The Additional Six-membered Hetero Ring Is One Of The Cyclos In A Polycyclo Ring System Patents (Class 544/150)
-
Patent number: 4908453Abstract: Reagents useful in the preparation of 5'-biotinylated oligonucleotides are disclosed.Type: GrantFiled: January 23, 1989Date of Patent: March 13, 1990Assignee: E. I. Du Pont De Nemours and CompanyInventor: Anthony J. Cocuzza
-
Patent number: 4883793Abstract: Novel hydrazinocarbonyloxylabdanes, intermediates and processes for the preparation thereof, and a method for treating cardiac failure utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: May 9, 1988Date of Patent: November 28, 1989Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Raymond W. Kosley, Jr., Gerard J. O'Malley
-
Patent number: 4841050Abstract: Benzopyrans of the formula ##STR1## where X is a radical ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and the ring A have the meanings stated in the description, a process for their preparation, and their use in pressure-sensitive or heat-sensitive layers.Type: GrantFiled: March 12, 1987Date of Patent: June 20, 1989Assignee: BASF AktiengesellschaftInventors: Andreas Guentner, Udo Mayer, Andreas Oberlinner
-
Patent number: 4837210Abstract: The invention relates to novel fluoran compounds of the general formula ##STR1## wherein R.sub.1 and R.sub.2, each independently of the other, are lower alkyl;A is ##STR2## or a pyrrolidinyl, piperidino, morpholino or piperazino radical; and R.sub.3 and R.sub.4, each independently of the other, are C.sub.1 -C.sub.12 alkyl, cycloalkyl, phenyl or phenyl substituted by lower alkyl or lower alkoxy.These compounds are particularly suitable for use as color formers in pressure-sensitive or heat-sensitive recording materials.Type: GrantFiled: January 27, 1987Date of Patent: June 6, 1989Assignee: Appleton Papers Inc.Inventors: Patricia Dwyer-Hallquist, William J. Becker, Robert E. Miller, Kenneth D. Glanz
-
Patent number: 4771049Abstract: Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: March 16, 1987Date of Patent: September 13, 1988Assignee: Hoechst-Roussel PharmaceuticalsInventors: Raymond W. Kosley, Jr., Robert J. Cherill
-
Patent number: 4713453Abstract: The present invention relates to a novel oxabicycloheptane derivative of the following formula and a pharmaceutically acceptable salt thereof: ##STR1## where D is a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group, an arylalkoxy group, an acyloxy group, a dialkylcarbamoyloxy group or an amidoalkyloxy group; B is a substituted or unsubstituted phenyl, thienyl or furyl group; A is the group ##STR2## (where l is 0 or 1; m and n are each 1 or more, provided that m+n is an interger of 2-8; R.sup.1 is an alkylamino group, a dialkylamino group, an arylalkylamino group, a morpholino group, a thiomorpholino group, a 1-pyrrolidinyl group, a piperidino group, an N-alkylpiperazinyl group, an N-hydroxyalkylpiperazinyl or a pyrrolizidinyl group; and R.sup.2 is a lower alkyl group or a hydroxl group), or the group ##STR3## (where l, m, n, R.sup.1 and R.sup.2 are each the same as defined above), or the group ##STR4## (where R.sup.3 and R.sup.Type: GrantFiled: February 27, 1987Date of Patent: December 15, 1987Assignee: Suntori LimitedInventors: Toshio Tatsuoka, Kenji Suzuki, Kayoko Imao, Fumio Satoh, Seiji Miyano, Kunihiro Sumoto
-
Patent number: 4673752Abstract: Novel aminoacyllabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: October 20, 1986Date of Patent: June 16, 1987Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
-
Patent number: 4672115Abstract: Novel aminoacyllabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: October 17, 1986Date of Patent: June 9, 1987Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
-
Patent number: 4647675Abstract: Novel compounds of the general formula I ##STR1## where A.sup..crclbar. is an anion, R is hydrogen or unsubstituted or substituted alkyl or cycloalkyl, R.sup.1 and R.sup.2 independently of one another are each hydrogen or unsubstituted or substituted alkyl or cycloalkyl, or one of the radicals may furthermore be aryl, or R.sup.1 and R.sup.2, together with the nitrogen atom, form a saturated heterocyclic structure, the radicals R.sup.3 independently of one another are each hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sup.4 and R.sup.5 independently of one another are each unsubstituted or substituted alkyl or cycloalkyl, or one of the radicals may furthermore be hydrogen, aryl or hetaryl, R.sup.4 and R.sup.5, together with the nitrogen atom, form a saturated heterocyclic structure, n is 1, 2 or 3, X is hydrogen, chlorine, bromine, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or nitro and Y is hydrogen or chlorine, are particularly useful for dyeing paper stocks.Type: GrantFiled: July 11, 1985Date of Patent: March 3, 1987Assignee: BASF AktiengesellschaftInventors: Udo Mayer, Andreas Oberlinner
-
Patent number: 4639446Abstract: Novel aminoacyllabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: December 4, 1985Date of Patent: January 27, 1987Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
-
Patent number: 4603202Abstract: Fluorans of the formula (I) ##STR1## where R.sup.1 is hydrogen or methyl, R.sup.2 is hydrogen or unsubstituted or substituted alkyl, R.sup.3 is hydrogen, unsubstituted or substituted alkyl, cycloalkyl or unsubstituted or substituted phenyl, or ##STR2## is a 5-membered or 6-membered saturated heterocyclic radical, R.sup.4 and R.sup.5 independently of one another are each hydrogen, alkyl, alkoxy or halogen, R.sup.6 is hydrogen, halogen, alkyl, alkoxy, phenylalkoxy, phenoxy, phenyl or unsubstituted or substituted amino, or is pyrrolidinyl, piperidinyl or morpholinyl, R.sup.7 is hydrogen, alkyl or halogen, R.sup.8 is C.sub.1 -C.sub.5 -alkyl, and the radicals R.sup.4 and R.sup.5 and/or R.sup.6 and R.sup.7 together may furthermore each be a --CH.dbd.CH--CH.dbd.CH-- bridge, and the fused-on benzo ring may be further substituted, are used for the preparation of pressure-sensitive and heat-sensitive recording materials.Type: GrantFiled: October 12, 1984Date of Patent: July 29, 1986Assignee: BASF AktiengesellschaftInventors: Udo Mayer, Andreas Oberlinner
-
Patent number: 4598090Abstract: The present invention relates to new condensed benzopyrone derivatives, to a process for their preparation and to pharmaceutical compositions containing them.Type: GrantFiled: March 22, 1984Date of Patent: July 1, 1986Assignee: Farmitalia Carlo Erba, S.p.A.Inventors: Gianfederico Doria, Carlo Passarotti, Ada Buttinoni
-
Patent number: 4569994Abstract: Dibenzopyran derivatives which possess antihypoxia activity are 7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyranyloxyaminopropanols having the formula: ##STR1## Where X is oxygen or dialkyl in which each alkyl group contains one to seven carbons (C.sub.1 -C.sub.7); R is hydrogen or alkyl containing one to seven carbons (C.sub.1 -C.sub.7); and A is --NR.sub.1 R.sub.2 where R.sub.1 and R.sub.2 may independently be hydrogen, C.sub.1 -C.sub.7 alkyl, C.sub.3 -C.sub.7 cycloalkyl, phenyl, C.sub.7 -C.sub.10 phenylalkyl, C.sub.7 -C.sub.10 phenoxyalkyl, C.sub.2 -C.sub.6 alkanol, 6-oxo-6H-dibenzo[b,d]pyran-3-yl, 2-hydroxy-3-(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyranyl-3-oxy)-propy l; or A is a heterocyclic ring of structure: ##STR2## where n=2 or 3; or A is a substituted heterocyclic ring of structure: ##STR3## where Y and Z may be independently hydrogen or methyl and B represents a single bond, methylene, ethylene, propylene, CH-phenyl, CHCH.sub.2 -phenyl, oxygen, sulfur, or N--R.sub.4 where R.sub.4 is hydrogen, C.sub.Type: GrantFiled: June 27, 1985Date of Patent: February 11, 1986Assignee: Pennwalt CorporationInventor: Ronald C. Griffith
-
Patent number: 4548929Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.Type: GrantFiled: April 18, 1983Date of Patent: October 22, 1985Assignee: SDS Biotech CorporationInventors: Thomas A. Magee, Robert D. Battershell, Lawrence E. Limpel, Andrew W. Ho, Arthur W. Friedman, H. Glenn Corkins, William W. Brand, Russell Buchman, Louis Storace, Edmond R. Osgood
-
Patent number: 4539412Abstract: 7-Hydroxylucanthone and 7-hydroxyhycanthone derivatives have been found to have significant antitumor effect. The derivatives are of the general formula: ##STR1## wherein the radicals R.sup.1 and R.sup.2 are lower alkyl groups or other simple groups and R.sup.3 is OH where X.dbd.O, and H or OH where X.dbd.S.Type: GrantFiled: February 1, 1984Date of Patent: September 3, 1985Assignee: Rensselaer Polytechnic InstituteInventor: Sydney Archer
-
Patent number: 4486428Abstract: Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH.sub.2 or NR.sub.6 ; R.sub.6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups;A' is:(1) A where one of A and B is hydrogen such that when A is hydrogen, B is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 1 or 2; when B is hydrogen, A is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 0 or 1, when taken together A and OR.sub.1 form a lactone or certain derivatives thereof;(2) A' is ##STR2## (3) A' is Q.sub.3 ; Q is CO.sub.2 R.sub.7, COR.sub.8, C(OH)R.sub.8 R.sub.9, CN, CONR.sub.12 R.sub.13, CH.sub.2 NR.sub.12 R.sub.13, CH.sub.2 NHCOR.sub.14, CH.sub.2 NHSO.sub.2 R.sub.17 or 5-tetrazoyl;Q.sub.3 is ##STR3## 5-tetrazolyl, CH.sub.2 CONHCOR.sub.7, COOH or certain ester, amide, carboximido or sulfonimido derivatives thereof, CONHOH, CONHCONH.sub.2, or COCH.sub.2 Q.sub.4 where Q.sub.Type: GrantFiled: January 13, 1983Date of Patent: December 4, 1984Assignee: Pfizer Inc.Inventors: James F. Eggler, Michael R. Johnson, Lawrence S. Melvin, Jr.
-
Patent number: 4463001Abstract: The present invention relates to new 6-substituted 6H-dibenzo [b,d]pyran derivatives, to a process for their preparation and pharmaceutical and veterinary compositions containing them.Type: GrantFiled: October 1, 1981Date of Patent: July 31, 1984Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Piero Melloni, Paolo Salvadori, Pier P. Lovisolo
-
Patent number: 4434295Abstract: The present specification provides novel analogs of khellin. These analogs are all useful as antiatherosclerotic agents. Particularly, the present specification provides 4-methoxy, 9-methoxy, or 4,9-dimethoxy-6,7-dihydro-7,7-disubstituted-5H-furo[3,2-g][1]benzopyran-5- ones.Type: GrantFiled: May 17, 1982Date of Patent: February 28, 1984Assignee: The Upjohn CompanyInventor: Ronald B. Gammill
-
Patent number: 4401824Abstract: Novel compounds of the following general formula: ##STR1##Type: GrantFiled: March 8, 1982Date of Patent: August 30, 1983Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
-
Patent number: 4374984Abstract: Compounds of the formula ##STR1## wherein the substituents A, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, n and m are defined hereinbeloware effective photoinitiators, especially for the photopolymerization of ethylenically unsaturated compounds and for the curing of printing inks.Type: GrantFiled: March 4, 1981Date of Patent: February 22, 1983Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Jurgen Eichler, Claus Herz, Karl-Heinz Neisius, Gregor Wehner
-
Patent number: 4290954Abstract: A tetrahydroxanthone derivative represented by the general formula: ##STR1## wherein R is a hydrogen atom, a hydroxyl, cyano, lower alkyl, lower alkoxy, lower acyloxy, benzoyloxy or tetrazolyl group, or ##STR2## (R.sub.3 is a hydrogen atom, R.sub.4 is a hydrogen atom, a phenyl group which may be optionally substituted, or a tetrazolyl group; or R.sub.3 and R.sub.4 commonly form a ring together with the adjacent nitrogen atom and another nitrogen atom or an oxygen atom); R.sub.1 is a hydrogen or halogen atom, a lower alkyl, cyano, carboxyl or tetrazolyl group, or ##STR3## (R.sub.5 is a hydrogen atom, R.sub.6 is a phenyl group which may be optionally substituted, or a tetrazolyl group; or R.sub.5 and R.sub.6 commonly form a ring together with the adjacent nitrogen atom and an oxygen atom); and R.sub.2 is a hydrogen or halogen atom, or a lower alkyl group; with the proviso that neither R nor R.sub.1 is a hydrogen atom; when R is --CONH.sub.2, R.sub.1 and R.sub.Type: GrantFiled: October 30, 1979Date of Patent: September 22, 1981Assignee: Kowa Company LimitedInventors: Kazuhiro Onogi, Hisashi Kunieda, Kiyoshi Kawamura, Masami Shiratsuchi, Masahiko Nagakura, Naoki Machida, deceased, by Takayasu Miwa, heir
-
Patent number: 4284569Abstract: The present specification relates to the antiatherosclerotic use of khellin and related furochromones, and further provides novel antiatherogenic furochromones.Type: GrantFiled: January 28, 1980Date of Patent: August 18, 1981Assignee: The Upjohn CompanyInventor: Ronald B. Gammill
-
Patent number: 4232018Abstract: Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans useful as analgesic agents, derivatives thereof, intermediates therefor and processes for their preparation.Type: GrantFiled: March 29, 1979Date of Patent: November 4, 1980Assignee: Pfizer Inc.Inventor: Michael R. Johnson
-
Patent number: 4206225Abstract: A compound of the formula ##STR1## wherein Q is CH.sub.2, C.dbd.O, CHOH or CHCH.sub.2 OH; M is O or NR.sub.6 ; where R.sub.6 is hydrogen, or certain alkyl, aralkyl, acyl or carboalkoxy substituted alkyl groups; R.sub.1 is hydrogen, or certain alkanoyl or amino substituted alkanoyl groups; R.sub.4 and R.sub.5 are each hydrogen or alkyl having from 1 to 4 carbon atoms; Z is alkylene having from 1 to 9 carbon atoms or --(alk.sub.1)--X--(alk.sub.2).sub.n -- where (alk.sub.1) and (alk.sub.2) are certain alkylene groups and X is O, S, SO or SO.sub.2 ; W is a methyl, phenyl, substituted phenyl, pyridyl, piperidyl, cycloalkyl or substituted cycloalkyl group and the pharmaceutically acceptable and addition salts of said compounds having a basic nitrogen atoms. Said compounds are useful as analgesics and as intermediates therefore.Type: GrantFiled: September 22, 1978Date of Patent: June 3, 1980Assignee: Pfizer Inc.Inventor: Michael R. Johnson
-
Patent number: 4201861Abstract: Derivatives of C-076, a series of macrolides, are described in which the substituents are acyl groups. The acyl substituents may be aromatic of non-aromatic. The acyl derivatives are prepared by various procedures depending upon the particular C-076 compound being substituted. The compounds thus produced have profound anthelmintic, insecticidal, ectoparasiticidal and acaracidal activity and compositions for such uses are also disclosed.Type: GrantFiled: April 17, 1978Date of Patent: May 6, 1980Assignee: Merck & Co., Inc.Inventors: Helmut H. Mrozik, Michael H. Fisher, Peter Kulsa
-
Patent number: 4169204Abstract: New psoralen compounds have been synthesized. The compounds all include the addition of substituent groups at the 4'-position on the basic trioxsalen structure. Specifically, the compounds have the structure ##STR1## wherein ##STR2## where R is a mono or dicyclic radical which can contain one additional hetero atom in the nitrogen containing ring.The new substituted psoralens exhibit high solubility in aqueous solution and low dissociation constants from deoxyribonucleic acid (DNA), as well as a reactivity with ribonucleic acids (RNA).Type: GrantFiled: August 28, 1978Date of Patent: September 25, 1979Assignee: Regents of the University of CaliforniaInventors: John E. Hearst, Henry Rapoport, Stephen Isaacs, Che-Kun J. Shen
-
Patent number: 4166062Abstract: 1-Alkoxyethanol-isochromas, -isothiochromas, -2-benzoxepins, and -2-benzothiepins are described. These compounds are useful for preparing the corresponding aminoalkoxyalkyl derivatives that possess antihypertensive and CNS activity.Type: GrantFiled: July 21, 1978Date of Patent: August 28, 1979Assignee: The Upjohn CompanyInventors: John M. McCall, Ruth E. TenBrink
-
Patent number: 4161589Abstract: Spirodipyrans of the formula ##STR1## where A is the radical of a fused benzene ring or 2,1-naphthalene ring, the rings being unsubstituted or substituted by alkyl, alkoxy, nitro, chlorine, bromine or carbalkoxy,R.sup.1 is alkyl, phenyl, substituted alkyl or phenalkyl andR.sup.2 is hydrogen, orR.sup.1 and R.sup.2 together are trimethylene which is unsubstituted or substituted by 1, 2 or 3 alkyl andB is N-morpholinyl, substituted morpholinyl, thiomorpholinyl-S-dioxide, N-(N'-alkyl)-piperazinyl or N-isoindolinyl,And pressure-sensitive recording materials containing these spirodipyrans as dye-forming components.With electron acceptors, the spirodipyrans give reddish violet to blue colorations, while no coloration is produced on paper which has not been coated with an electron acceptor.Type: GrantFiled: August 8, 1978Date of Patent: July 17, 1979Assignee: BASF AktiengesellschaftInventors: Hans Baumann, Andreas Oberlinner
-
Patent number: 4152450Abstract: 1-Hydroxy-3-substituted-tetrahydro and hexahydrodibenzo[b,d]pyrans having an amino group or amino derivative at the 9-position are useful as analgesics, anti-depressants, anti-anxiety agents, hypotensive agents, and intermediates. Pharmaceutical formulations containing such 9-amino derivatives are provided, as well as a method of treating hypertension.Type: GrantFiled: February 17, 1978Date of Patent: May 1, 1979Assignee: Eli Lilly and CompanyInventors: William A. Day, Edward R. Lavagnino
-
Patent number: 4143139Abstract: 9-Hydroxydibenzo[b,d]pyrans useful as analgesics, hypotensives, immunosuppressants, tranquilizers; as anti-secretory and anti-anxiety drugs; intermediates therefor and derivatives thereof having the formulae ##STR1## wherein R is hydrogen or alkanoyl having from one to five carbon atoms; R.sub.1 is hydrogen, alkanoyl having from one to five carbon atoms or --CO--(CH.sub.2).sub.P --NR.sub.2 R.sub.3 wherein p is 0 or an integer from 1 to 4; each of R.sub.2 and R.sub.3 when taken individually is hydrogen or alkyl having from one to four carbon atoms; R.sub.2 and R.sub.3 when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from piperidino, pyrrolo, pyrrolidino, morpholino and N-alkylpiperazino having from one to four carbon atoms in the alkyl group;Each of R.sub.4 and R.sub.5 is hydrogen, methyl or ethyl;R.sub.0 is oxo or alkylenedioxy having from two to four carbon atoms;Z is(a) alkylene having from one to nine carbon atoms;(b) --(alk.sub.1).sub.Type: GrantFiled: July 27, 1977Date of Patent: March 6, 1979Assignee: Pfizer Inc.Inventor: Jasjit S. Bindra
-
Patent number: 4133880Abstract: N.sup.2 -substituted-L-arginine esters and amides, and the pharmaceutically acceptable acid addition salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.Type: GrantFiled: July 28, 1977Date of Patent: January 9, 1979Assignees: Mitsubishi Chemical Industries Ltd., Shosuke OkamotoInventors: Shosuke Okamoto, Akiko Hijikata, Ryoji Kikumoto, Yoshikuni Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura
-
Patent number: 4110348Abstract: Dye intermediates of the formula ##STR1## where R.sup.1 is hydrogen, alkyl of 1 to 12 carbon atoms, phenyl which is unsubstituted or substituted by alkyl of 1 to 4 carbon atoms, methoxy, ethoxy, chlorine or bromine, or phenylalkyl of 7 to 10 carbon atoms, R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together are dimethylene, trimethylene or tetramethylene, which are unsubstituted or substituted by alkyl of 1 to 12 carbon atoms, R.sup.3 and R.sup.5 are hydrogen, alkyl of 1 to 12 carbon atoms, cyano-, chlorine-, methoxy- or ethoxy-substituted alkyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, phenylalkyl of 7 to 10 carbon atoms or trimethylene which is unsubstituted or substituted by 1 to 3 methyl and is bonded to the carbon atom in the 6-position or 6'-position of the benzene ring, R.sup.4 and R.sup.Type: GrantFiled: March 1, 1977Date of Patent: August 29, 1978Assignee: BASF AktiengesellschaftInventors: Hans Baumann, Andreas Oberlinner
-
Patent number: 4107317Abstract: Derivatives of trans-3-hydroxy-4-amino-chroman and pharmaceutical compositions containing such derivatives are useful for effecting vasodilation in mammals, including humans.Type: GrantFiled: April 11, 1977Date of Patent: August 15, 1978Assignee: Beecham Group LimitedInventor: Eric Alfred Watts
-
Patent number: 4085210Abstract: Novel morpholine compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, aryl-(C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.4)alkyl, polyhalo(C.sub.2 -C.sub.4)alkyl or hydroxy(C.sub.2 -C.sub.4)alkyl, A represents straight or branched C.sub.2 -C.sub.4 alkylene, B represents a divalent radical selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 --O--, --CH.sub.2 --S--, --S-- and --O--, >D --E-- represents a trivalent radical selected from the group consisting of >CH--CH.sub.2 -- and >C.dbd.CH-- and C.sub.1 and C.sub.2 each represent 1,2-phenylene optionally substituted with one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.Type: GrantFiled: January 6, 1976Date of Patent: April 18, 1978Assignee: Sumitomo Chemical Company, LimitedInventors: Junki Katsube, Atsuyuki Kojima, Makoto Sunagawa, Yoshinori Takashima, Yoshito Kameno, Hisao Yamamoto
-
Patent number: 4080335Abstract: Compounds within formula ##STR1## and their salts wherein X is alkylene of 2 - 4 carbon atoms; R.sub.1 is hydrogen or alkyl of 1 - 6 carbon atoms; R.sub.2 is hydrogen, alkyl of 1 - 6 carbon atoms or benzyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered saturated ring; R.sub.3 is aryl; R.sub.4 is hydrogen or alkyl of 1 - 4 carbon atoms; and R.sub.5 is hydrogen or alkyl of 1 - 4 carbon atoms; have been found to possess mood-modifying and anorexia inducing activity.Type: GrantFiled: January 26, 1976Date of Patent: March 21, 1978Assignee: Beecham Group LimitedInventor: Derek Victor Gardner
-
Patent number: 4079066Abstract: Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein X is an alkylene group of 2 - 4 carbon atoms; Y is CH.sub.2 or 0; R.sub.1 is a hydrogen atom or a C.sub.1-6 alkyl group; R.sub.2 is a hydrogen atom or a C.sub.1-6 alkyl or benzyl group or is joined to R.sub.1 so that NR.sub.1 R.sub.1 is a 5-, 6- or 7- membered saturated ring; R.sub.3 is a naphthyl group or a naphthyl group substituted by a fluorine, chlorine or bromine atom or a methyl, methoxyl, trifluoromethyl, hydroxy or acetoxy group; R.sub.4 is a hydrogen atom or a C.sub.1-4 alkyl group; and R.sub.5 is a hydrogen atom or a C.sub.1-4 alkyl group; have been found to be mood modifying agents.Type: GrantFiled: January 26, 1976Date of Patent: March 14, 1978Assignee: Beecham Group LimitedInventor: Derek Victor Gardner
-
Patent number: 4049653Abstract: Heterocyclic esters of benzopyrans represented by the formula ##STR1## wherein n is 1 or 2; each R and R.sub.1 are the same or different members of the group consisting of hydrogen or loweralkyl; R.sub.2 is loweralkyl; R.sub.3 is ##STR2## WITH Y' being a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, X is CH.sub.2, O, S or NR.sub.7 with R.sub.7 being hydrogen or loweralkyl, with the limitation that when X is O, S, or NR.sub.7, a and b each must be 2; R.sub.8 is hydrogen or loweralkyl; Y is a straight or branched chain alkylene group having from one to ten carbon atoms; and each R.sub.4 and R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof.Type: GrantFiled: February 13, 1974Date of Patent: September 20, 1977Assignee: Abbott LaboratoriesInventor: Martin Winn
-
Patent number: 4048317Abstract: Anti-hypertensive derivatives of trans-3-hydroxy-4-amino-chroman, their preparation from amines and chroman epoxide derivatives, and pharmaceutical compositions containing such anti-hypertensive derivatives for reducing blood pressure in mammals including humans.Type: GrantFiled: May 14, 1975Date of Patent: September 13, 1977Assignee: Beecham Group LimitedInventor: Eric Alfred Watts
-
Patent number: RE30739Abstract: Compounds within formula ##STR1## and their salts wherein X is alkylene of 2-4 carbon atoms; R.sub.1 is hydrogen or alkyl of 1-6 carbon atoms; R.sub.2 is hydrogen, alkyl of 1-6 carbon atoms or benzyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered saturated ring; R.sub.3 is aryl; R.sub.4 is hydrogen or alkyl of 1-4 carbon atoms; and R.sub.5 is hydrogen or alkyl of 1-4 carbon atoms; have been found to possess mood-modifying and anorexia inducing activity.Type: GrantFiled: May 14, 1979Date of Patent: September 8, 1981Assignee: Beecham Group LimitedInventor: Derek V. Gardner