability. The invention also provides a high-efficient, high-durable organic electroluminescent device using the compound. [Means for Resolution] The compound is of the following general formula having a carbazole ring structure. The organic electroluminescent device includes a pair of electrodes, and one or more organic layers sandwiched between the pair of electrodes, and the compound is used as a constituent material of at least one organic layer.
    Type: Application
    Filed: August 25, 2010
    Publication date: July 12, 2012
    Applicant: Hodogaya Chemical Co., Ltd.
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi, Shigeru Kusano
  • Publication number: 20120149697
    Abstract: The present invention relates to the medical field, in particular to the use of natural organic polyanions, i.e. humic substances, HSs, in the treatment of neurodegenerative diseases, such as Prion disease, Alzheimer's and Parkinson's disease.
    Type: Application
    Filed: July 13, 2010
    Publication date: June 14, 2012
    Applicant: SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI
    Inventors: Giuseppe Antonio Legname, Liviana Leita, Paolo Sequi