Two Substituent Nitrogens Bonded Directly To Two Carbons Of The Triazine Ring Patents (Class 544/204)
  • Patent number: 9549558
    Abstract: The present invention relates to azines of formula (I) wherein the variables are defined according to the description, processes and intermediated for preparing them, compositions comprising them and their use as herbicides, i.e. for controlling harmful plants and a method for controlling unwanted vegetation which comprises allowing a herbicidal effective amount of at least one azine of the formula I to act on plants, their seed and/or their habitat.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: January 24, 2017
    Assignee: BASF SE
    Inventors: Trevor William Newton, Florian Vogt, Julia Major, Kristin Hanzlik, Liliana Parra Rapado, Markus Kordes, Thomas Seitz, Matthias Witschel, Klaus Kreuz, Johannes Hutzler, Richard Roger Evans, Jens Lerchl
  • Patent number: 9321735
    Abstract: The present invention describes novel triazines, their related pyrimidines and their use in controlling insects. This invention also includes new synthetic procedures, intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of controlling insects using the compounds.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: April 26, 2016
    Assignee: Vestaron Corporation
    Inventors: Robert M. Kennedy, Bruce A. Steinbaugh
  • Patent number: 9035048
    Abstract: The invention relates to compounds of formula (I) wherein the radicals R1 to R6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with the activity of AMP-activated protein kinase (AMPK). Another object of the invention concerns the use of said compounds for enhancing glucose homeostasis, improving podocytopathy and/or decreasing the production of reactive oxygen species (ROS). The invention also relates to a method for in-vitro diagnosing diabetic nephropathy and a method for screening compounds that reduce podocytopathy, in each case by applying synaptopodin as biomarker.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: May 19, 2015
    Assignee: POXEL
    Inventors: Daniel Cravo, Sophie Hallakou-Bozec, Didier Mesangeau, Samer Elbawab
  • Publication number: 20150086911
    Abstract: An actinic ray-sensitive or radiation-sensitive resin composition includes; a compound (A) which generates an acid by irradiation with actinic rays or radiation, wherein the acid is linked with a group represented by the following general formula (M) through covalent bonding. In the formula, Y1 and Y2 each independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aryl group, or an acyl group. Z represents a hydrogen atom or a substituent.
    Type: Application
    Filed: December 4, 2014
    Publication date: March 26, 2015
    Applicant: FUJIFILM Corporation
    Inventors: Takuya TSURUTA, Tomotaka TSUCHIMURA, Tadeteru YATSUO
  • Patent number: 8952150
    Abstract: Disclosed are compounds for inhibiting prostaglandin transporter (PGT) activity, pharmaceuticals compositions including the compounds, and methods of treating subjects using the compounds.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: February 10, 2015
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Victor L. Schuster, Yuling Chi, Andrew S. Wasmuth, Richard S. Pottorf, Gary L. Olson
  • Patent number: 8937066
    Abstract: The invention relates to amino derivatives of dihydro-1,3,5-triazine, used for the treatment and/or prevention of diseases induced by ischemia and/or reperfusion, notably cardiac and renal complications.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: January 20, 2015
    Assignees: Poxel, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Didier Mesangeau, Daniel Cravo, Catherine Noe
  • Patent number: 8912323
    Abstract: The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: December 16, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Hong Zong, Thommey P. Thomas
  • Patent number: 8906475
    Abstract: Provide is a cellulose acylate film, of which the environmental humidity-dependent retardation change is small and which, when stuck to a polarizer and used in high-temperature and high-humidity environments, is effective for preventing the polarizing element from being deteriorated. A cellulose acylate film, which contains a hydrogen-bonding compound satisfying the following requirements (A) to (C), and at least one hydrophobizing agent selected from a polyalcohol ester-base hydrophobizing agent, a polycondensate ester-base hydrophobizing agent and a carbohydrate derivative-base hydrophobizing agent: (A) the compound has both a hydrogen-bonding donor part and a hydrogen-bonding acceptor part in one molecule, (B) the value computed by dividing the molecular weight of the compound by the total number of the hydrogen-bonding donor number and the hydrogen-bonding acceptor number in the compound is from 30 to 65, and (C) the total number of the aromatic ring structures in the compound is from 1 to 3.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: December 9, 2014
    Assignee: Fujifilm Corporation
    Inventors: Nobutaka Fukagawa, Masato Nagura, Takayasu Yasuda, Takahiro Ohno, Satoshi Tanaka, Aiko Yamamoto, Aiko Yoshida, Shinya Watanabe
  • Patent number: 8895732
    Abstract: Method for the chromatographic separation of compounds of the formula (I), in which R1, R2, R3, R4, R5, R6 have the meanings indicated in Claim 1, and acid-addition salts thereof, characterized in that the separation is carried out on a chiral ion-exchanger material.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: November 25, 2014
    Assignee: Merck Patent GmbH
    Inventors: Matthias Helmreich, Claus Peter Niesert, Michael Schulte, Wolfgang Lindner, Michael Laemmerhofer, Christian Hoffmann
  • Patent number: 8846911
    Abstract: The present invention discloses a process for isolating enantiomer components from a mixture of enantiomers through particle-size-controlled crystallization, comprising the steps of: (a) forming a solution of a mixture of enantiomers (R) and (S) in a solvent in the absence of any further additives or agents; (b) seeding the solution of step (a) simultaneously or consecutively with seed crystals of enantiomer (R) and with seed crystals of enantiomer (S), wherein the seed crystals of enantiomer (R) differ in size and/or in quantity from the seed crystals of enantiomer (S) to allow separation of the crystals composed of a mixture enriched with enantiomer (R) from the crystals composed of a mixture enriched with enantiomer (S); (c) inducing simultaneous crystallization of enantiomer (R) and enantiomer (S); and (d) isolating crystals composed of a mixture enriched with enantiomer (R) from crystals composed of a mixture enriched with enantiomer (S) through size separation of the crystals, preferably through sieving
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: September 30, 2014
    Assignee: Poxel
    Inventors: David Maillard, Guntram Koller, Ewgenij Wakaresko, Sabine Gottburg-Reininger
  • Patent number: 8759584
    Abstract: Compounds of formula (I) or salts thereof, in which R1, R2, R3, R4, R5, R6, X and Y are defined as in claim 1, can be prepared by a process characterized in that a compound of the formula (II) or a salt thereof, is reacted to a compound of the formula (III) or a salt thereof, and an aluminium(III) source, optionally, in the presence of a protic additive or solvent selected from the group consisting of alcohols or amines. The compounds (I) are suitable to be used for the preparation of heterocyclic compounds corresponding to (I) where the group Al(X)(Y) is replaced with an optionally substituted carbon atom, or s-triazine derivatives thereof.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: June 24, 2014
    Assignee: Bayer Cropscience AG
    Inventor: Mark James Ford
  • Patent number: 8742103
    Abstract: The present invention relates to a new process of separation of triazine derivatives enantiomers involving tartaric acid.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: June 3, 2014
    Assignee: Poxel
    Inventors: Daniel Cravo, Matthias Helmreich
  • Patent number: 8742102
    Abstract: A new process for the enantiomeric separation of racemic 3,6-dihydro-1,3,5-triazine derivatives for the treatment of disorders associated with insulin-resistance syndrome, by preferential crystallization.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: June 3, 2014
    Assignee: Poxel
    Inventors: Matthias Helmreich, Claus-Peter Niesert, Daniel Cravo, Gérard Coquerel, Guillaume Levilain, Saoussen Wacharine-Antar, Pascal Cardinael
  • Patent number: 8703940
    Abstract: A process for the synthesis of 3,6-dihydro-1,3,5-triazine derivatives is claimed wherein a biguanid is reacted with acetaldehyde in the presence of an inorganic and/or organic base. The process can be carried out at mild and therefore economical reaction conditions.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: April 22, 2014
    Assignee: Studiengesellschaft Kohle mbH
    Inventors: Benjamin List, Xu Cheng
  • Patent number: 8691982
    Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, where R1 is a (C1-C6)alkyl or (C3-C6)cycloalkyl group; R2 is a (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkenyl, (C1-C6)fluoroalkyl, (C1-C3)fluoroalkoxy, or (C1-C6)alkoxy(C1-C6)alkyl group, substituted: (i) with one to three hydroxyl groups, or (ii) with an NRaRb group, where Ra and Rb are independently a hydrogen atom or a (C1-C3)alkyl group; or a pyrrolidinylmethyl group substituted with one to three hydroxyl groups; R9 is the same as R2 or hydrogen; the R2 and R9 groups independently being substitutable with an —OCOR3 group, where R3 is a natural or unnatural amino acid derivative or a piperidyl group; alternatively, R2 and R9 together form a heterocyclic compound; X and Y are independently a substitutable phenyl or heteroaryl group, the heteroaryl group being a thienyl, pyridyl, pyrimidinyl, thiazolyl, pyrrolyl, or furanyl group; and R6 is a hydrogen or a (C1-C3)alkyl group.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: April 8, 2014
    Assignees: Centre National de la Recherche Scientifique, Universite Paris Descartes, Universite Claude Bernard Lyon 1, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Laurent Meijer, Hervé Galons, Benoit Joseph, Florence Popowycz, Nassima Oumata
  • Publication number: 20140057161
    Abstract: An electrolyte additive for a rechargeable lithium battery, represented by the following Chemical Formula 1: wherein, R1 to R4 are each independently selected from hydrogen, an aliphatic saturated hydrocarbon group, an aliphatic unsaturated hydrocarbon group, an aromatic hydrocarbon group, a heterocyclic group, or a combination thereof, provided that at least one of R1 or R2 and at least one of R3 or R4 are independently an unsaturated hydrocarbon group including at least one carbon-carbon double bond, and R5 is selected from hydrogen, a halogen, an aliphatic saturated or unsaturated hydrocarbon group, an aromatic hydrocarbon group, a hydroxyl group, a nitro group, a cyano group, an imino group, an amino group, an amidino group, a hydrazine group, a carboxyl group, a heterocyclic group, or a combination thereof.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 27, 2014
    Applicant: SAMSUNG SDI CO., LTD
    Inventors: Dae-Sik Kim, Jiten Singh, Eun-Cheol Lee, Maeng-eun Lee, Won-Il Jung
  • Publication number: 20130219634
    Abstract: Tanned leather, skin or pelt is produced by non-metal tanning, comprising the step of tanning a bated hide, skin or pelt with a tanning agent (A), the tanning agent (A) being at least one compound of formula (I), wherein X signifies fluorine, chlorine and/or (+NR3)0-1, wherein R is a substituted C1 to C6 alkyl group or an unsubstituted C1 to C6 alkyl group, an unsubstituted C6 to C10 aryl group or a substituted C6 to C10 aryl group or a C5 to C6 heteroaryl group, R1 signifies hydrogen, C1-8 alkyl or an alkyleneoxy radical of formula (Ia), —(—C2-3alkylene-O—)q—H??(Ia) R2 signifies substituted or unsubstituted C2 to C8 alkylenesulphonic acid, substituted or unsubstituted C2 to C8 alkylenecarboxylic acid or an alkyleneoxy radical of formula (Ib), —(—C2-3alkylene-O—)m—Y??(Ib) or an alkylene sulfonyl alkyleneoxy radical of formula (Ic), —(C2-3alkylene-O)p—C2-3alkylene-SO2CH2CH2O—Y??(Ic) m signifies 1 or 2, p signifies 0 or 1, q is of from 1 to 10, Y signifies hydrogen or —SO3M, M signifies
    Type: Application
    Filed: October 5, 2011
    Publication date: August 29, 2013
    Applicant: CLARIANT FINANCE (BVI) LIMITED
    Inventors: Claus Reineking, Roberta Gamarino, Licia Trimarco, Maurizio Quaglierini, Markus Gisler, Rainer Nusser
  • Patent number: 8507671
    Abstract: N-Azinyl-N?-aryl ureas and thioureas derivatives are effective at controlling insects.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: August 13, 2013
    Assignee: Dow Agrosciences LLC
    Inventors: Noormohamed M. Niyaz, Ricky Hunter, Timothy C. Johnson, Tony K. Trullinger, Annette V. Brown, Kristy Bryan
  • Patent number: 8501939
    Abstract: Compounds of the general formula (I): in which inter alia Q1 represents —NR1R3, —OR1 or —SR1 and Q2 represents —NR2R4, —OR2 or —SR2, and A represents the point of attachment to a support matrix, are useful as protein binding ligands when (a) at least one of R1, R2, R3 and R4 includes an alkyl group —CnH2n+1 in which n is greater than or equal to 7; (b) at least two of R1, R2, R3 and R4 independently include an alkyl group —CnH2n+1 or a cycloalkyl group —CnH2n?1 in which n is greater than or equal to 4; or (c) at least three of R1, R2, R3 and R4 independently include a C1-12 alkyl group substituted by —NR5R6 or aryl.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: August 6, 2013
    Assignee: Prometic Biosciences Limited
    Inventors: Jason Richard Betley, James Christopher Pearson, Helen Rosemary Tatton, Ben Martin Beacom
  • Patent number: 8465673
    Abstract: A humidity dependence improver for polymer film, comprising a compound of the following formula (1) or (2): wherein Ra, Rb and Rc represent an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group; X1 to X6 represent a single bond or a divalent linking group; R1 to R6 represent a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: June 18, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Takayasu Yasuda, Masato Nagura
  • Patent number: 8461331
    Abstract: Process for the preparation of compounds of the formula I in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in claim 1, which comprises the reaction of a compound of the formula II in which R1, R2, R3, R4 have the meanings indicated above, with a compound of the formula III in which R5, R6 have the meanings indicated above.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: June 11, 2013
    Assignee: Poxel SAS
    Inventors: Matthias Helmreich, Mike Brandner
  • Publication number: 20130137634
    Abstract: The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement.
    Type: Application
    Filed: August 18, 2011
    Publication date: May 30, 2013
    Applicant: EMORY UNIVERSITY
    Inventors: Scott D. Borden, Sreedhara Sangadala
  • Patent number: 8445490
    Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: May 21, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Annapurna Pendri, Zhongxing Zhang, Weixu Zhai, Guo Li, Samuel Gerritz, Paul Michael Scola, Li-Qiang Sun, Qian Zhao, Eric Mull
  • Patent number: 8389718
    Abstract: The present invention describes novel triazines, their related pyrimidines and their use in controlling insects. This invention also includes new synthetic procedures, intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of controlling insects using the compounds.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: March 5, 2013
    Assignee: Vestaron Corporation
    Inventors: Robert M. Kennedy, Bruce A. Steinbaugh
  • Patent number: 8324379
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: December 4, 2012
    Assignee: Koronis Pharmaceuticals, Inc.
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Patent number: 8318702
    Abstract: The present invention provides a compound which is useful as an inhibitor against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins. As a result of extensive and intensive studies on compounds having an inhibitory effect against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins, the inventors of the present invention have found that the di(arylamino)aryl compound of the present invention has inhibitory activity against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins. This finding led to the completion of the present invention.
    Type: Grant
    Filed: July 4, 2008
    Date of Patent: November 27, 2012
    Assignee: Astellas Pharma Inc.
    Inventors: Yutaka Kondoh, Kazuhiko Iikubo, Sadao Kuromitsu, Nobuaki Shindo, Takatoshi Soga, Takashi Furutani, Itsuro Shimada, Takahiro Matsuya, Kazuo Kurosawa, Akio Kamikawa, Hiroyuki Mano
  • Publication number: 20120264605
    Abstract: Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 18, 2012
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
    Inventors: Robin D. Rogers, Daniel T. Daly, Richard P. Swatloski, Whitney L. Hough-Troutman, James Hilliard Davis, JR., Marcin Smiglak, Juliusz Pernak, Scott K. Spear
  • Patent number: 8278443
    Abstract: The present invention relates to a resin composition for an optical film, comprising a polyarylate resin and an amino resin having a triazine structure, and to an optical film prepared by using the same. By using the resin composition for an optical film, a thickness direction retardation can be controlled, while having a negative value, during a step of fabricating the optical film, an in-plane retardation can be controlled, and the optical film can be used as a substrate of a display instead of a glass substrate without an additional retardation compensation film.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: October 2, 2012
    Assignee: LG Chem, Ltd.
    Inventors: Sang-Uk Ryu, Dong-Ryul Kim, Dae-Woo Nam
  • Patent number: 8227465
    Abstract: The present patent application relates to novel combinations of a triazine derivative and of an insulin secretion stimulator.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: July 24, 2012
    Assignee: Poxel SAS
    Inventors: Gérard Moinet, Daniel Cravo, Didier Mesangeau
  • Patent number: 8227599
    Abstract: A process for the separation of biological materials, such as dye-ligand affinity chromatography, wherein an adsorbent is used, which comprises a reaction product of certain reactive anthroquinone compounds and a substrate having a group capable of reaction with a reactive group in said reactive anthroquinone compounds to form a covalent bond.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: July 24, 2012
    Assignee: BASF SE
    Inventors: Vadiraj Subbanna Ekkundi, Narayan S. Punekar, Kamalesh Pai Fondekar, Georg Roentgen, Shilpa S. Korde, Ajit B. Shinde, Masana Moorthy
  • Patent number: 8187575
    Abstract: The present invention relates to new compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, and R8 independently from each other are hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7, cycloalkyl; C1-C6alkylene-C5-C7, cycloalkyl; R9 is hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7cycloalkyl; C1-C6alkylene-C5-C7cycloalkyl; C6-C10aryl; A is —S—; —O— or —NR10—, wherein R10 has the same meanings as R9; X is COOR11; CONR12R13; SO3, R14; or SO2NR15R16, wherein R11, R12, R13, R14, R15, and R16, have independently from each other the same meanings as R9; to their preparation and to their use as UV absorbers in cosmetic and pharmaceutical formulations.
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: May 29, 2012
    Assignee: BASF SE Ludwigshafen
    Inventors: Thomas Ehlis, Dietmar Hüglin, Elek Borsos
  • Patent number: 8153788
    Abstract: Compounds of the formula (I) or salts thereof, in which in which R1 is an optionally substituted amino group or analogous group, and R2 to R7 are each as described herein, are suitable as herbicides and crop growth regulators. The compounds (I) can be prepared by the processes described, via intermediates including novel intermediates for example of the formula (III).
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: April 10, 2012
    Inventors: Hartmut Ahrens, Hansjörg Dietrich, Thomas Auler, Martin Hills, Heinz Kehne, Dieter Feucht, Stefan Herrmann, Kristian Kather, Stefan Lehr
  • Publication number: 20120071655
    Abstract: A new process for the enantiomeric separation of racemic 3,6-dihydro-1,3,5-triazine derivatives for the treatment of disorders associated with insulin-resistance syndrome, by preferential crystallization.
    Type: Application
    Filed: March 26, 2010
    Publication date: March 22, 2012
    Inventors: Matthias Helmreich, Claus-Peter Niesert, Daniel Cravo, Gérard Coquerel, Gullaume Levilain, Saoussen Wacharine-Antar, Pascal Cardinael
  • Patent number: 8076477
    Abstract: Use of an affinity adsorbent for the separation, removal, isolation, purification, characterisation, identification or quantification of a proteinaceous material, wherein the affinity adsorbent is a compound of formula (III), wherein R1 is H, alkyl, aryl, hydroxyalkyl, cyciohexyl, amino or a heterocyclic group which is optionally substituted with one or more of alkyl, aryl, alkoxy, aryloxy, acyloxy, acylamino, amino, OH, CO2H, sulphonyl, carbamoyl, sulphamoyl, alkylsuiphonyl and halogen; one X is N and the other is N, C—Cl or C—CN; Y is O, S or NR2; Z is O, S or NR3; R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or ?-phenylethyl; Q is benzene, naphthalene, benzthiazole, benzoxazole, 1-phenylpyrazole, indazoie or benzimidazoie; R4, R5 and R6 are each H, OH, alkyl, aryl, heterocyclic, alkoxy, aryloxy, amino, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, suiphamoyl, alkylsulphonyl or halogen, or two or more of R4, R5 and R6 are linked to form a cyclic structure; U and V are the same or different C1-10
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: December 13, 2011
    Assignee: ProMetic BioSciences Ltd.
    Inventors: Jason Richard Betley, Helen Tatton, Kelly Le Riche, Matthew Webb
  • Patent number: 8030484
    Abstract: Compounds of formula (I) wherein R1 and R2 are the same or different and are each optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl groups; R3 is hydrogen or an aryl group substituent or R3 is a solid support optionally attached via a spacer; Z represents an oxygen atom, a sulphur atom or NR4; Y represents an oxygen atom, a sulphur atom or NR5; in which R4 and R5, which may be the same or different, represent hydrogen, optionally substituted alkyl containing 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted benzyl or optionally substituted ?-phenylethyl; and one of X1 and X2 represents a nitrogen atom and the other of X1 and X2 represents a nitrogen atom or CR6, in which R6 represents hydrogen or an aryl group substituent; are useful for the affinity binding of a prion protein.
    Type: Grant
    Filed: July 25, 2005
    Date of Patent: October 4, 2011
    Assignee: Prometic Biosciences Limited
    Inventors: James Christopher Pearson, Helen Rosemary Tatton, Patrick Vasconcelos Gurgel
  • Publication number: 20110207926
    Abstract: A compound represented by formula (1), a tautomer thereof, or a salt of the compound or tautomer, which is useful as a bactericide/disinfectant. In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like, R2 represents a hydrogen atom or an optionally substituted alkyl group, or alternatively R1 and R2 may combine together with an adjacent nitrogen atom to form an optionally substituted nitrogen-containing heterocyclic group; R4 represents a hydrogen atom or an optionally substituted alkyl group; R3 represents an optionally substituted alkyl group; and R5 and R6 each represents a hydrogen atom or a methyl group, excluding a compound wherein both R2 and R4 represent a hydrogen atom and a compound wherein both R1 and R4 represent a hydrogen atom are excluded.
    Type: Application
    Filed: August 24, 2009
    Publication date: August 25, 2011
    Applicant: HAMARI CHEMICALS, LTD.
    Inventors: Shirou Maeda, Akihisa Maeda
  • Patent number: 7982034
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: July 19, 2011
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Patent number: 7960182
    Abstract: For the separation, removal, isolation, purification, characterization, identification or quantification of Factor VIII, von Willebrand's Factor or a protein that is a analogue of either, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR2; Z is O, S or N—R3; R2 and R3 are each H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or &bgr;-phenylethyl; B and W are each an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and R7 is a group bearing a positive charge at neutral pH.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: June 14, 2011
    Assignee: Prometic Biosciences Ltd.
    Inventors: Jason Richard Betley, Baldev Singh Baines
  • Publication number: 20110124860
    Abstract: A new process for the synthesis of 3,6-dihydro-1,3,5-triazine derivatives for the treatment of disorders associated with insulin-resistance syndrome.
    Type: Application
    Filed: April 24, 2009
    Publication date: May 26, 2011
    Inventors: Stéphanie Aubourg, Bernard Boudet, Daniel Cravo, Matthias Helmreich
  • Patent number: 7947832
    Abstract: Sterically hindered hydroxy substituted alkoxyamine stabilizer compounds are made water compatible via certain backbones with affinity towards water. The sterically hindered amines are for example of the formula (8)-(10) These compounds are particularly effective in stabilizing aqueous polymer systems against the deleterious effects of oxidative, thermal and actinic radiation. The compounds are effective for example in stabilizing water borne coatings, aqueous inks, aqueous ink jet media and photocured aqueous systems.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: May 24, 2011
    Assignee: BASF SE
    Inventors: Mervin G. Wood, Robert Detlefsen, James Galbo, Wanda Martin, Paul Kondracki, Michael P. DiFazio, Joseph E. Babiarz
  • Publication number: 20110073007
    Abstract: A humidity dependence improver for polymer film, comprising a compound of the following formula (1) or (2): wherein Ra, Rb and Rc represent an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group; X1 to X6 represent a single bond or a divalent linking group; R1 to R6 represent a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group.
    Type: Application
    Filed: September 29, 2010
    Publication date: March 31, 2011
    Applicant: FUJIFILM Corporation
    Inventors: Takayasu Yasuda, Masato Nagura
  • Publication number: 20100326575
    Abstract: A method of forming 2-nitroimino-5-nitrohexahydro-1,3,5-triazine is presented. The method contains the steps of mixing nitroguanidine, formaldehyde, tert-butyl amine, and water to form an aqueous-based mixture containing an intermediate reaction product; separating the intermediate reaction product from the aqueous-based mixture by filtering out the suspended intermediate reaction product; and mixing the intermediate reaction product within a multi-acid solution containing sulfuric acid and nitric acid. Ammonium chloride is then added, thereby forming 2-nitroimino-5-nitrohexahydro-1,3,5-triazine. A gas generating system 200 containing a gas generant formed in accordance with the present invention is also contemplated.
    Type: Application
    Filed: January 29, 2007
    Publication date: December 30, 2010
    Inventor: Cory G. Miller
  • Patent number: 7767676
    Abstract: The invention relates to the compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. These compounds can be used in the treatment of pathological conditions associated with the insulin-resistance syndrome.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: August 3, 2010
    Assignee: Merck Sante
    Inventors: Gerard Moinet, Daniel Cravo, Liliane Doare, Micheline Kergoat, Didier Mesangeau
  • Publication number: 20100168115
    Abstract: The present patent application relates to the use of triazine derivatives as cicatrising or angiogenic agents, wherein the triazine is a molecule of formula (I).
    Type: Application
    Filed: December 18, 2006
    Publication date: July 1, 2010
    Inventors: Gérard Moinet, Daniel Cravo
  • Patent number: 7622469
    Abstract: The present invention relates to an antibacterial agent, which comprises, as an active ingredient, a compound represented by the following general formula (1): or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: November 24, 2009
    Assignee: Hamari Chemicals, Ltd.
    Inventors: Shirou Maeda, Toshiko Kita, Kanji Meguro
  • Patent number: 7589092
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: September 15, 2009
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Patent number: 7563792
    Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: July 21, 2009
    Assignee: Jacobus Pharmaceutical Company, Inc.
    Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
  • Publication number: 20090093485
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).
    Type: Application
    Filed: October 26, 2005
    Publication date: April 9, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Hakan Bladh, Krister Henriksson, Vijaykumar Hulikal, Matti Lepisto
  • Publication number: 20090005250
    Abstract: Compounds of the formula (I) or salts thereof, in which in which R1 is an optionally substituted amino group or analogous group, and R2 to R7 are each as described herein, are suitable as herbicides and crop growth regulators. The compounds (I) can be prepared by the processes described, via intermediates including novel intermediates for example of the formula (III).
    Type: Application
    Filed: December 14, 2007
    Publication date: January 1, 2009
    Applicant: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Hansjorg Dietrich, Thomas Auler, Martin Hills, Heinz Kehne, Dieter Feucht, Stefan Herrmann, Kristian Kather, Stefan Lehr
  • Publication number: 20080306261
    Abstract: Processes comprising: providing an alkanolic reaction mixture, the alkanolic reaction mixture comprising: at least one alkoxycarbonylaminotriazine; at least one carbonic ester; at least one C1-C13-alkanol, which alkanol may further comprise up to two ether-bound oxygen atoms and may further comprise a substituent selected from the group consisting of C1-C4-alkyls and hydroxyls; and at least one alkali metal alkoxide or alkaline earth metal alkoxide; and subjecting the alkanolic reaction mixture to extraction with a polar extractant such that at least a portion of polar/ionic components present in the reaction mixture are removed, wherein the polar extractant is less than entirely miscible with an organic phase of the reaction mixture, to form an alkanolic phase comprising the at least one alkoxycarbonylaminotriazine and a polar phase comprising the polar extractant and the portion of polar/ionic components; and wherein the extraction is carried out with one or more selected from the group consisting of mixer/
    Type: Application
    Filed: June 2, 2006
    Publication date: December 11, 2008
    Applicant: BASF Aktiengesellschaft
    Inventors: Jörg Schneider, Gunter Scherr, Rainer Erhardt, Andreas Eichfelder, Martin Reif, Stefan Hirsch, Georg Sieder, Thomas Holtmann, Jurgen Ciprian, Hermann Ascherl