Chalcogen Bonded Directly To Triazine Ring Carbon Patents (Class 544/219)
  • Patent number: 9629836
    Abstract: The present invention relates to compounds of formula I: in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: April 25, 2017
    Assignee: NOVARTIS AG
    Inventors: Mark Gary Bock, Henrik Moebitz, Sunil Kumar Panigrahi, Ramulu Poddutoori, Susanta Samajdar
  • Patent number: 9126954
    Abstract: To provide: a hydroxy group protecting agent which is stable and easy to use, does not have carcinogenicity, a tearing property or the like, and is inexpensive; and a hydroxy group protection method which enables the protection of a hydroxy group under acidic conditions. [Solution] A hydroxy group protecting agent in which at least one protecting group is bound to a nitrogen-containing electron-withdrawing heterocyclic ring through any one of an oxygen atom, a sulfur atom and a nitrogen atom. The heterocyclic ring is a triazine ring or the like, and the protecting group is a benzyl group or the like. Specifically, the hydroxy group protecting agent is 2,4,6-tribenzyloxy-1,3,5-triazine, 2,4,6-tris(4-methoxybenzyloxy)-1,3,5-triazine or the like. In addition, 2,4,6-tris(t-butoxy)-1,3,5-triazine or the like can also be used. For protecting a hydroxy group, a compound of interest which has a hydroxy group is reacted with the hydroxy group protecting agent under acidic conditions.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: September 8, 2015
    Assignee: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY
    Inventors: Munetaka Kunishima, Hikaru Fujita, Kohei Yamada
  • Patent number: 9102663
    Abstract: There is provided an epoxy compound that provides properties of cured products combining high transparency with high flexural strength by being thermally cured while maintaining advantageous handling properties in a liquid state thereof; and a method for producing a composition by using the epoxy compound. A method for producing an epoxy compound of Formula (1): (in Formula (1), n1, n2, and n3 are individually any one of integers of 2 to 6; n4, n5, and n6 are individually an integer of 2; n7, n8, and n9 are individually an integer of 1; and R1, R2, R3, R4, R5, and R6 are independently a hydrogen atom or a C1-10 alkyl group), including: reacting cyanuric chloride with a C4-8 alkenol and reacting the obtained compound having an unsaturated bond with a peroxide.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: August 11, 2015
    Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Toshiaki Takeyama, Yuki Endo, Sayoko Yanagisawa
  • Patent number: 9096551
    Abstract: The present application relates to a process based on the oxidative ring opening of a compound with oxindole structure for preparation of substituted 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) proceeding from N-sulfonyl-substituted 3-triazinyloxindole of the formula (2-1), and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) thus prepared, and to the use thereof as intermediates for the synthesis of fine chemicals and of active ingredients in the agricultural sector. The invention also relates to a multistage process for preparation of N-alkyl-N-[2-(1,3,5-triazin-2-ylcarbonyl)phenyl]alkanesulfonamides of the formula (4-1), proceeding from a 3-(alkylsulfanyl)-1,3-dihydro-2H-indol-2-one of the formula (7-1), wherein the multistage process also comprises, as a component step, the oxidative ring opening mentioned, and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) which are obtained by the oxidative ring opening and are used as intermediates in the multistage process.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: August 4, 2015
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Gunter Karig, Mark James Ford, Konrad Siegel
  • Publication number: 20150133660
    Abstract: Process for the selective N-sulfonylation of oxindoles, in particular process for the N-sulfonylation of 3-triazinyloxindoles, and also N-sulfonyl-substituted 3-triazinyl-oxindoles and the use of N-sulfonyl-substituted oxindoles and of N-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.
    Type: Application
    Filed: January 22, 2015
    Publication date: May 14, 2015
    Inventors: Gunter KARIG, Mark James FORD, Konrad SIEGEL, Stefan SCHNATTERER
  • Publication number: 20150126737
    Abstract: Process for the preparation of triazinyl-substituted oxindoles of formula (3) and salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3?) and the use of both for producing crop protection agents.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 7, 2015
    Inventors: Gunter KARIG, Mark James FORD, Konrad SIEGEL
  • Publication number: 20150119362
    Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.
    Type: Application
    Filed: October 24, 2013
    Publication date: April 30, 2015
    Inventors: Mark E. Gurney, Timothy J. Hagen, Joel R. Walker, Xuesheng Mo, A. Samuel Vellekoop, Robert Campbell, Lei Zhu, Donna L. Romero
  • Patent number: 9012582
    Abstract: A resin with a favorable index of refraction and transparency even without using heavy atoms or inorganic oxide fine particles by means of a polymerizable monomer having a 1,3,5-triazine ring represented by formula 1. (In formula 1: A is a group represented by formula 2, (in formula 2: R1 represents a hydrogen atom or a methyl group, T represents an alkylene having 1-10 carbon atoms, and R2 represents O or NH), and B1 and B2 are each independently groups represented by formula 3, formula 4, or formula 5 (in formulas 3-5: R3, R4, and R5 represent an alkyl group having 1-10 carbon atoms, an aryl group, or an aryloxy group, n1 and n3 are integers from 0-5, and n2 is an integer from 0-7, however when there are at least two of each of R3, R4, and R5, these may be the same or different from each other).
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: April 21, 2015
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Kenichi Osawa, Takuro Oda
  • Patent number: 8987264
    Abstract: Compounds of Formula I, including pharmaceutically acceptable salts, as well as compositions containing these compounds, have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: March 24, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Zhiwei Yin, Paul Michael Scola
  • Patent number: 8987265
    Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, as well as compositions containing these compounds, have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: March 24, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Zhiwei Yin, Paul Michael Scola
  • Patent number: 8969553
    Abstract: Process for the selective N-sulfonylation of oxindoles, in particular process for the N-sulfonylation of 3-triazinyloxindoles, and also N-sulfonyl-substituted 3-triazinyloxindoles and the use of N-sulfonyl-substituted oxindoles and of N-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: March 3, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Gunter Karig, Mark James Ford, Konrad Siegel, Stefan Schnatterer
  • Patent number: 8962828
    Abstract: Process for the preparation of triazinyl-substituted oxindoles of formula (3) and salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3?) and the use of both for producing crop protection agents.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: February 24, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Gunter Karig, Mark James Ford, Konrad Siegel
  • Publication number: 20150051209
    Abstract: The present invention relates to compounds of formula I: in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.
    Type: Application
    Filed: August 5, 2014
    Publication date: February 19, 2015
    Applicant: NOVARTIS AG
    Inventors: Mark Gary BOCK, Henrik MOEBITZ, Sunil Kumar PANIGRAHI, Ramulu PODDUTOORI, Susanta SAMAJDAR
  • Publication number: 20140378443
    Abstract: The present invention includes novel compositions useful for preventing or treating an HIV-1 infection in a subject in need thereof. The present invention further includes a novel method of preventing or treating an HIV-1 infection in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In one embodiment, the subject is further administered at least one additional therapeutic agent.
    Type: Application
    Filed: June 20, 2014
    Publication date: December 25, 2014
    Inventors: William L. Jorgensen, Karen S. Anderson
  • Patent number: 8906920
    Abstract: The present invention provides a novel antagonist: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide: or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected dual CCR-2 and CCR-5 receptor activity. Crystalline forms, metabolites, pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases are also disclosed. The present disclosure also provides processes for preparing compounds of Formula (I) as provided herein, including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide. Compounds that are useful intermediates of the process are also provided herein.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: December 9, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Percy H. Carter, Robert J. Cherney
  • Patent number: 8900797
    Abstract: The present invention provides a cross-linking agent capable of preventing formation of scum from a bottom anti-reflective coating, and also provides a composition for forming a bottom anti-reflection coating containing the agent. The cross-linking agent is a nitrogen-containing aromatic compound having at least one vinyloxy group or N-methoxymethylamide group, and the composition contains the cross-linking agent. The cross-linking agent of the formula (1) can be produced by reaction of a nitrogen-containing aromatic compound, a halogen compound having a vinyloxy group or N-methoxymethylamide group and a basic compound.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: December 2, 2014
    Assignee: AZ Electronic Materials (Luxembourg) S.A.R.L.
    Inventors: Shigemasa Nakasugi, Shinji Miyazaki, Munirathna Padmanaban, Alberto D. Dioses
  • Patent number: 8895137
    Abstract: The present invention relates to a multilayer system comprising a base layer consisting of a thermoplastic, a primer layer, and a scratch resistant layer consisting of a scratch resistant top coat, the multilayer system being characterized in that the primer layer contains a certain UV absorber and a certain amount of acid, preferably acetic acid, is added to the scratch resistant top coat.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: November 25, 2014
    Assignee: Bayer MaterialScience AG
    Inventors: Birgit Meyer Zu Berstenhorst, Peter Capellen
  • Publication number: 20140343281
    Abstract: To provide: a hydroxy group protecting agent which is stable and easy to use, does not have carcinogenicity, a tearing property or the like, and is inexpensive; and a hydroxy group protection method which enables the protection of a hydroxy group under acidic conditions. [Solution] A hydroxy group protecting agent in which at least one protecting group is bound to a nitrogen-containing electron-withdrawing heterocyclic ring through any one of an oxygen atom, a sulfur atom and a nitrogen atom. The heterocyclic ring is a triazine ring or the like, and the protecting group is a benzyl group or the like. Specifically, the hydroxy group protecting agent is 2,4,6-tribenzyloxy-1,3,5-triazine, 2,4,6-tris(4-methoxybenzyloxy)-1,3,5-triazine or the like. In addition, 2,4,6-tris(t-butoxy)-1,3,5-triazine or the like can also be used. For protecting a hydroxy group, a compound of interest which has a hydroxy group is reacted with the hydroxy group protecting agent under acidic conditions.
    Type: Application
    Filed: November 16, 2012
    Publication date: November 20, 2014
    Applicant: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY
    Inventors: Munetaka Kunishima, Hikaru Fujita, Kohei Yamada
  • Patent number: 8889677
    Abstract: This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: November 18, 2014
    Assignee: Boehringer Ingellheim International GmbH
    Inventors: Matthias Grauert, Daniel Bischoff, Georg Dahmann, Raimund Kuelzer, Klaus Rudolf
  • Patent number: 8772480
    Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: July 8, 2014
    Assignee: Amgen Inc.
    Inventors: Kristin L. Andrews, Yunxin Y. Bo, Shon Booker, Victor J. Cee, Noel D'Angelo, Bradley J. Herberich, Fang-Tsao Hong, Claire L. M. Jackson, Brian Alan Lanman, Hongyu Liao, Longbin Liu, Nobuko Nishimura, Mark H. Norman, Liping H. Pettus, Anthony B. Reed, Adrian Leonard Smith, Seifu Tadesse, Nuria A. Tamayo, Bin Wu, Ryan Wurz, Kevin C. Yang
  • Publication number: 20140154772
    Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.
    Type: Application
    Filed: November 27, 2013
    Publication date: June 5, 2014
    Applicant: ICOS CORPORATION
    Inventors: Chanchal SADHU, Ken DICK, Jennifer TREIBERG, C. Gregory SOWELL, Edward A. KESICKI, Amy OLIVER
  • Patent number: 8716474
    Abstract: The present invention provides a method of producing 2,4,6-tris(hydroxyphenyl)-1,3,5-triazine compound in which no rapid solidification or the like occurs and generation of by-products is suppressed, thereby enabling to reduce decrease in the yield. Particularly, the present invention is a method of producing 2,4,6-tris(hydroxyphenyl)-1,3,5-triazine compound represented by the following Formula (1): wherein the reaction between cyanuric halide compound represented by the following Formula (2): and hydroxyphenyl compound represented by the following Formula (3): is carried out by using, as the reaction solvent, a solvent containing sulfolane as the main component in the presence of a Lewis acid at an amount of 0.3 to 0.7 equivalent with respect to 1 equivalent of halogen atom of the cyanuric halide compound represented by the Formula (2), or by using a mixed solvent of inert solvent and cycloalkyl alkyl ether represented by the following Formula (4): Z1—O—Z2.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: May 6, 2014
    Assignee: Adeka Corporation
    Inventors: Tetsuo Kamimoto, Masato Suzuki, Yuji Yamazaki
  • Publication number: 20140099518
    Abstract: Disclosed herein are compounds of formula I: X-(L-Z)p-L-R[L-(Z-L)p-Y]q??(I) wherein L is a perfluoropolyether; R is q can be an integer equal to or greater than 1; p can independently be integers from 0 to 7; X and Y can independently be chosen from: —OH, —CH2CH2OH, CH2CH2OCH2CH2OH, —CH2CH(OH)CH2OH, —C6H5, —CH2C6H5, —CH2CH(OH)CH3, F, —CF3, —CF2CF3, piperonyl, triazine, benzotriazole, and derivatives thereof; and Z, if present, can independently be chosen from: —C6H4—, —CH2C6H4CH2—, —CH2CH(OH)CH2—, —CH2CH(OH)CH2CH(OH)CH2—, —CH(OH)CH(OH)CH2—, —CH(CH2OH)—, or —CH(C6H5)—.
    Type: Application
    Filed: October 5, 2012
    Publication date: April 10, 2014
    Applicant: SEAGATE TECHNOLOGY LLC
    Inventors: Xiaoping Yan, Michael Stirniman, Qian Guo, Wenhong Liu
  • Patent number: 8686155
    Abstract: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: April 1, 2014
    Assignee: Amgen Inc.
    Inventors: Victor J. Cee, Philip R. Olivieri, Laurie Schenkel
  • Publication number: 20140087311
    Abstract: The present invention provides a cross-linking agent capable of preventing formation of scum from a bottom anti-reflective coating, and also provides a composition for forming a bottom anti-reflection coating containing the agent. The cross-linking agent is a nitrogen-containing aromatic compound having at least one vinyloxy group or N-methoxymethylamide group, and the composition contains the cross-linking agent. The cross-linking agent of the formula (1) can be produced by reaction of a nitrogen-containing aromatic compound, a halogen compound having a vinyloxy group or N-methoxymethylamide group and a basic compound.
    Type: Application
    Filed: September 26, 2012
    Publication date: March 27, 2014
    Applicant: AZ ELECTRONIC MATERIALS (LUXEMBOURG) S.A.R.L.
    Inventors: Shigemasa NAKASUGI, Shinji MIYAZAKI, Munirathna PADMANABAN, Alberto D. DIOSES
  • Patent number: 8674092
    Abstract: The present invention provides triallyl isocyanurate comprising a less amount of corrosive substances by identifying the corrosive substances among impurities included in the triallyl isocyanurate. Triallyl isocyanurate of the present invention comprises an organic chlorine compound represented by the following chemical formula (I) in an amount of not more than 500 ppm: wherein a bond expressed by a wavy line indicates that the organic chlorine compound is a cis-type compound, a trans-type compound or a mixture comprising the cis-type and trans-type compounds at an optional ratio.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: March 18, 2014
    Assignee: Nippon Kasei Chemical Company Limited
    Inventor: Mabuko Yamaura
  • Publication number: 20140045779
    Abstract: This invention relates with anti-tumor activities of new compounds containing an adamantyl group or analogs thereof.
    Type: Application
    Filed: August 29, 2011
    Publication date: February 13, 2014
    Inventor: Lifeng Xu
  • Publication number: 20140024527
    Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein A is a radical selected from the group consisting of and B1, B2, B3, T, R1, R2 R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention. Also disclosed are compounds useful as intermediates for preparing compounds of Formula 1.
    Type: Application
    Filed: March 29, 2012
    Publication date: January 23, 2014
    Applicant: E I DU DE NEMOURS AND COMPANY
    Inventor: Thomas Martin Stevenson
  • Publication number: 20140024828
    Abstract: The present application relates to a process based on the oxidative ring opening of a compound with oxindole structure for preparation of substituted 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) proceeding from N-sulfonyl-substituted 3-triazinyloxindole of the formula (2-1), and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) thus prepared, and to the use thereof as intermediates for the synthesis of fine chemicals and of active ingredients in the agricultural sector. The invention also relates to a multistage process for preparation of N-alkyl-N-[2-(1,3,5-triazin-2-ylcarbonyl)phenyl]alkanesulfonamides of the formula (4-1), proceeding from a 3-(alkylsulfanyl)-1,3-dihydro-2H-indol-2-one of the formula (7-1), wherein the multistage process also comprises, as a component step, the oxidative ring opening mentioned, and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) which are obtained by the oxidative ring opening and are used as intermediates in the multistage process.
    Type: Application
    Filed: December 19, 2011
    Publication date: January 23, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Gunter Karig, Mark James Ford, Konrad Siegel
  • Publication number: 20140011715
    Abstract: Melamine derivatives and mixtures thereof with aqueous systems, a process for inhibiting corrosion of metals and metal alloys with melamine derivatives and mixtures thereof and the use of melamine derivatives and mixtures thereof as corrosion inhibitors for aqueous systems, for example water/oil mixtures, especially in the field of cleaning compositions, cooling fluids, oilfield chemicals or lubricants.
    Type: Application
    Filed: July 2, 2013
    Publication date: January 9, 2014
    Applicant: BASF SE
    Inventors: Roland BOEHN, Benjamin SCHAEFER, Christian BITTNER, Fabien Jean BRAND, Peter HAENGGI
  • Publication number: 20140005388
    Abstract: Process for the selective N-sulfonylation of oxindoles, in particular process for the N-sulfonylation of 3-triazinyloxindoles, and also N-sulfonyl-substituted 3-triazinyloxindoles and the use of N-sulfonyl-substituted oxindoles and of N-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.
    Type: Application
    Filed: December 19, 2011
    Publication date: January 2, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Gunter Karig, Mark James Ford, Konrad Siegel, Stefan Schnatterer
  • Patent number: 8618101
    Abstract: The present invention provides a novel antagonist: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide: or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected dual CCR-2 and CCR-5 receptor activity. Crystalline forms, metabolites, pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases are also disclosed. The present disclosure also provides processes for preparing compounds of Formula (I) as provided herein, including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide. Compounds that are useful intermediates of the process are also provided herein.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: December 31, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Percy H. Carter, Robert J. Cherney
  • Publication number: 20130345372
    Abstract: Disclosed are polyfunctional sulfur-containing epoxies and compositions containing polyfunctional sulfur-containing epoxies. The polyfunctional sulfur-containing epoxies may be used as a curing agent and combined with polythioethers and/or polysulfides used to provide high elongation sealants useful in aerospace applications.
    Type: Application
    Filed: June 21, 2012
    Publication date: December 26, 2013
    Applicant: PRC-DeSoto International, Inc.
    Inventors: Timothy Blackford, Juexiao Cai, Raquel Keledjian, Renhe Lin, Jose Lozano, Chandra B. Rao, Bruce Virnelson
  • Publication number: 20130345422
    Abstract: Process for the preparation of triazinyl-substituted oxindoles of formula (3) and salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3?) and the use of both for producing crop protection agents.
    Type: Application
    Filed: December 19, 2011
    Publication date: December 26, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Gunter Karig, Mark James Ford, Konrad Siegel
  • Publication number: 20130344287
    Abstract: Disclosed are sulfur-containing polymers containing copolymerizable adhesion promoters and compositions including sealant compositions useful in aerospace applications comprising sulfur-containing polymers containing copolymerizable adhesion promoters. In particular, polythioethers and polysulfides incorporating copolymerizable adhesion promoters are disclosed.
    Type: Application
    Filed: July 12, 2013
    Publication date: December 26, 2013
    Applicant: PRC-DeSoto International, Inc.
    Inventors: Raquel Keledjian, Renhe Lin, Bruce Virnelson
  • Publication number: 20130338312
    Abstract: Certain embodiments described herein are directed to silane coupling agents that may be used, for example, to covalently couple a polymer to a filler. In some examples, devices that include the polymer-silane coupling agent-filler compositions are also described.
    Type: Application
    Filed: August 14, 2013
    Publication date: December 19, 2013
    Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: HUILIN TU, AGATHE ROBISSON, JULIEN RAMIER
  • Publication number: 20130331266
    Abstract: The present invention provides a method for controlling weeds in paddy rice cultivation, which comprises steps of: applying a water-diluted solution comprising a herbicidal compound such as 1-(2-chloro-6-propylimidazo[1,2-b]pyridazin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea to a paddy field; and flooding the paddy field within the first week after the application of the herbicidal compound.
    Type: Application
    Filed: March 6, 2012
    Publication date: December 12, 2013
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Hajime Ikeda, Junko Inaba
  • Publication number: 20130320262
    Abstract: The present invention relates to a compound of a formula (I), (II) or (III), to the use of this compound in an electronic device, and to an electronic device comprising one or more compounds of the formula (I), (II) or (III). The invention furthermore relates to a process for the preparation of a compound of the formula (I), (II) or (III) and to a formulation comprising one or more compounds of the formula (I), (II) or (III).
    Type: Application
    Filed: January 18, 2012
    Publication date: December 5, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Irina Martynova, Amir Hossain Parham, Christof Pflumm
  • Patent number: 8580786
    Abstract: The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: November 12, 2013
    Assignee: Nant Holdings IP, LLC
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Chunlin Tao, Qinwei Wang
  • Publication number: 20130237462
    Abstract: The invention pertains to certain (per)fluoropolyether triazine derivatives comprising at least one triazine group and at least one fluoropolyoxyalkene chain (chain Rf) comprising a fluorocarbon segment having ether linkages in main chain, said chain Rf comprising at least one hydroxyl group, to a method for their manufacture and to their use in lubrication, in particular for lubricating sliding or moving parts of magnetic recording media.
    Type: Application
    Filed: November 28, 2011
    Publication date: September 12, 2013
    Applicant: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.
    Inventors: Roberto Valsecchi, Fabrizio Mutta, Claudio Adolfo Pietro Tonelli
  • Patent number: 8524896
    Abstract: A compound of the formula (I) where, for example, W, X and Y are each CH; R1 and R6 together with the adjacent nitrogen forms a 3 to 10-membered saturated ring, wherein the ring may contain, in addition to the nitrogen and carbon ring members, 1, 2 or 3 heteroatoms and/or heteroatom groups as ring members, independently of one another, selected from the group consisting of sulfur, CO, SO, SO2 and N—R7 and/or the ring may carry 1, 2 or 3 radicals, independently of one another, each selected, for example, from the group consisting of halogen, cyano, nitro, amino, and C1-C6-alkyl. R2 is, for example, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy or C1-C6-alkoxy-C1-C6-alkoxy, and R7 is for example, R10C(?O), C1-C6 alkyl or C1-C6-haloalkyl; and/or salts thereof; and their use as pesticidal agents.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: September 3, 2013
    Assignee: Syngenta Crop Protection LLC
    Inventors: Peter Maienfisch, Ottmar Hueter, Peter Renold, Werner Zambach, Thomas Pitterna
  • Patent number: 8507671
    Abstract: N-Azinyl-N?-aryl ureas and thioureas derivatives are effective at controlling insects.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: August 13, 2013
    Assignee: Dow Agrosciences LLC
    Inventors: Noormohamed M. Niyaz, Ricky Hunter, Timothy C. Johnson, Tony K. Trullinger, Annette V. Brown, Kristy Bryan
  • Patent number: 8492541
    Abstract: Energetic candidate azido heterocycles and their synthesis are described.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: July 23, 2013
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Raja Duddu, Paritosh Dave, Reddy Damavarapu, Rao Surapaneni
  • Patent number: 8461080
    Abstract: The invention relates to aqueous, aluminum silicate-free, highly concentrated suspension concentrates, containing the active substance metribuzin, one or more surfactants based on nonionic polymers from the ‘acrylic grafted polymers’ group, one or more thickeners based on anionic heteropolysaccharides from the xanthan gum group, one or more wetting agents and optionally other components such as antifoaming agents, antifreeze agents and preservatives and other surfactants differing from the aforesaid components.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: June 11, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Frank Sixl, Udo Bickers, Harry Koppert, Juergen Hopert
  • Patent number: 8431697
    Abstract: The present invention provides triallyl isocyanurate comprising a less amount of corrosive substances by identifying the corrosive substances among impurities included in the triallyl isocyanurate. Triallyl isocyanurate of the present invention comprises an organic chlorine compound represented by the following general formula (I) in an amount of not more than 100 ppm: wherein R1 and R2 are respectively a chlorine atom or an allyoxy group with the proviso that at least one of R1 and R2 is a chlorine atom.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: April 30, 2013
    Assignee: Nippon Kasei Chemical Company Limited
    Inventor: Mabuko Yamaura
  • Patent number: 8383812
    Abstract: The present invention provides a novel antagonist: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide: or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected dual CCR-2 and CCR-5 receptor activity. Crystalline forms, metabolites, pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases are also disclosed. The present disclosure also provides processes for preparing compounds of Formula (I) as provided herein, including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide. Compounds that are useful intermediates of the process are also provided herein.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: February 26, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Percy H. Carter, Robert J. Cherney, Victor W. Rosso, Jun Li
  • Patent number: 8362236
    Abstract: The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: January 29, 2013
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuo Shimma, Takuo Tsukuda, Hiroshi Koyano, Atsushi Suda, Tadakatsu Hayase, Kihito Hada, Ken-Ichi Kawasaki, Susumu Komiyama, Naomi Ono, Toshikazu Yamazaki, Ryoichi Saitoh, Masami Kohchi, Kiyoshi Hasegawa
  • Patent number: 8362241
    Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: January 29, 2013
    Assignee: Amgen Inc.
    Inventors: Noel D'Angelo, Fang-Tsao Hong, Mark H. Norman, Adrian L. Smith, Seifu Tadesse
  • Publication number: 20130018155
    Abstract: A polymer compound having a constituent unit represented by the following formula (P-a) and having a molecular weight of 5×102 to 1×107: (wherein Ar2 represents an aromatic group optionally having a substituent, R2 represents a direct bond or an organic group optionally having only an oxygen atom as a hetero atom, E represents a hetero atom, R3 represents a monovalent hydrocarbon group or a hydrogen atom, mt and nt represent each independently an integer of 1 or more, and lt represents an integer of 1 to 3. Each of a plurality of R3s, Es and lts may be mutually the same or different. When there exist a plurality of mts, these may be mutually the same or different. When there exist a plurality of groups in parentheses appended with mt and nt, these may be mutually the same or different.).
    Type: Application
    Filed: March 31, 2011
    Publication date: January 17, 2013
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Kenta Tanaka, Masahiro Fujioka
  • Publication number: 20120316171
    Abstract: Methods and compositions for the treatment and/or management of cancer are disclosed, which comprise the use of tryptophan hydroxylase inhibitors.
    Type: Application
    Filed: November 4, 2010
    Publication date: December 13, 2012
    Inventor: Tamas Oravecz