Oxygen Bonded Directly To The Diazine Ring Patents (Class 544/123)
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Patent number: 4906278Abstract: This invention relates to certain heterocyclic sulfonylurea herbicidal compounds, agriculturally suitable compositions thereof and a method of their use.Type: GrantFiled: March 30, 1987Date of Patent: March 6, 1990Assignee: E. I. Du Pont de Nemours and CompanyInventor: Barry A. Wexler
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Patent number: 4904783Abstract: N-Arylsulfonyl-N'-(4-mercaptomethyl-pyrimidinyl)-ureas of the formula ##STR1## (symbols in this formula defined herein) and the salts of these compounds with amines, alkali metal bases or alkaline-earth metal bases or with ammonium bases, have good pre- and post-emergence-selective, herbicidal and growth-regulating properties.Type: GrantFiled: September 19, 1988Date of Patent: February 27, 1990Assignee: Ciba-Geigy CorporationInventor: Werner Topfl
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Patent number: 4902336Abstract: N-Arylsulfonyl-N'-(4-mercaptomethyl-pyrimidinyl-ureas of the formula ##STR1## (symbols in this formula defined herein) and the salts of these compounds with amines, alkali metal bases or alkaline-earth metal bases or with ammonium bases, have good pre- and post-emergence-selective, herbicidal and growth-regulating properties.Type: GrantFiled: September 19, 1988Date of Patent: February 20, 1990Assignee: Ciba-Geigy CorporationInventor: Werner Topfl
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Patent number: 4874759Abstract: Hydroxyindole-3-carboxylic acid amide compounds of the general formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are, the same or different, respectively a hydrogen atom, an alkyl group, an aryl group, an aralkyl group or a heteroaryl group, or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 are respectively groups which are combined to each other taken together with the adjacent nitrogen atom to form a heterocyclic group, R.sup.5 is an alkyl group, R.sup.6 is a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group or an aralkyl group and X is a hydrogen atom, a halogen atom or a lower alkanoyl group, or their acid addition salts.These compounds are of use as diuretics or a therapeutic medicine for circulation system diseases.Type: GrantFiled: September 23, 1988Date of Patent: October 17, 1989Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Tetsuya Tahara, Tsuguo Ikebe, Ichiro Hakamada, Osamu Yaoka
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Patent number: 4855301Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;R is hydrogen, alkyl, cycloalkyl, aryl, or arylalkyl and R.sub.1 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, ##STR2## or halo substituted alkyl, or R and R.sub.1 taken together with the nitrogen atom to which they are attached are 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl, 4-diarylalkyl-1-piperazinyl or 1-pyrrolidinyl, 1-piperidinyl, or 1-azeipinyl substituted with alkyl, alkoxy, alkylthio, halo, trifluoromethyl or hydroxy;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, ##STR3## or halo substituted alkyl; R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, ##STR4## or halo substituted alkyl; R.sub.4 is aryl or heterocyclo;R.sub.5 and R.sub.6 are each independently hydrogen, alkyl, --(CH.sub.2).sub.q --aryl or --(CH.sub.2).sub.Type: GrantFiled: February 9, 1987Date of Patent: August 8, 1989Assignee: E. R. Squibb & Sons, Inc.Inventors: Karnail Atwal, George C. Rovnyak
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Patent number: 4854962Abstract: This invention relates to novel sulfonylurea herbicidal compounds, agriculturally suitable compositions thereof and a method-of-use of said compounds and compositions as general preemergence and/or postemergence herbicides or their use as plant growth regulants.Type: GrantFiled: February 16, 1988Date of Patent: August 8, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventors: David L. Douglass, Marcus P. Moon
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Patent number: 4851406Abstract: The present invention provides indole derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl or aryl radical, R.sub.2 is a hydrogen atom or an alkyl, trihalogenomethyl, hydroxyl, cycloalkyl, cyano, carboxyl, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl radical; R.sub.2 is a heterocyclic five-membered ring containing 1 to 4 heteroatoms or a heterocyclic six-membered ring containing 1 to 5 heteroatoms, the heteroatoms of the five- and six-membered rings being the same or different and being nitrogen, oxygen or sulphur and one or more of the nitrogen atoms optionally carrying an oxygen atom, the said five- and six-membered rings optionally being substituted by one or more alkyl, alkoxy, alkylthio, oxo, hydroxyl, nitro, amino, halogen or cyano groups; or R.sub.Type: GrantFiled: September 4, 1986Date of Patent: July 25, 1989Assignee: Boehringer Mannheim GmbHInventors: Alfred Mertens, Wolfgang von der Saal, Walter-Gunar Friebe, Bernd Muller-Beckmann, Gisbert Sponer
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Patent number: 4847379Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein X is oxygen or nitrogen and R.sub.4 is aryl, are disclosed. These novel compounds are useful, for example, as cardiovascular agents.Type: GrantFiled: November 30, 1987Date of Patent: July 11, 1989Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Phenoxyalkylaminopyrimidine derivatives and insecticidal and acaricidal compositions containing them
Patent number: 4845097Abstract: Compounds of formula (I): ##STR1## (where R.sup.1 -R.sup.5 are various conventional atoms or groups, m is 2 or 3 and R.sup.6 l is an optionally substituted alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl or heterocyclic-substituted alkyl group or --CH.sub.2 --CH.dbd.NOR.sup.7 where R.sup.7 is hydrogen, alkyl, alkenyl or aralkyl) have insecticidal and acaricidal activities.Type: GrantFiled: March 14, 1986Date of Patent: July 4, 1989Assignees: Sankyo Company Limited, UBE Industries LimitedInventors: Keigo Matsumoto, Shinji Yokoi, Katsutoshi Fujii -
Patent number: 4838926Abstract: This invention relates to certain novel pyridine sulfonamide compounds, to composition containing such compounds, and to a method of use of such compositions to control the growth of undesired vegetation.Type: GrantFiled: September 14, 1987Date of Patent: June 13, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventors: Mary A. Hanagan, Barry A. Wexler
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Patent number: 4830662Abstract: N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g. N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzenesulf onamide or N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-methoxycarbonylbenze nesulfonamide; are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.Type: GrantFiled: March 27, 1986Date of Patent: May 16, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4822403Abstract: The invention relates to certain sulfonamide compounds having substituents ortho to the sulfonylurea linkage, said substituents including alkenyl, substituted alkenyl, cycloalkenyl, substituted cycloalkenyl, alkynyl and substituted alkynyl.Type: GrantFiled: October 10, 1986Date of Patent: April 18, 1989Assignee: E. I. Du Pont De Nemours and CompanyInventors: James V. Hay, Barry A. Wexler, Donna F. Zimmerman
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Patent number: 4808591Abstract: 8-(2-Pyrimidylsulfinyl)quinolines, inhibitors of the H.sup.+ /K.sup.30 ATPase enzyme, are useful in the treatment of ulcers.Type: GrantFiled: February 16, 1988Date of Patent: February 28, 1989Assignee: Pfizer Inc.Inventor: Conrad Santini
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Patent number: 4802906Abstract: Ortho-Sulfonamide benzenesulfonylureas, such as N-cyclopropyl-N'-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1,2-benzened isulfonamide, are useful as pre-emergent and post-emergent herbicides.Type: GrantFiled: December 23, 1985Date of Patent: February 7, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventor: Donald J. Dumas
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Patent number: 4801327Abstract: The invention relates to certain sulfonylurea compounds having a carbocyclic or heterocyclic ring ortho to the sulfonylurea linkage, compositions thereof and a method of their use as herbicides or plant growth regulants.Type: GrantFiled: March 26, 1986Date of Patent: January 31, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventors: Joel R. Christensen, Morris P. Rorer
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Patent number: 4752322Abstract: This invention relates to herbicidally active sulfonylurea compounds, agriculturally suitable compositions thereof and their method of use as herbicides or plant growth regulants.Type: GrantFiled: November 4, 1986Date of Patent: June 21, 1988Inventors: Donald J. Dumas, Marcus P. Moon
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Patent number: 4747870Abstract: This invention relates to certain pyrazole sulfonylurea herbicidal compounds, agriculturally suitable compositions thereof and a method of their use.Type: GrantFiled: March 13, 1987Date of Patent: May 31, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Barry A. Wexler
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Patent number: 4746353Abstract: Tetrazole-substituted benzenesulfonamides are useful as agricultural chemicals and, in particular, as growth regulants and herbicides.Type: GrantFiled: November 24, 1986Date of Patent: May 24, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4745110Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.Type: GrantFiled: July 27, 1987Date of Patent: May 17, 1988Assignee: Rorer Pharmaceutical CorporationInventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
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Patent number: 4743292Abstract: The invention relates to certain pyrazole sulfonamide compounds having haloalkenyl substituents ortho to the sulfonylurea linkage.Type: GrantFiled: October 10, 1986Date of Patent: May 10, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: James V. Hay, Barry A. Wexler, Donna F. Zimmerman
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Patent number: 4743290Abstract: Thiophenesulfonamides of the formula ##STR1## are useful as herbicides.Type: GrantFiled: November 26, 1986Date of Patent: May 10, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: Joel R. Christensen, John Cuomo, George Levitt
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Patent number: 4741757Abstract: Thiophenesulfonamides useful as herbicides and plant growth regulants, herbicidal compositions containing thiophenesulfonamides, and methods of applying the compositions to areas containing undesired vegetation are described.Type: GrantFiled: March 11, 1987Date of Patent: May 3, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4741758Abstract: The invention relates to certain thiophene sulfonamide compounds having alkenyl substituents ortho to the sulfonylurea linkage.Type: GrantFiled: March 27, 1987Date of Patent: May 3, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: James V. Hay, Barry A. Wexler, Donna F. Zimmerman
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Patent number: 4732604Abstract: This invention relates to certain sulfonylurea compounds having substituents ortho to the sulfonylurea linkage that includes a 3- or 4- membered carbocyclic ring, a saturated 5- or 6- membered carbocyclic ring or a heterocyclic ring which contains 1 heteroatom selected from O, S and NR.sub.3, agriculturally suitable compositions thereof and a method of their use as herbicides or plant growth regulants.Type: GrantFiled: February 24, 1987Date of Patent: March 22, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: James V. Hay, Barry A. Wexler, Donna F. Zimmerman
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Patent number: 4728652Abstract: 1,4-Dihydropyrimidines of the formula ##STR1## wherein X is sulfur or oxygen and R.sub.4 is aryl or heterocyclo and disclosed. These compounds are useful as cardiovacular agents, particularly anti-hypertensive agents, due to their vasodilator activity.Type: GrantFiled: April 21, 1986Date of Patent: March 1, 1988Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Patent number: 4725303Abstract: Herbicidally active guanidine derivatives of the formula ##STR1## in which m represents the numbers zero, 1 or 2,R.sup.5 represents an optionally substituted radical from the series comprising alkyl, aralkyl, aryl and heteroaryl,R.sup.2 represents a pyrimidin-2-yl radical which is substituted by halogen, amino, cyano or formyl and/or by optionally substituted radicals from the series comprising alkyl, alkoxy, alkylamino, dialkylamino, alkylcarbonyl and alkoxycarbonyl,R.sup.3 represents hydrogen, an optionally substituted radical from series comprising alkyl, cycloalkyl, alkenyl, alkinyl and aralkyl,R.sup.9 represents hydrogen or optionally substituted alkyl andR.sup.10 represents an optionally substituted radical from the series comprising alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aryl, heteroaryl, alkyl- or alkoxycarbonyl and alkyl- or arylsulphonyl, or R.sup.9 and R.sup.Type: GrantFiled: November 14, 1986Date of Patent: February 16, 1988Assignee: Bayer AktiengesellschaftInventors: Koichi Moriya, Theodor Pfister, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt, Klaus Lurssen, Hans-Joachim Diehr, Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Uwe Priesnitz, Wolfgang Roy, Hans-Joachim Santel
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Patent number: 4721521Abstract: The invention relates to certain pyridine sulfonamide compounds having haloalkenyl substituents ortho to the sulfonylurea linkage.Type: GrantFiled: October 10, 1986Date of Patent: January 26, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: James V. Hay, Barry A. Wexler, Donna F. Zimmerman
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Patent number: 4689414Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3 or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;R.sub.5 is hydrogen, alkyl, aryl, arylalkyl, cyano, nitro, ##STR2## Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl-(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR3## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR4## amino, or substituted amino; m is 0 or an integer of 1 to 6;n is an integer of 1 to 6; andp is an integer of 2 to 6.Type: GrantFiled: February 24, 1986Date of Patent: August 25, 1987Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Patent number: 4687507Abstract: N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g. N-[(4,6-dimethylpyrimidin-2-yl)-aminocarbonyl]-2-methoxycarbonylbenzenesul fonamide or N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-methoxycarbonylbenze nesulfonamide; are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.Type: GrantFiled: August 9, 1985Date of Patent: August 18, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4684656Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl--(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl--(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR2## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR3## Y.sub.3 is hydroxyl, alkoxy, aryl--(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl--(CH.sub.2).sub.Type: GrantFiled: March 14, 1986Date of Patent: August 4, 1987Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Patent number: 4678499Abstract: Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]-pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide, agricultural compositions containing them, and their herbicidal utility are disclosed.Type: GrantFiled: January 30, 1986Date of Patent: July 7, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventors: Robert J. Pasteris, Ramaurthi Muthukrishnan
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Patent number: 4675045Abstract: Thiocarbonylsulfonylureas, useful as herbicides and plant growth regulants, herbicidal compositions employing these compounds and methods of applying them to soil or directly to plants have been discovered.Type: GrantFiled: May 2, 1986Date of Patent: June 23, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Wallace C. Petersen
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Patent number: 4675406Abstract: This invention relates to substituted 4-pyrimidinones which are useful as intermediates in preparing H.sub.2 -antagonists.Type: GrantFiled: January 13, 1986Date of Patent: June 23, 1987Assignee: SmithKline Beckman CorporationInventors: Bing L. Lam, Lendon N. Pridgen
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Patent number: 4675321Abstract: Pharmaceutical compositions of specific substituted pyrimidines and methods of treatment of certain cardiovascular disorders are disclosed. Also disclosed are novel substituted acrylated pyrimidines which are useful as calcium channel blockers.Type: GrantFiled: February 7, 1986Date of Patent: June 23, 1987Assignee: Merck & Co., Inc.Inventors: John J. Baldwin, Steven M. Pitzenberger, David E. McClure
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Patent number: 4664695Abstract: N-Phenylsulfonyl-N'-pyrimidinylureas of the general formula I ##STR1## and the salts of these compounds with amines, alkali metal bases or alkaline earth metal bases or with quaternary ammonium bases, have good selective herbicidal and growth regulating properties when applied pre- and postemergence.The symbols in formula I have the following meanings:R.sub.1 is hydrogen, halogen, nitro, cyano, or an alkyl, alkoxy, alkylthio, alkylsulfonyl, alkylcarbonyl, alkylcarbamoyl or alkoxycarbonyl group, each unsubstituted or substituted by halogen or alkoxy,R.sub.2 is hydrogen, halogen, alkyl, or an alkyl, alkoxy or alkylthio group, each unsubstituted or substituted by halogen or alkoxy,R.sub.3 is alkyl, haloalkyl, alkoxy or haloalkoxy,R.sub.4 is hydrogen, halogen, R.sub.3, alkylamino or dialkylamino,R.sub.Type: GrantFiled: March 29, 1985Date of Patent: May 12, 1987Assignee: Ciba-Geigy CorporationInventors: Rolf Schurter, Rudolph C. Thummel, Werner Topfl, Willy Meyer, Dieter Durr
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Patent number: 4634713Abstract: Certain 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives, such as the compounds of formula III below, represent novel and useful pharmaceutical agents, e.g. potent antihypertensive and cardioactive agents demonstrating both .alpha.- and .beta.-adrenergic blocking activity. ##STR1## R.sub.3 is hydrogen or lower alkyl; R.sub.7 is cyano, lower alkoxycarbonyl, pyrrolyl, morpholino, alkenyloxy of 3 to 6 carbon atoms, alkynyloxy of 3 to 6 carbon atoms, alkoxy of 1 to 3 carbon atoms substituted by cyclopropyl.Type: GrantFiled: August 19, 1985Date of Patent: January 6, 1987Assignee: Ciba-Geigy CorporationInventors: Lincoln H. Werner, Neville Ford
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Patent number: 4619688Abstract: Selectively herbicidal compounds of the formula ##STR1## in which R.sup.1 is a hydrogen atom or the group ##STR2## R.sup.2 is a hydroxy group, a lower alkoxy group or a di-lower alkylamino group,R.sup.3 and R.sup.4 each independently is a lower alkyl group or a lower alkoxy group,X is a lower alkoxy group, a lower alkylamino group or a morpholino group, andY is N or CH.Type: GrantFiled: January 4, 1985Date of Patent: October 28, 1986Assignee: Nihon Tokushu Noyaku Seizo K.K.Inventors: Kozo Shiokawa, Koichi Moriya, Toshio Goto, Atsumi Kamochi, Shigeo Kohama
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Patent number: 4618609Abstract: Dihydropyridine derivatives of the formula: ##STR1## and their pharmaceutically acceptable acid addition salts; wherein R is a substituted aryl group;R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.3 alkyl;Y is --(CH.sub.2).sub.n -- where n is 2, or --CH.sub.2 CH(CH.sub.3)--; and Het is a 6-membered aromatic heterocyclic group attached to the adjacent oxygen atom by a carbon atom.The compounds have utility as anti-ischaemic and anti-hypertensive agents.Type: GrantFiled: June 5, 1985Date of Patent: October 21, 1986Assignee: Pfizer Inc.Inventors: David Alker, Simon F. Campbell, Peter E. Cross
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Patent number: 4604466Abstract: Piperidino-substituted pyrimidines which are intermediates for preparing piperidino-substituted imidazo-[1,5-c]pyrimidines which are bronchodilators.Type: GrantFiled: August 16, 1984Date of Patent: August 5, 1986Assignee: Riker Laboratories, Inc.Inventor: James J. Wade
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Patent number: 4579583Abstract: The invention relates to N-pyridylsulfonyl-N'-pyrimidinyl- and -N'-triazinylureas of the formula I ##STR1## wherein A is a C.sub.3 -C.sub.6 alkynyl radical, a C.sub.1 -C.sub.6 alkyl radical which is substituted by halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 haloalkylsulfinyl or C.sub.1 -C.sub.4 haloalkylsulfonyl, or is a C.sub.2 -C.sub.4 alkenyl radical which is unsubstituted or substituted as for C.sub.1 -C.sub.6 alkyl, or is a phenyl radical which is unsubstituted or substituted by halogen, cyano, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, an --X--C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 alkoxycarbonyl, amino, mono- or di-(C.sub.1 -C.sub.4 alkyl)amino, carbamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)carbamoyl, sulfamoyl, mono- or di-(C.sub.1 -C.sub.4 alkyl)sulfamoyl radical orA--X-- forms an amino radical --NR.sub.6 R.sub.Type: GrantFiled: August 29, 1983Date of Patent: April 1, 1986Assignee: Ciba-Geigy CorporationInventors: Werner Fory, Karl Gass, Willy Meyer
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Patent number: 4576749Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and a 1-substituent of the formula ##STR1## (or a salt or ester thereof).Type: GrantFiled: April 13, 1984Date of Patent: March 18, 1986Assignee: E. R. Squibb & Sons, Inc.Inventors: Robert Zahler, William H. Koster, William A. Slusarchyk
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Patent number: 4568677Abstract: 1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl; R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl; X is a 5 or 6 membered nitrogen-containing heterocyclic ring which is substituted with one or more hydroxyl or oxo groups and which may optionally be fused to a further 5 or 6 membered nitrogen-containing heterocyclic ring, and which may optionally be further substituted in the heterocyclic ring or further fused heterocyclic ring; Y is --(CH.sub.2).sub.n --, --CH.sub.2 CH(CH.sub.3)-- or --CH.sub.2 C(CH.sub.3).sub.2 --; and n is 1 to 3 when X is linked to Y by a ring carbon atom, or 2 or 3 when X is linked to Y by a ring nitrogen atom; and their pharmaceutically acceptable salts, and pharmacuetical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.Type: GrantFiled: June 21, 1984Date of Patent: February 4, 1986Assignee: Pfizer Inc.Inventors: David Alker, Peter E. Cross, Simon F. Campbell
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Patent number: 4545808Abstract: N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g. N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzenesulf onamide or N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-methoxycarbonylbenze nesulfonamide; are useful for the regulation of plant growth and as pre-emergence and post-emergence herbicides.Type: GrantFiled: March 30, 1983Date of Patent: October 8, 1985Assignee: E. I. Du Pont de Nemours and CompanyInventor: George Levitt
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Patent number: 4539318Abstract: Novel tertiary aminohydroxypropoxy substituted thiadiazole compounds exhibit .alpha..sub.1 -adrenoceptor and serotonin antagonism and are also useful as antihypertensive agents.Type: GrantFiled: June 4, 1984Date of Patent: September 3, 1985Assignee: Merck & Co., Inc.Inventors: John J. Baldwin, Gerald S. Ponticello
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Patent number: 4521597Abstract: A novel process for producing sulfonylureas of the formula I having a herbicidal action and an action regulating plant growth ##STR1## wherein A is an unsubstituted or substituted phenyl, naphthyl, furan, thiophene or pyridine group, E is a nitrogen atom or the methine group, R.sub.a is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -haloalkyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -haloalkoxy, C.sub.1 -C.sub.5 -alkylthio or C.sub.2 -C.sub.10 -alkoxyalkoxy, and R.sub.b is the same as R.sub.Type: GrantFiled: October 14, 1983Date of Patent: June 4, 1985Assignee: Ciba Geigy CorporationInventors: Haukur Kristinsson, Werner Topfl
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Patent number: 4515624Abstract: Certain sulfonylurea compounds with oxysulfonyl-, thiosulfonyl- or aminosulfonyl-containing groups are useful as pre- and/or post-emergence herbicides.Type: GrantFiled: March 23, 1983Date of Patent: May 7, 1985Assignee: E. I. Du Pont de Nemours and CompanyInventor: James J. Reap
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Patent number: 4505910Abstract: Herein is disclosed amino-pyrimidine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for increasing cardiac contractility in a mammal.Type: GrantFiled: June 30, 1983Date of Patent: March 19, 1985Assignee: American Home Products CorporationInventor: Jehan F. Bagli
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Method and composition for enhancing the insecticidal activity of certain organophosphorus compounds
Patent number: 4489068Abstract: The insecticidal activity of certain pyridinyl phosphorus compounds is enhanced by the admixture therewith of certain 2,5,6-trisubstituted-4-pyrimidinyl phosphoramidates or phosphoramidothioates.Type: GrantFiled: April 28, 1983Date of Patent: December 18, 1984Assignee: The Dow Chemical CompanyInventors: Donald H. De Vries, Walter Reifschneider, Mark J. Costales -
Patent number: 4486589Abstract: N-(heterocyclicaminocarbonyl)-ortho-haloalkylbenzenesulfonamides, such as 2-(dichloromethyl)-N-[(4-methoxy-6-methylprimidin-2-yl) aminocarbonyl]-benzenesulfonamide, are useful as preemergent or postemergent herbicides or as plant growth regulants.Type: GrantFiled: October 21, 1982Date of Patent: December 4, 1984Assignee: E. I. Du Pont de Nemours and CompanyInventor: William B. Farnham
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Patent number: RE33125Type: GrantFiled: July 11, 1986Date of Patent: December 5, 1989Assignee: Rorer Pharmaceutical CorporationInventors: Henry F. Campbell, Thomas H. Scholtz, George H. Douglas