Abstract: This application relates to benzenesulphonamides and more specifically to 1-acylamino 2- alcoxy or alcenyloxy 5-morpholinylsulfonyl benzenes and their salts with a mineral or organic acid. It also relates to processes for producing these compounds.The disclosed compounds are useful for stimulating gastric evacuation while inhibiting emisis and gastric secretion in warm-blooded animals.
Type:
Grant
Filed:
January 9, 1975
Date of Patent:
September 13, 1977
Assignee:
Science Union et Cie
Inventors:
Michel Vincent, Georges Remond, Xavier Pascaud, Jean-Claude Poignant
Abstract: Indoaniline of the formula ##STR1## wherein R.sub.1 represents hydrogen, halogen, alkyl or alkoxy;R.sub.2 represents alkyl, hydroxyalkyl, carbamylalkyl, piperidinoalkyl, morpholinoalkyl, sulfoalkyl, dialkylaminoalkyl, acylaminoalkyl, (preferably acetylaminoalkyl or benzoylaminoalkyl) and mesylaminoalkyl;R.sub.3 represents hydroxyalkyl, carbamylalkyl, piperidinoalkyl, morpholinoalkyl, sulfoalkyl, dialkylaminoalkyl, acylaminoalkyl, (preferably acetylaminoalkyl or benzoylaminoalkyl), mesylaminoalkyl; or R.sub.2 and R.sub.3 together form with the nitrogen atom to which they are attached a heterocycle selected from piperidino or morpholino;R.sub.4, r.sub.5 and R.sub.6 each independently represents hydrogen, halogen, alkyl, alkoxy, acylamino, ureido or carbalkoxyamino, and R.sub.5 can also represent amino, alkylamino, hydroxyalkylamino or carbamylalkylamino. The alkyl and alkoxy groups above can contain from 1 to 6 carbon atoms and the acyl group can contain from 2 to 7 carbon atoms.
Abstract: Novel urea derivatives of the formula ##STR1## wherein R and R.sub.1 are individually selected from the group consisting of hydrogen, chlorine, bromine, nitro, trifluoromethyl, lower alkyl of 1 to 6 carbon atoms and lower alkoxy of 1 to 6 carbon atoms, n is 0 or 1, X is selected from the group consisting of lower alkyl of 1 to 6 carbon atoms optionally substituted with halogen and a nitrogen heterocyclic optionally containing 1 or more other heteroatoms, Y is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and S--Z wherein Z is a nitrogen heterocyclic optionally containing 1 or more other heteroatoms and the dotted lines indicate that the compound of formula I may contain no oxygen bound to the sulfur atom or may be in sulfoxide or sulfonyl form which are useful as herbicides and thereon preparation.
Type:
Grant
Filed:
September 22, 1975
Date of Patent:
August 30, 1977
Assignee:
Roussel Uclaf
Inventors:
Daniel Hainaut, Jean-Pierre Demoute, Andre Teche
Abstract: This disclosure describes homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenoic acid and of 9-hydroxy-13-trans-prostenoic acid, having antimicrobial activity and prostaglandin-like hypotensive activity.
Type:
Grant
Filed:
May 5, 1975
Date of Patent:
August 23, 1977
Assignee:
American Cyanamid Company
Inventors:
Karel Francis Bernady, Middleton Brawner Floyd, Jr., John Frank Poletto, Robert Eugene Schaub, Martin Joseph Weiss