Double Bonded Divalent Sulfur Patents (Class 544/161)
  • Patent number: 10836716
    Abstract: An exemplary process for the production of alkali metal salts of dialkyldithiocarbamic acids produced according to the following steps: i) reaction of one or more dialkylamines, carbon disulphide and alkali metal hydroxides to form alkali metal salts of dialkyldithiocarbamic acids; ii) crystallisation to form a crystal suspension of alkali metal salts of dialkyldithiocarbamic acids; iii) separation of crystals of alkali metal salts of dialkyldithiocarbamic acids from the mother liquor in step ii; (iv) recirculation of the separated mother liquor into the crystallisation process; and v) drying of the alkali metal salts of dialkyldithiocarbamic acids.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: November 17, 2020
    Assignee: EPC ENGINEERING & TECHNOLOGIES GMBH
    Inventors: Jens Henkel, Jurgen Rassbach, Tobias Przynosz
  • Patent number: 8937175
    Abstract: The invention relates to novel compounds as ligands for transition metal complexes and materials made thereof that can be used, for example, as emitters in organic light-emitting electrochemical cells (OLEECs). According to the invention, non-fluorinated electron-poor emitter materials are disclosed for the first time that can be used in organic light-emitting electrochemical cells.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: January 20, 2015
    Assignee: Osram GmbH
    Inventors: Andreas Kanitz, Daniel Stark
  • Publication number: 20130150574
    Abstract: The present invention provides efficient and economical methods for synthesis of (?)-2-exo-morpholinoisoborne-10-thiol, its enantiomer, and related chiral catalysts. Novel compounds and methods of asymmetric synthesis are also disclosed.
    Type: Application
    Filed: November 29, 2012
    Publication date: June 13, 2013
    Applicant: Scinopharm Taiwan, LTD.
    Inventor: Scinopharm Taiwan, LTD.
  • Patent number: 8431513
    Abstract: An object of the present invention is to provide a recording material that is excellent in color-developing properties and background and image stabilities, and a compound used therein. The present invention relates to a compound represented by the formula (I) [wherein R11 to R14 each independently represent a halogen atom or the like; n, p, q, and r each independently represent 0 or any integer of 1 to 4; m represents 0 or any integer of 1 to 2; a represents any integer of 1 to 10; R2 represents a hydrogen atom or the like; R3 represents an OR51 group or the like; and R41 and R42 each independently represent a hydrogen atom or the like], a composition containing the compound, a method for producing the compound, a recording material containing at least one compound represented by the formula (I), and a recording sheet having the recording material.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: April 30, 2013
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Toshio Aihara, Hiroshi Sakai, Shuntaro Kinoshita, Satoshi Kodama, Tadahiro Kondo, Kazumi Jyujyo
  • Publication number: 20120323004
    Abstract: Methods of preparing sulfate salts of heteroatomic compounds using dialkyl sulfates as a primary reactant are disclosed. Also disclosed are methods of making ionic liquids from the sulfate salts of the heteroatomic compound, and electrochemical cells comprising the ionic liquids.
    Type: Application
    Filed: June 18, 2012
    Publication date: December 20, 2012
    Applicant: FLUIDIC, INC.
    Inventors: Cody A. FRIESEN, Derek WOLFE, Paul Bryan JOHNSON
  • Publication number: 20120204763
    Abstract: An object of the present invention is to provide a recording material that is excellent in color-developing properties and background and image stabilities, and a compound used therein. The present invention relates to a compound represented by the formula (I) [wherein R11 to R14 each independently represent a halogen atom or the like; n, p, q, and r each independently represent 0 or any integer of 1 to 4; m represents 0 or any integer of 1 to 2; a represents any integer of 1 to 10; R2 represents a hydrogen atom or the like; R3 represents an OR51 group or the like; and R41 and R42 each independently represent a hydrogen atom or the like], a composition containing the compound, a method for producing the compound, a recording material containing at least one compound represented by the formula (I), and a recording sheet having the recording material.
    Type: Application
    Filed: September 28, 2010
    Publication date: August 16, 2012
    Inventors: Toshio Aihara, Hiroshi Sakai, Shuntaro Kinoshita, Satoshi Kodama, Tadahiro Kondo, Kazumi Jyujyo
  • Publication number: 20120178732
    Abstract: The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: December 6, 2011
    Publication date: July 12, 2012
    Inventors: Timothy Jon Luker, Timothy Nicholas Birkinshaw, Rukhsana Tasneem Mohammed
  • Patent number: 8044048
    Abstract: Derivatives of sulindac are provided along with pharmaceutical compositions containing them and use for precancerous conditions and treating cancer. Derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: October 25, 2011
    Assignee: Southern Research Institute
    Inventors: Gary Piazza, Robert Reynolds
  • Publication number: 20110142759
    Abstract: The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, administering to a subject an agent that binds specifically to myelin basic protein, and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
    Type: Application
    Filed: February 21, 2011
    Publication date: June 16, 2011
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Rong Zhang, Tiberiu Mircea Siclovan, Cristina Abucay Tan Hehir, Victoria Eugenia Cotero, Bruce Fletcher Johnson
  • Publication number: 20110059967
    Abstract: Compounds comprising Formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein J1, J2, U1, B, Y, and A are as described in claims 1-16. Methods, compositions, and medicaments related thereto are also disclosed, for treating glaucoma, inflammatory bowel disease and baldness.
    Type: Application
    Filed: May 4, 2009
    Publication date: March 10, 2011
    Applicant: Allergan Inc.
    Inventors: David W. Old, Vinh X. Ngo
  • Patent number: 7781613
    Abstract: Disclosed are compounds of the general formula (I), with the definitions of the substituents R1 to R5, A and X being detailed in the text, and to their physiologically tolerated salts, to processes for preparing these compounds and to the use thereof as inhibitors of hormone-sensitive lipase (HSL).
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: August 24, 2010
    Assignee: Sanofi-Aventis
    Inventors: Karl Schoenafinger, Stefan Petry, Guenter Mueller, Karl-Heinz Baringhaus
  • Publication number: 20100137250
    Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
    Type: Application
    Filed: November 9, 2009
    Publication date: June 3, 2010
    Inventors: Fariborz Firooznia, Paul Gillespie, Tai-An Lin, Eric Mertz, Achyutharao Sidduri, Sung-Sau So, Jenny Tan, Kshitij Chhabilbhai Thakkar
  • Patent number: 7560549
    Abstract: A compound having the formula (I) wherein R1 is a substituted phenyl, R2 is a phenyl substituted with halogen atoms, R3 is a substituted phenyl, D is an oxygen or a methylene, and n is 0 or 1. The compound is a synthetic intermediate for a neurokinin receptor antagonist.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: July 14, 2009
    Assignee: Sankyo Company, Limited
    Inventors: Hiroshi Tomori, Hiroshi Miyamoto, Keijiro Kobayashi
  • Patent number: 7015323
    Abstract: The invention provides novel thiocarbamate alpha-4 inhibitors of the general formula (I) that are resistant to metabolism having improved half-life and/or clearance properties compared to corresponding carbamate compounds wherein substituents L, X, Y, Z, R1–R4, m, n, o and p are as defined herein. Also provided are compositions comprising compounds of formula I and a carrier, diluent or excipient as well as methods of treating a disease or condition mediated by the binding interaction of alpha-4 integrins to its ligands such as inflammatory diseases.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: March 21, 2006
    Assignee: Genentech, Inc.
    Inventor: David Y. Jackson
  • Publication number: 20040122000
    Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
    Type: Application
    Filed: October 21, 2003
    Publication date: June 24, 2004
    Applicant: Vertex Pharmaceuticals Incorporated.
    Inventors: Michael R. Hale, Roger Tung, Stephen Price, Robin David Wilkes, Wayne Carl Schairer, Ashley Nicholas Jarvis, Andrew Spaltenstein, Eric Steven Furfine, Vicente Samano, Istvan Kaldor, John Franklin Miller, Michael Stephen Brieger, Ronald George Sherrill
  • Publication number: 20040058907
    Abstract: There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, X a, b, and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
    Type: Application
    Filed: July 21, 2003
    Publication date: March 25, 2004
    Inventors: Rachael Anne Ancliff, Caroline Mary Cook, Colin David Eldred, Paul Martin Gore, Lee Andrew Harrison, Simon Teanby Hodgson, Duncan Bruce Judd, Suzanne Elaine Keeling, Xiao Qing Lewell, Graeme Michael Robertson, Stephen Swanson
  • Patent number: 6492514
    Abstract: The present invention relates to compounds of general formula (I) wherein X1 and X2 are different form each other and have the meanings reported in the following description Y is a simple bond, C1-C12 linear or branched alkyl groups, —O—, —S—, >S═O, >SO2, NR17—, wherein R17 is H, C1-C12 linear or branched alkyl groups, COR1, and photopolymerisable formulations containing as photoinitiators the aforementioned compounds of formula (I).
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: December 10, 2002
    Assignee: Lamberti S.p.A.
    Inventors: Enzo Meneguzzo, Marco Visconti, Domenico Badone-Italy, Giuseppe Li Bassi
  • Patent number: 5935585
    Abstract: Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: August 10, 1999
    Assignee: Centre International de Recherches Dermatologiques Galderma
    Inventors: Jean-Michel Bernardon, Laurence Vigne
  • Patent number: 5753653
    Abstract: The invention relates to compounds of the formula I ##STR1## in which Q is a divalent radical having four ring atoms which together with C* and N form a six-membered ring, each of these four ring atoms being unsubstituted or substituted by a suitable substituent and at least one being a heteroatom selected from O, N and S, with the remainder being carbon atoms; and Ar is an aryl or heteroaryl group. The invention further relates to pharmaceutically acceptable prodrugs and pharmaceutically acceptable salts of these compounds. The invention also relates to methods of inhibiting the activity of metalloproteinases, especially MMPs or TNF-.alpha., by administering a compound of the formula I or a salt or prodrug thereof. The invention further relates to pharmaceutical compositions comprising an effective amount of these compounds, salts, and prodrugs.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: May 19, 1998
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Steven L. Bender, Michael J. Melnick
  • Patent number: 5523464
    Abstract: The present invention relates to benzenesulfonamide derivatives represented by Formula (I): ##STR1## in which R.sup.1 and R.sup.2 independently represent hydrogen or lower alkanoyl; and R.sup.3 and R.sup.4 independently represent hydrogen, lower alkyl, cycloalkyl, substituted or unsubstituted polycycloalkyl, substituted aryl, or a substituted or unsubstituted heterocyclic group, or R.sup.3 and R.sup.4 are combined together with the adjacent nitrogen atom to form a substituted or unsubstituted aliphatic heterocyclic group, or a pharmaceutically acceptable salt thereof. The derivatives are useful as therapeutic agents for osteoporosis.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: June 4, 1996
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Iwao Kinoshita, Haruki Takai, Nobuo Kosaka, Katsura Sugawara, Akio Ishii, Hiroyuki Ishida, Katsushige Gomi
  • Patent number: 5424309
    Abstract: The present invention provides an N-substituted acylamino acid compound of the formula: ##STR1## a process for their production and pharmaceutical uses, and intermediates useful for their production.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: June 13, 1995
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Hajime Morishima, Yutaka Kokie, Masato Nakano, Shugo Atsuumi, Seiichi Tanaka, Kenji Matsuyama
  • Patent number: 5401869
    Abstract: Aminomethylene compounds of the formula ##STR1## may advantageously be prepared by reacting C--H-acidic compounds of the formula ##STR2## with formamide acetals of the formula ##STR3## in which the radicals R.sup.1 to R.sup.6 have the meaning given in the description,if the process is carried out in the presence of a secondary amine of the formula ##STR4## in which R.sup.7 and R.sup.8 have the meaning given in the description.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: March 28, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Helmut Kraus, Nikolaus Muller, Gerhard Marzolph, Bernhard Beitzke
  • Patent number: 5185334
    Abstract: Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined in the specification.
    Type: Grant
    Filed: September 6, 1991
    Date of Patent: February 9, 1993
    Assignee: Schering Corporation
    Inventors: Daniel Solomon, James J. Kaminski, Steven K. White, Laura S. Lehman de Gaeta, Ashit K. Ganguly
  • Patent number: 5095133
    Abstract: Aminomethylene compounds of the formula ##STR1## can be prepared by reaction of C-H acid compounds of the formula ##STR2## with salts of the formula ##STR3## in the presence of alkoxides of the formulaM.sup.1 OR.sup.10 (IV)where the radicals R.sup.1 to R.sup.4, R.sup.7, R.sup.10, X.sup.- and M.sup.1 have the meaning mentioned in the description.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: March 10, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz U. Blank, Helmut Kraus
  • Patent number: 5086054
    Abstract: Novel arylcycloalkanepolyalkylamines useful as anti-psychotic, anti-ischemia, anti-stroke, anti-dementia and anti-convulsant agents. These arylcycloalkanepolyalkylamines are selective high-affinity ligands to the sigma binding-sites containing three basic units: arylcycloalkyl group, an amine group and an intermediate chain. Their preparation and use for treatment of psychoses, ischemia, stroke, dementia and convulsions are also disclosed.
    Type: Grant
    Filed: July 31, 1990
    Date of Patent: February 4, 1992
    Assignee: SRI International
    Inventor: Daniel W. Parish
  • Patent number: 5053504
    Abstract: A process is disclosed for providing benzazepine intermediates of the formulae ##STR1## wherein R.sub.3, R.sub.4 and Y are as defined herein, which intermediates are useful in a process for the preparation of pharmaceutically useful benzazepine derivatives.
    Type: Grant
    Filed: November 29, 1989
    Date of Patent: October 1, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Wen-Sen Li, John K. Thottathil, Michael Murphy
  • Patent number: 5035719
    Abstract: Middle distillate fuels may be treated to improve storage stability by addition of, as additive, an acrylate polymer containing moieties derived from an N-heterocyclic amine such as 4-vinyl pyridine or the enamine ester of morpholine and propionaldehyde.
    Type: Grant
    Filed: December 27, 1988
    Date of Patent: July 30, 1991
    Assignee: Texaco Inc.
    Inventors: Rodney L. Sung, Benjamin J. Kaufman
  • Patent number: 5025005
    Abstract: Novel lipid derivatives of the formula ##STR1## [wherein R.sup.1 is alkyl or alkylcarbamoyl; R.sup.2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R.sup.3 is a chemical binding or alkylene which may be substituted; R.sup.4 is hydrogen, alkyl or aralkyl; X and Y are independently O, S or an imino group which may be substituted, and when Y is an imino group, Y, together with the imino group represented by X or R.sup.4, may form a ring; and Z is imino or a nitrogen-containing heterocyclic ring which may be substituted] and salts thereof have inhibiting activity on platelet activating factor and are useful as a preventive or therapeutic agent for a variety of circulatory diseases and allergic disorders and also as an antineoplastic agent.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: June 18, 1991
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroaki Nomura, Kohei Nishikawa, Susumu Tsushima
  • Patent number: 4968677
    Abstract: 1-Aryl-2-naphthoylamines of formula I are described ##STR1## wherein R.sub.1 is halogen, nitro, cyano, C.sub.1 -C.sub.6 alkyl that is unsubstituted or mono- or poly-substituted by halogen and/or C.sub.1 -C.sub.3 alkoxy, or is C.sub.3 -C.sub.6 cycloalkyl, OR.sub.4, NR.sub.5 R.sub.6, CO2R.sub.5, CONR.sub.5 R.sub.6 or NHCOR.sub.7, or wherein two adjacent positions in the nucleus are bridged by a methylenedioxy or ethylenedioxy group that is unsubstituted or mono- or poly-substituted by fluorine, wherein further R.sub.4 is hydrogen or C.sub.1 -C.sub.6 alkyl that is unsubstituted or substituted by C.sub.1 -C.sub.3 alkoxy or mono- or poly-substituted by halogen, or is C.sub.3 -C.sub.4 alkenyl, 2-propynyl, 3-halo-2-propynyl, ##STR2## or COR.sub.7, each of R.sub.5 and R.sub.6, independently of the other, is H or C.sub.1 -C.sub.4 alkyl, R.sub.7 is C.sub.1 -C.sub.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: November 6, 1990
    Assignee: Ciba-Geigy Corporation
    Inventor: Peter Riebli
  • Patent number: 4933367
    Abstract: This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments or atherosclerosis.
    Type: Grant
    Filed: March 12, 1987
    Date of Patent: June 12, 1990
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans P. Wolff, Ernst-Christian Witte, Hans-Frieder Kuhnle
  • Patent number: 4910331
    Abstract: This invention relates to a process for producing a thiolsulfonic acid derivative of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is independently a lower alkyl group or a 5- or 6-membered cycloalkyl group, or alternatively R.sub.1 and R.sub.2 together with the adjacent nitrogen atom form a 5- or 6-membered heterocyclic group which may further contain an oxygen, sulfur or nitrogen atom; and R.sub.3 is (1) an aryl group which may optionally be substituted by a lower alkyl group, a halogen, a lower alkoxy group or a lower alkylthio group, (2) a lower alkyl group which may optionally be substituted by a lower alkoxy group, (3) an aralkyl group or (4) a cycloalkyl group, or a salt thereof, which comprises reacting a compound of the general formula: ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, or a salt thereof with a compound of the general formula:R.sub.3 SO.sub.2 H (II)wherein R.sub.3 is as defined above, or a salt thereof under an acid condition.
    Type: Grant
    Filed: October 7, 1988
    Date of Patent: March 20, 1990
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kazuaki Kihara, Makoto Kuroda, Toshiyuki Nakamura
  • Patent number: 4904661
    Abstract: A phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus;wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages,wherein R.sup.1 is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 -- or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --S--, --SO-- or --SO.sub.2 --, wherein R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene;wherein R.sup.12 is hydrogen or alkyl, and wherein R.sup.22 is hydrogen, cyano or nitro;or a salt thereof when appropriate.
    Type: Grant
    Filed: December 16, 1987
    Date of Patent: February 27, 1990
    Assignee: Imperial Chemical Industries PLC
    Inventors: William R. Pilgrim, Derek W. Young, Brian S. Tait, Graham C. Crawley, Philip N. Edwards, George B. Hill
  • Patent number: 4885365
    Abstract: Compounds having the formula: ##STR1## wherein: a. R is an organic radical selected from an alkyl group, an alkenyl group, an aryl group or an aralkyl group in which the alkyl or alkenyl groups contain up to 32 carbon atoms and the aryl or aralkyl groups contain up to 15 carbon atoms;b. R.sup.1 is hydrogen or an organic radical selected from an alkyl group or alkenyl group, an aryl or aralkyl group in which the alkyl or alkenyl groups contain up to 32 carbon atoms and the aryl or aralkyl groups contain up to 15 carbon atoms;c. R.sup.2 and R.sup.3 are the same or different alkyl groups containing from 1 to 32, more preferably 4 to 8, carbon atoms eachare effective antiwear and antioxidant additives in lubricating oil.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: December 5, 1989
    Assignee: Ethyl Petroleum Additives, Inc.
    Inventor: William Y. Lam
  • Patent number: 4836958
    Abstract: The instant invention relates to fluorinated cationic compounds of the formula ##STR1## wherein R.sub.f is a perfluoroalkyl or perfluoroalkoxy-perfluoroalkyl group;R.sub.1 is alkylene optionally interrupted by --O--, --S--, --SO.sub.2 --, --SO.sub.2 NR'--, --CO.sub.2 --, --NR'--, or --CONR'-- where R' is hydrogen or lower alkyl;m is 0, 1 or 2;R.sub.2 is linear or branched alkylene;R.sub.3, R.sub.4, and R.sub.5 independently of one another represent alkyl or arylalkyl groups which are unsubstituted or substituted by hydroxyl, lower alkoxy, halogen, cyano or by polyalkyleneoxy, or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached represent a 5- or 6-membered heterocyclic radical or R.sub.3, R.sub.4 and R.sub.5 together with nitrogen atom that links them represent a substituted or unsubstituted pyridine ring; andA.sup..crclbar. represents the anion of an organic or inorganic acid; and their particular use as surfactants.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: June 6, 1989
    Assignee: Ciba-Geigy Corporation
    Inventor: Athanasios Karydas
  • Patent number: 4737518
    Abstract: Novel lipid derivatives of the formula ##STR1## [wherein R.sup.1 is alkyl or alkylcarbamoyl; R.sup.2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R.sup.3 is a chemical binding or alkylene which may be substituted; R.sup.4 is hydrogen, alkyl or aralkyl; X and Y are independently O, S or an imino group which may be substituted, and when Y is an imino group, Y, together with the imino group represented by X or R.sup.4, may form a ring; and Z is imino or a nitrogen-containing heterocyclic ring which may be substituted] and salts thereof have inhibiting activity on platelet activating factor and are useful as a preventive or therapeutic agent for a variety of circulatory diseases and allergic disorders and also as an antineoplastic agent.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: April 12, 1988
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroaki Nomura, Kohei Nishikawa, Susumu Tsushima, Yoshio Kozai
  • Patent number: 4639517
    Abstract: The stability, especially to heat, of thiocarbamylsulfenamides is improved when the thiocarbamylsulfenamide in solution is treated with acidic aqueous solutions. The recovered and dried thiocarbamylsulfenamides demonstrate improved resistance to heat and improved storage stability.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: January 27, 1987
    Assignee: The B F Goodrich Company
    Inventors: Enrique G. Reynes, John O. Leising
  • Patent number: 4562287
    Abstract: Therapeutic compositions having anti-inflammatory and analgesic activity, containing as active compound 2-(4-biphenylyl)-4-hexenoic acid and/or derivatives thereof, characterized by low toxicity and by the absence or minimum level of ulcerogenic effect.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: December 31, 1985
    Assignee: Scharper S.p.A. per l'Industria Farmaceutica
    Inventors: Alfonso Del Vecchio, Grazia Sestini
  • Patent number: 4521242
    Abstract: There are provided novel substituted phenyl (thiono)carbamates capable of effectively controlling broad-leaved annual weeds and annual weeds belonging to the families Gramineae and Cyperaceae such as wild Echinochloa species, monochoria, toothcup and umbrella plant, herbicidal compositions containing these (thiono)carbamates as active ingredient and a method of controlling weeds using these (thiono)carbamates. The (thiono)carbamates are substantially nonphytotoxic to useful crop plants such as the paddy rice plant.
    Type: Grant
    Filed: August 3, 1982
    Date of Patent: June 4, 1985
    Assignee: Kuraray Co., Ltd.
    Inventors: Tetsuo Takematsu, Makoto Konnai, Takeo Hosogai, Takashi Nishida
  • Patent number: 4466980
    Abstract: A novel compound selected from the group consisting of 7-(or 6- or 4-)thiaprostaglandin E.sub.1 derivatives of the formula (I). ##STR1## wherein A represents --CH.sub.2 -- or ##STR2## in which n is 0, 1 or 2, provided that only one A cut of three is ##STR3## R.sup.1 -R.sup.7 and G are as defined in the specification, the 15-epimers of said thiaprostaglandin E.sub.1 derivatives, the enatiomers of said thiaprostaglandin E.sub.1 derivatives or their 15-epimers, and mixtures of these compounds.A 7-thiaprostaglandin E.sub.1 derivative and/or its optical isomer may be prepared by reacting a 2-organo-2-cyclopentenone (II) with an organic copper-lithium compound (III) to effect conjugation reaction. A 6-thiaprostaglandin E.sub.1 derivative and/or its optical isomer may be prepared by subjecting an .alpha.,.beta.-unsaturated ketone (IV) and a thiol (V) to the Michael addition reaction.
    Type: Grant
    Filed: October 30, 1981
    Date of Patent: August 21, 1984
    Assignee: Teijin Limited
    Inventors: Toshio Tanaka, Takeshi Toru, Takeo Oba, Noriaki Okamura, Kenzo Watanabe, Kiyoshi Bannai, Atsuo Hazato, Seizi Kurozumi, Fukuyoshi Kamimoto, Akira Ohtsu
  • Patent number: 4420434
    Abstract: The instant invention relates to the use of ion-pair complexes derived from anionic perfluoroalkyl sulfonates, carboxylates, phosphates and phosphonates and cationic perfluoroalkyl surfactants. Such complexes are capable of reducing the surface tension of aqueous solutions dramatically even at extremely low concentrations, and are useful as wetting, spreading and leveling agents and are especially preferred as components in so-called aqueous film forming foam compositions for fighting polar and non-polar solvent and fuel fires.
    Type: Grant
    Filed: January 9, 1981
    Date of Patent: December 13, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: Robert A. Falk
  • Patent number: 4310346
    Abstract: This invention relates to N(Substituted Phenylsulfonyl) N'(Substituted Pyrimidinyl) urea compounds having the formulae I and IA ##STR1## to agricultural compositions containing them and to their methods of use as general as well as selective pre- and post-emergence herbicides and as plant growth regulants.
    Type: Grant
    Filed: May 30, 1980
    Date of Patent: January 12, 1982
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: George Levitt, Richard F. Sauers
  • Patent number: 4185958
    Abstract: A composition suitable for dyeing keratin fibres, especially human hair, is provided comprising a direct dyestuff and, as a levelling agent, a 2,5-dihydroxyphenylcarboxylic acid or a salt thereof.
    Type: Grant
    Filed: August 18, 1978
    Date of Patent: January 29, 1980
    Inventors: Andree Bugaut, Jean-Francois Grollier, Jean-Jacques Vandenboosche
  • Patent number: 4153790
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: May 8, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • Patent number: 4153791
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: May 8, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • Patent number: 4118401
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: October 19, 1977
    Date of Patent: October 3, 1978
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • Patent number: 4113767
    Abstract: 6-Tert.-butyl-3-mercapto-4-amino-1,2,4-triazin-5(4H)-one is prepared by reacting pinacolone with a sulfur chloride at 0.degree. to 80.degree. C, optionally reacting the mixture with an aqueous amine solution, hydrolyzing the resulting product with an alkali metal hydroxide, heating the resulting mixture from 2 to 10 hours at 80.degree. to 150.degree. C, liberating a 3,3-dimethyl-2-oxo-butyric acid by acidifying with a mineral acid and reacting an aqueous solution of said 3,3-dimethyl-2-oxo-butyric acid with thiocarbohydrazide to yield the desired product.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: September 12, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventor: Walter Merz
  • Patent number: 4069326
    Abstract: The present invention relates to certain indane derivatives of general formula ##STR1## in which: X represents a hydrogen or halogen atom; R.sub.1 and R.sub.2, which may be identical or different, each represents a hydrogen atom, an alkyl group containing 1 to 5 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms; R.sub.3 represents a hydrogen atom or an alkyl group containing 1 to 5 carbon atoms; and Y represents --CH.sub.2 OH or a group of formula --COOR.sub.4 in which R.sub.4 represents a hydrogen atom, 1/v(M) where M is a metal of valency v, or a group of formula--(CH.sub.2).sub.n --NR.sub.5 R.sub.6wherein n is an integer of 1 to 5 and R.sub.5 and R.sub.6, which may be identical or different, each represents a hydrogen atom, an alkyl group containing 1 to 5 carbon atoms, a cycloalkyl group containing 3 to 7 carbon atoms, an aryl group or an aralkyl group, or R.sub.5 and R.sub.
    Type: Grant
    Filed: May 27, 1976
    Date of Patent: January 17, 1978
    Assignee: Societe Anonyme dite: Societe Hexachimie
    Inventor: Jean-Marie Teulon
  • Patent number: 4069244
    Abstract: The invention is directed to fluorinated compounds of the formula ##STR1## wherein R.sub.f is a perfluoroalkyl or perfluoroalkoxy-perfluoroalkyl group, R.sup.1 is a branched or straight chain alkylene, alkylenethioalkylene, alkyleneoxyalkylene or alkyleneiminoalkylene group, X is oxygen or an amino group, Q is an organic group containing at least one amino group and y is zero or 1, and the corresponding succinimides. These compounds are useful as surfactants.
    Type: Grant
    Filed: January 3, 1975
    Date of Patent: January 17, 1978
    Assignee: Ciba-Geigy Corporation
    Inventor: Karl Friedrich Mueller
  • Patent number: 4052514
    Abstract: Novel trihalosubstituted biphenylyl propionic and acetic acids and their derivatives are described together with processes for their preparation and composition of them. They are useful as anti-inflammatory agents.
    Type: Grant
    Filed: September 14, 1973
    Date of Patent: October 4, 1977
    Assignee: The Boots Company Limited
    Inventors: Stewart S. Adams, Bernard J. Armitage, John S. Nicholson