Boron Or Silicon Containing Patents (Class 544/229)
  • Patent number: 10065975
    Abstract: An amino-containing organosilicon compound having formula (1) is used for surface treatment of an inorganic filler for thereby rendering the filler more compatible with and adhesive to a polymer material. In formula (1), R1 is alkyl, alkenyl, aryl or aralkyl, R2 is alkenyl, aryl or aralkyl, R3 and R4 each are a monovalent hydrocarbon group, and n is 0, 1 or 2.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: September 4, 2018
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Takayuki Honma, Tohru Kubota, Yoichi Tonomura
  • Patent number: 10000529
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 19, 2018
  • Patent number: 9862745
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: January 9, 2018
  • Patent number: 9862812
    Abstract: A composition consisting essentially of 90-99 parts by weight of a nitrogen-containing organoxysilane compound and 1-10 parts by weight of an isomer affords an appropriate cure behavior and is useful as paint additive, adhesive, silane coupling agent, textile treating agent, and surface treating agent.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: January 9, 2018
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Yoichi Tonomura, Tohru Kubota, Masato Kawakami, Naoki Yamauchi, Takayuki Honma
  • Patent number: 9806271
    Abstract: The present disclosure relates to an organic electroluminescent compound of Formula 1 (variables Y1, Y2 and R1 to R4 defined herein), and an organic electroluminescent device comprising the same. The organic electroluminescent compound according to the present disclosure can be used for the manufacture of an organic electroluminescent device showing improvement in luminous efficiency, especially in current efficiency.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: October 31, 2017
    Assignee: ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.
    Inventors: Mi-Ja Lee, Bitnari Kim, Nam-Kyun Kim, Hee-Ryong Kang
  • Patent number: 9777026
    Abstract: Novel branched oligoarylsilanes of general formula (I) A method of preparation of branched oligoarylsilanes is that a compound of general formula (III) Y-Qk-SiArn—R)3??(III), where Y stands for a residue of boronic acid or its ester or Br or I, reacts under Suzuki conditions with a reagent of general formula (IV) A-Xm-A??(IV), where A stands for: Br or I, provided that Y stands for a residue of boronic acid or its ester; or a residue of boronic acid or its ester, provided that Y stands for Br or I. A technical result is preparation of novel compounds, featured by a high luminescence efficiency, efficient intramolecular energy transfer from some molecular fragments to others, and an increased thermal stability.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: October 3, 2017
    Assignee: Luminescent Innovation Technologies LLC
    Inventors: Sergey Anatolyevich Ponomarenko, Oleg Valentinovich Borshchev, Nikolai Mikhailovich Surin, Maksim Sergeevich Skorotetsky
  • Patent number: 9758533
    Abstract: A reaction method comprising combining a carbonyl-substituted arylboronic acid or ester and an ?-effect amine in aqueous solution at a temperature between about ?5 C to 55 C, and a pH between 2 and 8 to produce an adduct. A process is also provided comprising: contacting a composition having a boron atom bonded to a sp2 hybridized carbon, the boron having at least one labile substituent, conjugated with a cis-carbonyl, with an ?-effect amine, in an aqueous medium for a time sufficient to form an adduct, which may proceed to further products.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: September 12, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Susan Bane Tuttle, Ozlem Dilek, Kamalika Mukherjee
  • Patent number: 9315525
    Abstract: A process for producing bortezomib N-(pyrazin-2-yl)carbonyl-L-phenylalanine-L-leucine boronic acid) comprising the step of deprotecting the compound of formula XII: to yield bortezomib.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: April 19, 2016
    Assignee: Lek Pharmaceuticals D.D.
    Inventors: Ivana Gazic Smilovic, Zdenko Casar
  • Patent number: 9233988
    Abstract: Silyl-protected nitrogen-containing cyclic compounds having formula (1) are provided wherein R1, R2 and R3 each are a monovalent hydrocarbon group, R4 and R5 each are a divalent hydrocarbon group, R6, R7 and R8 each are H or a monovalent hydrocarbon group. A is —C(O)OR9 or —C?N, R9 is a monovalent hydrocarbon group, and a is 0 or 1. The compounds are added to polyurethane, polyester or polycarbonate resins to form one part type curable compositions for imparting stiffness, mechanical strength and transparency thereto.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: January 12, 2016
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Yoichi Tonomura, Tohru Kubota
  • Patent number: 9217001
    Abstract: The present invention provides process for preparation of crystalline Bortezomib (Ia) as its monohydrate which is designated as crystalline Form-SB and characterized by having water content ranging between 3.5-6.0% w/w; X-ray powder diffraction pattern comprising characteristic 2?° peaks selected from the XRPD peak set of 5.6, 7.5, 9.8, 10.2, 11.3, 15.1, 18.0, 20.5, 21.5 and 23.6±0.20 2?°, wherein peaks at 9.8 and 11.39±0.20 2?° are un-split and 100% intensity peak is present at 5.6±0.20 2?°, DSC isotherm comprising the endothermic peaks ranging between 45 to 60° C. (Peak-1) and 175 to 185° C. (Peak-2) and IR absorption characteristic peaks approximately at 3387 cm?1, 3304 cm?1, 2953 cm?1, 2927 cm?1, 2868 cm?1, 1627 cm?1, 1455 cm?1, 1400 cm?1, 1201 cm?1, 1150 cm?1, 1020 cm?1, 747 cm?1 and 702 cm?1 and Raman absorption spectra having characteristic peaks approximately at 3066 cm?1, 1583 cm?1, 1528 cm?1, 1281 cm?1, 1213 cm?1, 1035 cm?1, 1022 cm?1 and 1004 cm?1.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: December 22, 2015
    Assignee: SHILPA MEDICARE LIMITED
    Inventors: Vimal Kumar Shrawat, Rafiuddin, Vinod Kumar Singh, Akshay Kant Chaturvedi
  • Patent number: 9156858
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: October 13, 2015
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Raja Reddy, Tomasz Glinka, Maxim Totrov, Scott Hecker
  • Patent number: 9136484
    Abstract: The present invention relates to electroluminescent compounds of formula 1 where A and/or B represent fluorene, carbazole, dibenzo[b,d]thiophene or dibenzo[b,d]furan derivatives and L1, X1, Ar1, Ar2, R5, R6 and R7 are as defined herein, and organic electroluminescent devices comprising the same. The compounds according to the present invention have an advantage in manufacturing an organic electroluminescent device which has a high luminous efficiency and a long operational lifetime.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: September 15, 2015
    Assignee: Rohm and Haas Electronics Materials Korea Ltd.
    Inventors: Hee-Sook Kim, Seok-Keun Yoon, Kyung-Joo Lee, Hong-Yoep Na, Nam-Kyun Kim, Young-Jun Cho, Hyuck-Joo Kwon, Bong-Ok Kim
  • Patent number: 9090754
    Abstract: A method for producing a modified conjugated diene polymer usable as a raw material of a crosslinked polymer which is used for use in tires and the like of automobiles and can enhance low fuel consumption performance of automobiles and the like is provided. A method for producing a modified conjugated diene polymer comprising a polymerization step in which a monomer including a conjugated diene compound or a monomer including a conjugated diene compound and an aromatic vinyl compound is polymerized in the presence of at least one compound selected from the group consisting of the following formulae (1) and (2) and an alkali metal compound or an alkaline earth metal compound to obtain a modified conjugated diene polymer. (In the formulae, A1 is a hydrocarbylsilyl group in which three H's (hydrogen atoms) in a “—SiH3” structure are each substituted by a hydrocarbyl group, and R1 and R2 are hydrocarbylene groups.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: July 28, 2015
    Assignee: JSR CORPORATION
    Inventors: Hiroyuki Morita, Takeshi Yuasa, Koichiro Tani, Naoya Nosaka, Ryouji Tanaka
  • Patent number: 9089139
    Abstract: Agri-horticultural pest control compositions having outstanding control effect on pests, in particular, agri-horticultural pests, which comprise as active ingredients one or more 4-(3-butynyl)aminopyrimidine derivatives represented by the general formula [I], namely, where R1 is typically selected from among: a) phenyl c) —SiR5R6R7 (R5, R6, and R7 which may be the same or different represent a linear or branched alkyl having 1-6 carbon atoms, a linear or branched haloalkyl having 1-3 carbon atoms which is substituted by one halogen atom, a linear or branched cyanoalkyl having 1-3 carbon atoms which is substituted by one cyano group, and phenyl); d) hydropgen atom; R2 typically represents a hydrogen atom; R3 typically represents a hydrogen atom; R4 represents a hydrogen atom and one or more agri-horticultural pest control compounds selected from among agri-horticultural antimicrobial compounds, say, multi-site contact active compounds, nucleic acids synthesis inhibitory active compounds, mitosis and cell
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: July 28, 2015
    Assignee: SDS Biotech K. K.
    Inventors: Masaaki Sakai, Tomoaki Matsumura, Satohiro Midorikawa, Takashi Nomoto, Tomoko Muraki, Ryutaro Katsuki
  • Publication number: 20150147893
    Abstract: Classes of liquid aminosilanes have been found which allow for the production of silicon carbo-nitride films of the general formula SixCyNz. These aminosilanes, in contrast, to some of the precursors employed heretofore, are liquid at room temperature and pressure allowing for convenient handling. In addition, the invention relates to a process for producing such films. The classes of compounds are generally represented by the formulas: and mixtures thereof, wherein R and R1 in the formulas represent aliphatic groups typically having from 2 to about 10 carbon atoms, e.g., alkyl, cycloalkyl with R and R1 in formula A also being combinable into a cyclic group, and R2 representing a single bond, (CH2)n, a ring, or SiH2.
    Type: Application
    Filed: December 16, 2014
    Publication date: May 28, 2015
    Applicant: AIR PRODUCTS AND CHEMICALS, INC.
    Inventors: Manchao Xiao, Arthur Kenneth Hochberg
  • Publication number: 20150144937
    Abstract: Provided are a compound represented by the following Chemical Formula 1 for an organic optoelectronic device, an organic light emitting diode including the same, and a display device including the organic light emitting diode. The structure of Chemical Formula 1 is described in the specification. The compound for the organic photoelectric device provides an organic light emitting diode having excellent life-span characteristics due to excellent electrochemical and thermal stability and high luminous efficiency at a low driving voltage.
    Type: Application
    Filed: February 3, 2015
    Publication date: May 28, 2015
    Inventors: Moo-Jin PARK, Eun-Sun YU, Mi-Young CHAE, Byung-Ku KIM, Hyo-Ju SEO, Jae-Deuk YANG
  • Publication number: 20150147341
    Abstract: There is disclosed is a method of treating a pulmonary disease using a pyrimidinecarboxamide compound, and a pharmaceutical composition suitable for inhalation comprising the pyrimidinecarboxamide compound.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 28, 2015
    Inventors: John A. Zebala, Dean Y. Maeda, Aaron D. Schuler
  • Patent number: 9040504
    Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: May 26, 2015
    Assignee: VENATORX PHARMACEUTICALS, INC.
    Inventors: Christopher J. Burns, Denis Daigle, Bin Liu, Daniel McGarry, Daniel C. Pevear, Robert E. Lee Trout, Randy W. Jackson
  • Publication number: 20150141372
    Abstract: Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
    Type: Application
    Filed: May 8, 2013
    Publication date: May 21, 2015
    Inventors: Marion Hitchcock, Christoph-Stephan Hilger, Anne Mengel, Hans Briem, Simon Holton, Vera Pütter, Gerhard Siemeister, Stefan Prechtl, Amaury Ernesto Fernández-Montalván, Christian Stegmann, Cornelia Preuße, Mark Jean Gnoth
  • Publication number: 20150119364
    Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
    Type: Application
    Filed: November 10, 2014
    Publication date: April 30, 2015
    Inventors: Stephen J. BAKER, Tsutomu Akama, Michael Richard Kevin Alley, Stephen J. Benkovic, Michael DiPierro, Vincent S. Hernandez, Karin M. Hold, Isaac Kennedy, Igor Likhotvorik, Weimin Mao, Kirk Maples, Jacob J. Plattner, Fernando Rock, Virginia Sanders, Aaron M. Stemphoski, George Petros Yiannikouros, Siead Zegar, Yong-Kang Zhang, Huchen Zhou
  • Publication number: 20150119362
    Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.
    Type: Application
    Filed: October 24, 2013
    Publication date: April 30, 2015
    Inventors: Mark E. Gurney, Timothy J. Hagen, Joel R. Walker, Xuesheng Mo, A. Samuel Vellekoop, Robert Campbell, Lei Zhu, Donna L. Romero
  • Publication number: 20150111851
    Abstract: This present disclosure is related to the field of 5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 23, 2015
    Inventors: Timothy Boebel, Kristy Bryan, Peter Lee Johnson, Beth Lorsbach, Kevin G. Meyer, W. John Owen, Michael T. Sullenberger, Jeffery D. Webster, Chenglin Yao
  • Patent number: 9012431
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: April 21, 2015
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventor: Tsutomu Akama
  • Publication number: 20150105554
    Abstract: The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof, as well as to key intermediates towards their synthesis. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.
    Type: Application
    Filed: May 10, 2013
    Publication date: April 16, 2015
    Inventors: Carlo Gambacorti-Passerini, Luca Mologni, Leonardo Scapozza, William Bisson, Shaheen Ahmed, Peter Goekjian, Sébastien Tardy, Alexandre Orsato, David Gueyrard, Joseph Benoit
  • Publication number: 20150105553
    Abstract: The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 ?M and a linker element connected to the diversity element. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or non-covalent interaction with a binding partner of the linker element. The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof. Also disclosed is a method of screening for therapeutic multimer precursors which bind to a target molecule associated with a condition and a method of screening for linker elements capable of binding to one another.
    Type: Application
    Filed: July 29, 2014
    Publication date: April 16, 2015
    Inventors: Francis BARANY, Maneesh PINGLE, Donald BERGSTROM, Sarah Filippa GIARDINA
  • Publication number: 20150099277
    Abstract: Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines and diazonorcaradienes.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 9, 2015
    Inventors: Neal K. Devaraj, Jun Yang, Jolita Seckute
  • Patent number: 8999734
    Abstract: Disclosed herein are mono-functional silylating compounds that may exhibit enhanced silylating capabilities. Also disclosed are method of synthesizing and using these compounds. Finally methods to determine effective silylation are also disclosed.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: April 7, 2015
    Assignee: American Air Liquide, Inc.
    Inventors: James J. F. McAndrew, Curtis Anderson, Christian Dussarrat
  • Publication number: 20150072942
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: April 8, 2014
    Publication date: March 12, 2015
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross L. Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Publication number: 20150041770
    Abstract: A heterocyclic compound and an organic light-emitting device including the heterocyclic compound, the heterocyclic compound being represented by Formula 1 below:
    Type: Application
    Filed: March 21, 2014
    Publication date: February 12, 2015
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventor: Jung-Sub LEE
  • Publication number: 20150038460
    Abstract: The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Application
    Filed: October 16, 2014
    Publication date: February 5, 2015
    Applicant: Genentech, Inc.
    Inventors: Steven Staben, Jianwen Feng, Pui Leng Loke, Christian A.G.N. Montalbetti
  • Publication number: 20150038706
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: March 6, 2014
    Publication date: February 5, 2015
  • Publication number: 20150038461
    Abstract: There is disclosed a pyrimidinecarboxamide compound useful as a pharmaceutical agent, synthetic processes, and pharmaceutical compositions which include the pyrimidinecarboxamide compound. More specifically, there is disclosed a CXCR1/2 inhibitor useful for treating a variety of inflammatory and neoplastic disorders.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 5, 2015
    Applicant: Syntrix Biosystems, Inc.
    Inventors: John A. Zebala, Dean Y. Maeda, Aaron D. Schuler
  • Patent number: 8937183
    Abstract: The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: January 20, 2015
    Assignee: Promega Corporation
    Inventors: Dieter Klaubert, John Shultz, James Unch, Michael P. Valley, Hui Wang, Wenhui Zhou
  • Publication number: 20150018309
    Abstract: In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: February 23, 2013
    Publication date: January 15, 2015
    Inventors: Craig W Lindsley, P. Jeffrey Conn, Michael R. Wood, Bruce J. Melancon, James C. Tarr, James M. Salovich
  • Patent number: 8927557
    Abstract: The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: January 6, 2015
    Assignee: Takeda GmbH
    Inventors: Josef Stadlwieser, Beate Schmidt, Heiko Bernsmann, Torsten Dunkern, Ewald Benediktus, Andreas Pahl, Ragna Hussong, Olaf Nimz, Matthias Mueller, Martin Viertelhaus
  • Publication number: 20150005257
    Abstract: An arylalkyloxypyrimidine derivative represented by the formula (I) wherein R1 is an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a haloalkyl group, a haloalkenyl group, a haloalkynyl group, an alkoxyalkyl group, a dioxolane group and the like; R2 and R3 are each a hydrogen atom, an alkyl group and the like; X is an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a haloalkyl group, a haloalkenyl group, a haloalkynyl group, a trialkylsilyl group and the like; Y is CH or a nitrogen atom; q is an integer of 1 to 3; m is an integer of 0 to 5; and n is 0 or 1 or a salt thereof, and an agrohorticultural insecticide containing the compound as an active ingredient and a method of use thereof.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 1, 2015
    Applicant: NIHON NOHYAKU CO. OLTD.
    Inventors: Eikou Satoh, Tetsuya Murata, Hiroto Harayama, Motofumi Nakano, Kosuke Fukatsu, Kayo Inukai, Ryota Kasahara, Yutaka Abe, Nobuyuki Hayashi, Naoya Fujita
  • Patent number: 8920944
    Abstract: Use of a precursor of an n-dopant for doping an organic semiconductive material, as a blocking layer, as a charge injection layer, as an electrode material, as a storage material or as a semiconductor material itself in electronic or optoelectronic components, the precursor being selected from the following formulae 1-3c:
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: December 30, 2014
    Assignee: Novaled AG
    Inventors: Michael Limmert, Andrea Lux, Horst Hartmann
  • Publication number: 20140371175
    Abstract: Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.
    Type: Application
    Filed: August 28, 2014
    Publication date: December 18, 2014
    Inventors: Michael Van Zandt, Adam Golebiowski, Min Koo Ji, Darren Whitehouse, Todd Ryder, Raymond Paul Beckett
  • Publication number: 20140364395
    Abstract: The present invention is directed to pyranyl aryl methyl benzoquinazolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 11, 2014
    Inventors: Scott D. Kuduk, Ronald K. Chang, Thomas J. Greshock
  • Publication number: 20140361224
    Abstract: The present invention relates to boron compounds for use in electronic devices, especially organic electroluminescent devices, and to a process for preparing these compounds and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
    Type: Application
    Filed: November 26, 2012
    Publication date: December 11, 2014
    Inventors: Teresa Mjuica-Fernaud, Amir Hossain Parham, Stoessel Philipp, Christof Pflumm, Arne Buesing, Thomas Eberle
  • Publication number: 20140364560
    Abstract: This invention relates to hydrolysable silanes useful in the modification of elastomers, and as coupling agents for diene elastomer compositions containing a filler. In particular the invention relates to novel hydrolysable silanes containing a piperazine ring and an ether or thioether linkage.
    Type: Application
    Filed: December 7, 2012
    Publication date: December 11, 2014
    Inventors: Michael Wolfgang Backer, Thomas Chaussee, Damien Deheunynck, Sebastien Grofils
  • Publication number: 20140364396
    Abstract: The present invention provides compounds of Formula (I) as inhibitors of LMP7 for the treatment of autoimmune and inflammatory diseases.
    Type: Application
    Filed: December 21, 2012
    Publication date: December 11, 2014
    Inventors: Dominique Swinnen, Stefano Crosignani, Jeyaprakashnarayanan Seenisamy, Federica Morandi
  • Publication number: 20140357862
    Abstract: Silyl-protected nitrogen-containing cyclic compounds having formula (1) are provided wherein R1, R2 and R3 each are a monovalent hydrocarbon group, R4 and R5 each are a divalent hydrocarbon group, R6, R7 and R8 each are H or a monovalent hydrocarbon group. A is —C(O)OR9 or —C?N, R9 is a monovalent hydrocarbon group, and a is 0 or 1. The compounds are added to polyurethane, polyester or polycarbonate resins to form one part type curable compositions for imparting stiffness, mechanical strength and transparency thereto.
    Type: Application
    Filed: April 29, 2014
    Publication date: December 4, 2014
    Applicant: Shin-Etsu Chemical Co., Ltd.
    Inventors: Yoichi TONOMURA, Tohru KUBOTA
  • Publication number: 20140349282
    Abstract: The invention pertains to a near-infrared fluorescent dye that is cell permeable and can be attached to selected proteins in living cells. The dye has the general formula or its corresponding spirolactone wherein Y is chosen from the group consisting of Si, Ge and Sn; R0 is —COO? or COOH; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are substituents, including hydrogen, independently from each other. The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows minimal background binding to biomolecules and biomolecular structures.
    Type: Application
    Filed: August 26, 2011
    Publication date: November 27, 2014
    Inventors: Keitaro Umezawa, Lukinavicius Grazvydas, Kai Johnsson
  • Patent number: 8884009
    Abstract: The invention relates to processes of making bortezomib of formula (1) enantiomers thereof and/or intermediates thereof, comprising at least one step of coupling a carboxylic acid with an amine, wherein the coupling step is performed in a presence of the compound of formula (8), wherein A is C1-C6 alkyl group, preferably wherein A is n-propyl group.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 11, 2014
    Assignee: Synthon BV
    Inventors: Jakub Castulik, Miroslav Zabadal
  • Publication number: 20140330007
    Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
    Type: Application
    Filed: July 16, 2014
    Publication date: November 6, 2014
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Ankush Argade, Donald G. Payan, Susan Molineaux, Sacha J. Holland, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li, Alexander B. Rossi
  • Publication number: 20140330008
    Abstract: The present invention relates to a process for the preparation of 2-amino-pyrimidine-5-boronic acid of formula (I). or salts or esters thereof.
    Type: Application
    Filed: May 5, 2014
    Publication date: November 6, 2014
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Torsten Busch, Michael Nonnenmacher
  • Publication number: 20140329257
    Abstract: The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.
    Type: Application
    Filed: July 21, 2014
    Publication date: November 6, 2014
    Inventors: Dieter Klaubert, John Shultz, James Unch, Michael P. Valley, Hui Wang, Wenhui Zhou
  • Publication number: 20140323435
    Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.
    Type: Application
    Filed: May 22, 2014
    Publication date: October 30, 2014
    Applicants: Cancer Research Technology Limited, Cephalon, Inc.
    Inventors: Bruce D. Dorsey, Keith S. Learn, Emma L. Morris, Gregory R. Ott, Jonathan R.A. Roffey, Christelle N. Soudy, Jason C. Wagner
  • Publication number: 20140312338
    Abstract: An aromatic heterocyclic derivative is represented by a formula (1) below. In the formula (1), X1 to X3 each are a nitrogen atom or CR1, with a proviso that at least one of X1 to X3 is a nitrogen atom. A is represented by a formula (2) and B is represented by a formula (4) below.
    Type: Application
    Filed: November 21, 2012
    Publication date: October 23, 2014
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Sayaka Mizutani, Takayasu Sado