Four Or More Ring Hetero Atoms In The Polycyclo Ring System Patents (Class 544/184)
-
Patent number: 6057329Abstract: Fused polycyclic 2-aminopyrimidines of formula (1): ##STR1## wherein Ar is an optionally substituted aromatic or heteroaromatic group;X is a carbon or nitrogen atom;Y is a carbon or nitrogen atom;Z is a linker group;A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group;and the salts, solvates, hydrates and N-oxides thereof are described. The compounds are potent and selective inhibitors of the protein tyrosine kinases p56.sup.lck and p59.sup.fyn and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56.sup.lck and/or p59.sup.fyn activity is believed to have a role.Type: GrantFiled: December 22, 1997Date of Patent: May 2, 2000Assignee: Celltech Therapeutics LimitedInventors: Jeremy Martin Davis, Peter David Davis, David Festus Charles Moffat, Mark James Batchelor
-
Patent number: 5955465Abstract: The present invention encompasses structures of the Formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: X is oxygen, H.sub.2, or sulfur;Y is oxygen or sulfur;W is alkyl, arylalkyl, or heteroarylalkyl, each of which is optionally substituted; orW is aryl or heteroaryl; ##STR2## wherein: Z.sub.1, Z.sub.2, Z.sub.3, and Z.sub.4 independently represent nitrogen or C--R.sub.a, whereeach R.sub.a independently is hydrogen, an inorganic substitutent or an optionally substituted aromatic group;n is 1, 2 or 3; andR.sub.b is hydrogen, alkyl, or an optionally substituted aromatic group,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.Type: GrantFiled: October 7, 1997Date of Patent: September 21, 1999Assignee: Neurogen CorporationInventors: Paul Chen, Alan Hutchison
-
Patent number: 5869659Abstract: The present invention relates to heteroatom-containing cyclopentanopyridyl-oxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.Type: GrantFiled: January 13, 1997Date of Patent: February 9, 1999Assignee: Bayer AktiengesellschaftInventors: Andreas Stolle, Dieter Habich, Bernd Riedl, Martin Ruppelt, Stephen Bartel, Walter Guarnieri, Hanno Wild, Rainer Endermann, Hein-Peter Kroll
-
Patent number: 5846969Abstract: A sulfonamide derivative or a sulfonic ester derivative represented by the following general formula (I): ##STR1## {G represents an aromatic 5- or 6-membered ring; L represents O or --N(R.sup.1)-- (R.sup.1 represents hydrogen or lower alkyl); and M represents ##STR2## rings A and B represent each an unsaturated 5- or 6-membered ring; Y represents O, S(O).sub.n, C(R.sup.3)(R.sup.4), C(O), N(R.sup.5), CH(R.sup.6)CH(R.sup.7), C(R.sup.8).dbd.C(R.sup.9), N(R.sup.10)C(O), N.dbd.C(R.sup.11), OCH(R.sup.12), S(O).sub.n CH(R.sup.13) or N(R.sup.14)CH(R.sup.15).Type: GrantFiled: June 11, 1997Date of Patent: December 8, 1998Assignee: Eisai Co., Ltd.Inventors: Hiroshi Yoshino, Norihiro Ueda, Jun Niijima, Toru Haneda, Yoshihiko Kotake, Kentaro Yoshimatsu, Tatsuo Watanabe, Takeshi Nagasu, Naoko Tsukahara, Nozomu Koyanagi, Kyosuke Kitoh
-
Patent number: 5808060Abstract: Disclosed are biologically active, non-indole-containing compounds referred to as fused isoindolones, which are represented by the following general formula: ##STR1## The fused indolones can be obtained by complete chemical synthesis. Methods for making and using the fused isoindolones are disclosed.Type: GrantFiled: December 9, 1996Date of Patent: September 15, 1998Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Neil W. Johnson
-
Patent number: 5792766Abstract: Disclosed are compounds of compounds of the formula: ##STR1## or the pharmaceutically acceptable nontoxic salts thereof wherein: X is oxygen, H.sub.2 or sulfurY is hydrogen, or optionally substituted alkyl, alkenyl, (substituted)arylalkyl, aryl or heteroaryl, or a carbonyl group substituted with alkyl, cycloalkyl, aryl, or amino groups;W is alkyl, arylalkyl or heteroarylalkyl, where each aryl group is optionally substituted with up to two groups; orW is aryl, thienyl, pyridyl or heteroaryl, each of which is optionally substituted; andZ.sub.1, Z.sub.2, Z.sub.3, and Z.sub.4 independently represent nitrogen or C-R.sub.1 whereR.sub.1 is hydrogen, halogen, hydroxy, amino, or phenyl or pyridyl optionally mono- or independently disubstituted with halogen, hydroxy, lower alkyl, or lower alkoxy,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists or inverse agonists for GABAa brain receptors.Type: GrantFiled: March 13, 1996Date of Patent: August 11, 1998Assignee: Neurogen CorporationInventors: Paul Chen, Alan Hutchison, Guolin Cai
-
Patent number: 5786361Abstract: Compounds of the formula (I): ##STR1## are prepared by reaction of the phenylacetic acid derivatives substituted by the appropriate heterocycles, optionally in an activated form, with phenylglycinols. The compounds are suitable as active compounds in medicaments, in particular in medicaments having antiatherosclerotic activity.Type: GrantFiled: April 11, 1997Date of Patent: July 28, 1998Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Peter Eckenberg, Rudi Grutzmann, Hilmar Bischoff, Dirk Denzer, Ulrich Nielsch
-
Patent number: 5739326Abstract: Compounds of Formula I, and their N-oxides and agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein: X and Y are independently N or CH;Z is O, S(O).sub.n, NR.sup.7, C(.dbd.O), C(.dbd.S), C(.dbd.N--OR.sup.8), CH(OR.sup.9), or CR.sup.10 (R.sup.11);n is 0, 1 or 2; andR.sup.1 -R.sup.11 are as defined in the disclosure.Also disclosed are compositions containing the compounds of Formula I and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective amount of a compound of Formula I.Type: GrantFiled: December 3, 1996Date of Patent: April 14, 1998Assignee: E. I. du Pont de Nemours and CompanyInventors: Thomas Paul Selby, Michael Peter Winters
-
Patent number: 5726126Abstract: There is provided a 1-(3-heterocyclylphenyl)-s-triazine-2, 4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.Type: GrantFiled: November 26, 1996Date of Patent: March 10, 1998Assignee: American Cyanamid CompanyInventors: Alvin Donald Crews, Jr., Philip Mark Harrington, Gary Mitchell Karp, Mark Christopher Manfredi, Michael Anthony Guaciaro
-
Patent number: 5677309Abstract: The present invention encompasses structures of the Formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: X is oxygen, H.sub.2, or sulfur;Y is oxygen or sulfur;W is alkyl, arylalkyl, or heteroarylalkyl, each of which is optionally substituted; orW is aryl or heteroaryl; ##STR2## wherein: Z.sub.1, Z.sub.2, Z.sub.3, and Z.sub.4 independently represent nitrogen or C--R.sub.a, whereeach R.sub.a independently is hydrogen, an inorganic substitutent or an optionally substituted aromatic group;n is 1, 2 or 3; andR.sub.b is hydrogen, alkyl, or an optionally substituted aromatic group,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.Type: GrantFiled: March 22, 1996Date of Patent: October 14, 1997Assignee: Neurogen CorporationInventors: Paul Chen, Alan Hutchison
-
Patent number: 5658857Abstract: The invention relates to new imidazoazines of the general formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A, D, E and G have the meanings given in the description, to processes for their preparation, and to their use as herbicides.Type: GrantFiled: August 8, 1995Date of Patent: August 19, 1997Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Hans-Joachim Santel, Markus Dollinger
-
Patent number: 5658906Abstract: The present invention is directed to irreversible inhibitors of serine and cysteine proteases which most preferably contain a 1-oxytriazole or 1-oxyimidazole functionality. Methods for the use of the protease inhibitors are also described.Type: GrantFiled: January 26, 1996Date of Patent: August 19, 1997Assignee: Cephalon, Inc.Inventors: John P. Mallamo, Ron Bihovsky, Sankar Chatterjee, Rabindranath Tripathy
-
Patent number: 5641763Abstract: This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyclic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.Type: GrantFiled: October 11, 1994Date of Patent: June 24, 1997Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.Inventors: Antonin Holy, Ivan Rosenberg, Erik D. A. De Clercq
-
Carbocyclic and heterocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
Patent number: 5639759Abstract: This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, chronic inflammatory diseases, including but not limited to psoriasis and rheumatoid arthritis, and cancer in a mammal.Type: GrantFiled: March 27, 1995Date of Patent: June 17, 1997Assignee: The DuPont Merck Pharmaceutical CompanyInventors: Ronald Louis Magolda, William John Pitts, Irina Cipora Jacobson, Carl Henry Behrens, Michael James Orwat, Douglas Guy Batt -
Patent number: 5633218Abstract: Compounds of Formula I, and their N-oxides and agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein: ##STR2## T is O or S; W is a single bond, O, S or NR.sup.6 ;X is N or CH;Y is N or CH;Z is N or CR.sup.7 provided that when Z is CR.sup.7, then Y is N;R.sup.6 is H, CH.sub.3 or OCH.sub.3 ;m is 1 or 2; andR.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.7 are as defined in the disclosure.Also disclosed are compositions containing the compounds of Formula I and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective amount of a compound of Formula I.Type: GrantFiled: May 24, 1995Date of Patent: May 27, 1997Assignee: E. I. Du Pont de Nemours and CompanyInventors: Donna L. Spedding, Thomas M. Stevenson
-
Patent number: 5571773Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.Type: GrantFiled: June 2, 1995Date of Patent: November 5, 1996Assignee: American Cyanamid CompanyInventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
-
Patent number: 5532207Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.Type: GrantFiled: June 2, 1995Date of Patent: July 2, 1996Assignee: American Cyanamid CompanyInventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
-
Patent number: 5498616Abstract: The present invention is directed to irreversible inhibitors of serine and cysteine proteases which most preferably contain a 1-oxytriazole or 1-oxyimidazole functionality. Methods for the use of the protease inhibitors are also described.Type: GrantFiled: November 4, 1994Date of Patent: March 12, 1996Assignee: Cephalon, Inc.Inventors: John P. Mallamo, Ron Bihovsky, Sankar Chatterjee, Rabindranath Tripathy
-
Patent number: 5491126Abstract: This invention relates to substituted fused heterocyclic compounds of Formula I which have utility as herbicides: ##STR1##Type: GrantFiled: October 19, 1994Date of Patent: February 13, 1996Assignee: E. I. Du Pont de Nemours and CompanyInventor: Thomas P. Selby
-
Patent number: 5478827Abstract: This invention relates to heterocyclic derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.Type: GrantFiled: July 1, 1994Date of Patent: December 26, 1995Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Teruo Oku, Yoshio Kawai, Hiroshi Marusawa, Hitoshi Yamazaki, Yoshito Abe, Hirokazu Tanaka
-
Patent number: 5472964Abstract: Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.Type: GrantFiled: June 16, 1994Date of Patent: December 5, 1995Assignee: Merck Frosst Canada, Inc.Inventors: Robert N. Young, Marc Labelle, Yves Leblanc, Yi B. Xiang, Cheuk K. Lau, Claude Dufresne, Yves Gareau
-
Patent number: 5399560Abstract: The mechanism of the inhibition of advanced glycosylation by aminoguanidine and other hydrazine type compounds was investigated using a solution of one or two molecules of aminoguanidine or other hydrazine type compound incubated with an Amadori product (1-propylamine-1-deoxy-D-fructose) under physiological conditions. This inhibition was found to proceed through the reactive intermediate 1-propylamino-1, 4-dideoxyosone to form the corresponding triazine and the dehydrazone of 1,4-dideoxyglucosone, respectively.The triazine and dehydrazone products are useful as macrophage stimulants to activate a macrophage to effect removal of advanced glycosylation endproducts (AGEs). Additionally, they can be used in a variety of investigative methods in an effort to measure the extent of nonenzymatic glycosylation of a protein sample wherein aminoguanidine or other hydrazine-type compound is or was present during the glycosylation process.Type: GrantFiled: October 1, 1992Date of Patent: March 21, 1995Assignee: The Rockefeller UniversityInventors: Anthony Cerami, Hauh-Jyun C. Chen
-
Patent number: 5378679Abstract: Heteroaromatically condensed hydroxypyridonecarboxamides of the structure I ##STR1## where the substituents and the ring Q have the following meanings: R.sup.1 hydrogen, hydroxyl, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy;R.sup.2 hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, alkenyloxy, dialkylamino; orR.sup.1, R.sup.2 together denote an alkylene chain with 2-6 members and which may be interrupted by oxygen, sulfur or N-methyl;X oxygen or sulfur;Q a 5- or 6-membered heteroaromatic ring containing from 1 to 3 nitrogen atoms and/or one oxygen or sulfur atom as heteroatoms, and which may be substituted one to three times,and environmentally compatible salts thereof.Type: GrantFiled: August 17, 1993Date of Patent: January 3, 1995Assignee: BASF AktiengesellschaftInventors: Christoph Nuebling, Wolfgang von Deyn, Hans Theobald, Karl-Otto Westphalen, Uwe Kardorff, Helmut Walter, Thomas Kappe, Matthias Gerber
-
Patent number: 5332744Abstract: Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.Type: GrantFiled: May 4, 1990Date of Patent: July 26, 1994Assignee: Merck & Co., Inc.Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, Thomas F. Walsh
-
Patent number: 5256667Abstract: Substituted quinazolinones and pyridopyrimidines of structural formula I ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the renin-angiotensin system (RAS) such as hypertension, congestive heart failure, ocular hypertension and certain CNS disorders.Type: GrantFiled: July 31, 1992Date of Patent: October 26, 1993Assignees: Merck & Co., Inc., E. I. Du Pont De Nemours & Co.Inventors: Eric E. Allen, Richard E. Olson
-
Patent number: 5179093Abstract: Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein, R is H, halogen, (C.sub.1 -C.sub.6) alkyl, N(C.sub.1 -C.sub.6 alkyl/aryl).sub.2, OH, O--(C.sub.1 -C.sub.6) alkyl/aryl, CH.sub.2 OH, COOH, COO-alkyl/aryl, SO.sub.2 NH.sub.2, or SO.sub.2 NH (C.sub.1 -C.sub.6 alkyl/aryl);R.sub.1 is C.sub.1 -C.sub.6 alkyl, cycloalkyl, C.sub.2 -C.sub.6 alkenyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, --CH.sub.2 -aryl, --CH.sub.2 -substituted aryl, --CH.sub.2 -heteroaryl, or --CH.sub.2 -substituted heteroaryl;R.sub.2 is H, C.sub.1 -C.sub.6 alkyl or aryl; ##STR2## is an aromatic ring or a heteroaromatic ring; and X is O or N-(alkyl/aryl/alkyl-aryl/alkoxylalkoxyaryl)are described. These compounds are useful as agents for treating viruses.Type: GrantFiled: May 10, 1991Date of Patent: January 12, 1993Assignee: Schering CorporationInventors: Adriano Afonso, Stuart W. McCombie, Jay Weinstein
-
Patent number: 5102880Abstract: Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogren atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.Type: GrantFiled: September 5, 1991Date of Patent: April 7, 1992Assignee: Merck & Co., Inc.Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, Thomas F. Walsh
-
Patent number: 5069708Abstract: Herbicidal agents containing a pyrimido[5,4-e]-as-triazine-5,7-(6H,8H)-dione Ia ##STR1## (R.sup.1, R.sup.2 .dbd.H, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.2 -C.sub.8 -alkenyl, phenyl or benzyl, R.sup.3 .dbd.H, halogen, nitro, C.sub.1 -C.sub.8 -alkyl which may carry up to three further substituents, C.sub.2 -C.sub.6 -alkenyl, phenyl-C.sub.2 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -cycloalkyl which may carry up to 3 C.sub.1 -C.sub.4 -alkyl substituents, a 5- or 6-membered heterocyclic structure where up to 2 of the ring members are O, S or NR.sup.4 ; --CO--R.sup.4 or --CO--O--R.sup.4 ; phenyl or hetaryl, which may carry up to 3 further substituents; or ZR.sup.6 ; R.sup.4 .dbd.H, C.sub.1 -C.sub.6 -alkyl; Z.dbd.O, S or --N(R.sup.7)--; R.sup.6 .dbd.H, C.sub.1 -C.sub.6 -alkyl, phenyl or benzyl, which may carry up to 3 further substituents; R.sup.7 .dbd.H, C.sub.1 -C.sub.6 -alkyl or R.sup.6 and R.sup.Type: GrantFiled: July 3, 1990Date of Patent: December 3, 1991Assignee: BASF AktiengesellschaftInventors: Norbert Meyer, Ulrich Shirmer, Peter Plath, Bruno Wuerzer, Karl-Otto Westphalen
-
Patent number: 5047404Abstract: This invention relates to fused pyrimidine derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxyphenyl)pyrido[2,3-d]pyrimid-4(3H)-one.Type: GrantFiled: June 13, 1989Date of Patent: September 10, 1991Assignee: Smith Kline & French Laboratories, Ltd.Inventors: William J. Coates, Sean T. Flynn, Derek A. Rawlings
-
Patent number: 5028598Abstract: Oxetanocin derivatives represented by formula: ##STR1## wherein X represents H or ##STR2## or a pharmacologically acceptable salt thereof exhibit an anti-viral activity. Anti-viral compositions comprising the oxetanocin derivatives or their pharmacologically acceptable salts as the effective ingredient are also provided.Type: GrantFiled: August 27, 1990Date of Patent: July 2, 1991Assignee: Nippon Kayaku Kabushiki KaishaInventors: Katsuhiko Kurabayashi, Junichi Seki, Haruo Machida, Hiroshi Yoshikawa, Hiroo Hoshino, Seiichi Saito, Masayuki Kitagawa
-
Patent number: 5017212Abstract: A compound of the general formula: ##STR1## wherein Q is a condensed heterocyclic group having an N atom in the bridgehead which may be substituted, W is O or S, R.sub.1 and R.sub.2 each are an alkyl group, an alkoxy group or halogen and Z is CH or N, and a salt thereof, which is useful as a herbicide.Type: GrantFiled: March 17, 1987Date of Patent: May 21, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Yasuo Ishida, Kazunari Ohta, Tatsuo Nakahama, Harutoshi Yoshikawa
-
Patent number: 4981507Abstract: Herbicidal triazoloazines of the formula ##STR1## in which A stands for nitrogen or for a radical C--R.sup.3,R.sup.1, R.sup.2 and R.sup.3 independently of one another each stand for hydrogen, hydroxyl, halogen, for optionally substituted alkyl, for alkoxy, alkylthio or for optionally substituted aryl, or eitherR.sup.1 and R.sup.3 together or R.sup.3 and R.sup.2 together stand for a fused, optionally substituted carbocyclic or heterocyclic ring,X stands for oxygen, sulphur, a sulphinyl group, or a sulphonyl group andAr stands for in each case optionally substituted aryl or heteroaryl.Type: GrantFiled: April 5, 1989Date of Patent: January 1, 1991Assignee: Bayer AktiengesellschaftInventors: Klaus Jelich, Hans-Joachim Santel, Robert R. Schmidt, Harry Strang
-
Patent number: 4959367Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein X is N or CH;R.sub.1 and R.sub.2 are the same or different and are hydrogen, halogen, CF.sub.3, C.sub.1-6 alkyl, C.sub.1-7 acyl, C.sub.1-7 acylamino, or amino, aminocarbonyl or aminosulphonyl, optionally substituted by one or two C.sub.1-6 alkyl or C.sub.3-8 cycloalkyl groups, or by C.sub.4-5 polymethylene or by phenyl, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkylsuphinyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, hydroxy or nitro; or R.sub.1 and R.sub.2 taken together are methylenedioxy or ethylenedioxy;Z is a group of formula (a), (b) or (c) ##STR2## wherein n is 2 or 3; p is 1 or 2; q is 1 to 3; r is 1 to 3; andR.sub.3 or R.sub.4 is C.sub.1-4 alkyl;having 5-HT.sub.3 receptor antagonist activity, a process for their preparation and their use as pharmaceuticals.Type: GrantFiled: November 2, 1988Date of Patent: September 25, 1990Assignee: Beecham Group P.L.C.Inventor: Francis D. King
-
Patent number: 4921527Abstract: The invention relates to sulfonylurea compounds with a substituted or unsubstituted bicyclic nine-membered ring having one to five heteroatoms which are preemergent and/or postemergent herbicides or plant growth regulants.Type: GrantFiled: May 4, 1988Date of Patent: May 1, 1990Assignee: E. I. du Pont de Nemours and CompanyInventor: Chi-Ping Tseng
-
Patent number: 4920119Abstract: Compounds of the formula ##STR1## wherein A represents a grouping of the formula ##STR2## in which R.sup.1 and R.sup.2 each individually represent hydrogen, halogen, trifluoromethyl, nitro, amino, cyano, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 14 C.sub.6 -alkanoylamino, aryloxy, aryl-(C.sub.1 -C.sub.6 -alkyl), aryl-(C.sub.1 -C.sub.6 -alkoxy), aryl-(C.sub.1 -C.sub.6 -alkoxy)carbonylamino or a group of the formula --O--CH.sub.2 --R.sup.3 or R.sup.1 and R.sup.2 on adjacent carbon atoms together represent a group of the formula --CH.dbd.CH--CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --O-- and R.sup.3 represents hydroxy-(C.sub.1 -C.sub.4 -alkyl) or vicinal dihydroxy-(C.sub.2 -C.sub.5 -alkyl), and pharmaceutically acceptable acid addition salts of those compounds of formula I in which R.sup.1 and/or R.sup.Type: GrantFiled: November 24, 1987Date of Patent: April 24, 1990Assignee: Hoffmann-La Roche Inc.Inventors: Michael R. Attwood, Peter H. Crackett, Geoffrey Lawton
-
Patent number: 4908364Abstract: Novel substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]-triazin-7-ones of the formula I are disclosed ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the meaning recited in the specification. The compounds are suitable for prevention and treatment of inflammatory disorders.Type: GrantFiled: January 28, 1988Date of Patent: March 13, 1990Assignee: Hoechst AktiengesellschaftInventors: Werner Thorwart, Ulrich Gebert, Rudolf Schleyerbach, Robert R. Bartlett
-
Patent number: 4908056Abstract: This invention relates to novel heterocyclic carbonyl sulfonamides which are particularly useful as agricultural chemicals.Type: GrantFiled: February 17, 1989Date of Patent: March 13, 1990Assignee: E. I. Du Pont De Nemours and CompanyInventor: Chi-Ping Tseng
-
Patent number: 4880824Abstract: Heterocyclic compounds of formulae (I) and (II): ##STR1## where R.sup.1 and R.sup.2 are alkyl, R.sup.3 is H or alkyl, m is 2-5 and Het is a hetercycle such as thiazole, benzothiazole, substituted benzothiazole, pyrazine, triazine, thiadiazole, substituted thiadiazole, pyrimidine or substituted pyrimidine. The compounds are calcium channel blockers useful in the treatment of cardiovascular conditions such as hypertension or angina.Type: GrantFiled: September 21, 1987Date of Patent: November 14, 1989Assignee: Ortho Pharmaceutical CorporationInventors: Jeffery B. Press, Maud Urbanski
-
Patent number: 4803220Abstract: The invention concerns the novel racemic and laevorotatory optically active forms of the thromboxane A.sub.2 antagonist 5(Z)-7-([ 2,4,5-cis]-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl)heptenoic acid of formula I, their salts, pharmaceutical compositions, and processes for their manufacture and intermediates therefor. The pharmaceutical agents and their compositions are of value in certain pulmonary and/or vascular disorders.Type: GrantFiled: June 28, 1985Date of Patent: February 7, 1989Assignee: Imperial Chemical Industries PLCInventors: Andrew G. Brewster, George R. Brown, Michael J. Smithers
-
Patent number: 4778511Abstract: Novel fluorine-containing N-sulfenylated indazoles are prepared by reacting the corresponding indazoles with sulfenyl halides in the presence of a solvent and/or diluent and in the presence of an acid-binder. The novel fluorine-containing N-sulfenylated indazoles are useful in the protection of industrial materials against attack by microorganisms such as bacteria, fungi, yeast, algae, and slime as plant protection agents, and in combating insects and arachrids.Type: GrantFiled: February 18, 1986Date of Patent: October 18, 1988Assignee: Bayer AktiengesellschaftInventors: Gerhard Heywang, Bernd Baasner, Albrecht Marhold, Wilfried Paulus, Paul Reinecke, Hans-Georg Schmitt
-
Patent number: 4743586Abstract: This disclosure describes compositions of matter containing certain substituted imidazo[1,5-d]-1,2,4-triazin-1(2H)-ones and the method of treating hypertension therewith.Type: GrantFiled: October 29, 1986Date of Patent: May 10, 1988Assignee: American Cyanamid CompanyInventor: Peter S. Chan
-
Patent number: 4741765Abstract: Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide, agricultural compositions containing them, and their herbicidal utility are disclosed.Type: GrantFiled: April 3, 1987Date of Patent: May 3, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: Robert J. Pasteris, Ramaurthi Muthukrishnan
-
Patent number: 4722929Abstract: The invention relates to novel 2-phenyl-imidazoles of the formula ##STR1## and the tautomers and acid addition salts thereof, particularly the pharmacologically acceptable acid addition salts, which exhibit valuable pharmacological properties, particularly an effect on the contractility of the heart muscle. The compounds of Formula I may be prepared by methods conventionally used for similar compounds.Type: GrantFiled: December 20, 1984Date of Patent: February 2, 1988Assignee: Dr. Karl Thomae GmbHInventors: Volkhard Austel, Joachim Heider, Norbert Hauel, Manfred Reiffen, Josef Nickl, Jacobus C. A. van Meel, Willi Diederen
-
Patent number: 4670438Abstract: Compounds of the formula ##STR1## wherein A, B, C and D are --N.dbd., HN.dbd., R.sub.3 N.dbd., O.dbd.C.dbd., HC.tbd., HO--C.tbd. or R.sub.3 SO.sub.2 --O--C.tbd.; andR.sub.1 and R.sub.2 are substituents of various types.The compounds are useful as hypotensives and cardiotonics.Type: GrantFiled: June 22, 1984Date of Patent: June 2, 1987Assignee: Dr. Karl Thomae GmbHInventors: Volkhard Austel, Joachim Heider, Norbert Hauel, Manfred Reiffen, Jacobus C. A. van Meel, Willi Diederen
-
Patent number: 4656171Abstract: Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N.dbd. or --CH.dbd., provided, however, that at least two of them must be --N.dbd., and when A and C are both --N.dbd., at least one or both of B and D must be --N.dbd.; andR.sub.1, R.sub.2 and R.sub.3 are substituents of diverse types;tautomers thereof; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as cardiotonics.Type: GrantFiled: November 27, 1984Date of Patent: April 7, 1987Assignee: Dr. Karl Thomae GmbHInventors: Volkhard Austel, Norbert Hauel, Joachim Heider, Manfred Reiffen, Jacobus C. A. Van Meel, Willi Diederen
-
Patent number: 4636502Abstract: This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.Type: GrantFiled: May 17, 1985Date of Patent: January 13, 1987Assignee: Eli Lilly and CompanyInventor: Wayne A. Spitzer
-
Patent number: 4581448Abstract: Fused tetracyclic compounds containing two thiophene rings, one pyridine ring and a triazine ring and which are useful as antiallergic agents are described herein. The compounds are prepared by the reaction of an appropriate substituted aminocarboxamine with sodium nitrite in an acid such as acetic acid.Type: GrantFiled: October 10, 1984Date of Patent: April 8, 1986Assignee: Merrell Dow Pharmaceuticals Inc.Inventor: Terry L. Wright
-
Patent number: 4561881Abstract: A pollen suppressant of the formula ##STR1## wherein R.sup.1 and R.sup.4 independently represent C.sub.1 -C.sub.4 alkyl, phenyl, naphthyl, or phenyl or naphthyl substituted with one to three substituents selected from the group consisting of halogen, trihalomethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, and cyano; R.sup.2 is ##STR2## where R.sup.5 is a C.sub.1 -C.sub.12 alkyl group, optionally substituted with one or more halogen atoms, or an aryl group selected from the group consisting of 6-membered rings containing 0-3 nitrogens and fused bicyclic 10-membered rings containing 6 atoms in each ring and 0-3 nitrogens per ring with the remaining atoms in the ring or rings of said aryl group being carbon atoms, said aryl group being optionally substituted with a C.sub.1 -C.sub.4 alkyl group or an electron-withdrawing group, R.sup.3 is hydrogen, a halogen a C.sub.1 -C.sub.4 alkyl group, a carboxy group or an agronomically acceptable alkali metal salt thereof, or a group of the formula --COOR.sup.Type: GrantFiled: September 14, 1983Date of Patent: December 31, 1985Assignee: Lafarge CoppeeInventors: Jeffrey N. Labovitz, Lawrence Fang
-
Patent number: 4552878Abstract: This invention relates to benzo- and thieno-triazine-1,2,3 ones-4 represented by the formula ##STR1## in which m is 2, 3 or 4, X is the vinylene group --CH.dbd.CH-- or a sulfur atom; R.sub.1 and R.sub.2 can be alike or different and are hydrogen, halogen, a lower alkyl radical, lower alkoxy radical or trifluoromethyl radical; when X is --CH--CH-- n is 0, 1 or 2 and R is hydrogen, halogen, a lower alkyl radical, lower alkoxy radical or nitro group; when X is a sulfur atom, R is hydrogen or constitutes a --CH.sub.2 --.sub.4 chain between the two open positions of the thiophenic ring. The compounds are useful as antidepressant drugs.Type: GrantFiled: September 19, 1983Date of Patent: November 12, 1985Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Gerard Ferrand, Herve Dumas, Michel Bayssat, Jean-Claude Depin
-
Patent number: 4537889Abstract: This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.Type: GrantFiled: May 3, 1984Date of Patent: August 27, 1985Assignee: Eli Lilly and CompanyInventor: Wayne A. Spitzer