Tetrazines Patents (Class 544/179)
  • Process for the preparation of 4,6-dihalogeno-triazines
    Patent number: 4220765
    Abstract: A process for the preparation of a 4,6-dihalogeno-triazine of the formula ##STR1## wherein R represents an aryl or aryloxy radical or 5 or 6-membered nitrogen-containing aromatic heterocyclic radical which can be optionally mono or polysubstituted by a C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, halogeno, nitro, cyano, C.sub.1 -C.sub.4 -carbalkoxy, aryl or aryloxy andHal.sup.1 denotes a halogen atom is described wherein a trihalogenomethyl compound of the formulaR--C (Hal.sup.2).sub.3whereinR has the meaning indicated above andHal.sup.2 represents a halogen atom is reacted with Hal.sup.1 --CN in which Hal.sup.1 has the meaning indicated above at a temperature of 50.degree. to 200.degree. C. in the presence of a Lewis acid. Optionally the process can be conducted in the presence of an inert solvent.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: September 2, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventor: Kurt Findeisen
  • N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
    Patent number: 4154828
    Abstract: N.sup.2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
    Type: Grant
    Filed: October 21, 1977
    Date of Patent: May 15, 1979
    Assignees: Mitsubishi Chemical Industries, Ltd., Shosuke 0KAMOTO
    Inventors: Shosuke Okamoto, Ryoji Kikumoto, Yoshikuno Tamao, Kazuo Ohkubo, Shinji Tonomura
  • N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives and the pharmaceutically acceptable acid addition salts thereof
    Patent number: 4139529
    Abstract: N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides and the pharmaceutically acceptable acid addition salts thereof which have antithrombotic properties.
    Type: Grant
    Filed: August 31, 1977
    Date of Patent: February 13, 1979
    Assignees: Mitsubishi Chemical Industries Limited, Shosuke Okamoto
    Inventors: Shosuke Okamoto, Akiko Hijikata, Hyogi Kikumoto, Yoshikuni Tamao, Kazdo Ohkubo, Tohru Tezuka, Shinji Tonomura
  • N.sup.2 -Substituted-L-arginine derivatives and the pharmaceutically acceptable acid addition salts thereof
    Patent number: 4133880
    Abstract: N.sup.2 -substituted-L-arginine esters and amides, and the pharmaceutically acceptable acid addition salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
    Type: Grant
    Filed: July 28, 1977
    Date of Patent: January 9, 1979
    Assignees: Mitsubishi Chemical Industries Ltd., Shosuke Okamoto
    Inventors: Shosuke Okamoto, Akiko Hijikata, Ryoji Kikumoto, Yoshikuni Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura